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  1. Book ; Online: Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders

    Palazzo, Enza / Neugebauer, Volker / Maione, Sabatino

    2019  

    Keywords Science: general issues ; Neurosciences ; metabotropic glutamate receptors ; neurological disorders ; psychiatric disorders ; Neuroprotection ; Neuroinflammation ; excitotoxicity ; Neurogenesis ; Positive allosteric modulators ; negative allosteric modulators
    Size 1 electronic resource (139 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231136
    ISBN 9782889458622 ; 2889458628
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Neurotransmitters in the antinociceptive descending pathway

    Maione, Sabatino

    2007  

    Author's details ed. Sabatino Maione
    Language English
    Size 129 S. : Ill.
    Publisher Research Signpost
    Publishing place Trivandrum
    Publishing country India
    Document type Book
    HBZ-ID HT015489314
    ISBN 81-308-0149-3 ; 978-81-308-0149-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 2159 order for loan Magazin

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  3. Article ; Online: Mediator complex in neurological disease.

    Schiano, Concetta / Luongo, Livio / Maione, Sabatino / Napoli, Claudio

    Life sciences

    2023  Volume 329, Page(s) 121986

    Abstract: Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator complex (MED) is a ... ...

    Abstract Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator complex (MED) is a large, evolutionarily conserved multiprotein that facilities the interaction between transcription factors and RNA Polymerase II in eukaryotes. Some MED subunits have been found altered in the brain, although their specific functions in neurodegenerative diseases are not fully understood. Mutations in MED subunits were associated with a wide range of genetic diseases for MED12, MED13, MED13L, MED20, MED23, MED25, and CDK8 genes. In addition, MED12 and MED23 were deregulated in the Alzheimer's Disease. Interestingly, most of the genomic mutations have been found in the subunits of the kinase module. To date, there is only one evidence on MED1 involvement in post-stroke cognitive deficits. Although the underlying neurodegenerative disorders may be different, we are confident that the signal cascades of the biological-cognitive mechanisms of brain adaptation, which begin after brain deterioration, may also differ. Here, we analysed relevant studies in English published up to June 2023. They were identified through a search of electronic databases including PubMed, Medline, EMBASE and Scopus, including search terms such as "Mediator complex", "neurological disease", "brains". Thematic content analysis was conducted to collect and summarize all studies demonstrating MED alteration to understand the role of this central transcriptional regulatory complex in the brain. Improved and deeper knowledge of the regulatory mechanisms in neurological diseases can increase the ability of physicians to predict onset and progression, thereby improving diagnostic care and providing appropriate treatment decisions.
    MeSH term(s) Humans ; Cyclin-Dependent Kinase 8/genetics ; Cyclin-Dependent Kinase 8/metabolism ; Transcription Factors/metabolism ; Mutation ; Mediator Complex/genetics
    Chemical Substances Cyclin-Dependent Kinase 8 (EC 2.7.11.22) ; Transcription Factors ; MED25 protein, human ; Mediator Complex
    Language English
    Publishing date 2023-07-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Affective and Cognitive Impairments in Rodent Models of Diabetes.

    Palazzo, Enza / Marabese, Ida / Boccella, Serena / Belardo, Carmela / Pierretti, Gorizio / Maione, Sabatino

    Current neuropharmacology

    2024  

    Abstract: Diabetes and related acute and long-term complications have a profound impact on cognitive, emotional, and social behavior, suggesting that the central nervous system (CNS) is a crucial substrate for diabetic complications. When anxiety, depression, and ... ...

    Abstract Diabetes and related acute and long-term complications have a profound impact on cognitive, emotional, and social behavior, suggesting that the central nervous system (CNS) is a crucial substrate for diabetic complications. When anxiety, depression, and cognitive deficits occur in diabetic patients, the symptoms and complications related to the disease worsen, contributing to lower quality of life while increasing health care costs and mortality. Experimental models of diabetes in rodents are a fundamental and valuable tool for improving our understanding of the mechanisms underlying the close and reciprocal link between diabetes and CNS alterations, including the development of affective and cognitive disorders. Such models must reproduce the different components of this pathological condition in humans and, therefore, must be associated with affective and cognitive behavioral alterations. Beyond tight glycemic control, there are currently no specific therapies for neuropsychiatric comorbidities associated with diabetes; animal models are, therefore, essential for the development of adequate therapies. To our knowledge, there is currently no review article that summarizes changes in affective and cognitive behavior in the most common models of diabetes in rodents. Therefore, in this review, we have reported the main evidence on the alterations of affective and cognitive behavior in the different models of diabetes in rodents, the main mechanisms underlying these comorbidities, and the applicable therapeutic strategy.
    Language English
    Publishing date 2024-01-24
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X22666240124164804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
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  5. Article ; Online: Mediator complex in neurological disease

    Schiano, Concetta / Luongo, Livio / Maione, Sabatino / Napoli, Claudio

    Life Sciences. 2023 Sept., v. 329 p.121986-

    2023  

    Abstract: Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator complex (MED) is a ... ...

