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Article ; Online: Publisher Correction: Developmental dynamics of two bipotent thymic epithelial progenitor types.

Nusser, Anja / Sagar / Swann, Jeremy B / Krauth, Brigitte / Diekhoff, Dagmar / Calderon, Lesly / Happe, Christiane / Grün, Dominic / Boehm, Thomas

Nature

2024 Volume 626, Issue 8000, Page(s) E17

Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Published Erratum
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07129-1
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Article ; Online: A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons.

Swann, Jeremy B / Grammer, Christiane / Schorpp, Michael / Boehm, Thomas

BMC immunology

2023 Volume 24, Issue 1, Page(s) 20

Abstract: ... the core genes needed to mount adaptive T and B cell responses. These genes include those necessary ... signalling molecules, and antigen presenting molecules (both class I and class II) needed for B cell and T ...

Abstract	Background: The anglerfish, belonging to the teleost order Lophiiformes, are a diverse and species-rich group of fish that are known to exhibit a number of unique morphological, reproductive and immunological adaptations. Work to date has identified the loss of specific adaptive immune components in two of the five Lophiiformes sub-orders (Lophioidei and Ceratioidei), while no anomalies have been identified to date in two other sub-orders, Antennaroidei and Chaunacoidei. The immunogenome of the fifth sub-order, Ogcocephaloidei has not yet been investigated, and we have therefore used whole genome shotgun sequencing, combined with RNA-seq, to survey the adaptive immune capabilities of the polka-dot batfish, O. cubifrons, as a representative of this as yet unexplored sub-order. Results: We find that the O. cubifrons genome encodes the core genes needed to mount adaptive T and B cell responses. These genes include those necessary for rearranging and editing antigen receptors, the antigen receptors themselves; as well as the co-receptors, signalling molecules, and antigen presenting molecules (both class I and class II) needed for B cell and T cell development and activation. Conclusions: From an immune perspective, the polka-dot batfish has a canonical complement of adaptive immune genes, and does not exhibit any of the adaptive immune changes previously identified in monkfish and oceanic anglerfish.
MeSH term(s)	Animals ; B-Lymphocytes ; Cell Differentiation
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041500-X
ISSN	1471-2172 ; 1471-2172
ISSN (online)	1471-2172
ISSN	1471-2172
DOI	10.1186/s12865-023-00557-0
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Article ; Online: Lymphocyte pathway analysis using naturally lymphocyte-deficient fish.

Zhang, Gaoqun / Swann, Jeremy B / Felder, Marius / O'Meara, Connor / Boehm, Thomas

European journal of immunology

2023 Volume 53, Issue 12, Page(s) e2350577

Abstract: Comparative phylogenetic analyses are of potential value to establish the essential components of genetic networks underlying physiological traits. For species that naturally lack particular lymphocyte lineages, we show here that this strategy readily ... ...

Abstract	Comparative phylogenetic analyses are of potential value to establish the essential components of genetic networks underlying physiological traits. For species that naturally lack particular lymphocyte lineages, we show here that this strategy readily distinguishes trait-specific actors from pleiotropic components of the genetic network governing lymphocyte differentiation. Previously, three of the four members of the DNA polymerase X family have been implicated in the junctional diversification process during the somatic assembly of antigen receptors. Our phylogenetic analysis indicates that the presence of terminal deoxynucleotidyl transferase is strictly associated with the facility of V(D)J recombination, whereas PolL and PolM genes are retained even in species lacking Rag-mediated somatic diversification of antigen receptor genes.
MeSH term(s)	Animals ; Gene Regulatory Networks ; Phylogeny ; Lymphocytes ; V(D)J Recombination
Language	English
Publishing date	2023-08-31
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202350577
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Article ; Online: Foxn1 is not essential for T-cell development in teleosts.

Schorpp, Michael / Swann, Jeremy B / Hess, Isabell / Ho, Hsuan-Ching / Pietsch, Theodore W / Boehm, Thomas

European journal of immunology

2023 Volume 53, Issue 12, Page(s) e2350725

Abstract: In mammals, T-cell development depends on the activity of the Foxn1 transcription factor in the thymic epithelium; mutations in the vertebrate-specific Foxn1 gene are associated with profound T-cell lymphopenia and fatal immunodeficiency. Here, we ... ...

