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Article: The ESCMID Study Group for Clostridioides difficile: History, Role, and Perspectives.

Coia, John E / Kuijper, Ed J / Fitzpatrick, Fidelma

Advances in experimental medicine and biology

2024 Volume 1435, Page(s) 351–362

Abstract: Clostridioides difficile (C. difficile) is a major nosocomial pathogen but is also increasingly recognised as an important diarrhoeal pathogen in the community, not always associated with antibiotics. The European Society of Clinical Microbiology and ... ...

Abstract	Clostridioides difficile (C. difficile) is a major nosocomial pathogen but is also increasingly recognised as an important diarrhoeal pathogen in the community, not always associated with antibiotics. The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for C. difficile (ESGCD) is a group of clinicians, scientists, and others from many European countries and further afield, who share a common interest in C. difficile. The aims of the Study Group are centred around raising the profile of C. difficile infection (CDI) in humans and animals, fostering collaboration amongst centres in different European countries and providing a forum for discussing and disseminating information. One of the principal aims of the Study Group is to raise awareness of C. difficile infections in Europe. ESGCD has a particular interest in the development and dissemination of European guidance on prevention, diagnosis, and treatment of CDI. This chapter will discuss the organisation of ESGCD within the ESCMID Study Group structure, the origins of the Study Group, the aims, and objectives of the group, and will highlight some of the past and present activities of ESGCD in relation to these.
MeSH term(s)	Animals ; Humans ; Clostridioides difficile ; Communicable Diseases ; Anti-Bacterial Agents/therapeutic use ; Diarrhea ; Europe/epidemiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	410187-X
ISSN	0065-2598
ISSN	0065-2598
DOI	10.1007/978-3-031-42108-2_16
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Zs.A 3192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Surgeon reported treatment choices for AO type B and C thoracolumbar fractures without neurological deficits: An expert survey.

Kitzen, J / Bakker, W M / Jacobs, E / Kuijper, M T / Öner, F C

Injury

2024 Volume 55, Issue 3, Page(s) 111389

Abstract: Introduction: Less invasive spine surgery (LISS) has become well-established for thoracolumbar burst fractures without neurological deficits. However, notable controversy persists regarding the adequacy of LISS for more unstable AO type B and C injuries, ...

Abstract	Introduction: Less invasive spine surgery (LISS) has become well-established for thoracolumbar burst fractures without neurological deficits. However, notable controversy persists regarding the adequacy of LISS for more unstable AO type B and C injuries, as it does not allow for formal open fusion. Materials and methods: In this cross-sectional survey experienced spine surgeons of the Dutch Spine Society were invited to participate (56 participants). They were asked to indicate the most appropriate treatment for AO type B1, B2 (L1: A1 and L1: A3), B3 and C (L1: A4) injuries at level Th12-L1. Taking into account: age, AO N0-N1, or polytrauma. Specific agreement between participants was obtained applying Variation Ratio (VR). Results: A significant level of overall agreement was observed for AO type-B1 injuries with 73.8% of participants opting for percutaneous short-segment fixation (VR 0.775). For AO type-B3 injuries, 79.4% of participants favored percutaneous long-segment fixation (VR 0.794). for AO type-B2 injuries, there was less overall agreement (VR 0.571-0.657). Nonetheless, when considering all AO type-B injuries combined, percutaneous fixation emerged as the most preferred treatment option with substantial agreement (VR 0.871-0.923). Conversely, for AO type-C injuries, there was less agreement among the participants (VI 0.411), 26.5% of them chose additional open spinal fusion. Conclusion: For all AO type-B injuries there was substantial agreement to treat these fractures with percutaneous techniques. For AO type-C injuries, the survey results do not support a consensus. Nevertheless, the responses raise important questions about the necessity of spinal fusion for such injuries.
MeSH term(s)	Humans ; Infant, Newborn ; Spinal Fractures/surgery ; Cross-Sectional Studies ; Thoracic Vertebrae/surgery ; Thoracic Vertebrae/injuries ; Lumbar Vertebrae/surgery ; Lumbar Vertebrae/injuries ; Fracture Fixation, Internal/methods ; Fractures, Compression ; Surgeons ; Treatment Outcome ; Pedicle Screws
Language	English
Publishing date	2024-02-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2024.111389
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Zs.A 778: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clostridioides difficile-infecties in de eerste lijn.

van Prehn, Joffrey / Chernova, Vlada O / Vendrik, Karuna E W / Kuijper, Ed J

Nederlands tijdschrift voor geneeskunde

2023 Volume 167

Abstract: Here, we describe the epidemiology, diagnostics, and treatment ... ...

