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Article: Prevalence And Risk Factors Of Sarcopenia In Patients With Cirrhosis: An Observational Study.

Majeed, Ammara Abdul / Shaikh, Hafeezullah / Rasheed, Abdur / Khalid, Raheela / Qazi Arisa, Fakhar Ali / Ghias, Hafsa

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73, Issue 10, Page(s) 2004–2008

Abstract: Objective: To identify the prevalence and predictors of sarcopenia in cirrhotic patients.: Methods: This observational, cross-sectional study was conducted at the National Institute of Liver and Gastrointestinal Diseases, Karachi, from January 30 to ... ...

Abstract	Objective: To identify the prevalence and predictors of sarcopenia in cirrhotic patients. Methods: This observational, cross-sectional study was conducted at the National Institute of Liver and Gastrointestinal Diseases, Karachi, from January 30 to July 31, 2021, and comprised cirrhotic patients of either gender between aged 18-60 years. Clinical and laboratory data was recorded for each patient. Body weight was adjusted for ascites. Sarcopenia was determined based on the Asian Working Group for Sarcopenia-2019 guideline via hand grip strength and chair standing. Independent predictors for sarcopenia were identified. Data was analysed using SPSS 26. Results: Out of 434 cirrhotic patients assessed, 386(89%) were enrolled. Of them, 237(61.4%) were males, 149(38.6%) were females, 327(84.7%) were aged >45 years and 201(52.1%) had moderate professional activity. Sarcopenia was detected in 314(81.3%) patients; 185(59%) males and 129(41%) females. Age, chair exercise and hand grip scores as well as haemoglobin, albumin and potassium levels were significantly associated with sarcopenia (p<0.05). Conclusion: Sarcopenia was found to be very common in patients with cirrhosis. Increasing age, concomitant comorbidities, and presence of liver decompensation increased the risk of sarcopenia.
MeSH term(s)	Female ; Humans ; Male ; Cross-Sectional Studies ; Fibrosis ; Hand Strength ; Liver Cirrhosis/complications ; Liver Cirrhosis/epidemiology ; Prevalence ; Risk Factors ; Sarcopenia/epidemiology ; Adolescent ; Young Adult ; Adult ; Middle Aged
Language	English
Publishing date	2023-10-24
Publishing country	Pakistan
Document type	Observational Study ; Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.8461
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Article: Effects of Iron Oxide Nanoparticle Supplementation on the Growth Performance, Serum Metabolites, Meat Quality, and Jejunal Basal Morphology in Broilers.

Basharat, Sara / Tahir, Sajid Khan / Majeed, Khalid Abdul / Yousaf, Muhammad Shahbaz / Hussain, Khalil Khadim / Rashid, Muhammad A / Zaneb, Hafsa / Rehman, Habib

Animals : an open access journal from MDPI

2023 Volume 14, Issue 1

Abstract: The current research aimed to evaluate the supplemental effects of iron oxide nanoparticles (IONPs) on production performance, viscera development, blood metabolites, redox status, meat quality, and jejunal histology in broilers. A total of 300 day-old ... ...

Abstract	The current research aimed to evaluate the supplemental effects of iron oxide nanoparticles (IONPs) on production performance, viscera development, blood metabolites, redox status, meat quality, and jejunal histology in broilers. A total of 300 day-old broilers were randomly divided into six groups with five replicates per group. Birds were fed on a corn soybean-based diet supplemented with 0, 20, 40, 60, or 80 mg/kg IONPs or 80 mg/kg of FeSO
Language	English
Publishing date	2023-12-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14010099
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Article ; Online: Zieve Syndrome: A Clinical Triad, or Perchance a Quartet?

Reyes, Jonathan Vincent M / Ahmad, Saad / Majeed, Hafsa / Kandoth, Eugenio / Lieber, Joseph J

Journal of investigative medicine high impact case reports

2022 Volume 10, Page(s) 23247096221121393

Abstract: Zieve syndrome presents with a triad of hemolytic anemia, unexplained jaundice, and hyperlipidemia secondary to alcohol use/alcohol-induced liver injury, highlighting hemolytic anemia as the hallmark feature. Zieve syndrome is more common than originally ...

