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Article ; Online: Consequences of the Edge Effect in a Commercial Enzyme-Linked Immunosorbent Assay for the Diagnosis of Lyme Neuroborreliosis.

van Gorkom, Tamara / van Arkel, Gijs H J / Voet, Willem / Thijsen, Steven F T / Kremer, Kristin

2021 Volume 59, Issue 8, Page(s) e0328020

Abstract: The diagnosis of Lyme neuroborreliosis (LNB) is based on neurological symptoms, cerebrospinal fluid (CSF) pleocytosis, and intrathecally ... ...

Abstract	The diagnosis of Lyme neuroborreliosis (LNB) is based on neurological symptoms, cerebrospinal fluid (CSF) pleocytosis, and intrathecally produced
MeSH term(s)	Antibodies, Bacterial ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin M ; Lyme Neuroborreliosis/diagnosis ; Reproducibility of Results
Chemical Substances	Antibodies, Bacterial ; Immunoglobulin M
Language	English
Publishing date	2021-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.03280-20
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Article: Seroprevalence and Risk Factors of Lyme Borreliosis in The Netherlands: A Population-Based Cross-Sectional Study.

Hoeve-Bakker, B J A / van den Berg, Oda E / Doppenberg, H S / van der Klis, Fiona R M / van den Wijngaard, Cees C / Kluytmans, Jan A J W / Thijsen, Steven F T / Kerkhof, Karen

Microorganisms

2023 Volume 11, Issue 4

Abstract: Lyme borreliosis (LB) is not notifiable in many European countries, and accurate data on the incidence are often lacking. This study aimed to determine the seroprevalence ... ...

Abstract	Lyme borreliosis (LB) is not notifiable in many European countries, and accurate data on the incidence are often lacking. This study aimed to determine the seroprevalence of
Language	English
Publishing date	2023-04-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11041081
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Article ; Online: Differential abundance of IgG antibodies against the spike protein of SARS-CoV-2 and seasonal coronaviruses in patients with fatal COVID-19.

Smit, Wouter L / van Tol, Sophie / Haas, Lenneke E M / Limonard, Gijs J M / Bossink, Ailko / Reusken, Chantal / Heron, Michiel / Thijsen, Steven F T

Virology journal

2023 Volume 20, Issue 1, Page(s) 85

Abstract: Infection with the novel pandemic SARS-CoV-2 virus has been shown to elicit a cross-reactive immune response that could lead to a back-boost of memory recall to previously encountered seasonal (endemic) coronaviruses (eCoVs). Whether this response is ... ...

Abstract	Infection with the novel pandemic SARS-CoV-2 virus has been shown to elicit a cross-reactive immune response that could lead to a back-boost of memory recall to previously encountered seasonal (endemic) coronaviruses (eCoVs). Whether this response is associated with a fatal clinical outcome in patients with severe COVID-19 remains unclear. In a cohort of hospitalized patients, we have previously shown that heterologous immune responses to eCoVs can be detected in severe COVID-19. Here, we report that COVID-19 patients with fatal disease have decreased SARS-CoV-2 neutralizing antibody titers at hospital admission, which correlated with lower SARS-CoV-2 spike-specific IgG and was paralleled by a relative abundance of IgG against spike protein of eCoVs of the genus Betacoronavirus. Additional research is needed to assess if eCoV-specific back-boosted IgG is a bystander phenomenon in severe COVID-19, or a factor that influences the development of an efficient anti-viral immune response.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; Seasons ; Antibodies, Viral ; Antibodies, Neutralizing
Chemical Substances	Immunoglobulin G ; spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-023-02050-x
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Article ; Online: Teken-encefalitis in Nederland.

van Heusden, Hugo C / Voet, Willem / Sprong, Hein / Brandwagt, Diederik A H / Thijsen, Steven F T

Nederlands tijdschrift voor geneeskunde

2020 Volume 164

Abstract: Tick-borne encephalitis (TBE) is endemic in South-Scandinavia, Central Europe and Eastern Europe. In 2016 the first patient was reported with TBE virus infection contracted in the Netherlands, in a forested area between Driebergen and Maarn (near Utrecht) ...

Title translation	Tick-borne encephalitis in the Netherlands.
Abstract	Tick-borne encephalitis (TBE) is endemic in South-Scandinavia, Central Europe and Eastern Europe. In 2016 the first patient was reported with TBE virus infection contracted in the Netherlands, in a forested area between Driebergen and Maarn (near Utrecht). At the time, field research did not identify any TBE-positive ticks at the supposed infection site. In the last two years, two patients have been diagnosed with TBE in the Diakonessenhuis Hospital in Utrecht; one patient was bitten by a tick in the Netherlands. This time round, tests on ticks from a different area near Utrecht (the forests around Zeist) did identify TBE-positive ticks. TBE infection is often asymptomatic. However, in a small proportion of patients, disease can develop and there is currently no curative therapy available. An effective vaccine is available. At the moment no vaccination recommendation is issued in the Netherlands. TBE should be considered in patients presenting with fever after a recent tick bite. When neurological symptoms appear, referral to a neurologist is necessary.
MeSH term(s)	Animals ; Encephalitis Viruses, Tick-Borne ; Encephalitis, Tick-Borne/epidemiology ; Encephalitis, Tick-Borne/prevention & control ; Humans ; Netherlands/epidemiology ; Tick Bites ; Ticks/virology ; Vaccination
Language	Dutch
Publishing date	2020-02-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: The Usefulness of Two CXCL13 Assays on Cerebrospinal Fluid for the Diagnosis of Lyme Neuroborreliosis: a Retrospective Study in a Routine Clinical Setting.

