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Article ; Online: Functional Characterization of the m

Sinha, Ameya / Baumgarten, Sebastian / Distiller, Amy / McHugh, Emma / Chen, Patty / Singh, Meetali / Bryant, Jessica M / Liang, Jiaqi / Cecere, Germano / Dedon, Peter C / Preiser, Peter R / Ralph, Stuart A / Scherf, Artur

mBio

2021 Volume 12, Issue 2

Abstract: Posttranscriptional regulation of gene expression is central to the development and replication of the malaria parasite, ...

Abstract	Posttranscriptional regulation of gene expression is central to the development and replication of the malaria parasite,
MeSH term(s)	Adenosine/metabolism ; Erythrocytes/parasitology ; Gene Expression Regulation ; Humans ; Malaria, Falciparum/parasitology ; Methylation ; Plasmodium falciparum/genetics ; Plasmodium falciparum/metabolism ; Proteomics ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; RNA Processing, Post-Transcriptional ; RNA, Messenger/metabolism
Chemical Substances	Protozoan Proteins ; RNA, Messenger ; Adenosine (K72T3FS567)
Language	English
Publishing date	2021-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.00661-21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Neurosurgery and Global Health

Germano, Isabelle M.

2022

Author's details	Isabelle M. Germano, MD, MBA Professor of Neurosurgery, Neurology, Oncological Sciences§ Icahn School of Medicine at Mount Sinai§ New York NY§ USA§
Keywords	Neurosurgery Education ; Neuro-Oncology ; Disaster response ; economic impact ; Head trauma ; Cerebrovascular and stroke ; Neuro-oncology ; Disaster Response ; Economic Impact ; Head Trauma
Language	English
Size	388 p.
Edition	1
Publisher	Springer International Publishing
Document type	Book
Note	PDA Manuell_13
Format	160 x 241 x 26
ISBN	9783030866556 ; 3030866556
Database	PDA

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Book ; Online ; E-Book: Neurosurgery and global health

Germano, Isabelle M.

2022

Author's details	edited by Isabelle M. Germano
Keywords	Nervous system/Surgery
Subject code	617.48
Language	English
Size	1 online resource (377 pages)
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	9783030866563 ; 9783030866556 ; 3030866564 ; 3030866556
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Neurodevelopmental Disorders and Suicide: A Narrative Review.

Gagliano, Antonella / Costanza, Carola / Di Modica, Irene / Carucci, Sara / Donno, Federica / Germanò, Eva / Abbate, Costanza Scaffidi / Roccella, Michele / Vetri, Luigi

Journal of clinical medicine

2024 Volume 13, Issue 6

Abstract: Specific risk factors for self-harm and suicide in children and adolescents with neurodevelopmental disorders (NDD) may differ from those in the general population within this age range. In the present review paper, we conducted a narrative analysis of ... ...

Abstract	Specific risk factors for self-harm and suicide in children and adolescents with neurodevelopmental disorders (NDD) may differ from those in the general population within this age range. In the present review paper, we conducted a narrative analysis of the literature, aiming to establish a connection between suicide and affective disorders in children and adolescents with NDD. Emotion dysregulation (ED) as an individual factor and adverse childhood experiences (ACE) as environmental factors are discussed as risk factors for suicidality in all individuals with NDD. We propose a theoretical model in which ED and ACE can directly lead to self-harm or suicide, directly or indirectly by interacting with depressive spectrum disorders. Additionally, we suggest that specific risk factors are more frequently associated with each of the neurodevelopmental disorders listed in the DSM-V. This review underlines the key points useful to improve the knowledge of the trajectory leading to suicide risk in NDDs with the purpose to facilitate the early identification of the suicide risk.
Language	English
Publishing date	2024-03-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13061627
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Article: Rapid PCR real-time genotyping of M-Malton alpha1-antitrypsin deficiency alleles by molecular beacons.

