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Article ; Online: A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation.

Lui, Victor G / Hoenig, Manfred / Cabrera-Martinez, Berenice / Baxter, Ryan M / Garcia-Perez, Josselyn E / Bailey, Olivia / Acharya, Atanu / Lundquist, Karl / Capera, Jesusa / Matusewicz, Paul / Hartl, Frederike A / D'Abramo, Marco / Alba, Josephine / Jacobsen, Eva-Maria / Niewolik, Doris / Lorenz, Myriam / Pannicke, Ulrich / Schulz, Ansgar S / Debatin, Klaus-Michael /

Schamel, Wolfgang W / Minguet, Susana / Gumbart, James C / Dustin, Michael L / Cambier, John C / Schwarz, Klaus / Hsieh, Elena W Y

The Journal of experimental medicine

2023 Volume 221, Issue 1

Abstract: Lymphocyte-specific protein tyrosine kinase (LCK) is essential for T cell antigen receptor (TCR ... mediated signal transduction. Here, we report two siblings homozygous for a novel LCK variant (c.1318C>T ... P440S) characterized by T cell lymphopenia with skewed memory phenotype, infant-onset recurrent ...

Abstract	Lymphocyte-specific protein tyrosine kinase (LCK) is essential for T cell antigen receptor (TCR)-mediated signal transduction. Here, we report two siblings homozygous for a novel LCK variant (c.1318C>T; P440S) characterized by T cell lymphopenia with skewed memory phenotype, infant-onset recurrent infections, failure to thrive, and protracted diarrhea. The patients' T cells show residual TCR signal transduction and proliferation following anti-CD3/CD28 and phytohemagglutinin (PHA) stimulation. We demonstrate in mouse models that complete (Lck-/-) versus partial (LckP440S/P440S) loss-of-function LCK causes disease with differing phenotypes. While both Lck-/- and LckP440S/P440S mice exhibit arrested thymic T cell development and profound T cell lymphopenia, only LckP440S/P440S mice show residual T cell proliferation, cytokine production, and intestinal inflammation. Furthermore, the intestinal disease in the LckP440S/P440S mice is prevented by CD4+ T cell depletion or regulatory T cell transfer. These findings demonstrate that P440S LCK spares sufficient T cell function to allow the maturation of some conventional T cells but not regulatory T cells-leading to intestinal inflammation.
MeSH term(s)	Infant ; Humans ; Animals ; Mice ; CD28 Antigens ; CD4-Positive T-Lymphocytes ; Immunologic Deficiency Syndromes ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics ; Receptors, Antigen, T-Cell/genetics ; Inflammation/genetics ; Lymphopenia/genetics
Chemical Substances	CD28 Antigens ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (EC 2.7.10.2) ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20230927
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Article ; Online: Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells.

Łyszkiewicz, Marcin / Ziętara, Natalia / Frey, Laura / Pannicke, Ulrich / Stern, Marcel / Liu, Yanshan / Fan, Yanxin / Puchałka, Jacek / Hollizeck, Sebastian / Somekh, Ido / Rohlfs, Meino / Yilmaz, Tuğba / Ünal, Ekrem / Karakukcu, Musa / Patiroğlu, Türkan / Kellerer, Christina / Karasu, Ebru / Sykora, Karl-Walter / Lev, Atar /

Simon, Amos / Somech, Raz / Roesler, Joachim / Hoenig, Manfred / Keppler, Oliver T / Schwarz, Klaus / Klein, Christoph

Nature communications

2020 Volume 11, Issue 1, Page(s) 1031

Abstract: ... with variable T and B cell lymphopenia, who are homozygous for six distinct mutations in FCHO1. We demonstrate ... of clathrin coated pits (CCP). Patient T cells are unresponsive to T cell receptor (TCR) triggering ... Internalisation of the TCR receptor is severely perturbed in FCHO1-deficient Jurkat T cells but can be rescued ...