Abstract	Zieve syndrome presents with a triad of hemolytic anemia, unexplained jaundice, and hyperlipidemia secondary to alcohol use/alcohol-induced liver injury, highlighting hemolytic anemia as the hallmark feature. Zieve syndrome is more common than originally perceived as its incidence is estimated to be 1 in 1600 admissions, but its mechanism is still poorly understood. This is a case of a 29-year-old man who developed Zieve syndrome shortly after admission for pancreatitis secondary to alcohol use disorder. Early diagnosis is important to reduce unnecessary tests and interventions. Further studies should be considered to evaluate the association between Zieve syndrome and pancreatitis.
MeSH term(s)	Adult ; Alcoholism/complications ; Anemia, Hemolytic/complications ; Humans ; Hyperlipidemias/complications ; Jaundice/complications ; Male ; Pancreatitis/complications ; Pancreatitis/etiology
Language	English
Publishing date	2022-09-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2710326-2
ISSN	2324-7096 ; 2324-7096
ISSN (online)	2324-7096
ISSN	2324-7096
DOI	10.1177/23247096221121393
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Article ; Online: Integrated Water Resource Management Using Water Evaluation and Planning Model

Hira Khanam / Sikandar Ali / Muhammad Zaman / Muhammad Adnan Shahid / Hafsa Muzammal / Muhammad Zeeshan Khan / Muhammad Safdar / Muhammad Danish Majeed

Environmental Sciences Proceedings, Vol 25, Iss 55, p

A Case Study of Lower Bari Doab Canal, Pakistan

2023 Volume 55

Abstract: Freshwater scarcity is a global concern and is caused by the overuse of water, exceeding the sustainable level. In Pakistan, overpopulation, climate change alleviation, and economic development influence the asset of water. For water management, ... ...

Abstract	Freshwater scarcity is a global concern and is caused by the overuse of water, exceeding the sustainable level. In Pakistan, overpopulation, climate change alleviation, and economic development influence the asset of water. For water management, development, and conservation, policymakers need to formulate the right plans and projects. For this purpose, they need to evaluate the impact of different projects and plans and evaluate considerable data and information. Different tools are being adopted for integrated water resource management. Among them, WEAP is user-friendly, reliable, and efficient, and is used widely across the globe. It will aid the policymakers to develop suitable projects and plans. This study was carried out by using WEAP, in the Lower Bari Doab Canal command area (LBDC), Punjab, Pakistan. This study sheds light on the current water allocation situation and simulated scenarios of population growth rates and economic growth to evaluate the future water demand situation. The results of the current account year (2015) show that the domestic water demand of Okara (101.51 MCM) and the agricultural water demand (1713 MCM) of Sahiwal was seen to be the maximum among the four districts. Unmet demand was found to be maximum for the districts laying in the tail end (Sahiwal and Khanewal). The results of the scenarios show that, if the current water consumption, population growth, and economic development continue, unmet demand will increase in the future, and if the population grows at a higher rate and economic development increases, it will result in higher unmet water demand in the coming years. WEAP was found to be a user-friendly and efficient model to better understand water demand.
Keywords	demand ; WEAP ; LBDC ; unmet demand ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Impacts of Climate Change on Monsoon Flood Situations in Pakistan

Hafsa Muzammil / Muhammad Zaman / Muhammad Adnan Shahid / Muhammad Safdar / Muhammad Danish Majeed / Rehan Mehmood Sabir

Environmental Sciences Proceedings, Vol 25, Iss 63, p

2023 Volume 63

Abstract: In this study, we present a comprehensive and detailed analysis to identify and quantify spatial patterns of heavy, very heavy, and extremely heavy rainfall, as well as the trends that have developed over the past seven decades (1951 to 2020) of the ... ...

Abstract	In this study, we present a comprehensive and detailed analysis to identify and quantify spatial patterns of heavy, very heavy, and extremely heavy rainfall, as well as the trends that have developed over the past seven decades (1951 to 2020) of the monsoon months (June to September) under a warming scenario. We also project these extreme rainfall counts during the near (2036–2060) and late 21st century (2075–2099) for comparison to the historical period (1990–2014). The 5-day maximum rainfall over the provinces of Sindh and Baluchistan is currently about 75% more intense than it would have been without the climate warming by 1.2 °C, and the 60-day rainfall across the basin is currently about 50% more intense. This means that heavy rainfall is now more likely to occur. Due to the high-level of rainfall variability in the area, there is significant uncertainty regarding these estimations, and the causes of the observed changes are not just limited to climate change. However, most of the models and observations we have analyzed for the 5-day rainfall extreme indicate that severe rainfall has been heavier than Pakistan has warmed. According to some of these models, the intensity of the rainfall might have increased by 50% due to climate change under the 5-day event threshold. The model predicts that rainfall intensity will greatly rise in the future for the 5-day event in a climate that is 2 °C warmer than it was in pre-industrial times, while the uncertainty is still quite high for the 60-day monsoon rainfall.
Keywords	climate change ; floods ; heavy monsoon ; national disaster management authority ; precipitation variations ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Cerium oxide nanoparticles improve the post-thaw quality and in-vivo fertility of Beetal buck spermatozoa.

