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Book ; Online ; E-Book: Fifty years of magnetoencephalography

Papanicolaou, Andrew C. / Roberts, Timothy P. L. / Wheless, James W.

beginnings, technical advances, and applications

2020

Author's details	edited by Andrew C. Papanicolaou, Timothy P. L. Roberts, and James W. Wheless
Keywords	Magnetoencephalography/History
Subject code	616.8/047548
Language	English
Size	1 Online-Ressource (xvii, 416 Seiten), Illustrationen, Diagramme
Publisher	Oxford University Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020534174
ISBN	978-0-19-093569-6 ; 978-0-19-093570-2 ; 9780190935689 ; 9780190935719 ; 0-19-093569-3 ; 0-19-093570-7 ; 0190935685 ; 0190935715
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: 3.0 T versus 1.5 T imaging

Roberts, Timothy P. L.

(Neuroimaging clinics ; 16,2)

2006

Author's details	guest ed. Timothy P. L. Roberts
Series title	Neuroimaging clinics ; 16,2
Collection
Language	English
Size	XVI S., S. 217 - 369 : Ill., graph. Darst.
Publisher	Elsevier Saunders
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT014793001
ISBN	1-4160-3533-8 ; 978-1-4160-3533-6
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Genomic investigation of the emergence of

Baines, Sarah L / Guérillot, Romain / Ballard, Susan / Johnson, Paul D R / Stinear, Timothy P / Roberts, Sally / Howden, Benjamin P

Access microbiology

2023 Volume 5, Issue 12

Abstract: Vancomycin- ... ...

Abstract	Vancomycin-resistant
Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Journal Article
ISSN	2516-8290
ISSN (online)	2516-8290
DOI	10.1099/acmi.0.000712.v3
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Article ; Online: Biomarkers for autism spectrum disorder: opportunities for magnetoencephalography (MEG).

Roberts, Timothy P L / Kuschner, Emily S / Edgar, J Christopher

Journal of neurodevelopmental disorders

2021 Volume 13, Issue 1, Page(s) 34

Abstract: This paper reviews a candidate biomarker for ASD, the M50 auditory evoked response component, detected by magnetoencephalography (MEG) and presents a position on the roles and opportunities for such a biomarker, as well as converging evidence from allied ...

Abstract	This paper reviews a candidate biomarker for ASD, the M50 auditory evoked response component, detected by magnetoencephalography (MEG) and presents a position on the roles and opportunities for such a biomarker, as well as converging evidence from allied imaging techniques (magnetic resonance imaging, MRI and spectroscopy, MRS). Data is presented on prolonged M50 latencies in ASD as well as extension to include children with ASD with significant language and cognitive impairments in whom M50 latency delays are exacerbated. Modeling of the M50 latency by consideration of the properties of auditory pathway white matter is shown to be successful in typical development but challenged by heterogeneity in ASD; this, however, is capitalized upon to identify a distinct subpopulation of children with ASD whose M50 latencies lie well outside the range of values predictable from the typically developing model. Interestingly, this subpopulation is characterized by low levels of the inhibitory neurotransmitter GABA. Following from this, we discuss a potential use of the M50 latency in indicating "target engagement" acutely with administration of a GABA-B agonist, potentially distinguishing "responders" from "non-responders" with the implication of optimizing inclusion for clinical trials of such agents. Implications for future application, including potential evaluation of infants with genetic risk factors, are discussed. As such, the broad scope of potential of a representative candidate biological marker, the M50 latency, is introduced along with potential future applications.This paper outlines a strategy for understanding brain dysfunction in individuals with intellectual and developmental disabilities (IDD). It is proposed that a multimodal approach (collection of brain structure, chemistry, and neuronal functional data) will identify IDD subpopulations who share a common disease pathway, and thus identify individuals with IDD who might ultimately benefit from specific treatments. After briefly demonstrating the need and potential for scope, examples from studies examining brain function and structure in children with autism spectrum disorder (ASD) illustrate how measures of brain neuronal function (from magnetoencephalography, MEG), brain structure (from magnetic resonance imaging, MRI, especially diffusion MRI), and brain chemistry (MR spectroscopy) can help us better understand the heterogeneity in ASD and form the basis of multivariate biological markers (biomarkers) useable to define clinical subpopulations. Similar approaches can be applied to understand brain dysfunction in neurodevelopmental disorders (NDD) in general. In large part, this paper represents our endeavors as part of the CHOP/Penn NICHD-funded intellectual and developmental disabilities research center (IDDRC) over the past decade.
MeSH term(s)	Autism Spectrum Disorder/diagnosis ; Biomarkers ; Brain/diagnostic imaging ; Child ; Evoked Potentials, Auditory ; Humans ; Magnetoencephalography
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-09-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2487174-6
ISSN	1866-1955 ; 1866-1955
ISSN (online)	1866-1955
ISSN	1866-1955
DOI	10.1186/s11689-021-09385-y
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Article: Contributions to auditory system conduction velocity: insights with multi-modal neuroimaging and machine learning in children with ASD and XYY syndrome.