Abstract	Clathrin-mediated endocytosis (CME) is critical for internalisation of molecules across cell membranes. The FCH domain only 1 (FCHO1) protein is key molecule involved in the early stages of CME formation. The consequences of mutations in FCHO1 in humans were unknown. We identify ten unrelated patients with variable T and B cell lymphopenia, who are homozygous for six distinct mutations in FCHO1. We demonstrate that these mutations either lead to mislocalisation of the protein or prevent its interaction with binding partners. Live-cell imaging of cells expressing mutant variants of FCHO1 provide evidence of impaired formation of clathrin coated pits (CCP). Patient T cells are unresponsive to T cell receptor (TCR) triggering. Internalisation of the TCR receptor is severely perturbed in FCHO1-deficient Jurkat T cells but can be rescued by expression of wild-type FCHO1. Thus, we discovered a previously unrecognised critical role of FCHO1 and CME during T-cell development and function in humans.
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes/pathology ; Cell Differentiation ; Cells, Cultured ; Endocytosis/physiology ; Female ; HIV Infections/genetics ; HIV-1/pathogenicity ; Humans ; Jurkat Cells ; Loss of Function Mutation ; Lymphopenia/genetics ; Lymphopenia/pathology ; Male ; Membrane Proteins/chemistry ; Membrane Proteins/deficiency ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Pedigree ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes/physiology ; T-Lymphocytes/virology
Chemical Substances	FCHO1 protein, human ; Membrane Proteins ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2020-02-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-14809-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction: Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells.

Simon, Amos / Somech, Raz / Roesler, Joachim / Hoenig, Manfred / Keppler, Oliver T / Schwarz, Klaus / Klein, Christoph

Nature communications

2020 Volume 11, Issue 1, Page(s) 1963

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Language	English
Publishing date	2020-04-20
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-15946-x
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Article ; Online: Monocytes as Potential Mediators of Pathogen-Induced T-Helper 17 Differentiation in Patients With Primary Sclerosing Cholangitis (PSC).

Kunzmann, Lilly Kristin / Schoknecht, Tanja / Poch, Tobias / Henze, Lara / Stein, Stephanie / Kriz, Marvin / Grewe, Ilka / Preti, Max / Hartl, Johannes / Pannicke, Nadine / Peiseler, Moritz / Sebode, Marcial / Zenouzi, Roman / Horvatits, Thomas / Böttcher, Marius / Petersen, Britt-Sabina / Weiler-Normann, Christina / Hess, Leonard U / Ahrenstorf, Annika Elise /

Lunemann, Sebastian / Martrus, Gloria / Fischer, Lutz / Li, Jun / Carambia, Antonella / Kluwe, Johannes / Huber, Samuel / Lohse, Ansgar W / Franke, Andre / Herkel, Johannes / Schramm, Christoph / Schwinge, Dorothee

Hepatology (Baltimore, Md.)

2020 Volume 72, Issue 4, Page(s) 1310–1326

Abstract: Background and aims: T cells from patients with primary sclerosing cholangitis (PSC) show ... for this dominant T-helper 17 (Th17) response in PSC are not clear. Here, we analyzed the potential role ... of monocytes in microbial recognition and in skewing the T-cell response toward Th17.: Approach and results ...

Abstract	Background and aims: T cells from patients with primary sclerosing cholangitis (PSC) show a prominent interleukin (IL)-17 response upon stimulation with bacteria or fungi, yet the reasons for this dominant T-helper 17 (Th17) response in PSC are not clear. Here, we analyzed the potential role of monocytes in microbial recognition and in skewing the T-cell response toward Th17. Approach and results: Monocytes and T cells from blood and livers of PSC patients and controls were analyzed ex vivo and in vitro using transwell experiments with cholangiocytes. Cytokine production was measured using flow cytometry, enzyme-linked immunosorbent assay, RNA in situ hybridization, and quantitative real-time PCR. Genetic polymorphisms were obtained from ImmunoChip analysis. Following ex vivo stimulation with phorbol myristate acetate/ionomycin, PSC patients showed significantly increased numbers of IL-17A-producing peripheral blood CD4 Conclusions: PSC patients show increased Th17 differentiation already in vivo. Microbe-stimulated monocytes drive Th17 differentiation in vitro and induce cholangiocytes to produce chemokines mediating recruitment of Th17 cells and more monocytes into portal tracts. Taken together, these results point to a pathogenic role of monocytes in patients with PSC.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; CARD Signaling Adaptor Proteins/genetics ; Cell Differentiation ; Chemokines/biosynthesis ; Cholangitis, Sclerosing/immunology ; Female ; Humans ; Interleukin-1beta/physiology ; Interleukins/genetics ; Liver Cirrhosis/immunology ; Male ; Middle Aged ; Monocytes/physiology ; Th17 Cells/cytology ; Young Adult
Chemical Substances	CARD Signaling Adaptor Proteins ; CARD9 protein, human ; Chemokines ; Interleukin-1beta ; Interleukins ; interleukin-21 (MKM3CA6LT1)
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.31140
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Simulation of SAR Induced Heating in Infants undergoing 1.5 T Magnetic Resonance Imaging.