Khalique, Mubashir Ali / Andrabi, Syed Murtaza Hassan / Majeed, Khalid Abdul / Yousaf, Muhammad Shahbaz / Ahmad, Nisar / Tahir, Sajid Khan / Fayyaz, Muhammad Hammad / Haider, Muhammad Shafiq / Naz, Syeda Sohaila / Qureshi, Irfan Zia / Sulaiman, Sulaiman / Zaneb, Hafsa / Rehman, Habib

Theriogenology

2023 Volume 214, Page(s) 166–172

Abstract: The motility, health quality, and membrane disorders of spermatozoa are adversely affected during the process of semen cryopreservation due to the over-production of reactive oxygen species (ROS). Cerium oxide nanoparticles ( ... ...

Abstract	The motility, health quality, and membrane disorders of spermatozoa are adversely affected during the process of semen cryopreservation due to the over-production of reactive oxygen species (ROS). Cerium oxide nanoparticles (CeO
MeSH term(s)	Pregnancy ; Female ; Male ; Animals ; Semen/metabolism ; Antioxidants/pharmacology ; Semen Analysis/veterinary ; Reactive Oxygen Species/pharmacology ; Sperm Motility ; Cryoprotective Agents/pharmacology ; Semen Preservation/veterinary ; Semen Preservation/methods ; Spermatozoa ; Cryopreservation/veterinary ; Cryopreservation/methods ; Fertility ; Citrates/pharmacology
Chemical Substances	ceric oxide (619G5K328Y) ; Antioxidants ; Reactive Oxygen Species ; Cryoprotective Agents ; Citrates
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2023.10.022
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Article ; Online: Zieve Syndrome

Jonathan Vincent M. Reyes MD / Saad Ahmad DO / Hafsa Majeed MD / Eugenio Kandoth MD / Joseph J. Lieber MD

Journal of Investigative Medicine High Impact Case Reports, Vol

A Clinical Triad, or Perchance a Quartet?

2022 Volume 10

Abstract	Zieve syndrome presents with a triad of hemolytic anemia, unexplained jaundice, and hyperlipidemia secondary to alcohol use/alcohol-induced liver injury, highlighting hemolytic anemia as the hallmark feature. Zieve syndrome is more common than originally perceived as its incidence is estimated to be 1 in 1600 admissions, but its mechanism is still poorly understood. This is a case of a 29-year-old man who developed Zieve syndrome shortly after admission for pancreatitis secondary to alcohol use disorder. Early diagnosis is important to reduce unnecessary tests and interventions. Further studies should be considered to evaluate the association between Zieve syndrome and pancreatitis.
Keywords	Medicine (General) ; R5-920 ; Pathology ; RB1-214
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Iron Oxide Nanoparticle Supplementation on the Growth Performance, Serum Metabolites, Meat Quality, and Jejunal Basal Morphology in Broilers

Sara Basharat / Sajid Khan Tahir / Khalid Abdul Majeed / Muhammad Shahbaz Yousaf / Khalil Khadim Hussain / Muhammad A. Rashid / Hafsa Zaneb / Habib Rehman

Animals, Vol 14, Iss 1, p

2023 Volume 99

Abstract	The current research aimed to evaluate the supplemental effects of iron oxide nanoparticles (IONPs) on production performance, viscera development, blood metabolites, redox status, meat quality, and jejunal histology in broilers. A total of 300 day-old broilers were randomly divided into six groups with five replicates per group. Birds were fed on a corn soybean-based diet supplemented with 0, 20, 40, 60, or 80 mg/kg IONPs or 80 mg/kg of FeSO 4 for 35 days. The feed conversion ratio (FCR) was improved in birds supplemented with 60 mg/kg IONPs. The pH 24h was lower in birds supplemented with 40 mg/kg IONPs compared to that of the bulk group. Pectoral muscle fascicle diameter and fiber density were significantly increased in 20 mg/kg IONP-supplemented birds compared to those of the bulk group, respectively. The muscle fiber diameter was higher in 40 mg/kg IONP-supplemented birds compared with the bulk group. The jejunal villus height, crypt depth, and villus surface area were significantly increased with 60 mg/kg IONP supplementation, whereas villus width was decreased in birds supplemented with 40 mg/kg IONPs. The villus-height-to-crypt-depth ratio was lower in IONP-supplemented birds compared to the bulk group. IONP supplementation improved the FCR, jejunal, and pectoral muscle morphology without affecting the carcass characteristics and redox status of broilers.
Keywords	production performance ; trace minerals ; health biomarkers ; jejunal histology ; poultry ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	796
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characterization of structural changes occurring in insulin at different time intervals at room temperature by surface-enhanced Raman spectroscopy.