Berman, Jeffrey I / Bloy, Luke / Blaskey, Lisa / Jackel, Carissa R / Miller, Judith S / Ross, Judith / Edgar, J Christopher / Roberts, Timothy P L

Frontiers in psychiatry

2023 Volume 14, Page(s) 1057221

Abstract: Introduction: The M50 electrophysiological auditory evoked response time can be measured at the superior temporal gyrus with magnetoencephalography (MEG) and its latency is related to the conduction velocity of auditory input passing from ear to ... ...

Abstract	Introduction: The M50 electrophysiological auditory evoked response time can be measured at the superior temporal gyrus with magnetoencephalography (MEG) and its latency is related to the conduction velocity of auditory input passing from ear to auditory cortex. In children with autism spectrum disorder (ASD) and certain genetic disorders such as XYY syndrome, the auditory M50 latency has been observed to be elongated (slowed). Methods: The goal of this study is to use neuroimaging (diffusion MR and GABA MRS) measures to predict auditory conduction velocity in typically developing (TD) children and children with autism ASD and XYY syndrome. Results: Non-linear TD support vector regression modeling methods accounted for considerably more M50 latency variance than linear models, likely due to the non-linear dependence on neuroimaging factors such as GABA MRS. While SVR models accounted for ~80% of the M50 latency variance in TD and the genetically homogenous XYY syndrome, a similar approach only accounted for ~20% of the M50 latency variance in ASD, implicating the insufficiency of diffusion MR, GABA MRS, and age factors alone. Biologically based stratification of ASD was performed by assessing the conformance of the ASD population to the TD SVR model and identifying a sub-population of children with unexpectedly long M50 latency. Discussion: Multimodal integration of neuroimaging data can help build a mechanistic understanding of brain connectivity. The unexplained M50 latency variance in ASD motivates future hypothesis generation and testing of other contributing biological factors.
Language	English
Publishing date	2023-05-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1057221
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Article ; Online: An event-based magnetoencephalography study of simulated driving: Establishing a novel paradigm to probe the dynamic interplay of executive and motor function.

Walshe, Elizabeth A / Roberts, Timothy P L / Ward McIntosh, Chelsea / Winston, Flaura K / Romer, Dan / Gaetz, William

Human brain mapping

2023 Volume 44, Issue 5, Page(s) 2109–2121

Abstract: ... activity (at left precentral foot area, as well as bilateral superior parietal lobe: p < .01 corrected ... MRGS (at medial precentral gyrus: p < .01 corrected), and FMT band activity sustained around planned ... braking (at bilateral superior frontal gyrus: p < .01 corrected). This paradigm overcomes the limits ...

Abstract	Magnetoencephalography (MEG) is particularly well-suited to the study of human motor cortex oscillatory rhythms and motor control. However, the motor tasks studied to date are largely overly simplistic. This study describes a new approach: a novel event-based simulated drive made operational via MEG compatible driving simulator hardware, paired with differential beamformer methods to characterize the neural correlates of realistic, complex motor activity. We scanned 23 healthy individuals aged 16-23 years (mean age = 19.5, SD = 2.5; 18 males and 5 females, all right-handed) who completed a custom-built repeated trials driving scenario. MEG data were recorded with a 275-channel CTF, and a volumetric magnetic resonance imaging scan was used for MEG source localization. To validate this paradigm, we hypothesized that pedal-use would elicit expected modulation of primary motor responses beta-event-related desynchronization (B-ERD) and movement-related gamma synchrony (MRGS). To confirm the added utility of this paradigm, we hypothesized that the driving task could also probe frontal cognitive control responses (specifically, frontal midline theta [FMT]). Three of 23 participants were removed due to excess head motion (>1.5 cm/trial), confirming feasibility. Nonparametric group analysis revealed significant regions of pedal-use related B-ERD activity (at left precentral foot area, as well as bilateral superior parietal lobe: p < .01 corrected), MRGS (at medial precentral gyrus: p < .01 corrected), and FMT band activity sustained around planned braking (at bilateral superior frontal gyrus: p < .01 corrected). This paradigm overcomes the limits of previous efforts by allowing for characterization of the neural correlates of realistic, complex motor activity in terms of brain regions, frequency bands and their dynamic temporal interplay.
MeSH term(s)	Male ; Female ; Humans ; Young Adult ; Adult ; Magnetoencephalography/methods ; Brain/diagnostic imaging ; Brain/physiology ; Magnetic Resonance Imaging/methods ; Motor Cortex/diagnostic imaging ; Motor Cortex/physiology ; Prefrontal Cortex
Language	English
Publishing date	2023-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.26197
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Article ; Online: Magnetoencephalography Research in Pediatric Autism Spectrum Disorder.