Kowal, Robert / Prier, Marcus / Pannicke, Enrico / Vick, Ralf / Rose, Georg / Speck, Oliver

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021 Volume 2021, Page(s) 3382–3386

Abstract: RF absorption in patients undergoing MRI procedures poses a major safety risk due to resulting heating in the tissue. In order to stay below permitted temperature limits the SAR has to be quantified and limited. Based on the model of an infant inside a ... ...

Abstract	RF absorption in patients undergoing MRI procedures poses a major safety risk due to resulting heating in the tissue. In order to stay below permitted temperature limits the SAR has to be quantified and limited. Based on the model of an infant inside a birdcage coil we have investigated the SAR distribution in the body at 1.5T. Thermal simulations could thus be performed to establish a relationship between the limitations of SAR and temperature. Results show a thermal hotspot in the neck region caused by high local absorption. The temperature limits in this local area were exceeded after 7min of excitation within regulatory SAR limits. For a long-term exposure critical organs in the body's core also undergo thermal stress beyond limitations. This indicates the need for constraints in regard to long MR procedures to consider the temporal aspect of heating.Clinical Relevance-This work establishes a relationship between SAR and temperature in infants undergoing MRI and shows potential risks of long-term procedures due to induced thermal stress.
MeSH term(s)	Computer Simulation ; Heating ; Humans ; Magnetic Resonance Imaging/adverse effects ; Phantoms, Imaging ; Radio Waves
Language	English
Publishing date	2021-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC46164.2021.9630221
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Article ; Online: Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells

Marcin Łyszkiewicz / Natalia Ziętara / Laura Frey / Ulrich Pannicke / Marcel Stern / Yanshan Liu / Yanxin Fan / Jacek Puchałka / Sebastian Hollizeck / Ido Somekh / Meino Rohlfs / Tuğba Yilmaz / Ekrem Ünal / Musa Karakukcu / Türkan Patiroğlu / Christina Kellerer / Ebru Karasu / Karl-Walter Sykora / Atar Lev /

Amos Simon / Raz Somech / Joachim Roesler / Manfred Hoenig / Oliver T. Keppler / Klaus Schwarz / Christoph Klein

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 15

Abstract: ... the authors report homozygous FCHO1 mutations in individuals with variable T and B cell lymphopenia, which are ... associated with loss-of-function of FCHO1 and impaired formation of clathrin-coated pits in T cells. ...

Abstract	FCH domain only 1 (FCHO1) is a key molecule involved in clathrin-mediated endocytosis (CME). Here, the authors report homozygous FCHO1 mutations in individuals with variable T and B cell lymphopenia, which are associated with loss-of-function of FCHO1 and impaired formation of clathrin-coated pits in T cells.
Keywords	Science ; Q
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clustering individuals' temporal patterns of affective states, hunger, and food craving by latent class vector-autoregression.

Pannicke, Björn / Blechert, Jens / Reichenberger, Julia / Kaiser, Tim

The international journal of behavioral nutrition and physical activity

2022 Volume 19, Issue 1, Page(s) 57

Abstract: Background: Eating plays an important role in mental and physical health and is influenced by affective (e.g., emotions, stress) and appetitive (i.e., food craving, hunger) states, among others. Yet, substantial temporal variability and marked ... ...

Abstract	Background: Eating plays an important role in mental and physical health and is influenced by affective (e.g., emotions, stress) and appetitive (i.e., food craving, hunger) states, among others. Yet, substantial temporal variability and marked individual differences in these relationships have been reported. Exploratory data analytical approaches that account for variability between and within individuals might benefit respective theory development and subsequent confirmatory studies. Methods: Across 2 weeks, 115 individuals (83% female) reported on momentary affective states, hunger, and food craving six times a day. Based on these ecological momentary assessment (EMA) data we investigated whether latent class vector-autoregression (LCVAR) can identify different clusters of participants based on similarities in their temporal associations between these states. Results: LCVAR allocated participants into three distinct clusters. Within clusters, we found both positive and negative associations between affective states and hunger/food craving, which further varied temporally across lags. Associations between hunger/food craving and subsequent affective states were more pronounced than vice versa. Clusters differed on eating-related traits such as stress-eating and food craving as well as on EMA completion rates. Discussion: LCVAR provides novel opportunities to analyse time-series data in affective science and eating behaviour research and uncovers that traditional models of affect-eating relationships might be overly simplistic. Temporal associations differ between subgroups of individuals with specific links to eating-related traits. Moreover, even within subgroups, differences in associations across time and specific affective states can be observed. To account for this high degree of variability, future research and theories should consider individual differences in direction and time lag of associations between affective states and eating behaviour, daytime and specific affective states. In addition to that, methodological implications for EMA research are discussed.
MeSH term(s)	Cluster Analysis ; Craving ; Emotions ; Feeding Behavior/psychology ; Female ; Humans ; Hunger ; Male
Language	English
Publishing date	2022-05-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2134691-4
ISSN	1479-5868 ; 1479-5868
ISSN (online)	1479-5868
ISSN	1479-5868
DOI	10.1186/s12966-022-01293-1
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Article ; Online: Networks of stress, affect and eating behaviour: anticipated stress coping predicts goal-congruent eating in young adults.

