Article ; Online: Integration of non-targeted multicomponent profiling, targeted characteristic chromatograms and quantitative to accomplish systematic quality evaluation strategy of Huo-Xiang-Zheng-Qi oral liquid.
Journal of pharmaceutical and biomedical analysis
2023 Volume 236, Page(s) 115715
Abstract: Huo-Xiang-Zheng-Qi oral liquid (HXZQOL) is a well-known traditional Chinese medicine formula ...
Abstract | Huo-Xiang-Zheng-Qi oral liquid (HXZQOL) is a well-known traditional Chinese medicine formula for the treatment of gastrointestinal diseases, with the pharmacologic effects of antiinflammatory, immune protection and gastrointestinal motility regulation. More significantly, HXZQOL is recommended for the treatment of COVID-19 patients with gastrointestinal symptoms, and it has been clinically proven to reduce the inflammatory response in patients with COVID-19. However, the effective and overall quality control of HXZQOL is currently limited due to its complex composition, especially the large amount of volatile and non-volatile active components involved. In this study, aimed to fully develop a comprehensive strategy based on non-targeted multicomponent identification, targeted authentication and quantitative analysis for quality evaluation of HXZQOL from different batches. Firstly, the non-targeted high-definition MS |
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MeSH term(s) | Humans ; Qi ; Chromatography, High Pressure Liquid/methods ; COVID-19 ; Medicine, Chinese Traditional ; Mass Spectrometry ; Drugs, Chinese Herbal/analysis |
Chemical Substances | Drugs, Chinese Herbal |
Language | English |
Publishing date | 2023-09-11 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 604917-5 |
ISSN | 1873-264X ; 0731-7085 |
ISSN (online) | 1873-264X |
ISSN | 0731-7085 |
DOI | 10.1016/j.jpba.2023.115715 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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