Meraj, Lubna / Mehmood, Nasir / Majeed, Muhammad Irfan / Nawaz, Haq / Rashid, Nosheen / Fatima, Rida / Habiba, Umm E / Tahseen, Hira / Naz, Maira / Asghar, Maria / Ghafoor, Nida / Ahmad, Hafsa

Photodiagnosis and photodynamic therapy

2023 Volume 44, Page(s) 103796

Abstract: Background: Insulin storage above the temperature recommended by food and drug administration (FDA) causes decrease in its functional efficacy due to degradation and aggregation of its protein based active pharmaceutical ingredient (API) that results ... ...

Abstract	Background: Insulin storage above the temperature recommended by food and drug administration (FDA) causes decrease in its functional efficacy due to degradation and aggregation of its protein based active pharmaceutical ingredient (API) that results poor glycemic control in diabetic patients. The aggregation of protein causes serious neurodegenerative diseases such as type-2 diabetes, Huntington disease, Parkinson's disease, and Alzheimer's disease. Surface-enhanced Raman spectroscopy (SERS) has been employed for the denaturation study of many proteins at the temperature above the recommendations of food and drug administration (FDA) (above 30 °C) which indicates potential of technique for such studies. Objective: SERS along with multivariate discriminating analysis techniques-based analysis of degradation of liquid pharmaceutical insulin protein after regular intervals of time at room temperature to analyze the structural changes in this protein during the storage of insulin pharmaceutical at room temperature. Methods: Silver nanoparticles (Ag-NPs) prepared by chemical reduction method are used as SERS active substrate for the surface enhancement of the insulin spectral signal. SERS spectral measurements of insulin were collected from eight different samples of insulin in the time range of 7 pm to 7 am first at fridge temperature (5 °C), second after half hour and next six with the time difference of 2 h each time at room temperature. The acquired SERS spectral data was preprocessed and analyzed. SERS structural transformations detection and discrimination potential in insulin was further confirmed by applying multivariate discriminating analysis techniques including principal component analysis (PCA) and Partial least square regression analysis (PLSR). Results: SERS significantly detects the structural changes produced in insulin even after 2 h of insulin placement at room temperature. PCA successfully differentiates the insulin spectral data obtained after regular intervals of time according to PC-1 (77 %) explained variance. Application of PLSR model provides quantitative confirmation of SERS efficiency, by providing insulin data regression coefficients plot, efficient prediction of time with calibration data set having 0.77 mean square absolute error of calibration (RMSAEC), validation data set with 0.80 mean square absolute error of prediction (RMSAEP) and 0.98 coefficient of determination (R Conclusion: SERS is proved as a highly sensitive and discriminating technique to detect and discriminate insulin structural changes after regular intervals of time at room temperature.
MeSH term(s)	Humans ; Spectrum Analysis, Raman/methods ; Insulin ; Silver/chemistry ; Metal Nanoparticles/chemistry ; Temperature ; Photochemotherapy/methods ; Photosensitizing Agents ; Pharmaceutical Preparations
Chemical Substances	Insulin ; Silver (3M4G523W1G) ; Photosensitizing Agents ; Pharmaceutical Preparations
Language	English
Publishing date	2023-09-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2023.103796
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Article ; Online: Development of Statistically Optimized Chemically Cross-Linked Hydrogel for the Sustained-Release Delivery of Favipiravir.

Salawi, Ahmad / Khan, Arooj / Zaman, Muhammad / Riaz, Tehseen / Ihsan, Hafsa / Butt, Muhammad Hammad / Aman, Waqar / Khan, Rahima / Majeed, Imtiaz / Almoshari, Yosif / Alshamrani, Meshal

Polymers

2022 Volume 14, Issue 12

Abstract: Nowadays, the use of statistical approaches, i.e., Box-Bhenken designs, are becoming very effective for developing and optimizing pharmaceutical drug formulations. In the current work, a Box-Bhenken design was employed using Design Expert version 11 to ... ...

Abstract	Nowadays, the use of statistical approaches, i.e., Box-Bhenken designs, are becoming very effective for developing and optimizing pharmaceutical drug formulations. In the current work, a Box-Bhenken design was employed using Design Expert version 11 to develop, evaluate, and optimize a hydrogel-based formulation for sustained release of an antiviral drug, i.e., favipiravir. The hydrogels were prepared using the free radical polymerization technique. β-Cyclodextrin (β-CD),
Language	English
Publishing date	2022-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14122369
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