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  1. Article ; Online: Elementary lesions in dermatological semiology: literature review.

    Cardili, Renata Nahas / Roselino, Ana Maria

    Anais brasileiros de dermatologia

    2016  Volume 91, Issue 5, Page(s) 629–633

    Abstract: Discrepancies in the terminology of elementary lesions persist when texts from Dermatology and Semiology books are compared, which can cause some confusion in both the teaching of undergraduate medical students and the learning acquired by professionals ... ...

    Abstract Discrepancies in the terminology of elementary lesions persist when texts from Dermatology and Semiology books are compared, which can cause some confusion in both the teaching of undergraduate medical students and the learning acquired by professionals in the field. This review aims to compare and clarify the differences in the description of elementary lesions by many authors, used as references for specialists in dermatology.
    MeSH term(s) Dermatology/education ; Education, Medical, Undergraduate ; Humans ; Skin Diseases/classification ; Terminology as Topic ; Textbooks as Topic
    Language English
    Publishing date 2016-10-25
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1590/abd1806-4841.20164931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 359: Show issues Location:
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    Zs.MO 344: Show issues

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  2. Article ; Online: Evidence for Epistatic Interaction between

    Oliveira-Caramez, Maria Luiza de / Veiga-Castelli, Luciana / Souza, Andreia S / Cardili, Renata Nahas / Courtin, David / Flória-Santos, Milena / Donadi, Eduardo / Giuliatti, Silvana / Sabbagh, Audrey / Castelli, Erick C / Mendes-Junior, Celso Teixeira

    Cells

    2023  Volume 12, Issue 4

    Abstract: Vitiligo is the most frequent cause of depigmentation worldwide. Genetic association studies have discovered about 50 loci associated with disease, many with immunological functions. Among them is HLA-G, which modulates immunity by interacting with ... ...

    Abstract Vitiligo is the most frequent cause of depigmentation worldwide. Genetic association studies have discovered about 50 loci associated with disease, many with immunological functions. Among them is HLA-G, which modulates immunity by interacting with specific inhibitory receptors, mainly LILRB1 and LILRB2. Here we investigated the
    MeSH term(s) Humans ; Antigens, CD ; HLA-G Antigens/genetics ; Leukocyte Immunoglobulin-like Receptor B1/genetics ; Polymorphism, Genetic ; Receptors, Immunologic/genetics ; Vitiligo/metabolism
    Chemical Substances Antigens, CD ; HLA-G Antigens ; Leukocyte Immunoglobulin-like Receptor B1 ; LILRB1 protein, human ; Receptors, Immunologic
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12040630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Malignant Syphilis in a Young Patient With Juvenile Idiopathic Arthritis Under Biological Therapy.

    Dos Santos, Cecília Anatriello / Benevides, Luana Coelho / Cardili, Renata Nahas / Pileggi, Gecilmara Cristina Salviato / Ferriani, Virginia Paes Leme / Roselino, Ana Maria Ferreira

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2020  Volume 27, Issue 8S, Page(s) S382–S383

    MeSH term(s) Arthritis, Juvenile/complications ; Arthritis, Juvenile/diagnosis ; Arthritis, Juvenile/drug therapy ; Biological Therapy ; Humans ; Syphilis/complications ; Syphilis/diagnosis ; Syphilis/drug therapy
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4815: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study.

    Paschoal, Renato Soriani / Silva, Daniela Antoniali / Cardili, Renata Nahas / Souza, Cacilda da Silva

    Anais brasileiros de dermatologia

    2018  Volume 93, Issue 2, Page(s) 222–228

    Abstract: Background: Psoriasis has been associated with co-morbidities and elevated cardiovascular risk.: Objectives: To analyze the relationships among metabolic syndrome, cardiovascular risk, C-reactive protein, gender, and Psoriasis severity.: Methods: ... ...