Green, Heather L / Edgar, J Christopher / Matsuzaki, Junko / Roberts, Timothy P L

Neuroimaging clinics of North America

2020 Volume 30, Issue 2, Page(s) 193–203

Abstract: Magnetoencephalography (MEG) research indicates differences in neural brain measures in children with autism spectrum disorder (ASD) compared to typically developing (TD) children. As reviewed here, resting-state MEG exams are of interest as well as MEG ... ...

Abstract	Magnetoencephalography (MEG) research indicates differences in neural brain measures in children with autism spectrum disorder (ASD) compared to typically developing (TD) children. As reviewed here, resting-state MEG exams are of interest as well as MEG paradigms that assess neural function across domains (e.g., auditory, resting state). To date, MEG research has primarily focused on group-level differences. Research is needed to explore whether MEG measures can predict, at the individual level, ASD diagnosis, prognosis (future severity), and response to therapy.
MeSH term(s)	Autism Spectrum Disorder/diagnostic imaging ; Autism Spectrum Disorder/physiopathology ; Brain/diagnostic imaging ; Brain/physiopathology ; Child ; Humans ; Magnetoencephalography
Language	English
Publishing date	2020-03-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1314594-0
ISSN	1557-9867 ; 1052-5149
ISSN (online)	1557-9867
ISSN	1052-5149
DOI	10.1016/j.nic.2020.01.001
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Article: Magnetoencephalography Studies of the Envelope Following Response During Amplitude-Modulated Sweeps: Diminished Phase Synchrony in Autism Spectrum Disorder.

Roberts, Timothy P L / Bloy, Luke / Liu, Song / Ku, Matthew / Blaskey, Lisa / Jackel, Carissa

Frontiers in human neuroscience

2021 Volume 15, Page(s) 787229

Abstract: Prevailing theories of the neural basis of at least a subset of individuals with autism spectrum disorder (ASD) include an imbalance of excitatory and inhibitory neurotransmission. These circuitry imbalances are commonly probed in adults using auditory ... ...

Abstract	Prevailing theories of the neural basis of at least a subset of individuals with autism spectrum disorder (ASD) include an imbalance of excitatory and inhibitory neurotransmission. These circuitry imbalances are commonly probed in adults using auditory steady-state responses (ASSR, driven at 40 Hz) to elicit coherent electrophysiological responses (EEG/MEG) from intact circuitry. Challenges to the ASSR methodology occur during development, where the optimal ASSR driving frequency may be unknown. An alternative approach (more agnostic to driving frequency) is the amplitude-modulated (AM) sweep in which the amplitude of a tone (with carrier frequency 500 Hz) is modulated as a sweep from 10 to 100 Hz over the course of ∼15 s. Phase synchrony of evoked responses, measured
Language	English
Publishing date	2021-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2021.787229
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Article ; Online: Decreased levels of γ-aminobutyric acid in temporal lobe of children with 47,XYY syndrome.

Roberts, Timothy P L / Bloy, Luke / Miller, Judith S / Blaskey, Lisa / Ross, Judith

Neuroreport

2021 Volume 32, Issue 7, Page(s) 541–547

Abstract: Background: 47,XYY syndrome (XYY) is a male sex chromosome disorder where subjects have one X chromosome and two copies of the Y chromosome. XYY is associated with a physical phenotype and carries increased risk of neurodevelopmental disorders such as ... ...

