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Article ; Online: Marie T. Filbin: in memoriam.

Ashe, Jim / Roskams, Jane

2014 Volume 82, Issue 3, Page(s) 509–510

MeSH term(s)	Female ; History, 20th Century ; History, 21st Century ; Humans ; Laboratory Personnel/history ; Myelin Sheath/physiology ; Neurosciences/history
Language	English
Publishing date	2014-05-02
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2014.04.033
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Zs.MG 92: Show issues

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Article ; Online: Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis.

Hammerich, Linda / Bangen, Jörg M / Govaere, Olivier / Zimmermann, Henning W / Gassler, Nikolaus / Huss, Sebastian / Liedtke, Christian / Prinz, Immo / Lira, Sergio A / Luedde, Tom / Roskams, Tania / Trautwein, Christian / Heymann, Felix / Tacke, Frank

Hepatology (Baltimore, Md.)

2013 Volume 59, Issue 2, Page(s) 630–642

Abstract: ... which may regulate migration of T-helper (Th)17, regulatory, and gamma-delta (γδ) T cells. CCR6 and CCL20 expression ... livers, CCR6 was expressed by macrophages, CD4 and γδ T-cells, and up-regulated in fibrosis ... 17- and IL-22-expressing γδ T cells for accumulation in injured liver. The adoptive transfer of WT γδ ...

Abstract	Unlabelled: Chronic liver injury promotes hepatic inflammation, representing a prerequisite for organ fibrosis. We hypothesized a contribution of chemokine receptor CCR6 and its ligand, CCL20, which may regulate migration of T-helper (Th)17, regulatory, and gamma-delta (γδ) T cells. CCR6 and CCL20 expression was intrahepatically up-regulated in patients with chronic liver diseases (n = 50), compared to control liver (n = 5). Immunohistochemistry revealed the periportal accumulation of CCR6(+) mononuclear cells and CCL20 induction by hepatic parenchymal cells in liver disease patients. Similarly, in murine livers, CCR6 was expressed by macrophages, CD4 and γδ T-cells, and up-regulated in fibrosis, whereas primary hepatocytes induced CCL20 upon experimental injury. In two murine models of chronic liver injury (CCl4 and methionine-choline-deficient diet), Ccr6(-/-) mice developed more severe fibrosis with strongly enhanced hepatic immune cell infiltration, compared to wild-type (WT) mice. Although CCR6 did not affect hepatic Th-cell subtype composition, CCR6 was explicitly required by the subset of interleukin (IL)-17- and IL-22-expressing γδ T cells for accumulation in injured liver. The adoptive transfer of WT γδ, but not CD4 T cells, into Ccr6(-/-) mice reduced hepatic inflammation and fibrosis in chronic injury to WT level. The anti-inflammatory function of hepatic γδ T cells was independent of IL-17, as evidenced by transfer of Il-17(-/-) cells. Instead, hepatic γδ T cells colocalized with hepatic stellate cells (HSCs) in vivo and promoted apoptosis of primary murine HSCs in a cell-cell contact-dependent manner, involving Fas-ligand (CD95L). Consistent with γδ T-cell-induced HSC apoptosis, activated myofibroblasts were more frequent in fibrotic livers of Ccr6(-/-) than in WT mice. Conclusion: γδ T cells are recruited to the liver by CCR6 upon chronic injury and protect the liver from excessive inflammation and fibrosis by inhibiting HSCs.
MeSH term(s)	Animals ; Apoptosis ; Case-Control Studies ; Cell Movement ; Chemokine CCL20/metabolism ; Disease Models, Animal ; Female ; Hepatitis/metabolism ; Hepatitis/pathology ; Hepatitis/prevention & control ; Humans ; Interleukin-17/metabolism ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Liver Cirrhosis/prevention & control ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Receptors, CCR6/deficiency ; Receptors, CCR6/genetics ; Receptors, CCR6/metabolism ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/pathology ; Th17 Cells/metabolism ; Th17 Cells/pathology ; Up-Regulation
Chemical Substances	CCR6 protein, human ; Chemokine CCL20 ; Interleukin-17 ; Receptors, Antigen, T-Cell, gamma-delta ; Receptors, CCR6
Language	English
Publishing date	2013-12-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.26697
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Article ; Online: Hepatosplenic gammadelta T-cell lymphoma after liver transplantation: report of the first 2 cases and review of the literature.