van Gorkom, Tamara / van Arkel, Gijs H J / Heron, Michiel / Voet, Willem / Thijsen, Steven F T / Kremer, Kristin

Journal of clinical microbiology

2021 Volume 59, Issue 9, Page(s) e0025521

Abstract: Recent studies have shown elevated levels of the B-cell chemokine (C-X-C motif) ligand 13 (CXCL13) in the cerebrospinal fluid (CSF) of patients with early Lyme neuroborreliosis (LNB). In this retrospective study, we evaluated the diagnostic performance ... ...

Abstract	Recent studies have shown elevated levels of the B-cell chemokine (C-X-C motif) ligand 13 (CXCL13) in the cerebrospinal fluid (CSF) of patients with early Lyme neuroborreliosis (LNB). In this retrospective study, we evaluated the diagnostic performance of the Quantikine CXCL13 enzyme-linked immunosorbent assay (ELISA) (R&D Systems, Inc., MN, USA) and the
MeSH term(s)	Chemokine CXCL13 ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunologic Tests ; Lyme Neuroborreliosis/diagnosis ; ROC Curve ; Retrospective Studies
Chemical Substances	CXCL13 protein, human ; Chemokine CXCL13
Language	English
Publishing date	2021-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.00255-21
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Zs.A 1188: Show issues

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Article ; Online: The Performance of Nine Commercial Serological Screening Assays for the Diagnosis of Lyme Borreliosis: a Multicenter Modified Two-Gate Design Study.

Hoeve-Bakker, B J A / Jonker, Mark / Brandenburg, Afke H / den Reijer, P Martijn / Stelma, Foekje F / van Dam, Alje P / van Gorkom, Tamara / Kerkhof, Karen / Thijsen, Steven F T / Kremer, Kristin

Microbiology spectrum

2022 Volume 10, Issue 2, Page(s) e0051022

Abstract: In this retrospective study, the performance of nine serological screening assays for Lyme borreliosis (LB) diagnostics was evaluated using a study population of LB cases and controls. Sera derived from 74 well-defined LB cases and 122 controls were ... ...

Abstract	In this retrospective study, the performance of nine serological screening assays for Lyme borreliosis (LB) diagnostics was evaluated using a study population of LB cases and controls. Sera derived from 74 well-defined LB cases and 122 controls were included. The LB cases were diagnosed with erythema migrans (EM;
MeSH term(s)	Antibodies, Bacterial ; Borrelia ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Lyme Disease/diagnosis ; Retrospective Studies
Chemical Substances	Antibodies, Bacterial ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00510-22
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Article ; Online: Retrospective Evaluation of Various Serological Assays and Multiple Parameters for Optimal Diagnosis of Lyme Neuroborreliosis in a Routine Clinical Setting.

van Gorkom, Tamara / Voet, Willem / van Arkel, Gijs H J / Heron, Michiel / Hoeve-Bakker, B J A / Notermans, Daan W / Thijsen, Steven F T / Kremer, Kristin

Microbiology spectrum

2022 Volume 10, Issue 3, Page(s) e0006122

Abstract: Laboratory diagnosis of Lyme neuroborreliosis (LNB) is challenging, and validated diagnostic algorithms are lacking. Therefore, this retrospective cross-sectional study aimed to compare the diagnostic performance of seven commercial antibody assays for ... ...

Abstract	Laboratory diagnosis of Lyme neuroborreliosis (LNB) is challenging, and validated diagnostic algorithms are lacking. Therefore, this retrospective cross-sectional study aimed to compare the diagnostic performance of seven commercial antibody assays for LNB diagnosis. Random forest (RF) modeling was conducted to investigate whether the diagnostic performance using the antibody assays could be improved by including several routine cerebrospinal fluid (CSF) parameters (i.e., leukocyte count, total protein, blood-CSF barrier functionality, and intrathecal total antibody synthesis), two-tier serology on serum, the CSF level of the B-cell chemokine (C-X-C motif) ligand 13 (CXCL13), and a
MeSH term(s)	Antibodies ; Borrelia ; Cross-Sectional Studies ; Humans ; Leukocytosis/diagnosis ; Lyme Neuroborreliosis/cerebrospinal fluid ; Lyme Neuroborreliosis/diagnosis ; Prospective Studies ; Retrospective Studies
Chemical Substances	Antibodies
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00061-22
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Article ; Online: Elevated nucleoprotein-induced interferon-γ release in COVID-19 patients detected in a SARS-CoV-2 enzyme-linked immunosorbent spot assay.

