LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 109

Search options

  1. Article ; Online: Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections.

    Ciurkiewicz, Malgorzata / Herder, Vanessa / Beineke, Andreas

    International journal of molecular sciences

    2020  Volume 21, Issue 5

    Abstract: Neurotropic viruses infect the central nervous system (CNS) and cause acute or chronic neurologic disabilities. Regulatory T cells (Treg) play a critical role for immune homeostasis, but may inhibit pathogen-specific immunity in infectious disorders. The ...

    Abstract Neurotropic viruses infect the central nervous system (CNS) and cause acute or chronic neurologic disabilities. Regulatory T cells (Treg) play a critical role for immune homeostasis, but may inhibit pathogen-specific immunity in infectious disorders. The present review summarizes the current knowledge about Treg in human CNS infections and their animal models. Besides dampening pathogen-induced immunopathology, Treg have the ability to facilitate protective responses by supporting effector T cell trafficking to the infection site and the development of resident memory T cells. Moreover, Treg can reduce virus replication by inducing apoptosis of infected macrophages and attenuate neurotoxic astrogliosis and pro-inflammatory microglial responses. By contrast, detrimental effects of Treg are caused by suppression of antiviral immunity, allowing for virus persistence and latency. Opposing disease outcomes following Treg manipulation in different models might be attributed to differences in technique and timing of intervention, infection route, genetic background, and the host's age. In addition, mouse models of virus-induced demyelination revealed that Treg are able to reduce autoimmunity and immune-mediated CNS damage in a disease phase-dependent manner. Understanding the unique properties of Treg and their complex interplay with effector cells represents a prerequisite for the development of new therapeutic approaches in neurotropic virus infections.
    MeSH term(s) Animals ; Central Nervous System Diseases/immunology ; Central Nervous System Diseases/virology ; Humans ; T-Lymphocytes, Regulatory/immunology ; Virus Diseases/immunology
    Keywords covid19
    Language English
    Publishing date 2020-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21051705
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection.

    Hülskötter, Kirsten / Lühder, Fred / Flügel, Alexander / Herder, Vanessa / Baumgärtner, Wolfgang

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen is described as having a negative impact on adult neurogenesis. The present study investigated the effect of a high-dose ... ...

    Abstract Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen is described as having a negative impact on adult neurogenesis. The present study investigated the effect of a high-dose tamoxifen application on Theiler's murine encephalomyelitis virus (TMEV)-induced hippocampal damage. Two weeks after TMEV infection, 42% of the untreated TMEV-infected mice were affected by marked inflammation with neuronal loss, whereas 58% exhibited minor inflammation without neuronal loss. Irrespective of the presence of neuronal loss, untreated mice lacked TMEV antigen expression within the hippocampus at 14 days post-infection (dpi). Interestingly, tamoxifen application 0, 2 and 4, or 5, 7 and 9 dpi decelerated virus elimination and markedly increased neuronal loss to 94%, associated with increased reactive astrogliosis at 14 dpi. T cell infiltration, microgliosis and expression of water channels were similar within the inflammatory lesions, regardless of tamoxifen application. Applied at 0, 2 and 4 dpi, tamoxifen had a negative impact on the number of doublecortin (DCX)-positive cells within the dentate gyrus (DG) at 14 dpi, without a long-lasting effect on neuronal loss at 147 dpi. Thus, tamoxifen application during a TMEV infection is associated with transiently increased neuronal loss in the hippocampus, increased reactive astrogliosis and decreased neurogenesis in the DG.
    MeSH term(s) Animals ; Cardiovirus Infections/complications ; Cardiovirus Infections/pathology ; Cardiovirus Infections/veterinary ; Cell Death/drug effects ; Doublecortin Protein ; Estrogen Antagonists/adverse effects ; Hippocampus/drug effects ; Hippocampus/pathology ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/pathology ; Tamoxifen/adverse effects ; Theilovirus/physiology ; Mice
    Chemical Substances Dcx protein, mouse ; Doublecortin Protein ; Estrogen Antagonists ; Tamoxifen (094ZI81Y45)
    Language English
    Publishing date 2021-08-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168486
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Thesis: Characterization of Schmallenberg virus-induced pathology in aborted and neonatal ruminants