Orrù, Germano / Faa, Gavino / Pillai, Sara / Pilloni, Luca / Montaldo, Caterina / Pusceddu, Gesuina / Piras, Vincenzo / Coni, Pierpaolo

Diagnostic molecular pathology : the American journal of surgical pathology, part B

2005 Volume 14, Issue 4, Page(s) 237–242

Abstract: ... Another pathologic allele, the M-Malton variant (also known as Mnichinan and Mcagliari), can mimic the Pi Z clinical ... fluorescent real-time PCR assay designed for the detection of the M-Malton alpha1-antitrypsin deficiency ...

Abstract	Alpha1-Antitrypsin deficiency is an autosomal codominant inherited disorder, with increased risk of developing lung and liver disease. The large majority of subjects affected by alpha1-antitrypsin deficiency carry the PIZZ or PISZ genotypes, which can be easily detected using several molecular methods. Another pathologic allele, the M-Malton variant (also known as Mnichinan and Mcagliari), can mimic the Pi Z clinical phenotype, but this alpha1-antitrypsin deficiency variant is not easily recognizable and, therefore, seems to be more under-recognized than the Z or S alleles. We report the development of a rapid qualitative fluorescent real-time PCR assay designed for the detection of the M-Malton alpha1-antitrypsin deficiency alleles using 2 specific molecular beacons. The assay is able to detect in a single tube the homozygous as well the heterozygous genotypes. The procedure combines the great sensitivity of the polymerase chain reaction, the specificity provided by allele-specific molecular beacons, and the throughput of a multi-color fluorescence detection procedure. This technique will be useful for research and molecular diagnostic laboratories involved in the study of alpha1-antitrypsin deficiency-related diseases.
MeSH term(s)	Adolescent ; Adult ; Alleles ; Base Sequence ; Child ; Child, Preschool ; Female ; Gene Frequency ; Genetic Variation ; Genotype ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Polymerase Chain Reaction/methods ; alpha 1-Antitrypsin/genetics ; alpha 1-Antitrypsin Deficiency/genetics
Chemical Substances	alpha 1-Antitrypsin
Language	English
Publishing date	2005-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1098858-0
ISSN	1533-4066 ; 1052-9551
ISSN (online)	1533-4066
ISSN	1052-9551
DOI	10.1097/01.pas.0000178221.44474.b3
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Zs.A 3393: Show issues

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Article: Correlation Between Cervical Spine Sagittal Alignment and Clinical Outcome After Standalone Intersomatic Titanium Cage CeSPACE for Cervical Anterior Discectomy and Fusion in Cervical Degenerative Disk Diseases.

Zaccaria, R / Cacciola, F / Caruso, G / Ferri, S / Caffo, M / Curcio, A / Ghetti, I / Germanò, A

Acta neurochirurgica. Supplement

2022 Volume 135, Page(s) 361–366

Abstract: The aim of this study was to determine the relationship between cervical spine sagittal alignment and clinical outcomes after using a standalone intersomatic titanium cage CeSPACE for anterior cervical discectomy and arthrodesis. We present our clinical ... ...

Abstract	The aim of this study was to determine the relationship between cervical spine sagittal alignment and clinical outcomes after using a standalone intersomatic titanium cage CeSPACE for anterior cervical discectomy and arthrodesis. We present our clinical experience in a group of 180 patients with a mean follow-up for at least 2 years. Patients were evaluated by clinical and radiological assessment preoperatively, immediately after surgery and at regular follow-up. There were 97 male and 83 female patients (average age: 56.6 years) who were preoperatively affected by cervical radiculomyelopathy that was due to spondylosis or cervical disk herniation and who underwent surgical treatment. All patients underwent an anterior discectomy and interbody fusion through the positioning of one or more levels of the CeSPACE device. Compared with the preoperative scores, improvement was seen in postoperative visual analog scale (VAS) scores and Neck Disability Index (NDI) values. The standalone intersomatic titanium cage CeSPACE for anterior cervical discectomy and arthrodesis improved radiculomyelopathy and increased the probability of cervical kyphotic alignment. However, cervical sagittal alignment after surgery was not significantly associated with clinical outcomes in terms of postoperative improvement in VAS scores and NDI values. Similarly, the change in cervical sagittal alignment was not related to visual analog scale scores or Neck Disability Index values.
MeSH term(s)	Humans ; Female ; Male ; Middle Aged ; Titanium ; Diskectomy ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Neck ; Spondylosis/diagnostic imaging ; Spondylosis/surgery
Chemical Substances	Titanium (D1JT611TNE)
Language	English
Publishing date	2022-10-29
Publishing country	Austria
Document type	Journal Article
ISSN	0065-1419
ISSN	0065-1419
DOI	10.1007/978-3-031-36084-8_55
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Advanced techniques in image-guided brain and spine surgery

Germano, Isabelle M.

