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  1. Article ; Online: Stressed out neutrophils drive metastasis.

    Lupo, Federico / Coffelt, Seth B

    Immunity

    2024  Volume 57, Issue 4, Page(s) 840–842

    Abstract: Stress hormones can contribute to cancer progression, but how immune cells play a role in this process is unclear. In a recent study in Cancer Cell, He et al. showed that glucocorticoids potentiate metastasis by skewing neutrophils toward pro-tumorigenic ...

    Abstract Stress hormones can contribute to cancer progression, but how immune cells play a role in this process is unclear. In a recent study in Cancer Cell, He et al. showed that glucocorticoids potentiate metastasis by skewing neutrophils toward pro-tumorigenic functions.
    MeSH term(s) Humans ; Neutrophils ; Neoplasms/pathology ; Tumor Microenvironment ; Neoplasm Metastasis/pathology
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2024.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
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  2. Article ; Online: The two sides of the γδ T cell coin.

    Coffelt, Seth B / Suzuki, Toshiyasu

    Nature cancer

    2023  Volume 4, Issue 8, Page(s) 1056–1057

    MeSH term(s) Receptors, Antigen, T-Cell, gamma-delta ; Intraepithelial Lymphocytes
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Journal Article
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00587-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: γδ T cells turn the tables on immune-evasive colon cancer.

    Coffelt, Seth B / Suzuki, Toshiyasu

    Med (New York, N.Y.)

    2023  Volume 4, Issue 3, Page(s) 141–142

    Abstract: Why is checkpoint blockade immunotherapy still effective in tumors that are unrecognizable to ... ...

    Abstract Why is checkpoint blockade immunotherapy still effective in tumors that are unrecognizable to CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes/metabolism ; Colonic Neoplasms/metabolism
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2023.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: LOXL2 in pancreatic tumourigenesis: the complexity of tumour-stromal crosstalk exemplified.

    Coffelt, Seth B / Morton, Jennifer P

    Gut

    2022  Volume 72, Issue 2, Page(s) 221–222

    MeSH term(s) Humans ; Neoplasms ; Pancreas ; Carcinogenesis/genetics ; Amino Acid Oxidoreductases/genetics ; Pancreatic Neoplasms/genetics ; Tumor Microenvironment
    Chemical Substances Amino Acid Oxidoreductases (EC 1.4.-) ; LOXL2 protein, human (EC 1.4.3.-)
    Language English
    Publishing date 2022-04-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2022-327430
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  5. Article ; Online: The duplexity of unconventional T cells in cancer.

    Lawrence, Mark / Wiesheu, Robert / Coffelt, Seth B

    The international journal of biochemistry & cell biology

    2022  Volume 146, Page(s) 106213

    Abstract: Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition. Here, we briefly review the ... ...

    Abstract Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition. Here, we briefly review the dichotomous role of three unconventional T cell lineages: γδ T cells, MAIT cells and NKT cells. Studies using mouse models of cancer show how this unconventional trilogy interacts with cancer epithelial cells and other immune cell populations during tumour evolution. These reports highlight various potential avenues for therapeutic intervention that may be exploited for cancer immunotherapy.
    MeSH term(s) Animals ; Cell Lineage ; Immunotherapy ; Mice ; Mucosal-Associated Invariant T Cells ; Natural Killer T-Cells ; Neoplasms/therapy
    Language English
    Publishing date 2022-04-18
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2022.106213
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  6. Article: The duplexity of unconventional T cells in cancer

    Lawrence, Mark / Wiesheu, Robert / Coffelt, Seth B.

    international journal of biochemistry & cell biology. 2022 May, v. 146

    2022  

    Abstract: Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition. Here, we briefly review the ... ...

    Abstract Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition. Here, we briefly review the dichotomous role of three unconventional T cell lineages: γδ T cells, MAIT cells and NKT cells. Studies using mouse models of cancer show how this unconventional trilogy interacts with cancer epithelial cells and other immune cell populations during tumour evolution. These reports highlight various potential avenues for therapeutic intervention that may be exploited for cancer immunotherapy.
    Keywords T-lymphocytes ; biochemistry ; epithelium ; immunotherapy ; mice ; neoplasm progression ; neoplasms
    Language English
    Dates of publication 2022-05
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2022.106213
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Assessment of CAR-T Cell-Mediated Cytotoxicity in 3D Microfluidic Cancer Co-Culture Models for Combination Therapy.

    Paterson, Karla / Paterson, Sarah / Mulholland, Theresa / Coffelt, Seth B / Zagnoni, Michele

    IEEE open journal of engineering in medicine and biology

    2022  Volume 3, Page(s) 86–95

    Abstract: Chimeric antigen receptor (CAR)-T cell therapy is efficacious against many haematological malignancies, but challenges remain when using this cellular immunotherapy for treating solid tumours. Classical ... ...

