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  1. Article ; Online: Structural biology in the age of AI.

    Subramaniam, Sriram

    Nature methods

    2023  Volume 21, Issue 1, Page(s) 18–19

    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-023-02123-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Learning from Gobind Khorana: "The difficult we do today, the impossible tomorrow".

    Subramaniam, Sriram

    Biophysical reviews

    2022  Volume 15, Issue 1, Page(s) 89–91

    Abstract: Prof. Har Gobind Khorana was one of the greatest scientists of the twentieth century. Drawing on his strong roots in organic chemistry, he had a remarkable ability to select and focus his intellect on successfully addressing some of the most important ... ...

    Abstract Prof. Har Gobind Khorana was one of the greatest scientists of the twentieth century. Drawing on his strong roots in organic chemistry, he had a remarkable ability to select and focus his intellect on successfully addressing some of the most important challenges in modern biology in a career spanning nearly 6 decades. His pioneering contributions in gene synthesis and protein structure-function studies, and more broadly in what he termed "chemical biology," continue to have a major impact on modern biomedical science.
    Language English
    Publishing date 2022-11-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2486483-3
    ISSN 1867-2469 ; 1867-2450
    ISSN (online) 1867-2469
    ISSN 1867-2450
    DOI 10.1007/s12551-022-01019-4
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  3. Article: COVID-19 and cryo-EM.

    Subramaniam, Sriram

    IUCrJ

    2020  Volume 7, Issue Pt 4, Page(s) 575–576

    Abstract: The application of cryo-EM methods to study SARS-CoV-2 proteins provides a convincing demonstration of the power of cryo-EM in the arsenal of structural biology. ...

    Abstract The application of cryo-EM methods to study SARS-CoV-2 proteins provides a convincing demonstration of the power of cryo-EM in the arsenal of structural biology.
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2754953-7
    ISSN 2052-2525
    ISSN 2052-2525
    DOI 10.1107/S2052252520008799
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  4. Article ; Online: COVID-19 and cryo-EM

    Sriram Subramaniam

    IUCrJ, Vol 7, Iss 4, Pp 575-

    2020  Volume 576

    Keywords covid-19 ; cryo-em ; coronaviruses ; sars-cov-2 ; editorial ; Science ; Q ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher International Union of Crystallography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: The cryo-EM revolution: fueling the next phase.

    Subramaniam, Sriram

    IUCrJ

    2019  Volume 6, Issue Pt 1, Page(s) 1–2

    Abstract: Cryo-EM has seen unabated growth and adoption in the last three years. Continued support at institutional, regional and national levels is essential to sustain its evolution. ...

    Abstract Cryo-EM has seen unabated growth and adoption in the last three years. Continued support at institutional, regional and national levels is essential to sustain its evolution.
    Language English
    Publishing date 2019-01-01
    Publishing country England
    Document type Editorial
    ZDB-ID 2754953-7
    ISSN 2052-2525
    ISSN 2052-2525
    DOI 10.1107/S2052252519000277
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  6. Article ; Online: Introduction: Cryo-EM in Biology and Materials Research.

    Subramaniam, Sriram / Danino, Dganit

    Chemical reviews

    2022  Volume 122, Issue 17, Page(s) 13881–13882

    MeSH term(s) Biology ; Cryoelectron Microscopy ; Models, Molecular
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.2c00494
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    In stock of ZB MED Bonn / Germany

    Z 4' 49/78: Show issues
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  7. Article ; Online: A paradigm shift in structural biology.

    Subramaniam, Sriram / Kleywegt, Gerard J

    Nature methods

    2022  Volume 19, Issue 1, Page(s) 20–23

    MeSH term(s) Algorithms ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/metabolism ; Computational Biology/methods ; Cryoelectron Microscopy ; Databases, Protein/statistics & numerical data ; Humans ; Ligands ; Models, Molecular ; Protein Conformation ; Protein Interaction Maps ; Proteins/chemistry ; Transcription Factors/chemistry ; Transcription Factors/metabolism
    Chemical Substances BRD4 protein, human ; Cell Cycle Proteins ; Ligands ; Proteins ; Transcription Factors
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-021-01361-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: AAA ATPase protein-protein interactions as therapeutic targets in cancer.