    Herder, Vanessa

    2013  

    Title variant Hochsauerlandkreis
    Author's details by Vanessa Herder
    Language English
    Size iv, 61 S., Ill., Kt.
    Edition 1. Aufl.
    Publisher DVG
    Publishing place Gießen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zugl.: Hannover, Tierärztl. Hochsch., Inst. für Pathologie., Diss., 2013
    ISBN 9783863451547 ; 3863451546
    Database Special collection on veterinary medicine and general parasitology

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections

    Malgorzata Ciurkiewicz / Vanessa Herder / Andreas Beineke

    International Journal of Molecular Sciences, Vol 21, Iss 5, p

    2020  Volume 1705

    Abstract: Neurotropic viruses infect the central nervous system (CNS) and cause acute or chronic neurologic disabilities. Regulatory T cells (Treg) play a critical role for immune homeostasis, but may inhibit pathogen-specific immunity in infectious disorders. The ...

    Abstract Neurotropic viruses infect the central nervous system (CNS) and cause acute or chronic neurologic disabilities. Regulatory T cells (Treg) play a critical role for immune homeostasis, but may inhibit pathogen-specific immunity in infectious disorders. The present review summarizes the current knowledge about Treg in human CNS infections and their animal models. Besides dampening pathogen-induced immunopathology, Treg have the ability to facilitate protective responses by supporting effector T cell trafficking to the infection site and the development of resident memory T cells. Moreover, Treg can reduce virus replication by inducing apoptosis of infected macrophages and attenuate neurotoxic astrogliosis and pro-inflammatory microglial responses. By contrast, detrimental effects of Treg are caused by suppression of antiviral immunity, allowing for virus persistence and latency. Opposing disease outcomes following Treg manipulation in different models might be attributed to differences in technique and timing of intervention, infection route, genetic background, and the host’s age. In addition, mouse models of virus-induced demyelination revealed that Treg are able to reduce autoimmunity and immune-mediated CNS damage in a disease phase-dependent manner. Understanding the unique properties of Treg and their complex interplay with effector cells represents a prerequisite for the development of new therapeutic approaches in neurotropic virus infections.
    Keywords regulatory t cells ; foxp3 ; central nervous system ; neurotropic viruses ; neuroinflammation ; animal models ; demyelination ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Tamoxifen Application Is Associated with Transiently Increased Loss of Hippocampal Neurons following Virus Infection

    Kirsten Hülskötter / Fred Lühder / Alexander Flügel / Vanessa Herder / Wolfgang Baumgärtner

    International Journal of Molecular Sciences, Vol 22, Iss 8486, p

    2021  Volume 8486

    Abstract: Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen is described as having a negative impact on adult neurogenesis. The present study investigated the effect of a high-dose ... ...

    Abstract Tamoxifen is frequently used in murine knockout systems with CreER/LoxP. Besides possible neuroprotective effects, tamoxifen is described as having a negative impact on adult neurogenesis. The present study investigated the effect of a high-dose tamoxifen application on Theiler’s murine encephalomyelitis virus (TMEV)-induced hippocampal damage. Two weeks after TMEV infection, 42% of the untreated TMEV-infected mice were affected by marked inflammation with neuronal loss, whereas 58% exhibited minor inflammation without neuronal loss. Irrespective of the presence of neuronal loss, untreated mice lacked TMEV antigen expression within the hippocampus at 14 days post-infection (dpi). Interestingly, tamoxifen application 0, 2 and 4, or 5, 7 and 9 dpi decelerated virus elimination and markedly increased neuronal loss to 94%, associated with increased reactive astrogliosis at 14 dpi. T cell infiltration, microgliosis and expression of water channels were similar within the inflammatory lesions, regardless of tamoxifen application. Applied at 0, 2 and 4 dpi, tamoxifen had a negative impact on the number of doublecortin (DCX)-positive cells within the dentate gyrus (DG) at 14 dpi, without a long-lasting effect on neuronal loss at 147 dpi. Thus, tamoxifen application during a TMEV infection is associated with transiently increased neuronal loss in the hippocampus, increased reactive astrogliosis and decreased neurogenesis in the DG.
    Keywords tamoxifen ; C57BL/6 ; TMEV ; hippocampus ; astrocytes ; CreER/LoxP ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Book ; Online ; Thesis: Characterization of Schmallenberg virus-induced pathology in aborted and neonatal ruminants

    Herder, Vanessa

    2013  

    Abstract: Schmallenberg Virus, Pathologie, zentrales Nervensystem. - Bei dem Schmallenberg-Virus (SBV) handelt es sich um ein neues, in Europa auftretendes Orthobunyavirus, das milde klinische Symptome bei adulten Kühen hervorruft und Missbildungen bei ... ...