    Abstract Background: Psoriasis has been associated with co-morbidities and elevated cardiovascular risk.
    Objectives: To analyze the relationships among metabolic syndrome, cardiovascular risk, C-reactive protein, gender, and Psoriasis severity.
    Methods: In this cross-sectional study, plaque Psoriasis patients (n=90), distributed equally in gender, were analyzed according to: Psoriasis Area and Severity Index, cardiovascular risk determined by the Framingham risk score and global risk assessment, C-reactive protein and metabolic syndrome criteria (NCEPT-ATP III).
    Results: Metabolic syndrome frequency was 43.3% overall, without significance between genders (P=0.14); but women had higher risk for obesity (OR 2.56, 95%CI 1.02-6.41; P=0.04) and systemic arterial hypertension (OR 3.29, 95%CI 1.39-7.81; P=0.006). The increase in the Psoriasis Area and Severity Index also increased the risk for metabolic syndrome (OR 1.060, 95%CI 1.006-1.117; P=0.03). Absolute 10-year cardiovascular risk was higher in males (P=0.002), but after global risk assessment, 51.1% patients, 52.2% women, were re-classified as high-intermediate cardiovascular risk; without significance between genders (P=0.83). C-reactive protein level was elevated nearly six-fold overall, higher in metabolic syndrome (P=0.05), systemic arterial hypertension (P=0.004), and high-intermediate 10-year cardiovascular risk patients (P<0.001); positively correlated to: Framingham risk score (P<0.001; r=0.60), absolute 10-year cardiovascular risk (P<0.001; r=0.58), and age (P=0.001; r=0.35); but not to Psoriasis Area and Severity Index (P=0.14; r=0.16); increased the 10-year cardiovascular risk (R2=33.6; P<0.001), MetS risk (OR 1.17, 95%CI 0.99-1.37; P=0.05) and with age (P=0.001). HDL-cholesterol level was higher in normal C-reactive protein patients (t=1.98; P=0.05).
    Study limitations: Restricted sample, hospital-based and representative of a single center and no specification of psoriatic arthritis.
    Conclusions: Psoriasis, metabolic syndrome, systemic arterial hypertension and age share the increase in C-reactive protein, which could implicate in additional burden for increasing the cardiovascular risk and be an alert for effective interventions.
    MeSH term(s) Adult ; Anthropometry ; Brazil/epidemiology ; C-Reactive Protein/analysis ; Cardiovascular Diseases/etiology ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Middle Aged ; Multivariate Analysis ; Obesity/complications ; Obesity/epidemiology ; Prevalence ; Psoriasis/complications ; Psoriasis/epidemiology ; Psoriasis/metabolism ; Reference Values ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Sex Distribution ; Sex Factors
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2018-03-19
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1590/abd1806-4841.20186397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 359: Show issues Location:
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    Zs.MO 344: Show issues

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  5. Article: A New Approach to Atopic Dermatitis Control with Low-Concentration Propolis-Loaded Cold Cream.

    Martin, Bianca Aparecida / Lemos, Camila Nunes / Dalmolin, Luciana Facco / Arruda, Caroline / Brait, Íris Sperchi Camilo / Cazarim, Maurílio de Souza / da Cruz-Cazarim, Estael Luzia Coelho / Bueno, Paula Carolina Pires / Júnior, Maurílio Polizello / Pereira, Leonardo Régis Leira / Cardili, Renata Nahas / Fonseca Vianna Lopez, Renata

    Pharmaceutics

    2021  Volume 13, Issue 9

    Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease that is difficult to treat. Traditional cold cream, a water-in-oil emulsion made from beeswax, is used to alleviate AD symptoms in clinical practice, although its effectiveness has not been ... ...

    Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease that is difficult to treat. Traditional cold cream, a water-in-oil emulsion made from beeswax, is used to alleviate AD symptoms in clinical practice, although its effectiveness has not been scientifically proven. The addition of propolis has the potential to impart anti-inflammatory properties to cold cream. However, in high concentrations, propolis can trigger allergic reactions. Thus, the objective of this work was to develop a cold cream formulation based on purified beeswax containing the same amount of green propolis present in raw beeswax. The impact of adding this low propolis concentration to cold cream on AD control was evaluated in patients compared to cold cream without added propolis (CBlank). Raw beeswax was chemically characterized to define the propolis concentration added to the propolis-loaded cold cream (CPropolis). The creams were characterized as to their physicochemical, mechanical, and rheological characteristics. The effect of CPropolis and CBlank on the quality of life, disease severity, and skin hydration of patients with AD was evaluated in a triple-blind randomized preclinical study. Concentrations of 34 to 120 ng/mL of green propolis extract reduced TNF-α levels in LPS-stimulated macrophage culture. The addition of propolis to cold cream did not change the cream's rheological, mechanical, or bioadhesive properties. The preclinical study suggested that both creams improved the patient's quality of life. Furthermore, the use of CPropolis decreased the disease severity compared to CBlank.
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13091346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Efficacy of House Dust Mite Sublingual Immunotherapy in Patients with Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.

    Langer, Sarah Sella / Cardili, Renata Nahas / Melo, Janaina Michelle Lima / Ferriani, Mariana Paes Leme / Moreno, Adriana Santos / Dias, Marina Mendonça / Bueno-Filho, Roberto / Pocente, Renata Helena Candido / Roxo-Junior, Pérsio / Silva, Jorgete / Valera, Fabiana Cardoso Pereira / Coelho, Eduardo Barbosa / Galvão, Clóvis Eduardo Santos / Carmona, Fábio / Aragon, Davi Casale / Arruda, Luisa Karla

    The journal of allergy and clinical immunology. In practice

    2021  Volume 10, Issue 2, Page(s) 539–549.e7

    Abstract: Background: Sensitization to house dust mites (HDMs) is frequent in patients with atopic dermatitis.: Objective: To investigate the efficacy of sublingual immunotherapy (SLIT) with Dermatophagoides pteronyssinus extract in patients with atopic ... ...

    Abstract Background: Sensitization to house dust mites (HDMs) is frequent in patients with atopic dermatitis.
    Objective: To investigate the efficacy of sublingual immunotherapy (SLIT) with Dermatophagoides pteronyssinus extract in patients with atopic dermatitis sensitized to HDM.
    Methods: In this randomized, double-blind, placebo-controlled trial, we enrolled 91 patients 3 years or older, with SCORing Atopic Dermatitis (SCORAD) score greater than or equal to 15 and positive skin test result and/or IgE to D pteronyssinus. Patients were stratified according to age (<12 and ≥12 years) to receive HDM SLIT or placebo for 18 months. Primary outcome was a greater than or equal to 15-point decrease in SCORAD score. Secondary outcomes were decreases in SCORAD and objective SCORAD, Eczema Area and Severity Index, visual analog scale for symptoms, and pruritus scale scores; Investigator's Global Assessment 0/1; and decrease greater than or equal to 4 points in Dermatology Life Quality Index. Background therapy was maintained.
    Results: A total of 66 patients completed the study (35 HDM SLIT, 31 placebo). After 18 months, 74.2% and 58% of patients in the HDM SLIT group and the placebo group, respectively, showed greater than or equal to 15-point decrease in SCORAD score (relative risk, 1.28; 95% CI, 0.89-1.83). Significant SCORAD score decreases from baseline of 55.6% and 34.5% in HDM SLIT and placebo groups (mean difference, 20.4; 95% CI, 3.89-37.3), significant objective SCORAD score decreases of 56.8% and 34.9% in HDM SLIT and placebo groups (mean difference, 21.3; 95% CI, 0.66-41.81), and more patients with Investigator's Global Assessment 0/1 in the HDM SLIT group as compared with the placebo group (14 of 35 vs 5 of 31; relative risk, 2.63; 95% CI, 1.09-6.39) were observed at 18 months.
    Conclusions: Our results suggest that HDM SLIT may be effective in HDM-sensitized patients as an add-on treatment for atopic dermatitis.
    MeSH term(s) Animals ; Antigens, Dermatophagoides/therapeutic use ; Child ; Dermatitis, Atopic/drug therapy ; Dermatophagoides pteronyssinus ; Double-Blind Method ; Eczema/drug therapy ; Humans ; Pyroglyphidae ; Sublingual Immunotherapy/methods ; Treatment Outcome
    Chemical Substances Antigens, Dermatophagoides
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.10.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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