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  1. Article ; Online: The impact of colchicine on patients with acute and chronic coronary artery disease.

    Madanchi, Mehdi / Young, Mabelle / Tersalvi, Gregorio / Maria Cioffi, Giacomo / Attinger-Toller, Adrian / Cuculi, Florim / Kurmann, Reto / Bossard, Matthias

    European journal of internal medicine

    2024  

    Abstract: Inflammation plays a central role in coronary artery disease (CAD), and recent data have shown that anti-inflammatory drugs have the potential to reduce ischemic events in CAD patients. Colchicine is an ancient anti-inflammatory drug that targets ... ...

    Abstract Inflammation plays a central role in coronary artery disease (CAD), and recent data have shown that anti-inflammatory drugs have the potential to reduce ischemic events in CAD patients. Colchicine is an ancient anti-inflammatory drug that targets neutrophil and inflammasome activities. It has been prescribed for decades for different rheumatological conditions. Given the important role of inflammation in the development of cardiovascular disease, there has been considerable interest in studying colchicine's potential to limit the progression of atherosclerosis among afflicted patients. In fact, there is a growing body of randomized data suggesting that use of low-dose colchicine reduces the risk of ischemic events in patients with CAD, particularly repeated revascularizations, new myocardial infarctions and strokes. This review article summarizes background information-including possible side effects and contraindications-as well as the current evidence backing up the use of colchicine in patients with established CAD.
    Language English
    Publishing date 2024-01-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2024.01.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effect of Additionally Integrating Clinical Information Into the Brugada Algorithm.

    Moccetti, Federico / Brugada, Pedro / Tersalvi, Gregorio / Yadava, Mrinal / Latifi, Yllka / Berte, Benjamin / Kobza, Richard / Sticherling, Christian / Reichlin, Tobias

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 6, Page(s) 868–870

    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Letter
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2022.12.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Emerging evidence of myocardial injury in COVID-19: A path through the smoke.

    Tersalvi, Gregorio / Veronese, Giacomo / Winterton, Dario

    Theranostics

    2020  Volume 10, Issue 21, Page(s) 9888–9889

    Abstract: Although Coronavirus Disease 2019 (COVID-19) presents primarily as a respiratory condition, a growing body of evidence shows it is a systemic disease. Recently, many authors have described myocardial damage in COVID-19, suggesting various ... ...

    Abstract Although Coronavirus Disease 2019 (COVID-19) presents primarily as a respiratory condition, a growing body of evidence shows it is a systemic disease. Recently, many authors have described myocardial damage in COVID-19, suggesting various pathophysiological mechanisms. In this issue, Cao
    MeSH term(s) COVID-19 ; Cardiomyopathies/etiology ; Coronavirus Infections/complications ; Humans ; Pandemics ; Pneumonia, Viral/complications
    Keywords covid19
    Language English
    Publishing date 2020-08-02
    Publishing country Australia
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.50788
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  4. Article ; Online: Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application.

    Tersalvi, Gregorio / Beltrani, Vittorio / Grübler, Martin R / Molteni, Alessandra / Cristoforetti, Yvonne / Pedrazzini, Giovanni / Treglia, Giorgio / Biasco, Luigi

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 5

    Abstract: Imaging modalities are increasingly being used to evaluate the underlying pathophysiology of heart failure. Positron emission tomography (PET) is a non-invasive imaging technique that uses radioactive tracers to visualize and measure biological processes ...

    Abstract Imaging modalities are increasingly being used to evaluate the underlying pathophysiology of heart failure. Positron emission tomography (PET) is a non-invasive imaging technique that uses radioactive tracers to visualize and measure biological processes in vivo. PET imaging of the heart uses different radiopharmaceuticals to provide information on myocardial metabolism, perfusion, inflammation, fibrosis, and sympathetic nervous system activity, which are all important contributors to the development and progression of heart failure. This narrative review provides an overview of the use of PET imaging in heart failure, highlighting the different PET tracers and modalities, and discussing fields of present and future clinical application.
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10050220
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  5. Article ; Online: Impact of Sacubitril-Valsartan on Markers of Glomerular Function.

    Tersalvi, Gregorio / Dauw, Jeroen / Martens, Pieter / Mullens, Wilfried

    Current heart failure reports

    2020  Volume 17, Issue 4, Page(s) 145–152

    Abstract: Purpose of review: To provide pathophysiological and clinical insights into the effects of sacubitril/valsartan on glomerular function.: Recent findings: Heart failure and glomerular dysfunction are closely intertwined. In addition to reduced heart ... ...