    Title variant Hochsauerlandkreis
    Author's details by Vanessa Herder
    Abstract Schmallenberg Virus, Pathologie, zentrales Nervensystem. - Bei dem Schmallenberg-Virus (SBV) handelt es sich um ein neues, in Europa auftretendes Orthobunyavirus, das milde klinische Symptome bei adulten Kühen hervorruft und Missbildungen bei abortierten und neugeborenen Wiederkäuern verursacht. Das SBV gehört zur Familie der Bunyaviridae und wird durch blutsaugende Insekten übertragen. Zum ersten Mal wurde das Virus im November 2011 mittels Metagenomanalyse in Blutproben von infizierten, adulten Kühen nachgewiesen, die aus Nordrhein-Westfalen nahe der Stadt Schmallenberg (Deutschland) stammten. Seit dieser Zeit hat sich das Virus großflächig über viele Länder Europas ausgebreitet. Ziel der vorliegenden Arbeit war es, die Pathologie dieser neuen Erkrankung in neugeborenen, natürlich infizierten Schaf- und Ziegenlämmern sowie Kälbern zu charakterisieren. Bei dieser Untersuchung standen insbesondere die Veränderungen des zentralen Nervensystems (ZNS) im Vordergrund. Hierfür wurden die makroskopischen Veränderungen von SBV-positiv getesteten und aus Nordrhein-Westfalen stammenden Wiederkäuern, die abortiert, totgeboren oder perinatal verstorben waren, untersucht. Darüber hinaus wurde eine immunhistologische Phänotypisierung der ZNS-Läsionen durchgeführt und die Verteilung des Virus im ZNS bestimmt. Die Ergebnisse dieser Studie wurden mit Veränderungen von nahe verwandten Viren, wie dem Akabane- oder Aino virus und ...
    Language English
    Size Online-Ressource (iv, 61 S. = 3.529 kb, text), Ill., Kt.
    Edition 1. Aufl.
    Publisher Tierärztl. Hochsch ; DVG
    Publishing place Hannover ; Gießen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Tierärztl. Hochsch., Inst. für Pathologie., Diss.--Hannover, 2013
    ISBN 9783863451547 ; 3863451546
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Book ; Online ; Thesis: Characterization of Schmallenberg virus-induced pathology in aborted and neonatal ruminants

    Herder, Vanessa

    2013  

    Abstract: Schmallenberg Virus, Pathologie, zentrales Nervensystem. - Bei dem Schmallenberg-Virus (SBV) handelt es sich um ein neues, in Europa auftretendes Orthobunyavirus, das milde klinische Symptome bei adulten Kühen hervorruft und Missbildungen bei ... ...

    Title variant Hochsauerlandkreis
    Author's details by Vanessa Herder
    Abstract Schmallenberg Virus, Pathologie, zentrales Nervensystem. - Bei dem Schmallenberg-Virus (SBV) handelt es sich um ein neues, in Europa auftretendes Orthobunyavirus, das milde klinische Symptome bei adulten Kühen hervorruft und Missbildungen bei abortierten und neugeborenen Wiederkäuern verursacht. Das SBV gehört zur Familie der Bunyaviridae und wird durch blutsaugende Insekten übertragen. Zum ersten Mal wurde das Virus im November 2011 mittels Metagenomanalyse in Blutproben von infizierten, adulten Kühen nachgewiesen, die aus Nordrhein-Westfalen nahe der Stadt Schmallenberg (Deutschland) stammten. Seit dieser Zeit hat sich das Virus großflächig über viele Länder Europas ausgebreitet. Ziel der vorliegenden Arbeit war es, die Pathologie dieser neuen Erkrankung in neugeborenen, natürlich infizierten Schaf- und Ziegenlämmern sowie Kälbern zu charakterisieren. Bei dieser Untersuchung standen insbesondere die Veränderungen des zentralen Nervensystems (ZNS) im Vordergrund. Hierfür wurden die makroskopischen Veränderungen von SBV-positiv getesteten und aus Nordrhein-Westfalen stammenden Wiederkäuern, die abortiert, totgeboren oder perinatal verstorben waren, untersucht. Darüber hinaus wurde eine immunhistologische Phänotypisierung der ZNS-Läsionen durchgeführt und die Verteilung des Virus im ZNS bestimmt. Die Ergebnisse dieser Studie wurden mit Veränderungen von nahe verwandten Viren, wie dem Akabane- oder Aino virus und ...
    Language English
    Size Online-Ressource (iv, 61 S. = 3.529 kb, text), Ill., Kt.
    Edition 1. Aufl.
    Publisher Tierärztl. Hochsch ; DVG
    Publishing place Hannover ; Gießen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Zugl.: Hannover, Tierärztl. Hochsch., Inst. für Pathologie., Diss., 2013
    Note IMD-Felder maschinell generiert
    ISBN 9783863451547 ; 3863451546
    Database Special collection on veterinary medicine and general parasitology