Roelandt, Philip R / Maertens, Johan / Vandenberghe, Peter / Verslype, Chris / Roskams, Tania / Aerts, Raymond / Nevens, Frederik / Dierickx, Daan

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2009 Volume 15, Issue 7, Page(s) 686–692

Abstract: Hepatosplenic gammadelta T-cell lymphoma is a rare lymphoproliferative disorder originating ...

Abstract	Hepatosplenic gammadelta T-cell lymphoma is a rare lymphoproliferative disorder originating from natural killer-like Vdelta1-lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation. Both patients had thrombocytopenia with (hepato)splenomegaly but without peripheral lymphadenopathies and sinusoidal infiltration of the liver and spleen by monomorphic gammadelta-lymphocytes on pathological examination. The clinical and pathological findings, immunophenotypical profile, prognosis, and treatment are highlighted. In order to make an early diagnosis, physicians who take care of liver transplant recipients should be aware of the characteristic features of this posttransplant lymphoproliferative disorder. Therefore, a diagnostic algorithm is proposed.
MeSH term(s)	Adult ; Algorithms ; Female ; Humans ; Immunophenotyping ; Leukemia-Lymphoma, Adult T-Cell/etiology ; Leukemia-Lymphoma, Adult T-Cell/therapy ; Liver Neoplasms/etiology ; Liver Neoplasms/therapy ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Male ; Medical Oncology/methods ; Positron-Emission Tomography/methods ; Prognosis ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Splenic Neoplasms/etiology ; Splenic Neoplasms/therapy ; Treatment Outcome
Chemical Substances	Receptors, Antigen, T-Cell, gamma-delta
Language	English
Publishing date	2009-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1002/lt.21748
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Article: The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.

Klein, Christian / Wüstefeld, Torsten / Assmus, Ulrike / Roskams, Tania / Rose-John, Stefan / Müller, Michael / Manns, Michael P / Ernst, Mattias / Trautwein, Christian

The Journal of clinical investigation

2005 Volume 115, Issue 4, Page(s) 860–869

Abstract: Increasing evidence demonstrates that IL-6 has a protective role during liver injury. IL-6 activates intracellular pathways via the gp130 receptor. In order to identify IL-6-gp130 pathways involved in mediating liver protection, we analyzed hepatocyte- ... ...

Abstract	Increasing evidence demonstrates that IL-6 has a protective role during liver injury. IL-6 activates intracellular pathways via the gp130 receptor. In order to identify IL-6-gp130 pathways involved in mediating liver protection, we analyzed hepatocyte-specific gp130 knockout mice in a concanavalin A-induced (Con A-induced) model of immune-mediated hepatitis. We demonstrated that IL-6-gp130-dependent pathways in hepatocytes alone are sufficient for triggering protection in Con A-induced hepatitis. gp130-STAT3 signaling in hepatocytes mediates the IL-6-triggered protective effect. This was demonstrated by analysis of IL-6-induced protection in mice selectively deficient for gp130-dependent STAT1/3 or gp130-SHP2-RAS signaling in hepatocytes. To identify IL-6-gp130-STAT1/3 dependently expressed liver-protective factors, we performed gene array analysis of hepatic gene expression in hepatocyte-specific gp130(-/-) mice as well as in gp130-STAT1/3- and gp130-SHP2-RAS-MAPK-deficient mice. The mouse IL-8 ortholog KC (also known as Gro-alpha) and serum amyloid A2 (SAA2) was identified as differentially IL-6-gp130-STAT3-regulated genes. Hepatic expression of KC and SAA2 mediate the liver-protective potential of IL-6, since treatment with recombinant KC or serum SAA2 effectively reduced liver injury during Con A-induced hepatitis. In summary, this study defines IL-6-gp130-STAT3-dependent gene expression in hepatocytes that mediates IL-6-triggered protection in immune-mediated Con A-induced hepatitis. Additionally, we identified the IL-6-gp130-STAT3-dependent proteins KC and SAA2 as new candidates for therapeutic targets in liver diseases.
MeSH term(s)	Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Concanavalin A/toxicity ; Cytokine Receptor gp130 ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Enzyme Activation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Profiling ; Hepatitis/immunology ; Hepatocytes/physiology ; Interferon-gamma/metabolism ; Interleukin-6/metabolism ; Liver/cytology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; STAT1 Transcription Factor ; STAT3 Transcription Factor ; Serum Amyloid A Protein/metabolism ; Signal Transduction/physiology ; T-Lymphocytes/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Antigens, CD ; DNA-Binding Proteins ; Il6st protein, mouse ; Interleukin-6 ; Membrane Glycoproteins ; STAT1 Transcription Factor ; STAT3 Transcription Factor ; Saa2 protein, mouse ; Serum Amyloid A Protein ; Stat1 protein, mouse ; Stat3 protein, mouse ; Trans-Activators ; Tumor Necrosis Factor-alpha ; Concanavalin A (11028-71-0) ; Cytokine Receptor gp130 (133483-10-0) ; Interferon-gamma (82115-62-6) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
Language	English
Publishing date	2005-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI23640
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Article ; Online: Validation of large animal models in mechanical valve research: a histologic comparison.