    Abstract Chimeric antigen receptor (CAR)-T cell therapy is efficacious against many haematological malignancies, but challenges remain when using this cellular immunotherapy for treating solid tumours. Classical 2D
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article
    ISSN 2644-1276
    ISSN (online) 2644-1276
    DOI 10.1109/OJEMB.2022.3178302
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  8. Article ; Online: Emerging immunotherapies for metastasis.

    Edwards, Sarah C / Hoevenaar, Wilma H M / Coffelt, Seth B

    British journal of cancer

    2020  Volume 124, Issue 1, Page(s) 37–48

    Abstract: Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types of ... ...

    Abstract Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types of immunotherapy is the immune checkpoint inhibitors, such as anti-CTLA-4 and anti-PD-1, that keep anti-tumour T cells active. However, not every patient with metastatic disease benefits from this class of drugs and patients often develop resistance to these therapies over time. Tremendous research effort is now underway to uncover new immunotherapeutic targets that can be used in patients who are refractory to anti-CTLA-4 or anti-PD-1 treatment. Here, we discuss results from experimental model systems demonstrating that modulating the immune response can negatively affect metastasis formation. We focus on molecules that boost anti-tumour immune cells and opportunities to block immunosuppression, as well as cell-based therapies with enhanced tumour recognition properties for solid tumours. We also present a list of challenges in treating metastatic disease with immunotherapy that must be considered in order to move laboratory observations into clinical practice and maximise patient benefit.
    MeSH term(s) Animals ; Humans ; Immunotherapy/methods ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/therapy ; Neoplasms/pathology ; Neoplasms/therapy
    Language English
    Publishing date 2020-12-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-020-01160-5
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  9. Article ; Online: γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer.

    Silva-Santos, Bruno / Mensurado, Sofia / Coffelt, Seth B

    Nature reviews. Cancer

    2019  Volume 19, Issue 7, Page(s) 392–404

    Abstract: The potential of cancer immunotherapy relies on the mobilization of immune cells capable of producing antitumour cytokines and effectively killing tumour cells. These are major attributes of γδ T cells, a lymphoid lineage that is often underestimated ... ...

    Abstract The potential of cancer immunotherapy relies on the mobilization of immune cells capable of producing antitumour cytokines and effectively killing tumour cells. These are major attributes of γδ T cells, a lymphoid lineage that is often underestimated despite its major role in tumour immune surveillance, which has been established in a variety of preclinical cancer models. This situation notwithstanding, in particular instances the tumour microenvironment seemingly mobilizes γδ T cells with immunosuppressive or tumour-promoting functions, thus emphasizing the importance of regulating γδ T cell responses in order to realize their translation into effective cancer immunotherapies. In this Review we outline both seminal work and recent advances in our understanding of how γδ T cells participate in tumour immunity and how their functions are regulated in experimental models of cancer. We also discuss the current strategies aimed at maximizing the therapeutic potential of human γδ T cells, on the eve of their exploration in cancer clinical trials that may position them as key players in cancer immunotherapy.
    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/etiology ; Neoplasms/pathology ; Neoplasms/therapy ; T-Lymphocytes/physiology ; Tumor Microenvironment/physiology
    Language English
    Publishing date 2019-08-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-019-0153-5
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    Zs.MG 24: Show issues

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  10. Article ; Online: Neutrophil Maturity in Cancer.

    Mackey, John B G / Coffelt, Seth B / Carlin, Leo M

    Frontiers in immunology

    2019  Volume 10, Page(s) 1912

    Abstract: Neutrophils are implicated in almost every stage of oncogenesis and paradoxically display anti- and pro-tumor properties. Accumulating evidence indicates that neutrophils display diversity in their phenotype resulting from functional plasticity and/or ... ...

    Abstract Neutrophils are implicated in almost every stage of oncogenesis and paradoxically display anti- and pro-tumor properties. Accumulating evidence indicates that neutrophils display diversity in their phenotype resulting from functional plasticity and/or changes to granulopoiesis. In cancer, neutrophils at a range of maturation stages can be identified in the blood and tissues (i.e., outside of their developmental niche). The functional capacity of neutrophils at different states of maturation is poorly understood resulting from challenges in their isolation, identification, and investigation. Thus, the impact of neutrophil maturity on cancer progression and therapy remains enigmatic. In this review, we discuss the identification, prevalence, and function of immature and mature neutrophils in cancer and the potential impact of this on tumor progression and cancer therapy.
    MeSH term(s) CCAAT-Binding Factor/genetics ; CCAAT-Binding Factor/immunology ; CCAAT-Binding Factor/metabolism ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/metabolism ; Humans ; Leukopoiesis/genetics ; Leukopoiesis/immunology ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; Neutrophils/cytology ; Neutrophils/immunology ; Neutrophils/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/immunology ; Proto-Oncogene Proteins/metabolism ; Trans-Activators/genetics ; Trans-Activators/immunology ; Trans-Activators/metabolism
    Chemical Substances CCAAT-Binding Factor ; Proto-Oncogene Proteins ; Trans-Activators ; proto-oncogene protein Spi-1
    Language English
    Publishing date 2019-08-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01912
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