2002

Author's details	Isabelle M. Germano
Keywords	Hirnchirurgie ; Computerassistierte Chirurgie ; Wirbelsäulenchirurgie
Subject	Navigationschirurgie ; Roboterchirurgie ; Roboterassistierte Chirurgie ; Computer-assistierte Navigationschirurgie ; Computer-assistierte Chirurgie ; computer aided surgery ; CAS ; CANS ; Computergestützte Chirurgie ; Computergestützte Intervention ; Bild geführte Chirurgie ; Chirurgische Navigation ; Wirbelsäule ; Hirnkrankheit ; Hirnoperation ; Gehirnchirurgie
Language	English
Size	XIII, 233 S. : Ill., graph. Darst.
Publisher	Thieme
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT013399870
ISBN	3-13-131521-0 ; 1-58890-067-3 ; 978-3-13-131521-2 ; 978-1-58890-067-8
Database	Catalogue ZB MED Medicine, Health

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2002 A 3534	order for loan	Magazin

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Article ; Online: The Current Landscape of Neurosurgical Oncology in Low-Middle-Income Countries (LMIC): Strategies for the Path Forward.

Young, Tirone / Tropeano, Maria Pia / Cannizzaro, Delia / Jelmoni, Alice J M / Servadei, Franco / Germano, Isabelle M

World neurosurgery

2024 Volume 184, Page(s) e291–e298

Abstract: Objective: To promote global equity in research, innovation, and care, sharing knowledge and grasping current benchmarks is crucial. Despite LIC/LMIC constituting around 80% of the global population, their contribution to neurosurgery research is less ... ...

Abstract	Objective: To promote global equity in research, innovation, and care, sharing knowledge and grasping current benchmarks is crucial. Despite LIC/LMIC constituting around 80% of the global population, their contribution to neurosurgery research is less than 5%. This study aims to assess the status of neurosurgical oncology in LIC/LMIC using published data, offering strategic insights for progress. Methods: Conducting a retrospective bibliometric analysis via PubMed and Scopus databases, we documented reports published (2015-2021) by neurosurgical department-affiliated investigators in LICs/LMICs. World Bank classifications identified LIC and LMIC. Reviewed papers underwent further scrutiny based on independent and associated keyword lists. Results: Our systematic approach revealed 189 studies from LMIC in 10 neurosurgery journals. Of these, 53% were case reports, with 88% focusing on brain pathologies and 12% on the spine. Intra-axial brain tumors (45.8%), extra-axial/skull base (38.4%), and metastasis (3.68%) were prominent. Among noncase report publications, surgical technique and outcome were common themes. India, Egypt, and Tunisia led in publications, with 94% appearing in journals with an impact factor below 5. No papers originated from LIC. Conclusions: This study reinforces existing findings that data from LMIC inadequately represent their populations, impeding a comprehensive understanding of their neurosurgical oncology landscape. Language barriers and data collection difficulties contribute to this gap. Addressing these challenges could significantly enhance progress in shaping the future of neurosurgical oncology in these regions.
MeSH term(s)	Humans ; Developing Countries ; Retrospective Studies ; Neurosurgery ; Neurosurgical Procedures ; Bibliometrics
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.01.118
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Zs.A 1159: Show issues

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Article ; Online: Effect of vertical central plication on vertical deviations.

Strube, Yi Ning J / Cheung, Kevin / Germano, Bella R / Hopman, Wilma M / Wright, Kenneth W

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

2024 Volume 28, Issue 2, Page(s) 103861

Abstract: Purpose: To evaluate the surgical effect of the Wright central plication on vertical rectus muscles to correct vertical strabismus.: Methods: In this multicenter, retrospective, observational outcomes study, data were collected from two surgeons in ... ...