Van Hecke, Manon / Langenaeken, Tom / Rega, Filip / Roskams, Tania / Meuris, Bart

Interdisciplinary cardiovascular and thoracic surgery

2024

Abstract: Objectives: Mechanical valves still require life-long anticoagulation. Preclinical animal testing is a crucial step in the assessment of valves, however the chosen animal model should be carefully considered, and a well-controlled animal model of ... ...

Abstract	Objectives: Mechanical valves still require life-long anticoagulation. Preclinical animal testing is a crucial step in the assessment of valves, however the chosen animal model should be carefully considered, and a well-controlled animal model of mechanical valve thrombosis has not been established yet. In this study, a histopathologic comparison was performed to evaluate the representativity of pigs and sheep as large animal models in bileaflet mechanical valve thrombosis research. Methods: 10 pigs and 8 sheep were implanted with a bileaflet mechanical valve in pulmonary position. During follow-up, no anticoagulative therapy was administered. Pigs were sacrificed between 14-38 days for explantation and assessment of the valve. Sheep were sacrificed between 71-155 days. Thrombus samples were processed and (immuno)histochemical stainings were applied. A pathologist evaluated the samples morphologically and semiquantitatively and compared these samples to available slides from 3 human patients who underwent redo surgery for acute bileaflet mechanical valve thrombosis, caused by insufficient anticoagulation. Results: All pigs showed macroscopically evident thrombi on the mechanical valve surface at sacrifice. In contrast, none of the sheep showed any sign of thrombus formation. Histology showed a high fibrin content in thrombi of both human and porcine cases (3/3 vs 8/10). Porcine thrombi showed more cellular organization (0/3 vs 6/10), more calcification (0/3 vs 9/10) and more endothelialisation (0/3 vs 6/10). Inflammatory cells were present in all samples and were considered physiological. Conclusions: Contrary to sheep, pigs develop thrombi on their mechanical valves in the short-term if no anticoagulation is administered. Histologic comparison of human and porcine thrombi shows comparable findings. The pig model might serve interestingly for further research on valve thrombosis, if it shows not to be an overly aggressive model.
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ISSN	2753-670X
ISSN (online)	2753-670X
DOI	10.1093/icvts/ivae070
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Article: Fulminant ectopic Cushing's syndrome caused by metastatic small intestine neuroendocrine tumour - a case report and review of the literature.

Alliet, B / Severi, C / Veekmans, T / Cuypers, J / Topal, H / Deroose, C M / Roskams, T / Bex, M / Dekervel, J

Acta gastro-enterologica Belgica

2024 Volume 87, Issue 1, Page(s) 48–51

Abstract: Cushing's syndrome (CS) secondary to adrenocorticotropic hormone (ACTH) producing tumours is a severe condition with a challenging diagnosis. Ectopic ACTH-secretion often involves neuroendocrine tumours (NET) in the respiratory tract. ACTH-secreting ... ...