Title translation	Clostridioides difficile infections.
Abstract	Here, we describe the epidemiology, diagnostics, and treatment of
MeSH term(s)	Humans ; Middle Aged ; Clostridioides difficile ; Anti-Bacterial Agents/therapeutic use ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy ; Clostridium Infections/epidemiology ; Cross Infection ; Hospitalization
Chemical Substances	Anti-Bacterial Agents
Language	Dutch
Publishing date	2023-10-18
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: Long-term beneficial effect of faecal microbiota transplantation on colonisation of multidrug-resistant bacteria and resistome abundance in patients with recurrent Clostridioides difficile infection.

Nooij, Sam / Vendrik, Karuna E W / Zwittink, Romy D / Ducarmon, Quinten R / Keller, Josbert J / Kuijper, Ed J / Terveer, Elisabeth M

Genome medicine

2024 Volume 16, Issue 1, Page(s) 37

Abstract: Background: Multidrug-resistant (MDR) bacteria are a growing global threat, especially in healthcare facilities. Faecal microbiota transplantation (FMT) is an effective prevention strategy for recurrences of Clostridioides difficile infections and can ... ...

Abstract	Background: Multidrug-resistant (MDR) bacteria are a growing global threat, especially in healthcare facilities. Faecal microbiota transplantation (FMT) is an effective prevention strategy for recurrences of Clostridioides difficile infections and can also be useful for other microbiota-related diseases. Methods: We study the effect of FMT in patients with multiple recurrent C. difficile infections on colonisation with MDR bacteria and antibiotic resistance genes (ARG) on the short (3 weeks) and long term (1-3 years), combining culture methods and faecal metagenomics. Results: Based on MDR culture (n = 87 patients), we notice a decrease of 11.5% in the colonisation rate of MDR bacteria after FMT (20/87 before FMT = 23%, 10/87 3 weeks after FMT). Metagenomic sequencing of patient stool samples (n = 63) shows a reduction in relative abundances of ARGs in faeces, while the number of different resistance genes in patients remained higher compared to stools of their corresponding healthy donors (n = 11). Furthermore, plasmid predictions in metagenomic data indicate that patients harboured increased levels of resistance plasmids, which appear unaffected by FMT. In the long term (n = 22 patients), the recipients' resistomes are still donor-like, suggesting the effect of FMT may last for years. Conclusions: Taken together, we hypothesise that FMT restores the gut microbiota to a composition that is closer to the composition of healthy donors, and potential pathogens are either lost or decreased to very low abundances. This process, however, does not end in the days following FMT. It may take months for the gut microbiome to re-establish a balanced state. Even though a reservoir of resistance genes remains, a notable part of which on plasmids, FMT decreases the total load of resistance genes.
MeSH term(s)	Humans ; Fecal Microbiota Transplantation/methods ; Clostridioides difficile/genetics ; Feces/microbiology ; Microbiota ; Clostridium Infections/therapy ; Clostridium Infections/microbiology ; Treatment Outcome
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2484394-5
ISSN	1756-994X ; 1756-994X
ISSN (online)	1756-994X
ISSN	1756-994X
DOI	10.1186/s13073-024-01306-7
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Article ; Online: Fungal and bacterial gut microbiota differ between

Henderickx, Jannie G E / Crobach, Monique J T / Terveer, Elisabeth M / Smits, Wiep Klaas / Kuijper, Ed J / Zwittink, Romy D

Microbiome research reports

2023 Volume 3, Issue 1, Page(s) 8

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ISSN	2771-5965
ISSN (online)	2771-5965
DOI	10.20517/mrr.2023.52
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Article: The ESCMID Study Group for Clostridium difficile: History, Role and Perspectives.