Pannicke, Björn / Kaiser, Tim / Reichenberger, Julia / Blechert, Jens

The international journal of behavioral nutrition and physical activity

2021 Volume 18, Issue 1, Page(s) 9

Abstract: Background: Many people aim to eat healthily. Yet, affluent food environments encourage consumption of energy dense and nutrient-poor foods, making it difficult to accomplish individual goals such as maintaining a healthy diet and weight. Moreover, goal- ...

Abstract	Background: Many people aim to eat healthily. Yet, affluent food environments encourage consumption of energy dense and nutrient-poor foods, making it difficult to accomplish individual goals such as maintaining a healthy diet and weight. Moreover, goal-congruent eating might be influenced by affects, stress and intense food cravings and might also impinge on these in turn. Directionality and interrelations of these variables are currently unclear, which impedes targeted intervention. Psychological network models offer an exploratory approach that might be helpful to identify unique associations between numerous variables as well as their directionality when based on longitudinal time-series data. Methods: Across 14 days, 84 diet-interested participants (age range: 18-38 years, 85.7% female, mostly recruited via universities) reported their momentary states as well as retrospective eating episodes four times a day. We used multilevel vector autoregressive network models based on ecological momentary assessment data of momentary affects, perceived stress and stress coping, hunger, food craving as well as goal-congruent eating behaviour. Results: Neither of the momentary measures of stress (experience of stress or stress coping), momentary affects or craving uniquely predicted goal-congruent eating. Yet, temporal effects indicated that higher anticipated stress coping predicted subsequent goal-congruent eating. Thus, the more confident participants were in their coping with upcoming challenges, the more they ate in line with their goals. Conclusion: Most eating behaviour interventions focus on hunger and craving alongside negative and positive affect, thereby overlooking additional important variables like stress coping. Furthermore, self-regulation of eating behaviours seems to be represented by how much someone perceives a particular eating episode as matching their individual eating goal. To conclude, stress coping might be a potential novel intervention target for eating related Just-In-Time Adaptive Interventions in the context of intensive longitudinal assessment.
MeSH term(s)	Adaptation, Psychological ; Adolescent ; Adult ; Affect ; Craving ; Diet ; Diet, Healthy ; Eating/psychology ; Ecological Momentary Assessment ; Feeding Behavior ; Female ; Goals ; Humans ; Hunger ; Male ; Retrospective Studies ; Stress, Psychological ; Universities ; Young Adult
Language	English
Publishing date	2021-01-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2134691-4
ISSN	1479-5868 ; 1479-5868
ISSN (online)	1479-5868
ISSN	1479-5868
DOI	10.1186/s12966-020-01066-8
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Article: A variant of SCID with specific immune responses and predominance of gamma delta T cells.

Ehl, Stephan / Schwarz, Klaus / Enders, Anselm / Duffner, Ulrich / Pannicke, Ulrich / Kühr, Joachim / Mascart, Françoise / Schmitt-Graeff, Annette / Niemeyer, Charlotte / Fisch, Paul

The Journal of clinical investigation

2005 Volume 115, Issue 11, Page(s) 3140–3148

Abstract: ... against autoantigens. The patient had severely reduced levels of oligoclonal T cells expressing ... the alphabeta TCR but surprisingly normal numbers of T cells expressing the gammadelta TCR. Analysis at a clonal ... level and TCR complementarity-determining region-3 spectratyping for gammadelta T cells revealed ...