    Abstract Purpose of review: To provide pathophysiological and clinical insights into the effects of sacubitril/valsartan on glomerular function.
    Recent findings: Heart failure and glomerular dysfunction are closely intertwined. In addition to reduced heart failure hospitalization and all-cause mortality, patients treated with sacubitril/valsartan have a slower deterioration of glomerular filtration rate over time compared with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. The effects of sacubitril/valsartan are probably mediated through enhancement of natriuretic peptides, reduction of glomerular inflammation and fibrosis, and relaxation of mesangial cells and podocytes. Further studies will elucidate underlying pathophysiological mechanisms of sacubitril/valsartan on glomerular function and their prognostic significance in subjects with and without heart failure.
    MeSH term(s) Aminobutyrates/pharmacology ; Angiotensin Receptor Antagonists/pharmacology ; Drug Combinations ; Glomerular Filtration Rate/drug effects ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Neprilysin ; Stroke Volume/drug effects ; Stroke Volume/physiology ; Tetrazoles/pharmacology
    Chemical Substances Aminobutyrates ; Angiotensin Receptor Antagonists ; Drug Combinations ; Tetrazoles ; Neprilysin (EC 3.4.24.11) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-020-00463-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5936: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Sex Differences in Epidemiology, Morphology, Mechanisms, and Treatment of Mitral Valve Regurgitation.

    Tersalvi, Gregorio / Gaiero, Lorenzo / Capriolo, Michele / Cristoforetti, Yvonne / Salizzoni, Stefano / Senatore, Gaetano / Pedrazzini, Giovanni / Biasco, Luigi

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 6

    Abstract: Sex-related disparities have been recognized in incidence, pathological findings, pathophysiological mechanisms, and diagnostic pathways of non-rheumatic mitral regurgitation. Furthermore, access to treatments and outcomes for surgical and interventional ...

    Abstract Sex-related disparities have been recognized in incidence, pathological findings, pathophysiological mechanisms, and diagnostic pathways of non-rheumatic mitral regurgitation. Furthermore, access to treatments and outcomes for surgical and interventional therapies among women and men appears to be different. Despite this, current European and US guidelines have identified common diagnostic and therapeutic pathways that do not consider patient sex in decision-making. The aim of this review is to summarize the current evidence on sex-related differences in non-rheumatic mitral regurgitation, particularly regarding incidence, imaging modalities, surgical-derived evidence, and outcomes of transcatheter edge-to-edge repair, with the goal of informing clinicians about sex-specific challenges to consider when making treatment decisions for patients with mitral regurgitation.
    MeSH term(s) Humans ; Female ; Male ; Mitral Valve Insufficiency/epidemiology ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/therapy ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation/methods ; Sex Characteristics ; Cardiac Catheterization/methods ; Treatment Outcome
    Language English
    Publishing date 2023-05-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59061017
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Acute Coronary Syndrome, Antiplatelet Therapy, and Bleeding: A Clinical Perspective.

    Tersalvi, Gregorio / Biasco, Luigi / Cioffi, Giacomo Maria / Pedrazzini, Giovanni

    Journal of clinical medicine

    2020  Volume 9, Issue 7

    Abstract: Inhibition of platelet function by means of dual antiplatelet therapy (DAPT) is the cornerstone of treatment of acute coronary syndrome (ACS). While preventing ischemic recurrences, inhibition of platelet function is clearly associated with an increased ... ...

    Abstract Inhibition of platelet function by means of dual antiplatelet therapy (DAPT) is the cornerstone of treatment of acute coronary syndrome (ACS). While preventing ischemic recurrences, inhibition of platelet function is clearly associated with an increased bleeding risk, a feared complication that may lead to significant morbidity and mortality. Since bleeding risk management is intrinsically associated with therapeutic adjustments undertaken during the whole clinical history of patients with acute coronary syndrome, single decisions taken from the very first day to years of follow-up might be decisive. This review aims at providing a clinically oriented, patient-tailored approach in reducing the risk and manage bleeding complications in ACS patients treated with DAPT. The steps in clinical decision making from the day of ACS to follow-up are analyzed. New treatment strategies to enhance the safety of DAPT are also described.
    Language English
    Publishing date 2020-07-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9072064
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  8. Article ; Online: Sex Differences in Epidemiology, Morphology, Mechanisms, and Treatment of Mitral Valve Regurgitation