Abstract	Background: 47,XYY syndrome (XYY) is a male sex chromosome disorder where subjects have one X chromosome and two copies of the Y chromosome. XYY is associated with a physical phenotype and carries increased risk of neurodevelopmental disorders such as autism spectrum disorder (ASD). Imbalance of excitation and inhibition has been proposed as a putative biological basis of disorders such as ASD [1-3] and several studies have reported atypical brain γ-aminobutyric acid (GABA) levels in this population. Given the male preponderance in the prevalence of ASD, the unique presence of the Y chromosome in males leads to the intriguing possibility of investigating boys with XYY syndrome as a model of excess Y-chromosome genes. Method: In this study, we investigated the associations of genotype and clinical phenotype with levels of GABA, estimated by regionally localized edited magnetic resonance spectroscopy in boys with 47, XYY syndrome compared to age-matched typically developing (XY) peers. Results: Overall, we observed a decrease in GABA levels in XYY vs. XY, which appeared more significant in the left compared to the right hemisphere. There was no additional significant modulation of GABA levels in XYY according to presence/absence of ASD diagnosis. Interestingly, a positive correlation between bilateral GABA levels and testosterone levels was observed in pubescent XY boys that was not observed in XYY. Conclusion: The inhibitory neurotransmitter GABA appears to be reduced in boys with 47,XYY, especially in the left hemisphere. Further, the typical association between GABA and testosterone levels, observed in older typically developing control boys was not evident in boys with 47,XYY.
MeSH term(s)	Adolescent ; Child ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Sex Chromosome Disorders/diagnostic imaging ; Sex Chromosome Disorders/metabolism ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/metabolism ; XYY Karyotype/diagnostic imaging ; XYY Karyotype/metabolism ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2021-03-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1049746-8
ISSN	1473-558X ; 0959-4965
ISSN (online)	1473-558X
ISSN	0959-4965
DOI	10.1097/WNR.0000000000001628
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Article ; Online: Comparison of evoked potentials across four related developmental encephalopathies.

Saby, Joni N / Peters, Sarika U / Benke, Timothy A / Standridge, Shannon M / Swanson, Lindsay C / Lieberman, David N / Olson, Heather E / Key, Alexandra P / Percy, Alan K / Neul, Jeffrey L / Nelson, Charles A / Roberts, Timothy P L / Marsh, Eric D

Journal of neurodevelopmental disorders

2023 Volume 15, Issue 1, Page(s) 10

Abstract: Background: Developing biomarkers is a priority for drug development for all conditions, but vital in the rare neurodevelopmental disorders where sensitive outcome measures are lacking. We have previously demonstrated the feasibility and tracking of ... ...

Abstract	Background: Developing biomarkers is a priority for drug development for all conditions, but vital in the rare neurodevelopmental disorders where sensitive outcome measures are lacking. We have previously demonstrated the feasibility and tracking of evoked potentials to disease severity in Rett syndrome and CDKL5 deficiency disorder. The aim of the current study is to characterize evoked potentials in two related developmental encephalopathies, MECP2 duplication syndrome and FOXG1 syndrome, and compare across all four groups to better understand the potential of these measures to serve as biomarkers of clinical severity for the developmental encephalopathies. Methods: Visual and auditory evoked potentials were acquired from participants with MECP2 duplication syndrome and FOXG1 syndrome across five sites of the Rett Syndrome and Rett-Related Disorders Natural History Study. A group of age-matched individuals (mean = 7.8 years; range = 1-17) with Rett syndrome, CDKL5 deficiency disorder, and typically-developing participants served as a comparison group. The analysis focused on group-level differences as well as associations between the evoked potentials and measures of clinical severity from the Natural History Study. Results: As reported previously, group-level comparisons revealed attenuated visual evoked potentials (VEPs) in participants with Rett syndrome (n = 43) and CDKL5 deficiency disorder (n = 16) compared to typically-developing participants. VEP amplitude was also attenuated in participants with MECP2 duplication syndrome (n = 15) compared to the typically-developing group. VEP amplitude correlated with clinical severity for Rett syndrome and FOXG1 syndrome (n = 5). Auditory evoked potential (AEP) amplitude did not differ between groups, but AEP latency was prolonged in individuals with MECP2 duplication syndrome (n = 14) and FOXG1 syndrome (n = 6) compared to individuals with Rett syndrome (n = 51) and CDKL5 deficiency disorder (n = 14). AEP amplitude correlated with severity in Rett syndrome and CDKL5 deficiency disorder. AEP latency correlated with severity in CDKL5 deficiency disorder, MECP2 duplication syndrome, and FOXG1 syndrome. Conclusions: There are consistent abnormalities in the evoked potentials in four developmental encephalopathies some of which correlate with clinical severity. While there are consistent changes amongst these four disorders, there are also condition specific findings that need to be further refined and validated. Overall, these results provide a foundation for further refinement of these measures for use in future clinical trials for these conditions.
MeSH term(s)	Humans ; Child ; Rett Syndrome ; Evoked Potentials, Visual ; Evoked Potentials ; Spasms, Infantile
Language	English
Publishing date	2023-03-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2487174-6
ISSN	1866-1955 ; 1866-1955
ISSN (online)	1866-1955
ISSN	1866-1955
DOI	10.1186/s11689-023-09479-9
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