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Der klinische Fall: Intraokulares Melanom bei einer Ponystute

    Einhellig, Stefanie / Bartke, Sebastian / Herder, Vanessa

    pferde spiegel

    2019  Volume 22, Issue 03, Page(s) 120–125

    Language German
    Publishing date 2019-09-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 1868-0445 ; 1860-3203
    ISSN (online) 1868-0445
    ISSN 1860-3203
    DOI 10.1055/a-0977-8827
    Database Thieme publisher's database

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book ; Thesis: The impact of cuprizone on the murine spinal cord and the progression of Theiler's murine encephalomyelitis

    Herder, Vanessa

    2012  

    Title variant The impact of cuprizone on the murine spinal cord and the progression of Theiler's murine encephalomyelitis virus ; virus
    Author's details by Vanessa Herder
    Language English
    Size vii,72 S., Ill.
    Edition 1. Aufl.
    Publisher DVG Service
    Publishing place Gießen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tierärztl. Hochsch., ZSN, Diss.--Hannover, 2012
    ISBN 9783863450724 ; 3863450728
    Database Special collection on veterinary medicine and general parasitology

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Book ; Online ; Thesis: The impact of cuprizone on the murine spinal cord and the progrssion of Theiler's murine encephalomyelitis

    Herder, Vanessa

    2012  

    Abstract: Theilervirus Enzephalomyelitis, Cuprizon, Multiple Sklerose. - Die Multiple Sklerose (MS) stellt eine der häufigsten Erkrankungen des zentralen Nervensystems von jungen Erwachsenen dar. Die Ursache dieser Erkrankung ist bis jetzt nicht geklärt. Derzeit ... ...

    Title variant virus
    Author's details by Vanessa Herder
    Abstract Theilervirus Enzephalomyelitis, Cuprizon, Multiple Sklerose. - Die Multiple Sklerose (MS) stellt eine der häufigsten Erkrankungen des zentralen Nervensystems von jungen Erwachsenen dar. Die Ursache dieser Erkrankung ist bis jetzt nicht geklärt. Derzeit werden allerdings verschiedene virale Infektionen in Betracht gezogen, welche die autoimmune Komponente der MS initiieren und infolge dessen eine Demyelinisierung in Gehirn und Rückenmark verursachen. Die aktuellen Therapiestrategien fokussieren sich auf eine Reduktion der Entzündung und dem damit verbundenen Gewebsschaden bei erkrankten Patienten. Die murine Theilervirus-Enzephalomyelitis (TME) ist ein gut etabliertes, virusinduziertes Tiermodell für die MS und ermöglicht die Untersuchung von Therapiestrategien. Durch immunsuppressive Therapien wird die allgemeine antivirale Immunantwort vermindert und infolge dessen kommt es zu einer Virus-Ausbreitung und einer klinischen Verschlechterung der Tiere im TME-Modell. Aus diesem Grund ist es das Ziel der Studie gewesen, den Einfluss von ...
    Language English
    Size Online-Ressource (vii,72 S. : 19.703 kb, text), Ill.
    Edition 1. Aufl.
    Publisher Tierärztl. Hochsch ; DVG Service
    Publishing place Hannover ; Gießen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Zugl.: Hannover, Tierärztl. Hochsch., ZSN, Diss., 2012
    Note IMD-Felder maschinell generiert
    ISBN 9783863450724 ; 3863450728
    Database Special collection on veterinary medicine and general parasitology

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top