Abstract	In mammals, T-cell development depends on the activity of the Foxn1 transcription factor in the thymic epithelium; mutations in the vertebrate-specific Foxn1 gene are associated with profound T-cell lymphopenia and fatal immunodeficiency. Here, we examined the extent of T-cell development in teleosts lacking a functional foxn1 gene. In zebrafish carrying a deleterious internal deletion of foxn1, reduced but robust lymphopoietic activity is maintained in the mutant thymus. Moreover, pseudogenization or loss of foxn1 in the genomes of deep-sea anglerfishes is independent of the presence or absence of the canonical signatures of the T-cell lineage. Thus, in contrast to the situation in mammals, the teleost thymus can support foxn1-independent lymphopoiesis, most likely through the activity of the Foxn4, an ancient metazoan paralog of Foxn1. Our results imply that during the early stages of vertebrate evolution, genetic control of thymopoiesis was functionally redundant and thus robust; in mammals, the genetic network was reorganized to become uniquely dependent on the FOXN1 transcription factor.
MeSH term(s)	Mice ; Animals ; Mice, Transgenic ; Zebrafish/genetics ; Gene Regulatory Networks ; T-Lymphocytes ; Thymus Gland ; Transcription Factors/genetics ; Forkhead Transcription Factors/genetics ; Epithelial Cells ; Mammals/genetics ; Zebrafish Proteins/genetics
Chemical Substances	Transcription Factors ; Forkhead Transcription Factors ; Foxn1 protein, zebrafish ; Zebrafish Proteins
Language	English
Publishing date	2023-09-29
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202350725
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Article ; Online: Developmental dynamics of two bipotent thymic epithelial progenitor types.

Nusser, Anja / Sagar / Swann, Jeremy B / Krauth, Brigitte / Diekhoff, Dagmar / Calderon, Lesly / Happe, Christiane / Grün, Dominic / Boehm, Thomas

Nature

2022 Volume 606, Issue 7912, Page(s) 165–171

Abstract: T cell development in the thymus is essential for cellular immunity and depends on the organotypic thymic epithelial microenvironment. In comparison with other organs, the size and cellular composition of the thymus are unusually dynamic, as exemplified ... ...

Abstract	T cell development in the thymus is essential for cellular immunity and depends on the organotypic thymic epithelial microenvironment. In comparison with other organs, the size and cellular composition of the thymus are unusually dynamic, as exemplified by rapid growth and high T cell output during early stages of development, followed by a gradual loss of functional thymic epithelial cells and diminished naive T cell production with age
MeSH term(s)	Aging ; Animals ; Autocrine Communication ; CRISPR-Cas Systems ; Cellular Microenvironment ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Epithelium ; Fibroblast Growth Factor 7 ; Mice ; RNA-Seq ; Single-Cell Analysis ; Stem Cells/cytology ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism ; Thymus Gland/cytology
Chemical Substances	Fgf7 protein, mouse ; Fibroblast Growth Factor 7 (126469-10-1)
Language	English
Publishing date	2022-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04752-8
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Article ; Online: Retracing the evolutionary emergence of thymopoiesis.

Swann, Jeremy B / Nusser, Anja / Morimoto, Ryo / Nagakubo, Daisuke / Boehm, Thomas

Science advances

2020 Volume 6, Issue 48

Abstract: The onset of lymphocyte development in the vertebrate primordial thymus, about 500 million years ago, represents one of the foundational events of the emerging adaptive immune system. Here, we retrace the evolutionary trajectory of thymopoiesis, from ... ...

Abstract	The onset of lymphocyte development in the vertebrate primordial thymus, about 500 million years ago, represents one of the foundational events of the emerging adaptive immune system. Here, we retrace the evolutionary trajectory of thymopoiesis, from early vertebrates to mammals, guided by members of the
MeSH term(s)	Animals ; B-Lymphocytes ; Lymphopoiesis/genetics ; Mammals ; Mice ; Mice, Transgenic ; Phylogeny ; T-Lymphocytes ; Vertebrates
Language	English
Publishing date	2020-11-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abd9585
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Article ; Online: The immunogenetics of sexual parasitism.

Swann, Jeremy B / Holland, Stephen J / Petersen, Malte / Pietsch, Theodore W / Boehm, Thomas

Science (New York, N.Y.)

2020 Volume 369, Issue 6511, Page(s) 1608–1615

Abstract: Sexual parasitism has evolved as a distinctive mode of reproduction among deep-sea anglerfishes. The permanent attachment of males to host females observed in these species represents a form of anatomical joining, which is otherwise unknown in nature. ... ...

Abstract	Sexual parasitism has evolved as a distinctive mode of reproduction among deep-sea anglerfishes. The permanent attachment of males to host females observed in these species represents a form of anatomical joining, which is otherwise unknown in nature. Pronounced modifications to immune facilities are associated with this reproductive trait. The genomes of species with temporarily attaching males lack functional
MeSH term(s)	Adaptive Immunity/genetics ; Animals ; Antibodies/genetics ; Antibody Affinity/genetics ; Biological Coevolution ; Cytidine Deaminase/genetics ; Female ; Fishes/classification ; Fishes/genetics ; Fishes/immunology ; Genetic Variation ; Host-Parasite Interactions/genetics ; Host-Parasite Interactions/immunology ; Immunity, Innate/genetics ; Immunogenetics ; Major Histocompatibility Complex/genetics ; Male ; Phylogeny ; Receptors, Antigen ; Reproduction/genetics ; Reproduction/immunology ; Sexual Behavior, Animal
Chemical Substances	Antibodies ; Receptors, Antigen ; AICDA (activation-induced cytidine deaminase) (EC 3.5.4.-) ; Cytidine Deaminase (EC 3.5.4.5)
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aaz9445
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Article ; Online: Origin and evolution of adaptive immunity.