    Gregorio Tersalvi / Lorenzo Gaiero / Michele Capriolo / Yvonne Cristoforetti / Stefano Salizzoni / Gaetano Senatore / Giovanni Pedrazzini / Luigi Biasco

    Medicina, Vol 59, Iss 1017, p

    2023  Volume 1017

    Abstract: Sex-related disparities have been recognized in incidence, pathological findings, pathophysiological mechanisms, and diagnostic pathways of non-rheumatic mitral regurgitation. Furthermore, access to treatments and outcomes for surgical and interventional ...

    Abstract Sex-related disparities have been recognized in incidence, pathological findings, pathophysiological mechanisms, and diagnostic pathways of non-rheumatic mitral regurgitation. Furthermore, access to treatments and outcomes for surgical and interventional therapies among women and men appears to be different. Despite this, current European and US guidelines have identified common diagnostic and therapeutic pathways that do not consider patient sex in decision-making. The aim of this review is to summarize the current evidence on sex-related differences in non-rheumatic mitral regurgitation, particularly regarding incidence, imaging modalities, surgical-derived evidence, and outcomes of transcatheter edge-to-edge repair, with the goal of informing clinicians about sex-specific challenges to consider when making treatment decisions for patients with mitral regurgitation.
    Keywords mitral regurgitation ; sex differences ; transcatheter mitral valve repair ; Medicine (General) ; R5-920
    Subject code 150
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Ventricular Unloading Using the Impella

    Attinger-Toller, Adrian / Bossard, Matthias / Cioffi, Giacomo Maria / Tersalvi, Gregorio / Madanchi, Mehdi / Bloch, Andreas / Kobza, Richard / Cuculi, Florim

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 856870

    Abstract: Cardiogenic shock (CS) remains a leading cause of hospital death. However, the use of mechanical circulatory support has fundamentally changed CS management over the last decade and is rapidly increasing. In contrast to extracorporeal membrane ... ...

    Abstract Cardiogenic shock (CS) remains a leading cause of hospital death. However, the use of mechanical circulatory support has fundamentally changed CS management over the last decade and is rapidly increasing. In contrast to extracorporeal membrane oxygenation as well as counterpulsation with an intraaortic balloon pump, ventricular unloading by the Impella™ device actively reduces ventricular volume as well as pressure and augments systemic blood flow at the same time. By improving myocardial oxygen supply and enhancing systemic circulation, the Impella device potentially protects myocardium, facilitates ventricular recovery and may interrupt the shock spiral. So far, the evidence supporting the use of Impella™ in CS patients derives mostly from observational studies, and there is a need for adequate randomized trials. However, the Impella™ device appears a promising technology for management of CS patients. But a profound understanding of the device, its physiologic impact and clinical application are all important when evaluating CS patients for percutaneous circulatory support. This review provides a comprehensive overview of the percutaneous assist device Impella™. Moreover, it highlights in depth the rationale for ventricular unloading in CS and describes practical aspects to optimize care for patients requiring hemodynamic support.
    Language English
    Publishing date 2022-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.856870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Emerging evidence of myocardial injury in COVID-19: A path through the smoke

    Tersalvi, Gregorio / Veronese, Giacomo / Winterton, Dario

    Theranostics

    Abstract: Although Coronavirus Disease 2019 (COVID-19) presents primarily as a respiratory condition, a growing body of evidence shows it is a systemic disease. Recently, many authors have described myocardial damage in COVID-19, suggesting various ... ...

    Abstract Although Coronavirus Disease 2019 (COVID-19) presents primarily as a respiratory condition, a growing body of evidence shows it is a systemic disease. Recently, many authors have described myocardial damage in COVID-19, suggesting various pathophysiological mechanisms. In this issue, Cao et al. demonstrate the prognostic value of cardiac troponin I in patients with COVID-19, showing how even minor elevations in this molecule carry a great impact on patient mortality. In a situation such as the worldwide COVID-19 pandemic, where healthcare resources are placed under enormous stress, readily available tests such as this play an important role in helping clinicians identify patients at greater risk of developing severe forms of the disease, and should be included in the initial triage panel.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #732687
    Database COVID19

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