Abstract	Purpose: To evaluate the surgical effect of the Wright central plication on vertical rectus muscles to correct vertical strabismus. Methods: In this multicenter, retrospective, observational outcomes study, data were collected from two surgeons in different practice settings (2017-22). All patients who underwent vertical rectus central plication were included; those undergoing any concurrent strabismus surgery for vertical strabismus were excluded. Primary outcome was amount of strabismus correction in prism diopters per vertical rectus central plication. Secondary outcome was to determine factors associated with better or worse surgical outcomes and patient and patient responses. Data were analyzed using descriptive and bivariate statistics. Results: A total of 36 patients were included. Mean age was 60 years. Mean follow-up was 8.4 months. Of the 36 patients, 11 (31%) had idiopathic strabismus, and 7 (19%) had congenital superior oblique palsy. The remainder had a history that included prior ocular surgery, trauma, and Brown syndrome; 16 (44 %) had prior strabismus surgery. Of 31 patients with preoperative diplopia, 23 (74%) had postoperative resolution of diplopia, and 10 of 16 patients with preoperative prisms (63%) no longer required prisms postoperatively. Mean vertical deviation change was 4.7 Conclusions: In our study cohort, vertical rectus central plication corrected approximately 5
MeSH term(s)	Humans ; Middle Aged ; Ophthalmologic Surgical Procedures ; Diplopia/etiology ; Diplopia/surgery ; Retrospective Studies ; Strabismus/etiology ; Strabismus/surgery ; Oculomotor Muscles/surgery ; Paralysis/surgery ; Treatment Outcome
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	1412476-2
ISSN	1528-3933 ; 1091-8531
ISSN (online)	1528-3933
ISSN	1091-8531
DOI	10.1016/j.jaapos.2024.103861
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Zs.A 5188: Show issues

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Article: Temporalis Muscle Transposition in Irreversible Facial Nerve Palsy:‎ A Vestibular Approach.

Krastinova, Darina / Al-Mekhlafi, Ghaleb A / El-Badawy, Fatma M / El-Badawy, Hossein M / Germanò, Demetrio

Cureus

2023 Volume 15, Issue 12, Page(s) e51348

Abstract: Background The facial nerve plays a crucial role in innervating the motor supply of facial muscles, enabling essential facial expressions that facilitate human communication. Defects or damages to this nerve can have significant consequences, leading to ... ...

Abstract	Background The facial nerve plays a crucial role in innervating the motor supply of facial muscles, enabling essential facial expressions that facilitate human communication. Defects or damages to this nerve can have significant consequences, leading to functional, emotional, and social difficulties caused by the immobility of facial muscles. Patients suffering from irreversible facial nerve palsy often experience functional symptoms such as eyelid closure defects, mouth deviation, and limited movement. Methods This study aims to address these challenges and offer potential solutions for patients with irreversible facial nerve palsy. In this study, 18 patients (three males and 15 females) underwent temporalis transfer with an intraoral approach in the cranio-orbito-palpebral unity. Preoperative facial reanimation planning involved evaluating the smile's appearance on the unaffected side. Photographs were captured in various positions, and facial expressions were examined. Following this, botulinum toxin was injected into the normal side of the face seven days before the procedure to address the hyperactive condition of the mimic muscles. Results Temporalis transfer with an intraoral approach for oral commissure reanimation in the context of irreversible facial nerve palsy was performed. The surgical procedure combined coronal and orbital approaches and achieved the desired outcomes. Postoperative complications observed included hematomas and ossification. Functional outcomes, assessed using the House-Brackmann grading system, indicated a mean improvement of 2.5, signifying moderate dysfunction with normal tone and facial symmetry. Conclusion This intervention represents an alternative approach to actual techniques of facial palsy reanimation, especially in selected patients who can benefit from the absence of visible scars, such as young patients and those prone to hypertrophic and keloid scarring, as well as patients with non-prominent nasolabial folds.
Language	English
Publishing date	2023-12-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.51348
Database	MEDical Literature Analysis and Retrieval System OnLINE

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