Coia, John E / Kuijper, Ed J

Advances in experimental medicine and biology

2018 Volume 1050, Page(s) 245–254

Abstract: C. difficile is a major nosocomial pathogen, but is also increasingly recognised as an important diarrhoeal pathogen in the community, not always associated with antibiotics. The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) ... ...

Abstract	C. difficile is a major nosocomial pathogen, but is also increasingly recognised as an important diarrhoeal pathogen in the community, not always associated with antibiotics. The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Clostridium difficile (ESGCD) is a group of clinicians and scientists from many European countries and further afield, who share a common interest in C. difficile. The aims of the Study Group are centred around raising the profile of CDI in humans and animals, fostering collaboration amongst centres in different European countries and providing a forum for discussing and disseminating information. One of the principal aims of the Study Group is to raise awareness of C. difficile infections in European hospitals. ESGCD has a particular interest in the development and dissemination of European guidance on prevention, diagnosis and treatment of CDI. This chapter will discuss the organisation of ESGCD within the ESCMID Study Group structure, the origins of the Study Group, the aims and objectives of the group, and will highlight some of the past and present activities of ESGCD in relation to these.
MeSH term(s)	Animals ; Clostridium Infections/epidemiology ; Clostridium Infections/microbiology ; Clostridium difficile/physiology ; Europe/epidemiology ; Humans ; Population Surveillance ; Societies, Scientific
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-319-72799-8_14
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Article ; Online: Recreation reduces tick density through fine-scale risk effects on deer space-use.

Mols, B / Churchill, J E / Cromsigt, J P G M / Kuijper, D P J / Smit, C

The Science of the total environment

2022 Volume 839, Page(s) 156222

Abstract: Altered interactions between pathogens, their hosts and vectors have potential consequences for human disease risk. Notably, tick-borne pathogens, many of which are associated with growing deer abundance, show global increasing prevalence and pose ... ...

Abstract	Altered interactions between pathogens, their hosts and vectors have potential consequences for human disease risk. Notably, tick-borne pathogens, many of which are associated with growing deer abundance, show global increasing prevalence and pose increasing challenges for disease prevention. Human activities can largely affect the patterns of deer space-use and can therefore be potential management tools to alleviate human-wildlife conflicts. Here, we tested how deer space-use patterns are influenced by human recreational activities, and how this in turn affects the spatial distribution of the sheep tick (Ixodes ricinus), a relevant disease vector of zoonoses such as Lyme borrelioses. We compared deer dropping and questing tick density on transects near (20 m) and further away from (100 m) forest trails that were either frequently used (open for recreation) or infrequently used (closed for recreation, but used by park managers). In contrast to infrequently used trails, deer dropping density was 31% lower near (20 m) than further away from (100 m) frequently used trails. Similarly, ticks were 62% less abundant near (20 m) frequently used trails compared to further away from (100 m) these trails, while this decline in tick numbers was only 14% near infrequently used trails. The avoidance by deer of areas close to human-used trails was thus associated with a similar reduction in questing tick density near these trails. As tick abundance generally correlates to pathogen prevalence, the use of trails for recreation may reduce tick-borne disease risk for humans on and near these trails. Our study reveals an unexplored effect of human activities on ecosystems and how this knowledge could be potentially used to mitigate zoonotic disease risk.
MeSH term(s)	Animals ; Deer ; Ecosystem ; Ixodes ; Recreation ; Tick-Borne Diseases ; Zoonoses
Language	English
Publishing date	2022-05-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.156222
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Article ; Online: Risk Factors for 30-Days Mortality After Proximal Femoral Fracture Surgery, a Cohort Study.

de Haan, Eveline / Roukema, Gert R / van Rijckevorsel, Veronique A J I M / Kuijper, Tjallingius M / de Jong, Louis

Clinical interventions in aging

2024 Volume 19, Page(s) 539–549

Abstract: Purpose: The primary objective of this study was to identify new risk factors and to confirm previously reported risk factors associated with 30-day mortality after hip fracture surgery.: Patients and methods: A prospective hip fracture database was ... ...