Boehm, Thomas / Swann, Jeremy B

Annual review of animal biosciences

2014 Volume 2, Page(s) 259–283

Abstract: ... including B- and T-like lymphocyte lineages and primary lymphoid organs, such as the thymus, but possibly ...

Abstract	The evolutionary emergence of vertebrates was accompanied by major morphological and functional innovations, including the development of an adaptive immune system. Vertebrate adaptive immunity is based on the clonal expression of somatically diversifying antigen receptors on lymphocytes. This is a common feature of both the jawless and jawed vertebrates , although these two groups of extant vertebrates employ structurally different types of antigen receptors and principal mechanisms for their somatic diversification . These observations suggest that the common vertebrate ancestor must have already possessed a complex immune system, including B- and T-like lymphocyte lineages and primary lymphoid organs, such as the thymus, but possibly lacked the facilities for somatic diversification of antigen receptors. Interestingly, memory formation, previously considered to be a defining feature of adaptive immunity, also occurs in the context of innate immune responses and can even be observed in unicellular organisms, attesting to the convergent evolutionary history of distinct aspects of adaptive immunity.
MeSH term(s)	Adaptive Immunity/genetics ; Animals ; Biological Evolution ; Lymphoid Tissue/immunology ; Vertebrates/genetics ; Vertebrates/immunology
Language	English
Publishing date	2014-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2700164-7
ISSN	2165-8110 ; 2165-8102
ISSN (online)	2165-8110
ISSN	2165-8102
DOI	10.1146/annurev-animal-022513-114201
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Article ; Online: Elevated levels of Wnt signaling disrupt thymus morphogenesis and function.

Swann, Jeremy B / Happe, Christiane / Boehm, Thomas

Scientific reports

2017 Volume 7, Issue 1, Page(s) 785

Abstract: All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its morphogenesis remain unanswered. Here, ...

Abstract	All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its morphogenesis remain unanswered. Here, we demonstrate that, in contrast to the situation in many other epithelial cell types, differentiation of thymic epithelial cells (TECs) proceeds normally in the absence of canonical Wnt signaling and the classical adhesion molecule E-cadherin. By contrast, TEC-intrinsic activation of β-catenin-dependent Wnt signaling blocks the morphogenesis of the thymus, and overexpression of a secreted Wnt ligand by TECs dominantly modifies the morphogenesis not only of the thymus, but also of the parathyroid and thyroid. These observations indicate that Wnt signaling activity in the thymus needs to be precisely controlled to support normal TEC differentiation, and suggest possible mechanisms underlying anatomical variations of the thymus, parathyroid and thyroid in humans.
MeSH term(s)	Animals ; Biomarkers ; Bone Morphogenetic Proteins/metabolism ; Cadherins ; Cell Differentiation/genetics ; Cell Movement/genetics ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Gene Expression ; Immunohistochemistry ; Mice ; Mice, Knockout ; Mice, Transgenic ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Morphogenesis ; Signal Transduction ; Thymus Gland/embryology ; Thymus Gland/metabolism ; Wnt Proteins/metabolism ; Wnt Signaling Pathway ; beta Catenin/genetics ; beta Catenin/metabolism
Chemical Substances	Biomarkers ; Bone Morphogenetic Proteins ; Cadherins ; Wnt Proteins ; beta Catenin ; Nlk protein, mouse (EC 2.7.11.1) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2017-04-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-00842-0
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Article ; Online: Elevated levels of Wnt signaling disrupt thymus morphogenesis and function

Jeremy B. Swann / Christiane Happe / Thomas Boehm

Scientific Reports, Vol 7, Iss 1, Pp 1-

2017 Volume 15

Abstract: Abstract All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its morphogenesis remain ... ...

Abstract	Abstract All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its morphogenesis remain unanswered. Here, we demonstrate that, in contrast to the situation in many other epithelial cell types, differentiation of thymic epithelial cells (TECs) proceeds normally in the absence of canonical Wnt signaling and the classical adhesion molecule E-cadherin. By contrast, TEC-intrinsic activation of β-catenin-dependent Wnt signaling blocks the morphogenesis of the thymus, and overexpression of a secreted Wnt ligand by TECs dominantly modifies the morphogenesis not only of the thymus, but also of the parathyroid and thyroid. These observations indicate that Wnt signaling activity in the thymus needs to be precisely controlled to support normal TEC differentiation, and suggest possible mechanisms underlying anatomical variations of the thymus, parathyroid and thyroid in humans.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2017-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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