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  1. Article: Anna M. Wobus. Interview by Fiona Watt.

    Wobus, Anna M

    Journal of cell science

    2004  Volume 117, Issue Pt 7, Page(s) 977–978

    MeSH term(s) Animals ; Female ; Germany ; Humans ; Research ; Stem Cells/cytology ; Women's Rights
    Language English
    Publishing date 2004-03-01
    Publishing country England
    Document type Interview
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.01046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book: Stem cells

    Wobus, Anna M. / Alison, M. R.

    [with 24 tables]

    (Handbook of experimental pharmacology ; 174)

    2006  

    Author's details ed. Anna M. Wobus ... Contributors: M. R. Alison
    Series title Handbook of experimental pharmacology ; 174
    Collection
    Keywords Stammzelle
    Subject Stem cell
    Language English
    Size X, 414 S. : Ill., 235 mm x 155 mm
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014583309
    ISBN 978-3-540-26133-9 ; 3-540-26133-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 6733 order for loan Magazin
    2006 A 681 order for loan Magazin

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  3. Book ; Conference proceedings: Die Verfügbarkeit des Lebendigen

    Wobus, Anna M.

    am 28. und 29. Mai 1999 ; mit 6 Tabellen

    (Nova acta Leopoldina ; N.F., Nr. 315 : Bd. 82)

    2000  

    Institution Institut für Pflanzengenetik und Kulturpflanzenforschung
    Event/congress Gaterslebener Begegnung (8, 1999, Gatersleben)
    Author's details Gaterslebener Begegnung 1999. Gemeinsam veranst. vom Institut für Pflanzengenetik und Kulturpflanzenforschung Gatersleben und von der Deutschen Akademie der Naturforscher Leopoldina. Hrsg. von Anna M. Wobus
    Series title Nova acta Leopoldina ; N.F., Nr. 315 : Bd. 82
    Collection
    Keywords Gentechnologie
    Subject Gentechnik ; Genchirurgie ; Genetic engineering ; Genetische Manipulation ; Genetische Technik ; Genmanipulation
    Language German
    Size 285 S. : Ill., graph. Darst.
    Publisher Barth
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT012798215
    ISBN 3-8304-5085-0 ; 978-3-8304-5085-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 1/20 -395- verfügbar in Königswinter Königswinter

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  4. Article ; Online: The Janus face of pluripotent stem cells--connection between pluripotency and tumourigenicity.

    Wobus, Anna M

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2010  Volume 32, Issue 11, Page(s) 993–1002

    Abstract: Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity in vitro. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. ...

    Abstract Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity in vitro. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. Here three types of in vitro cultured pluripotent stem cells (embryonic carcinoma, embryonic stem and induced pluripotent stem cells) are compared in their historical context with respect to their different origin and properties. It became evident that tumourigenicity is an inherent property of pluripotent cells based on p53 down-regulation, expression of tumour-related genes and high telomerase activity that allow unlimited proliferation. In addition, culture-adapted genetic and epigenetic changes may induce tumourigenicity of pluripotent cells. The use of stem cells in regenerative medicine, however, requires non-malignant cell types and strategies that circumvent stages of malignancy.Reprogramming strategies of adult somatic cells that avoid the tumourigenic state of pluripotency may offer alternatives for future biomedical application.
    MeSH term(s) Embryonic Stem Cells/metabolism ; Embryonic Stem Cells/pathology ; Humans ; Induced Pluripotent Stem Cells/pathology ; Neoplasms/pathology ; Pluripotent Stem Cells/pathology
    Language English
    Publishing date 2010-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201000065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stem cell research within the Priority Program 1109 of the German Research Foundation, 2001-2007.

    Wobus, Anna M

    Cells, tissues, organs

    2008  Volume 188, Issue 1-2, Page(s) 6–8

    MeSH term(s) Animals ; Cell Differentiation ; Congresses as Topic ; Embryonic Stem Cells/cytology ; Germany ; Humans ; Mice ; Research ; Research Support as Topic ; Stem Cells/cytology
    Language English
    Publishing date 2008
    Publishing country Switzerland
    Document type Introductory Journal Article
    ZDB-ID 1468141-9
    ISSN 1422-6421 ; 1422-6405
    ISSN (online) 1422-6421
    ISSN 1422-6405
    DOI 10.1159/000118785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Epidemiological and Microbiome Associations Between

    Collingwood, Abigail / Blostein, Freida / Seekatz, Anna M / Wobus, Christiane E / Woods, Robert J / Foxman, Betsy / Bachman, Michael A

    Open forum infectious diseases

    2020  Volume 7, Issue 1, Page(s) ofaa012

    Abstract: Background: Prior colonization by : Methods: ICU patients were screened for VRE and : Results: K. pneumoniae: Conclusions: K. ... ...

    Abstract Background: Prior colonization by
    Methods: ICU patients were screened for VRE and
    Results: K. pneumoniae
    Conclusions: K. pneumoniae
    Language English
    Publishing date 2020-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofaa012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: In vitro differentiation of embryonic stem cells into cardiomyocytes or skeletal muscle cells is specifically modulated by retinoic acid.

    Wobus, Anna M / Rohwedel, Jürgen / Maltsev, Victor / Hescheler, Jürgen

    Roux's archives of developmental biology : the official organ of the EDBO

    2017  Volume 204, Issue 1, Page(s) 36–45

    Abstract: Pluripotent embryonic stem cells (ES cells) differentiating via embryo-like aggregates (embryoid bodies) into derivatives of the primary germ layers were used as a model system to investigate the time- and concentration dependent effects of retinoic acid ...