Abstract	Purpose: The primary objective of this study was to identify new risk factors and to confirm previously reported risk factors associated with 30-day mortality after hip fracture surgery. Patients and methods: A prospective hip fracture database was used to obtain data. In total, 3523 patients who underwent hip fracture surgery between 2011 and 2021 were included. Univariable and multivariable logistic regression was used to screen and identify candidate risk factors. Twenty-seven baseline factors and 16 peri-operative factors were included in the univariable analysis and 28 of those factors were included in multivariable analysis. Results: 8.6% of the patients who underwent hip fracture surgery died within 30 days after surgery. Prognostic factors associated with 30-day mortality after hip fracture surgery were as follows: age 90-100 years (OR = 4.7, 95% CI: 1.07-19.98, p = 0.041) and above 100 years (OR = 11.3, 95% CI: 1.28-100.26, p = 0.029), male gender (OR = 2.6, 95% CI: 1.97-3.33, p < 0.001), American Society of Anesthesiologists (ASA) 3 and ASA 4 (OR = 2.1, 95% CI: 1.44-3.14, p < 0.001), medical history of dementia (OR = 1.7, 95% CI: 1.25-2.36, p = 0.001), decreased albumin level (OR = 0.94, 95% CI: 0.92-0.97, p < 0.001), decreased glomerular filtration rate (GFR) (OR = 0.98, 95% CI: 0.98-0.99, p < 0.001), residential status of nursing home (OR = 2.1, 95% CI: 1.44-2.87, p < 0.001), higher Katz Index of Independence in Activities of Daily Living (KATZ-ADL) score (OR = 1.1, 95% CI: 1.01-1.16, p=0.018) and postoperative pneumonia (OR = 2.4, 95% CI: 1.72-3.38, p < 0.001). Conclusion: A high mortality rate in patients after acute hip fracture surgery is known. Factors that are associated with an increased mortality are age above 90 years, male gender, ASA 3 and ASA 4, medical history of dementia, decreased albumin, decreased GFR, residential status of nursing home, higher KATZ-ADL score and postoperative pneumonia.
MeSH term(s)	Humans ; Male ; Aged, 80 and over ; Cohort Studies ; Proximal Femoral Fractures ; Activities of Daily Living ; Hip Fractures/surgery ; Risk Factors ; Pneumonia ; Dementia ; Albumins ; Retrospective Studies
Chemical Substances	Albumins
Language	English
Publishing date	2024-03-21
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364924-0
ISSN	1178-1998 ; 1176-9092
ISSN (online)	1178-1998
ISSN	1176-9092
DOI	10.2147/CIA.S441280
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Article ; Online: International travel, the gut microbiome, and ESBL-E coli carriage - Authors' reply.

Ducarmon, Quinten R / Smits, Wiep K / Goeman, Jelle J / Kuijper, Ed J

The Lancet. Microbe

2022 Volume 3, Issue 10, Page(s) e731

MeSH term(s)	Enterobacteriaceae Infections ; Escherichia coli ; Gastrointestinal Microbiome ; Humans ; beta-Lactamases/genetics
Chemical Substances	beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2022-07-21
Publishing country	England
Document type	Letter
ISSN	2666-5247
ISSN (online)	2666-5247
DOI	10.1016/S2666-5247(22)00199-9
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Article: Children's Pronoun Interpretation Problems Are Related to Theory of Mind and Inhibition, But Not Working Memory.

Kuijper, Sanne J M / Hartman, Catharina A / Hendriks, Petra

Frontiers in psychology

2021 Volume 12, Page(s) 610401

Abstract: ... of object pronouns (e.g., ...

Abstract	In several languages, including English and Dutch, children's acquisition of the interpretation of object pronouns (e.g.,
Language	English
Publishing date	2021-06-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.610401
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