Abstract	Cushing's syndrome (CS) secondary to adrenocorticotropic hormone (ACTH) producing tumours is a severe condition with a challenging diagnosis. Ectopic ACTH-secretion often involves neuroendocrine tumours (NET) in the respiratory tract. ACTH-secreting small intestine neuro-endocrine tumours (siNET) are extremely rare entities barely reported in literature. This review is illustrated by the case of a 75-year old woman with fulminant ectopic CS caused by a ACTH-secreting metastatic siNET. Severe hypokalemia, fluid retention and refractory hypertension were the presenting symptoms. Basal and dynamic laboratory studies were diagnostic for ACTH-dependent CS. Extensive imaging studies of the pituitary and thorax-abdomen areas were normal, while [68Ga]Ga-DOTATATE PET-CT revealed increased small intestine uptake in the left iliac fossa. The hypercortisolism was well controlled with somatostatin analogues, after which a debulking resection of the tumour was performed. Pathological investigation confirmed a well-differentiated NET with sporadic ACTH immunostaining and post-operative treatment with somatostatin analogues was continued with favourable disease control.
MeSH term(s)	Female ; Humans ; Aged ; Cushing Syndrome/diagnosis ; Cushing Syndrome/etiology ; Cushing Syndrome/pathology ; Neuroendocrine Tumors/complications ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/pathology ; Positron Emission Tomography Computed Tomography ; Adrenocorticotropic Hormone ; Intestinal Neoplasms/complications ; Intestinal Neoplasms/diagnosis ; Somatostatin/therapeutic use
Chemical Substances	Adrenocorticotropic Hormone (9002-60-2) ; Somatostatin (51110-01-1)
Language	English
Publishing date	2024-03-02
Publishing country	Belgium
Document type	Review ; Case Reports
ZDB-ID	127060-6
ISSN	1784-3227 ; 0001-5644
ISSN	1784-3227 ; 0001-5644
DOI	10.51821/87.1.11872
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Article ; Online: Diagnostic challenges in patients with alcohol-related liver disease.

Krag, Aleksander / Roskams, Tania / Pinzani, Massimo / Mueller, Sebastian

Zeitschrift fur Gastroenterologie

2022 Volume 60, Issue 1, Page(s) 45–57

Abstract: Alcohol is globally the leading risk factor for cirrhosis and is subsumed under the term alcohol-related liver disease (ALD). However, only ca. 10% of people with harmful alcohol consumption (>40 gram alcohol per day) develop cirrhosis, while 15% have ... ...

Title translation	Diagnostische Herausforderungen bei Patienten mit alkoholischer Lebererkrankung.
Abstract	Alcohol is globally the leading risk factor for cirrhosis and is subsumed under the term alcohol-related liver disease (ALD). However, only ca. 10% of people with harmful alcohol consumption (>40 gram alcohol per day) develop cirrhosis, while 15% have normal liver histology. Unfortunately, laboratory parameters and ultrasound hold little value to neither rule-in nor rule out alcohol related liver fibrosis. While several indices with combinations of liver associated markers such as FIB4 seem to be promising, non-invasive test strategies are urgently needed with cut-off's that can be applied to guide clinical decision making. The aims of this review article are to highlight novel developments for the diagnosis of ALD and to identify topics of controversy and potential future directions. In the last 15 years, elastography to measure liver stiffness (LS) has significantly improved our screening strategies for cirrhosis. LS values below 6 kPa are considered as normal and exclude ALD. LS of 8 and 12.5 kPa represent generally accepted cut-off values for F3 and F4 fibrosis. Especially, transient elastography (TE) has been assessed in numerous studies, but similar performance can be obtained with point shear wave elastography, 2 SD shear wave elastography or MR elastography. Important confounders of elevated LS such as inflammation should also be considered and alcohol withdrawal not only improves liver inflammation but also LS. Liver stiffness measurement has signficiantly improved early diagnosis and follow-up of fibrosis in patients with ALD and patients with diagnosed manifest but clinically compensated cirrhosis should undergo further clinical examinations to rule out complications of portal hypertension. In addition, surveillance for the occurrence of hepatocellular carcinoma is recommended in all cirrhotic patients.
MeSH term(s)	Alcoholism/pathology ; Elasticity Imaging Techniques ; Humans ; Hypertension, Portal ; Liver/pathology ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/pathology ; Substance Withdrawal Syndrome/pathology
Language	English
Publishing date	2022-01-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-1713-4372
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Article: Regression of multiple hepatocellular adenomas after cessation of oral contraceptive pills: a case report and review of the current literature.

Moors, G / Poels, H / Vandecaveye, V / Roskams, T / Verslype, C

Acta gastro-enterologica Belgica

2021 Volume 84, Issue 3, Page(s) 505–508

Abstract: Hepatocellular adenoma (HCA) is an uncommon benign liver neoplasm usually solitary and identified incidentally on imaging. We report a case of a 50-year old female who was diagnosed with multiple hepatic adenomas of the inflammatory subtype. After ... ...