Thijsen, Steven / Heron, Michiel / Gremmels, Hendrik / van der Kieft, Robert / Reusken, Chantal / Kremer, Kristin / Limonard, Gijs / Bossink, Ailko

The Journal of infection

2020 Volume 81, Issue 3, Page(s) 452–482

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Immunosorbents ; Interferon-gamma ; Nucleoproteins ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
Chemical Substances	Immunosorbents ; Nucleoproteins ; Interferon-gamma (82115-62-6)
Keywords	covid19
Language	English
Publishing date	2020-06-12
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2020.06.015
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Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Differential vaccine-induced kinetics of humoral and cellular immune responses in SARS-CoV-2 naive and convalescent health care workers.

Smit, Wouter / Thijsen, Steven / van der Kieft, Robert / van Tol, Sophie / Reimerink, Johan / Reusken, Chantal / Rümke, Lidewij / Bossink, Ailko / Limonard, Gijs / Heron, Michiel

Pathogens and disease

2022 Volume 80, Issue 1

Abstract: Effective vaccination is a key element in the exit strategy from the current severe acute respiratory syndrome-CoV coronavirus-2 (SARS-CoV-2) pandemic, and may also offer protection against severe disease from future variants of concern. Here, we ... ...

Abstract	Effective vaccination is a key element in the exit strategy from the current severe acute respiratory syndrome-CoV coronavirus-2 (SARS-CoV-2) pandemic, and may also offer protection against severe disease from future variants of concern. Here, we prospectively monitored T-cell responses over time, using ELISpot interferon-γ (INF-y) release assays, and B-cell responses, using serological tests, after vaccination and booster with BioNTech/Pfizer mRNA (Pfizer) and Janssen vector (Janssen/Johnson & Johnson) vaccines in hospital health care workers. Vaccine recipients were divided into seropositive and seronegative individuals at baseline, in order to determine the effect of natural immunity on vaccine-induced immune kinetics. We found that convalescent individuals mounted higher spike-specific INF-y-secreting T-cell responses and B-cell-mediated IgG responses, after receiving the Janssen vaccine or the first dose of the Pfizer vaccine. IgG levels corresponded to the virus neutralization capacity as measured by VNT assay. At 8 months postvaccination, spike-specific cellular immunity waned to low levels in individuals with or without prior natural immunity, whereas waning of humoral immunity occurred predominantly in naive individuals. The booster shot effectively reinduced both cellular and humoral immune responses. To conclude, our data supports the implemented single-dose mRNA booster strategy employed in the Netherlands. Furthermore, the level of pre-existing natural immunity may be factored into determining the optimal time window between future booster vaccines.
MeSH term(s)	Antibodies, Viral ; COVID-19/prevention & control ; Health Personnel ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunoglobulin G ; Interferon-gamma ; Kinetics ; RNA, Messenger ; SARS-CoV-2 ; Vaccination ; Viral Vaccines
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; RNA, Messenger ; Viral Vaccines ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2049-632X
ISSN (online)	2049-632X
DOI	10.1093/femspd/ftac035
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Article ; Online: A two minute liquid based sample preparation for rapid SARS-CoV2 real-time PCR screening: A multicentre evaluation.

Claas, Eric C J / Smit, Pieter W / van Bussel, Mario J A W M / Verbakel, Harold / Taouil, Mohammed / Verweij, Jaco J / Thijsen, Steven F T

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2020 Volume 135, Page(s) 104720

Abstract: Background: Apart from major health concerns associated to the SARS-coronavirus-2 (SARS-CoV-2) pandemic, also the diagnostic workflow encountered serious problems. Limited availability of kit components, buffers and even plastics has resulted in ... ...

Abstract	Background: Apart from major health concerns associated to the SARS-coronavirus-2 (SARS-CoV-2) pandemic, also the diagnostic workflow encountered serious problems. Limited availability of kit components, buffers and even plastics has resulted in suboptimal testing procedures worldwide. Alternative workflows have been implemented to overcome these difficulties. Recently a liquid based sample prep has been launched as solution to overcome limitations in relation to nucleic acid extraction. Objective: Multicenter evaluation of the QIAprep& Viral RNA UM kit (QIA P&A) for rapid sample preparation and real-time PCR detection of SARS-CoV-2 in comparison to standardized laboratory testing methods. Study design: Selected samples of the routine diagnostic workflow at Clinical Microbiology Laboratories of four Dutch hospitals have been subjected to the rapid QIA P&A protocol and the results have been compared to routine diagnostic data. Results: Combining results of manual and automated procedures, a total of 377 clinical samples of which 202 had been tested positive with a wide range of C Conclusions: Despite an input of only 8 μL of clinical sample, the QIA P&A kit showed good performance for sample preparation and amplification of SARS-CoV-2 and can contribute as a rapid molecular testing strategy in managing the CoV-2 pandemic.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Testing/methods ; Clinical Laboratory Techniques/methods ; Humans ; Mass Screening/methods ; Molecular Diagnostic Techniques/methods ; Pandemics/prevention & control ; Prospective Studies ; Real-Time Polymerase Chain Reaction/methods ; SARS-CoV-2/genetics ; Specimen Handling/methods ; Workflow
Language	English
Publishing date	2020-12-31
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2020.104720
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