Abstract	We describe here a patient with a clinical and molecular diagnosis of recombinase activating gene 1-deficient (RAG1-deficient) SCID, who produced specific antibodies despite minimal B cell numbers. Memory B cells were detected and antibodies were produced not only against some vaccines and infections, but also against autoantigens. The patient had severely reduced levels of oligoclonal T cells expressing the alphabeta TCR but surprisingly normal numbers of T cells expressing the gammadelta TCR. Analysis at a clonal level and TCR complementarity-determining region-3 spectratyping for gammadelta T cells revealed a diversified oligoclonal repertoire with predominance of cells expressing a gamma4-delta3 TCR. Several gammadelta T cell clones displayed reactivity against CMV-infected cells. These observations are compatible with 2 non-mutually exclusive explanations for the gammadelta T cell predominance: a developmental advantage and infection-triggered, antigen-driven peripheral expansion. The patient carried the homozygous hypomorphic R561H RAG1 mutation leading to reduced V(D)J recombination but lacked all clinical features characteristic of Omenn syndrome. This report describes a new phenotype of RAG deficiency and shows that the ability to form specific antibodies does not exclude the diagnosis of SCID.
MeSH term(s)	Amino Acid Sequence ; Base Sequence ; Cells, Cultured ; Clone Cells ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/immunology ; Female ; Fibroblasts/immunology ; Fibroblasts/virology ; Homeodomain Proteins/genetics ; Humans ; Immunophenotyping ; Infant ; Molecular Sequence Data ; Receptors, Antigen, T-Cell, gamma-delta/analysis ; Receptors, Antigen, T-Cell, gamma-delta/biosynthesis ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Severe Combined Immunodeficiency/genetics ; Severe Combined Immunodeficiency/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Chemical Substances	Homeodomain Proteins ; Receptors, Antigen, T-Cell, gamma-delta ; RAG-1 protein (128559-51-3)
Language	English
Publishing date	2005-11
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI25221
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Article: Clustering individuals' temporal patterns of affective states, hunger, and food craving by latent class vector-autoregression

Pannicke, Björn / Blechert, Jens / Reichenberger, Julia / Kaiser, Tim

International Journal of Behavioral Nutrition and Physical Activity

2022 Volume 19, Issue 1, Page(s) No

Title translation	Gruppierung der zeitlichen Muster von affektiven Zuständen, Hunger und Heißhunger von Personen durch latente Klassenvektor-Autoregression
Abstract	Background: Eating plays an important role in mental and physical health and is influenced by affective (e.g., emotions, stress) and appetitive (i.e., food craving, hunger) states, among others. Yet, substantial temporal variability and marked individual differences in these relationships have been reported. Exploratory data analytical approaches that account for variability between and within individuals might benefit respective theory development and subsequent confirmatory studies. Methods: Across 2 weeks, 115 individuals (83% female) reported on momentary affective states, hunger, and food craving six times a day. Based on these ecological momentary assessment (EMA) data, we investigated whether latent class vector-autoregression (LCVAR) can identify different clusters of participants based on similarities in their temporal associations between these states. Results: LCVAR allocated participants into three distinct clusters. Within clusters, we found both positive and negative associations between affective states and hunger/food craving, which further varied temporally across lags. Associations between hunger/food craving and subsequent affective states were more pronounced than vice versa. Clusters differed on eating-related traits such as stress-eating and food craving, as well as on EMA completion rates. Discussion: LCVAR provides novel opportunities to analyze time-series data in affective science and eating behavior research and uncovers that traditional models of affect-eating relationships might be overly simplistic. Temporal associations differ between subgroups of individuals with specific links to eating-related traits. Moreover, even within subgroups, differences in associations across time and specific affective states can be observed. To account for this high degree of variability, future research and theories should consider individual differences in direction and time lag of associations between affective states and eating behavior, daytime and specific affective states. In addition to that, methodological implications for EMA research are discussed.
Keywords	Craving ; Eating Behavior ; Ecological Momentary Assessment ; Emotional States ; Emotionale Zustände ; Essverhalten ; Hunger ; Individual Differences ; Individuelle Unterschiede ; Statistical Analysis ; Statistische Analyse ; Stress Management ; Stressverarbeitung ; Time ; Time Series ; Zeit ; Zeitreihen
Language	English
Document type	Article
ZDB-ID	2134691-4
ISSN	1479-5868
ISSN	1479-5868
DOI	10.1186/s12966-022-01293-1
Database	PSYNDEX

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