Abstract	Hepatocellular adenoma (HCA) is an uncommon benign liver neoplasm usually solitary and identified incidentally on imaging. We report a case of a 50-year old female who was diagnosed with multiple hepatic adenomas of the inflammatory subtype. After discontinuation of oral contraception a decrease of both the number and size of the liver lesions was seen on magnetic resonance imaging (MRI) without the need of further intervention. The major challenge in the clinical management of patients with multiple HCAs resides in the risk assessment for future complications. In the case of multiple HCAs subtype seemed to be more relevant than the actual number of lesions. Because little is known about the natural evolution in patients with multiple HCAs, we performed a review of the current literature with focus on the different subtypes and their clinical relevance.
MeSH term(s)	Adenoma, Liver Cell/chemically induced ; Carcinoma, Hepatocellular ; Contraception ; Contraceptives, Oral/adverse effects ; Female ; Humans ; Liver Neoplasms ; Magnetic Resonance Imaging ; Middle Aged
Chemical Substances	Contraceptives, Oral
Language	English
Publishing date	2021-10-02
Publishing country	Belgium
Document type	Case Reports ; Review
ZDB-ID	127060-6
ISSN	1784-3227 ; 0001-5644
ISSN	1784-3227 ; 0001-5644
DOI	10.51821/84.3.017
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Article: Diagnostic challenges in patients with alcohol-related liver disease

Krag, Aleksander / Roskams, Tania / Pinzani, Massimo / Mueller, Sebastian

Zeitschrift für Gastroenterologie

2022 Volume 60, Issue 01, Page(s) 45–57

Abstract	Alcohol is globally the leading risk factor for cirrhosis and is subsumed under the term alcohol-related liver disease (ALD). However, only ca. 10% of people with harmful alcohol consumption (>40 gram alcohol per day) develop cirrhosis, while 15% have normal liver histology. Unfortunately, laboratory parameters and ultrasound hold little value to neither rule-in nor rule out alcohol related liver fibrosis. While several indices with combinations of liver associated markers such as FIB4 seem to be promising, non-invasive test strategies are urgently needed with cut-off’s that can be applied to guide clinical decision making. The aims of this review article are to highlight novel developments for the diagnosis of ALD and to identify topics of controversy and potential future directions. In the last 15 years, elastography to measure liver stiffness (LS) has significantly improved our screening strategies for cirrhosis. LS values below 6 kPa are considered as normal and exclude ALD. LS of 8 and 12.5 kPa represent generally accepted cut-off values for F3 and F4 fibrosis. Especially, transient elastography (TE) has been assessed in numerous studies, but similar performance can be obtained with point shear wave elastography, 2 SD shear wave elastography or MR elastography. Important confounders of elevated LS such as inflammation should also be considered and alcohol withdrawal not only improves liver inflammation but also LS. Liver stiffness measurement has signficiantly improved early diagnosis and follow-up of fibrosis in patients with ALD and patients with diagnosed manifest but clinically compensated cirrhosis should undergo further clinical examinations to rule out complications of portal hypertension. In addition, surveillance for the occurrence of hepatocellular carcinoma is recommended in all cirrhotic patients.
Keywords	Alkoholische Lebererkrankung ; Lebersteifigkeit ; Leberzirrhose ; alcoholic liver disease ; liver stiffness ; liver cirrhosis
Language	English
Publishing date	2022-01-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0044-2771 ; 0172-8504
ISSN (online)	1439-7803
ISSN	0044-2771 ; 0172-8504
DOI	10.1055/a-1713-4372
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Article ; Online: Anatomic pathology of hepatocellular carcinoma: impact on prognosis and response to therapy.

Roskams, Tania

Clinics in liver disease

2011 Volume 15, Issue 2, Page(s) 245–59, vii–x

Abstract: A better understanding of signaling pathways in HCC pathogenesis has led to targeted therapies against HCC. Identification of liver cancer stem cell markers and their related pathways is one of the most important goals of liver cancer research. New ... ...

Abstract	A better understanding of signaling pathways in HCC pathogenesis has led to targeted therapies against HCC. Identification of liver cancer stem cell markers and their related pathways is one of the most important goals of liver cancer research. New therapies should ideally target cancer stem cells and not normal stem/progenitor cells, because the latter are very important in regeneration and repair. Individualized HCC therapy will require better definition of patient subgroups that benefit most or should be protected from therapy failure and unwanted side effects. Tumor tissue acquisition should be mandatory, reversing the practice that was established years ago when targeted HCC therapy was but a pipe dream.
MeSH term(s)	Animals ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/diagnosis ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/pathology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology
Language	English
Publishing date	2011-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1472315-3
ISSN	1557-8224 ; 1089-3261
ISSN (online)	1557-8224
ISSN	1089-3261
DOI	10.1016/j.cld.2011.03.004
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