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  1. Article ; Online: Institutional Benchmarks of Joint Replacement Analgesia and Mobilization After Intrathecal Morphine vs Multimodal Peripheral Nerve/Plexus Blocks.

    Williams, Brian A / Dalessandro, James H / Kennedy, Patrick J / Ezaru, Catalin S / Ritter, Marsha E / Maerz, David A / Ibinson, James W / Piva, Sara R

    Pain medicine (Malden, Mass.)

    2021  Volume 22, Issue 12, Page(s) 3116–3119

    MeSH term(s) Analgesia ; Analgesics, Opioid/therapeutic use ; Arthroplasty, Replacement ; Benchmarking ; Humans ; Injections, Spinal ; Morphine/therapeutic use ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Peripheral Nerves
    Chemical Substances Analgesics, Opioid ; Morphine (76I7G6D29C)
    Language English
    Publishing date 2021-07-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnab193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Preinduction check-up of the anesthesia machine.

    Ezaru, Catalin S

    Anesthesia and analgesia

    2006  Volume 102, Issue 5, Page(s) 1588–1589

    MeSH term(s) Anesthesia, Inhalation/instrumentation ; Anesthesia, Inhalation/methods ; Equipment Failure ; Female ; Humans ; Middle Aged
    Language English
    Publishing date 2006-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/01.ANE.0000215201.76420.57
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Translational Interpretations of Combined Bupivacaine-Clonidine-Buprenorphine-Dexamethasone.

    Williams, Brian A / Ibinson, James W / Ezaru, Catalin S / Rakesh, Hulimangala / Mangione, Michael P

    Regional anesthesia and pain medicine

    2017  Volume 42, Issue 2, Page(s) 271–272

    MeSH term(s) Anesthetics, Local ; Bupivacaine ; Buprenorphine ; Clonidine ; Dexamethasone ; Humans ; Nerve Block ; Pain, Postoperative
    Chemical Substances Anesthetics, Local ; Buprenorphine (40D3SCR4GZ) ; Dexamethasone (7S5I7G3JQL) ; Clonidine (MN3L5RMN02) ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2017-02-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1097/AAP.0000000000000547
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  4. Article ; Online: Day-One Pain Reductions After Hip and Knee Replacement When Buprenorphine-Clonidine-Dexamethasone Is Added to Bupivacaine Nerve/Plexus Blocks: A Randomized Clinical Trial.

    Williams, Brian A / Ibinson, James W / Mikolic, Joseph M / Boudreaux-Kelly, Monique Y / Paiste, Henry J / Gilbert, Karen L / Bonant, Samantha A / Ritter, Marsha E / Ezaru, Catalin S / Muluk, Visala S / Piva, Sara R

    Pain medicine (Malden, Mass.)

    2021  Volume 23, Issue 1, Page(s) 57–66

    Abstract: Objective: To compare pain outcome reports of patients undergoing hip or knee replacement who received single-injection nerve/plexus blocks with plain bupivacaine (BPV) with those of patients who received injections of buprenorphine-clonidine- ... ...

    Abstract Objective: To compare pain outcome reports of patients undergoing hip or knee replacement who received single-injection nerve/plexus blocks with plain bupivacaine (BPV) with those of patients who received injections of buprenorphine-clonidine-dexamethasone (BCD) admixed with BPV.
    Design: Prospective, parallel-arm, randomized, double-blind trial.
    Setting: A single veterans' hospital.
    Subjects: Ninety-eight veterans scheduled for total hip or knee replacement surgery with spinal as the primary anesthetic.
    Methods: Participants were randomized to BPV-BCD or plain BPV groups. They underwent nerve/plexus blocks in the L2-L4 and L4-S3 distributions in advance of joint replacement surgery. The primary outcome was change in pain from baseline during the postoperative day, as assessed by the total pain score on the short-form McGill Pain Questionnaire-v2 (SF-MPQ-2). Secondary outcomes were pain during movement, pain interference, range of motion, mobility, and quality of recovery.
    Results: On postoperative day one, the SF-MPQ-2 total score for the BPV-BCD group demonstrated greater pain reduction than that of the plain BPV group (mean difference 1.8 points, 95% confidence interval 0.6 to 3.0, P = 0.003). The BPV-BCD group also had larger reductions in pain during movement in the surgical joint and less pain interference, along with increased range of hip and knee flexion, compared with the plain BPV group. Outcomes of mobility and quality of recovery were not different between groups.
    Conclusions: Preoperative BPV-BCD blocks in the L2-L4 and L4-S3 nerve distributions for hip and knee replacements led to less pain on postoperative day one and increased knee and hip range of motion, compared with plain BPV blocks.
    Trial registration: ClinicalTrials.gov ID NCT02891798.
    MeSH term(s) Anesthetics, Local/therapeutic use ; Bupivacaine/therapeutic use ; Buprenorphine/therapeutic use ; Clonidine ; Dexamethasone/therapeutic use ; Double-Blind Method ; Humans ; Nerve Block/adverse effects ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Prospective Studies
    Chemical Substances Anesthetics, Local ; Buprenorphine (40D3SCR4GZ) ; Dexamethasone (7S5I7G3JQL) ; Clonidine (MN3L5RMN02) ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2021-11-29
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnab325
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  5. Article: GlideScope Use improves intubation success rates: an observational study using propensity score matching.