    Abstract Pluripotent embryonic stem cells (ES cells) differentiating via embryo-like aggregates (embryoid bodies) into derivatives of the primary germ layers were used as a model system to investigate the time- and concentration dependent effects of retinoic acid (RA) on the in vitro differentiation pattern. When ES cells, cultivated normally under conditions resulting in cardiomyocyte differentiation, were treated during the first 2 days of embryoid body formation with high RA concentrations (10
    Language English
    Publishing date 2017-03-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 14096-x
    ISSN 0930-035X ; 0340-0794
    ISSN 0930-035X ; 0340-0794
    DOI 10.1007/BF00189066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bone marrow-derived mesenchymal stromal cells obstruct AML-targeting CD8

    Towers, Russell / Trombello, Lidia / Fusenig, Maximilian / Tunger, Antje / Baumann, Anna-Lena / Savoldelli, Roberto / Wehner, Rebekka / Fasslrinner, Frederick / Arndt, Claudia / Dazzi, Francesco / Von Bonin, Malte / Feldmann, Anja / Bachmann, Michael P / Wobus, Manja / Schmitz, Marc / Bornhäuser, Martin

    Cancer immunology, immunotherapy : CII

    2024  Volume 73, Issue 1, Page(s) 8

    Abstract: Bone marrow mesenchymal stromal cells (MSCs) have been described as potent regulators of T-cell function, though whether they could impede the effectiveness of immunotherapy against acute myeloid leukemia (AML) is still under investigation. We examine ... ...

    Abstract Bone marrow mesenchymal stromal cells (MSCs) have been described as potent regulators of T-cell function, though whether they could impede the effectiveness of immunotherapy against acute myeloid leukemia (AML) is still under investigation. We examine whether they could interfere with the activity of leukemia-specific clonal cytotoxic T-lymphocytes (CTLs) and chimeric antigen receptor (CAR) T cells, as well as whether the immunomodulatory properties of MSCs could be associated with the induction of T-cell senescence. Co-cultures of leukemia-associated Wilm's tumor protein 1 (WT1) and tyrosine-protein kinase transmembrane receptor 1 (ROR1)-reactive CTLs and of CD123-redirected switchable CAR T cells were prepared in the presence of MSCs and assessed for cytotoxic potential, cytokine secretion, and expansion. T-cell senescence within functional memory sub-compartments was investigated for the senescence-associated phenotype CD28
    MeSH term(s) Humans ; Bone Marrow ; Interleukin-2 ; CD28 Antigens ; Leukocytes, Mononuclear ; Leukemia, Myeloid, Acute/therapy ; Mesenchymal Stem Cells ; T-Lymphocytes, Cytotoxic ; Clone Cells
    Chemical Substances Interleukin-2 ; CD28 Antigens
    Language English
    Publishing date 2024-01-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-023-03594-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1237: Show issues Location:
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  9. Article: The Janus face of pluripotent stem cells - Connection between pluripotency and tumourigenicity

    Wobus, Anna M

    BioEssays. 2010 Nov., v. 32, no. 11

    2010  

    Abstract: Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity in vitro. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. ...

    Abstract Pluripotent stem cells have gained special attraction because of their almost unlimited proliferation and differentiation capacity in vitro. These properties substantiate the potential of pluripotent stem cells in basic research and regenerative medicine. Here three types of in vitro-cultured pluripotent stem cells (embryonic carcinoma, embryonic stem and induced pluripotent stem cells) are compared in their historical context with respect to their different origin and properties. It became evident that tumourigenicity is an inherent property of pluripotent cells based on p53 down-regulation, expression of tumour-related genes and high telomerase activity that allow unlimited proliferation. In addition, culture-adapted genetic and epigenetic changes may induce tumourigenicity of pluripotent cells. The use of stem cells in regenerative medicine, however, requires non-malignant cell types and strategies that circumvent stages of malignancy. Reprogramming strategies of adult somatic cells that avoid the tumourigenic state of pluripotency may offer alternatives for future biomedical application.
    Language English
    Dates of publication 2010-11
    Size p. 993-1002.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201000065
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  10. Book ; Conference proceedings: Wachstum und Reifung in Natur und Gesellschaft

    Parthier, Benno / Wobus, Anna M / Wobus, Ulrich

    Gaterslebener Begegnung 2011 ; vom 12. bis 14. Mai 2011

    (Nova acta Leopoldina ; N.F., 393 = Bd. 115)

    2012  

    Title variant Gaterslebener Begegnung 2011 ; zweitausendelf
    Institution Deutsche Akademie der Naturforscher Leopoldina
    Gaterslebener Begegnung
    Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
    Event/congress Gaterslebener Begegnung (12, 2011.05.12-14, Gatersleben)
    Author's details gemeinsam veranst. vom Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung Gatersleben und von der Deutschen Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften. Hrsg. von Anna M. Wobus; Ulrich Wobus; Benno Parthier
    Series title Nova acta Leopoldina ; N.F., 393 = Bd. 115
    Keywords Growth ; Maturation (Psychology) ; Nature ; Wachstumsprozess
    Language German
    Size 287 S., Ill., graph. Darst.
    Publisher Wiss. Verl.-Ges
    Publishing place Stuttgart
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 3804730590 ; 9783804730595
    Database Former special subject collection: coastal and deep sea fishing

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