    Abstract Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator complex (MED) is a large, evolutionarily conserved multiprotein that facilities the interaction between transcription factors and RNA Polymerase II in eukaryotes. Some MED subunits have been found altered in the brain, although their specific functions in neurodegenerative diseases are not fully understood. Mutations in MED subunits were associated with a wide range of genetic diseases for MED12, MED13, MED13L, MED20, MED23, MED25, and CDK8 genes. In addition, MED12 and MED23 were deregulated in the Alzheimer's Disease. Interestingly, most of the genomic mutations have been found in the subunits of the kinase module. To date, there is only one evidence on MED1 involvement in post-stroke cognitive deficits. Although the underlying neurodegenerative disorders may be different, we are confident that the signal cascades of the biological-cognitive mechanisms of brain adaptation, which begin after brain deterioration, may also differ. Here, we analysed relevant studies in English published up to June 2023. They were identified through a search of electronic databases including PubMed, Medline, EMBASE and Scopus, including search terms such as “Mediator complex”, “neurological disease”, “brains”. Thematic content analysis was conducted to collect and summarize all studies demonstrating MED alteration to understand the role of this central transcriptional regulatory complex in the brain. Improved and deeper knowledge of the regulatory mechanisms in neurological diseases can increase the ability of physicians to predict onset and progression, thereby improving diagnostic care and providing appropriate treatment decisions.
    Keywords Alzheimer disease ; DNA-directed RNA polymerase ; brain ; cognition ; death ; eukaryotic cells ; genomics ; stroke ; transcription (genetics) ; Mediator complex ; Personalized medicine ; Neurological diseases
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121986
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 73/732: Show issues

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  6. Article ; Online: Exploitation of Autophagy Inducers in the Management of Dementia: A Systematic Review.

    Corasaniti, Maria Tiziana / Bagetta, Giacinto / Nicotera, Pierluigi / Maione, Sabatino / Tonin, Paolo / Guida, Francesca / Scuteri, Damiana

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: The social burden of dementia is remarkable since it affects some 57.4 million people all over the world. Impairment of autophagy in age-related diseases, such as dementia, deserves deep investigation for the detection of novel disease-modifying ... ...

    Abstract The social burden of dementia is remarkable since it affects some 57.4 million people all over the world. Impairment of autophagy in age-related diseases, such as dementia, deserves deep investigation for the detection of novel disease-modifying approaches. Several drugs belonging to different classes were suggested to be effective in managing Alzheimer's disease (AD) by means of autophagy induction. Useful autophagy inducers in AD should be endowed with a direct, measurable effect on autophagy, have a safe tolerability profile, and have the capability to cross the blood-brain barrier, at least with poor penetration. According to the PRISMA 2020 recommendations, we propose here a systematic review to appraise the measurable effectiveness of autophagy inducers in the improvement of cognitive decline and neuropsychiatric symptoms in clinical trials and retrospective studies. The systematic search retrieved 3067 records, 10 of which met the eligibility criteria. The outcomes most influenced by the treatment were cognition and executive functioning, pointing at a role for metformin, resveratrol, masitinib and TPI-287, with an overall tolerable safety profile. Differences in sample power, intervention, patients enrolled, assessment, and measure of outcomes prevents generalization of results. Moreover, the domain of behavioral symptoms was found to be less investigated, thus prompting new prospective studies with homogeneous design. PROSPERO registration: CRD42023393456.
    MeSH term(s) Humans ; Prospective Studies ; Retrospective Studies ; Alzheimer Disease/drug therapy ; Cognitive Dysfunction/drug therapy ; Cognition
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Amyloid-β-Induced Transglutaminase 2 Expression and Activities are Modulated by 2-Pentadecyl-2-Oxazoline in Mouse and Human Microglial Cell Lines.

    Parente, Andrea / Giacca, Rosa / Arena, Roberta / Rullo, Ilenia / Guida, Francesca / Maione, Sabatino / Gentile, Vittorio

    Current Alzheimer research

    2023  Volume 20, Issue 4, Page(s) 289–300

    Abstract: Background: Transglutaminase 2 is an ubiquitously multifunctional enzyme and the most widely studied of the transglutaminase family. Consistent with its role in promoting post-translational modifications of proteins, Transglutaminase 2 is involved in ... ...