    Ibinson, James W / Ezaru, Catalin S / Cormican, Daniel S / Mangione, Michael P

    BMC anesthesiology

    2014  Volume 14, Page(s) 101

    Abstract: Background: Rigid video laryngoscopes are popular alternatives to direct laryngoscopy for intubation, but further large scale prospective studies comparing these devices to direct laryngoscopy in routine anesthesiology practice are needed. We ... ...

    Abstract Background: Rigid video laryngoscopes are popular alternatives to direct laryngoscopy for intubation, but further large scale prospective studies comparing these devices to direct laryngoscopy in routine anesthesiology practice are needed. We hypothesized that the first pass success rate with one particular video laryngoscope, the GlideScope, would be higher than the success rate with direct laryngoscopy.
    Methods: 3831 total intubation attempts were tracked in an observational study comparing first-pass success rate using a Macintosh or Miller-style laryngoscope with the GlideScope. Propensity scoring was then used to select 626 subjects matched between the two groups based on their morphologic traits.
    Results: Comparing the GlideScope and direct laryngoscopy groups suggested that intubation would be more difficult in the GlideScope group based on the Mallampati class, cervical range of motion, mouth opening, dentition, weight, and past intubation history. Thus, a propensity score based on these factors was used to balance the groups into two 313 patient cohorts. Direct laryngoscopy was successful in 80.8% on the first-pass intubation attempt, while the GlideScope was successful in 93.6% (p <0.001; risk difference of 0.128 with a 95% CI of 0.0771 - 0.181).
    Conclusion: A greater first-attempt success rate was found when using the GlideScope versus direct laryngoscopy. In addition, the GlideScope was found to be 99% successful for intubation after initial failure of direct laryngoscopy, helping to reduce the incidence of failed intubation.
    MeSH term(s) Adult ; Aged ; Anesthesiology/methods ; Equipment Design ; Female ; Humans ; Intubation, Intratracheal/instrumentation ; Intubation, Intratracheal/methods ; Laryngoscopes ; Laryngoscopy/instrumentation ; Laryngoscopy/methods ; Male ; Middle Aged ; Propensity Score ; Prospective Studies ; Video Recording ; Young Adult
    Language English
    Publishing date 2014-11-05
    Publishing country England
    Document type Comparative Study ; Controlled Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1471-2253
    ISSN 1471-2253
    DOI 10.1186/1471-2253-14-101
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  6. Article ; Online: Extended Perineural Analgesia After Hip and Knee Replacement When Buprenorphine-Clonidine-Dexamethasone Is Added to Bupivacaine: Preliminary Report from a Randomized Clinical Trial.

    Williams, Brian A / Ibinson, James W / Ritter, Marsha E / Ezaru, Catalin S / Rakesh, Hulimangala R / Paiste, Henry J / Gilbert, Karen L / Mikolic, Joseph M / Muluk, Visala S / Piva, Sara R

    Pain medicine (Malden, Mass.)

    2020  Volume 21, Issue 11, Page(s) 2893–2902

    Abstract: Objective: We tested the hypothesis that buprenorphine-clonidine-dexamethasone (BCD) extends perineural analgesia compared with plain bupivacaine (BPV) nerve blocks used for hip and knee replacement surgery.: Design: Prospective, parallel-arms, ... ...

