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  1. Article ; Online: Statins for Coronary Patients Exposed to Wildfire-Related Air Pollution: An Opportunity to Reduce the Increased Risk of Coronary Events.

    Vuorio, Alpo / Kovanen, Petri T

    The Canadian journal of cardiology

    2023  Volume 39, Issue 9, Page(s) 1278

    MeSH term(s) Humans ; Wildfires ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Air Pollution/adverse effects ; Air Pollution/analysis ; Environmental Exposure ; Particulate Matter/analysis
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Particulate Matter
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Letter
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.06.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2150: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: SARS-CoV-2 reinfection: Adding insult to dysfunctional endothelium in patients with atherosclerotic cardiovascular disease.

    Kovanen, Petri T / Vuorio, Alpo

    Atherosclerosis plus

    2023  Volume 53, Page(s) 1–5

    Abstract: In this short narrative review, we aim at defining the pathophysiological role endothelial dysfunction in the observed COVID-19-associated rise in risk of cardiovascular disease. Variants of the SARS-CoV-2 virus have caused several epidemic waves of ... ...

    Abstract In this short narrative review, we aim at defining the pathophysiological role endothelial dysfunction in the observed COVID-19-associated rise in risk of cardiovascular disease. Variants of the SARS-CoV-2 virus have caused several epidemic waves of COVID-19, and the emergence and rapid spread of new variants and subvariants are likely. Based on a large cohort study, the incidence rate of SARS-CoV-2 reinfection is about 0.66 per 10 000 person-weeks. Both the first infection and reinfection with SARS-CoV-2 increase cardiac event risk, particularly in vulnerable patients with cardiovascular risk factors and the accompanying systemic endothelial dysfunction. By worsening pre-existing endothelial dysfunction, both the first infection and reinfection with ensuing COVID-19 may turn the endothelium procoagulative and prothrombotic, and ultimately lead to local thrombus formation. When occurring in an epicardial coronary artery, the risk of an acute coronary syndrome increases, and when occurring in intramyocardial microvessels, scattered myocardial injuries will ensue, both predisposing the COVID-19 patients to adverse cardiovascular outcomes. In conclusion, considering weakened protection against the cardiovascular risk-enhancing reinfections with emerging new subvariants of SARS-CoV-2, treatment of COVID-19 patients with statins during the illness and thereafter is recommended, partly because the statins tend to reduce endothelial dysfunction.
    Language English
    Publishing date 2023-06-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2667-0895
    ISSN (online) 2667-0895
    DOI 10.1016/j.athplu.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Safety of Health Care Workers in a War Zone-A European Issue.

    Vuorio, Alpo / Bor, Robert

    Frontiers in public health

    2022  Volume 10, Page(s) 886394

    MeSH term(s) Health Personnel ; Humans ; Stress Disorders, Post-Traumatic
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.886394
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  4. Article ; Online: Safety of Health Care Workers in a War Zone—A European Issue

    Alpo Vuorio / Robert Bor

    Frontiers in Public Health, Vol

    2022  Volume 10

    Keywords health care workers ; war ; mental health ; safety ; PTSD ; COVID-19 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Statins as Adjuvant Therapy for COVID-19 to Calm the Stormy Immunothrombosis and Beyond.

    Vuorio, Alpo / Kovanen, Petri T

    Frontiers in pharmacology

    2021  Volume 11, Page(s) 579548

    Language English
    Publishing date 2021-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.579548
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  6. Article: Wildfire smoke exposure and cardiovascular disease-should statins be recommended to prevent cardiovascular events?

    Vuorio, Alpo / Budowle, Bruce / Raal, Frederick / Kovanen, Petri T

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1259162

    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1259162
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  7. Article ; Online: Self-Harm in Aviation Medicine-A Complex Challenge During a Pandemic.

    Vuorio, Alpo / Bor, Robert

    Frontiers in public health

    2021  Volume 9, Page(s) 681618

    MeSH term(s) Aerospace Medicine ; Humans ; Pandemics ; Self-Injurious Behavior ; Suicide
    Language English
    Publishing date 2021-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2021.681618
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  8. Article: Editorial: Genetics of familial hypercholesterolemia: New insight-Volume II.

    Vuorio, Alpo / Ramaswami, Uma / Holven, Kirsten B

    Frontiers in genetics

    2022  Volume 13, Page(s) 1041342

    Language English
    Publishing date 2022-10-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.1041342
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  9. Book ; Thesis: A molecular and clinical study of heterozygous familial hypercholesterolemia in the Finnish North Karelia

    Vuorio, Alpo

    1998  

    Author's details Alpo Vuorio
    Language English
    Size Getr. Zählung : graph. Darst., Kt.
    Publishing country Finland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Helsinki, Univ., Diss., 1998
    HBZ-ID HT011074352
    ISBN 951-45-8333-7 ; 978-951-45-8333-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    99 E 2072 order for loan Magazin

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  10. Article ; Online: Coronary microcirculatory dysfunction in hypercholesterolemic patients with COVID-19: potential benefit from cholesterol-lowering treatment.

    Vuorio, Alpo / Kovanen, Petri T / Raal, Frederick J

    Annals of medicine

    2023  Volume 55, Issue 1, Page(s) 2199218

    Abstract: Patients with hypercholesterolemia often have coronary microvascular dysfunction (CMD). Viral infections, such as the SARS-CoV-2 infection, may also result in CMD. Three non-randomized studies have shown significant beneficial effects of statins on CMD ... ...

    Abstract Patients with hypercholesterolemia often have coronary microvascular dysfunction (CMD). Viral infections, such as the SARS-CoV-2 infection, may also result in CMD. Three non-randomized studies have shown significant beneficial effects of statins on CMD in non-infected patients. Similarly, in SARS-CoV-2 - infected patients one beneficial mechanism of action of statins may be the amelioration of endothelial dysfunction, which is a major driver of CMD. Apart from statins, lipoprotein apheresis and PCSK9 inhibitors can also improve or even reverse CMD. The potential reversal of CMD by using effective cholesterol-lowering medications during and after COVID-19 infection, especially in hypercholesterolemic COVID-19 patients, is important.KEY MESSAGESCoronary microvascular dysfunction (CMD) is common in patients hospitalized with SARS-CoV-2 infectionThree nonrandomized studies in non-infected patients are showing the beneficial effects of statin treatment on CMDEffective cholesterol-lowering medication during and after SARS-CoV-2 infection, especially in hypercholesterolemic COVID-19 patients, is of great significance.
    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Proprotein Convertase 9 ; COVID-19/complications ; Cholesterol, LDL ; Microcirculation ; SARS-CoV-2 ; Anticholesteremic Agents/therapeutic use ; Anticholesteremic Agents/pharmacology ; Cholesterol
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Cholesterol, LDL ; Anticholesteremic Agents ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2023-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2199218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 680: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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