    Abstract Background: Transglutaminase 2 is an ubiquitously multifunctional enzyme and the most widely studied of the transglutaminase family. Consistent with its role in promoting post-translational modifications of proteins, Transglutaminase 2 is involved in many physiological processes such as apoptosis, signal transduction, and cellular adhesion. Several findings indicate that Transglutaminase 2 plays a role in the pathological processes of various inflammation-related diseases, including neurodegenerative diseases.
    Objective: We tested the potential modulatory effects on amyloid-β-induced Transglutaminase 2 expression and activities of 2-pentadecyl-2-oxazoline, a plant-derived agent, which has shown effectiveness against chronic pain and associated neuropsychiatric disorders, both in mouse and human microglial cell lines.
    Methods: We used biochemistry, molecular and cell biology techniques to evaluate the potential modulatory effects on amyloid-β-induced Transglutaminase 2 expression and activities of 2- pentadecyl-2-oxazoline in mouse and human microglial cell lines.
    Results: 2-pentadecyl-2-oxazoline was able to modulate amyloid-β-induced Transglutaminase 2 expression and activities in mouse and human microglial cell lines.
    Conclusion: Transglutaminase 2 confirms its role as a neuroinflammation marker, the inhibition of which could be a potential preventive and therapeutic approach, while 2-pentadecyl-2-oxazoline is a potent modulator of the amyloid-β-induced Transglutaminase 2 expression and activities in mouse and human microglial cell lines.
    Language English
    Publishing date 2023-08-07
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2205170-3
    ISSN 1875-5828 ; 1567-2050
    ISSN (online) 1875-5828
    ISSN 1567-2050
    DOI 10.2174/1567205020666230804100831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6235: Show issues Location:
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  8. Article ; Online: Morphological and molecular changes in the Harderian gland of streptozotocin-induced diabetic rats.

    Romano, Maria Zelinda / Boccella, Serena / Venditti, Massimo / Maione, Sabatino / Minucci, Sergio

    Journal of experimental zoology. Part A, Ecological and integrative physiology

    2023  Volume 339, Issue 10, Page(s) 915–924

    Abstract: Using a rat model of type 1 diabetes (T1D) obtained by treatment with streptozotocin, an antibiotic that destroys pancreatic β-cells, we evaluated the influence of subsequent hyperglycemia on the morphology and physiology of the Harderian gland (HG). HG ... ...

    Abstract Using a rat model of type 1 diabetes (T1D) obtained by treatment with streptozotocin, an antibiotic that destroys pancreatic β-cells, we evaluated the influence of subsequent hyperglycemia on the morphology and physiology of the Harderian gland (HG). HG is located in the medial corner of the orbit of many terrestrial vertebrates and, in rodents, is characterized by the presence of porphyrins, which being involved in the phototransduction, through photo-oxidation, produce reactive oxygen species activating the autophagy pathway. The study focused on the expression of some morphological markers involved in cell junction formation (occludin, connexin-43, and α-tubulin) and mast cell number (MCN), as well as autophagic and apoptotic pathways. The expression of enzymes involved in steroidogenesis [steroidogenic acute regulatory protein (StAR), and 3β-hydroxysteroid dehydrogenase (3β-HSD)] and the level of lipid peroxidation by thiobarbituric acid reactive species assay were also evaluated. The results strongly indicate, for the first time, that T1D has a negative impact on the pathophysiology of rat HG, as evidenced by increased oxidative stress, morphological and biochemical alterations, hyperproduction and secretion of porphyrins, increased MCN, reduced protein levels of StAR and 3β-HSD, and, finally, induced autophagy and apoptosis. All the combined data support the use of the rat HG as a suitable experimental model to elucidate the molecular damage/survival pathways elicited by stress conditions.
    MeSH term(s) Animals ; Rats ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 1/metabolism ; Harderian Gland/metabolism ; Porphyrins/adverse effects ; Porphyrins/metabolism ; Streptozocin/adverse effects ; Streptozocin/metabolism
    Chemical Substances Porphyrins ; Streptozocin (5W494URQ81)
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474896-4
    ISSN 2471-5646 ; 1932-5223 ; 2471-5646 ; 1932-5231 ; 1552-499X
    ISSN (online) 2471-5646 ; 1932-5223
    ISSN 2471-5646 ; 1932-5231 ; 1552-499X
    DOI 10.1002/jez.2741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Adenosine Metabotropic Receptors in Chronic Pain Management.

    Luongo, Livio / Guida, Francesca / Maione, Sabatino / Jacobson, Kenneth A / Salvemini, Daniela

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 651038

    Language English
    Publishing date 2021-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.651038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Synergistic effects of Boswellia serrata and Acmella oleracea extract combination for treating neuropathic pain in a preclinical model of spared nerve injury.

    Boccella, Serena / Mattia, Consalvo / Perrone, Michela / Morace, Andrea Maria / Karabacak, Elif / Guida, Francesca / Maione, Sabatino / Luongo, Livio

    Phytotherapy research : PTR

    2023  Volume 38, Issue 4, Page(s) 1731–1734

    MeSH term(s) Humans ; Boswellia ; Neuralgia/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Immunologic Factors
    Chemical Substances Plant Extracts ; Immunologic Factors
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Letter
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.8001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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