    Abstract Objective: We tested the hypothesis that buprenorphine-clonidine-dexamethasone (BCD) extends perineural analgesia compared with plain bupivacaine (BPV) nerve blocks used for hip and knee replacement surgery.
    Design: Prospective, parallel-arms, randomized, double-blind trial.
    Setting: A single veterans' hospital.
    Subjects: Seventy-eight veterans scheduled for total hip or knee replacement with plans for spinal as the primary anesthetic.
    Methods: Participants underwent nerve/plexus blocks at L2-L4 and L4-S3 in advance of hip or knee joint replacement surgery. Patients were randomized to receive BPV-BCD or plain BPV in a 4:1 allocation ratio. Patients answered four block duration questions (listed below). Time differences between treatments were analyzed using the t test.
    Results: Significant (P < 0.001) prolongation of the time parameters was reported by patients after the BPV-BCD blocks (N = 62) vs plain BPV (N = 16). The time until start of postoperative pain was 26 vs 11 hours (mean difference = 15 hours, 95% CI = 8 to 21). The time until no pain relief from the blocks was 32 vs 15 hours (mean difference = 17 hours, 95% CI = 10 to 24). The time until the numbness wore off was 37 vs 21 hours (mean difference = 16 hours, 95% CI = 8 to 23). The time until the worst postoperative pain was 39 vs 20 hours (mean difference = 19 hours, 95% CI = 11 to 27).
    Conclusions: BPV-BCD provided 26-39 hours of perineural analgesia in the L2-L4 and L4-S3 nerve distributions after hip/knee replacement surgery, compared with 11-21 hours for plain BPV.
    MeSH term(s) Analgesia ; Anesthetics, Local ; Bupivacaine ; Buprenorphine ; Clonidine ; Dexamethasone ; Double-Blind Method ; Humans ; Hypesthesia ; Pain Measurement ; Pain, Postoperative/drug therapy ; Prospective Studies
    Chemical Substances Anesthetics, Local ; Buprenorphine (40D3SCR4GZ) ; Dexamethasone (7S5I7G3JQL) ; Clonidine (MN3L5RMN02) ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnaa229
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  7. Article ; Online: Clarification of issues regarding manometry for central venous catheterization.

    Ibinson, James W / Oravitz, Todd M / Ezaru, Catalin S / Mangione, Michael P

    Anesthesia and analgesia

    2009  Volume 109, Issue 6, Page(s) 2028; author reply 2028

    MeSH term(s) Arteries/injuries ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/instrumentation ; Catheterization, Central Venous/methods ; Equipment Design ; Humans ; Manometry/instrumentation ; Medical Errors/prevention & control ; Wounds, Penetrating/etiology ; Wounds, Penetrating/prevention & control
    Language English
    Publishing date 2009-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ane.0b013e3181bea1be
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  8. Article ; Online: Eliminating arterial injury during central venous catheterization using manometry.

    Ezaru, Catalin S / Mangione, Michael P / Oravitz, Todd M / Ibinson, James W / Bjerke, Richard J

    Anesthesia and analgesia

    2009  Volume 109, Issue 1, Page(s) 130–134

    Abstract: Background: Unintended arterial puncture occurs in 2%-4.5% of central venous catheterizations, resulting in arterial injury in 0.1%-0.5% of patients. Routine performance of manometry during catheterization may successfully identify unintended arterial ... ...

    Abstract Background: Unintended arterial puncture occurs in 2%-4.5% of central venous catheterizations, resulting in arterial injury in 0.1%-0.5% of patients. Routine performance of manometry during catheterization may successfully identify unintended arterial puncture and avoid arterial cannulation and injury.
    Methods: We conducted a retrospective review of all cases of central venous catheter placement during a 15-yr period after implementation of a safety program requiring mandatory use of manometry to verify venous access. Arterial injuries were defined as unintended arterial cannulations with a 7-French or larger catheter or dilator. Arterial punctures were defined as the unintended placement of an 18-gauge catheter or needle into the artery. Data were reviewed for all arterial injuries during the entire 15-yr period. In addition, data on both arterial puncture and subsequent arterial injury were evaluated during the final year of analysis.
    Results: A total of 9348 central venous catheters were placed during the observation period. During the full 15 yr of observation, there were no cases of arterial injury. During the final year of assessment, 511 central venous catheters were placed, with arterial punctures in 28 patients (5%). Arterial puncture was recognized without manometry in 24 cases. Arterial puncture was identified only with manometry in 4 cases, with no incidents of arterial injury.
    Conclusions: Consistent use of manometry, to verify venous placement, during central venous catheterization effectively eliminated arterial injury from unintended arterial cannulation during the 15-yr assessment.
    MeSH term(s) Arteries/injuries ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/instrumentation ; Catheterization, Central Venous/methods ; Humans ; Manometry/instrumentation ; Manometry/methods ; Retrospective Studies
    Language English
    Publishing date 2009-07
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ane.0b013e31818f87e9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: When ultrasound is not enough.

    Ezaru, Catalin S / Murray, Andrew W / Oravitz, Todd M / Ibinson, James W / Mangine, Michael P / Blaivas, Michael / Duncan, James R / Tabriz, David M / Vannucci, Andrea

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2010  Volume 29, Issue 3, Page(s) 505; discussion 506–8

    MeSH term(s) Adolescent ; Aged ; Carotid Artery Injuries/diagnostic imaging ; Carotid Artery Injuries/etiology ; Catheterization, Central Venous/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Ultrasonography/methods ; Ultrasonography, Interventional/adverse effects ; Video Recording/methods ; Wounds, Penetrating/diagnostic imaging ; Wounds, Penetrating/etiology
    Language English
    Publishing date 2010-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
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