    Mannar, Dhiraj / Ahmed, Sana / Subramaniam, Sriram

    Current opinion in cell biology

    2023  Volume 86, Page(s) 102291

    Abstract: AAA ATPases are a conserved group of enzymes that couple ATP hydrolysis to diverse activities critical for cellular homeostasis by targeted protein-protein interactions. Some of these interactions are potential therapeutic targets because of their role ... ...

    Abstract AAA ATPases are a conserved group of enzymes that couple ATP hydrolysis to diverse activities critical for cellular homeostasis by targeted protein-protein interactions. Some of these interactions are potential therapeutic targets because of their role in cancers which rely on increased AAA ATPase activities for maintenance of genomic stability. Two well-characterized members of this family are p97/VCP and RUVBL ATPases where there is a growing understanding of their structure and function, as well as an emerging landscape of selective inhibitors. Here we highlight recent progress in this field, with particular emphasis on structural advances enabled by cryo-electron microscopy (cryo-EM).
    MeSH term(s) Humans ; ATPases Associated with Diverse Cellular Activities ; Cryoelectron Microscopy ; Adenosine Triphosphatases/metabolism ; Neoplasms/drug therapy ; Adenosine Triphosphate
    Chemical Substances ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; Adenosine Triphosphatases (EC 3.6.1.-) ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2023.102291
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    Zs.A 2963: Show issues Location:
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  9. Article: Cryo-EM at ACA 2022.

    Subramaniam, Sriram / Kotecha, Abhay / Davis, Joseph H

    IUCrJ

    2022  Volume 9, Issue Pt 6, Page(s) 713–714

    Abstract: The 2022 meeting of the American Crystallographic Association in Portland was an inspiring event, addressing a range of both conventional and emerging themes in structural biology. The increasing emphasis at the conference on methods outside the ... ...

    Abstract The 2022 meeting of the American Crystallographic Association in Portland was an inspiring event, addressing a range of both conventional and emerging themes in structural biology. The increasing emphasis at the conference on methods outside the conventional envelope of crystallography, especially cryo-electron microscopy, is discussed.
    Language English
    Publishing date 2022-10-14
    Publishing country England
    Document type Editorial
    ZDB-ID 2754953-7
    ISSN 2052-2525
    ISSN 2052-2525
    DOI 10.1107/S2052252522009721
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  10. Article ; Online: Surgery for deep infiltrating rectal endometriosis-Selecting the right approach.

    Jeyabalan, Tamyenthini / Ambikapathi, Theiyallen / Subramaniam, Sentilnathan / Sriram, Ratha Krishnan / Azizan, Nornazirah / Hayati, Firdaus

    The journal of obstetrics and gynaecology research

    2022  Volume 48, Issue 8, Page(s) 2219–2223

    Abstract: Endometriosis involving the bowel is a form of deep infiltrating endometriosis (DIE). The endometriotic lesions can infiltrate the bowel layers mimicking a malignancy. The majority of bowel involvement happens in the colon and rectum. We report our ... ...

    Abstract Endometriosis involving the bowel is a form of deep infiltrating endometriosis (DIE). The endometriotic lesions can infiltrate the bowel layers mimicking a malignancy. The majority of bowel involvement happens in the colon and rectum. We report our experience in surgically managing rectal endometriosis in two patients, one via a conservative approach and the other with a more radical approach and their associated short-term and long-term outcomes are observed. In principle, surgery remains the mainstay of treatment in managing rectal DIE with adjuvant hormonal therapy. The selection of surgical approach should be based on disease factors such as the size of the lesions and extent of the disease, patient factors including fitness for surgery and expectations as well as logistics and resource limitations.
    MeSH term(s) Digestive System Surgical Procedures ; Endometriosis/pathology ; Endometriosis/surgery ; Female ; Humans ; Laparoscopy ; Postoperative Complications/pathology ; Rectal Diseases/surgery ; Rectum/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-06-05
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1327307-3
    ISSN 1447-0756 ; 1341-8076
    ISSN (online) 1447-0756
    ISSN 1341-8076
    DOI 10.1111/jog.15322
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