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  1. Book ; Online: List of genomes used in Identification of a low pathogenicity clade of SARS-CoV-2

    Takahiko, Koyama

    2020  

    Abstract: Supplemental table 1: list of genomes used in the analysis. ...

    Abstract Supplemental table 1: list of genomes used in the analysis.
    Keywords covid19
    Publishing date 2020-06-16
    Publishing country eu
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: acknowledgement table

    Koyama, Takahiko

    2020  

    Abstract: This file contains list of genomes used in a publication "Identification of a low pathogenic clade of SARS-CoV-2" ...

    Abstract This file contains list of genomes used in a publication "Identification of a low pathogenic clade of SARS-CoV-2"
    Keywords covid19
    Publishing date 2020-07-15
    Publishing country eu
    Document type Book ; Online
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  3. Article ; Online: Synthetic assembly of α-O-linked-type GlcNAc using polymer chemistry affords sugar clusters, which effectively bind to lectins.

    Nakada, Jyuichi / Matsushita, Takahiko / Koyama, Tetsuo / Hatano, Ken / Matsuoka, Koji

    Bioorganic & medicinal chemistry letters

    2024  Volume 99, Page(s) 129616

    Abstract: Fischer's glycoside synthesis was applied to linker precursor alcohols of two different lengths having appropriate alkane chains to obtain the corresponding α-glycoside and it was found to be applicable with moderate yields. Water-soluble glycomonomers ... ...

    Abstract Fischer's glycoside synthesis was applied to linker precursor alcohols of two different lengths having appropriate alkane chains to obtain the corresponding α-glycoside and it was found to be applicable with moderate yields. Water-soluble glycomonomers were systematically prepared from N-acetyl-d-glucosamine (GlcNAc) by introducing two kinds of alcohols having different methylene lengths. Typical radical polymerizations of the glycomonomers with acrylamide as a modulator for control of the distance between carbohydrate residues in water in the presence of ammonium persulfate (APS)-N,N,N',N'-tetramethylethylenediamine (TEMED) gave a series of glycopolymers with various α-glycoside-type GlcNAc residue densities. Fluorometric analysis of the interaction of wheat germ agglutinin (WGA) with the glycopolymers was performed and the results showed unique binding specificities based on structural differences.
    MeSH term(s) Acetylglucosamine/chemistry ; Acetylglucosamine/metabolism ; Carbohydrates/chemistry ; Glycosides ; Lectins/metabolism ; Polymerization ; Polymers/chemistry ; Sugars ; Water
    Chemical Substances Acetylglucosamine (V956696549) ; Carbohydrates ; Glycosides ; Lectins ; Polymers ; Sugars ; Water (059QF0KO0R) ; N,N,N',N'-tetramethylethanediamine
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2024.129616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3203: Show issues Location:
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  4. Article ; Online: Preparation of

    Matsushita, Takahiko / Nozaki, Momoka / Sunaga, Mio / Koyama, Tetsuo / Hatano, Ken / Matsuoka, Koji

    ACS omega

    2023  Volume 8, Issue 40, Page(s) 37329–37340

    Abstract: Glycomonomers ... ...

    Abstract Glycomonomers having
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation.

    Adachi, Ryota / Matsushita, Takahiko / Koyama, Tetsuo / Hatano, Ken / Matsuoka, Koji

    Polymers

    2023  Volume 15, Issue 4

    Abstract: A polymerizable alcohol having 9 PEG repeats was prepared in order to mimic an oligosaccharide moiety. Sialyl α(2→3) lactose, which is known as a sugar moiety of GM3 ganglioside, was also prepared, and the polymerizable alcohol was condensed with the ... ...

    Abstract A polymerizable alcohol having 9 PEG repeats was prepared in order to mimic an oligosaccharide moiety. Sialyl α(2→3) lactose, which is known as a sugar moiety of GM3 ganglioside, was also prepared, and the polymerizable alcohol was condensed with the sialyl α(2→3) lactose derivative to afford the desired glycomonomer, which was further polymerized with or without acrylamide to give water-soluble glycopolymers. The glycopolymers had higher affinities than those of glycopolymers having sialyl lactose moieties with shorter aglycon moieties.
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15040998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Synthetic assembly of a series of glycopolymers having sialyl α2-3 lactose moieties connected with longer spacer arms.

    Adachi, Ryota / Matsushita, Takahiko / Koyama, Tetsuo / Hatano, Ken / Matsuoka, Koji

    Bioorganic & medicinal chemistry

    2023  Volume 81, Page(s) 117209

    Abstract: Glycopolymers having sialyl α2-3 lactose moieties via longer spacer arms were systematically prepared from the corresponding glycomonomers. Radical polymerization of glycomonomers gave a series of glycopolymers displaying various sugar densities. ... ...

    Abstract Glycopolymers having sialyl α2-3 lactose moieties via longer spacer arms were systematically prepared from the corresponding glycomonomers. Radical polymerization of glycomonomers gave a series of glycopolymers displaying various sugar densities. Fluorometric analyses of wheat germ agglutinin (WGA) against the glycopolymers were conducted and the results showed unique binding specificities on the basis of sugar densities.
    MeSH term(s) Lactose ; Polymers ; Sugars ; Sialic Acids
    Chemical Substances N-acetylneuraminoyllactose (3J7TAL60G3) ; Lactose (J2B2A4N98G) ; Polymers ; Sugars ; Sialic Acids
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2023.117209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3815: Show issues Location:
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  7. Article ; Online: Dendritic maleimide-thiol adducts carrying pendant glycosides as high-affinity ligands.

    Matsushita, Takahiko / Toda, Naomichi / Koyama, Tetsuo / Hatano, Ken / Matsuoka, Koji

    Bioorganic chemistry

    2022  Volume 128, Page(s) 106061

    Abstract: We synthesized N-acetylglucosamine-terminated hexavalent carbosilane dendrimers and investigated their binding to wheat germ agglutinin (WGA). The glycodendrimers were prepared by the conjugation of 3-mercaptopropyl, 4-mercaptobutyl, or 5‑mercaptopentyl ... ...

    Abstract We synthesized N-acetylglucosamine-terminated hexavalent carbosilane dendrimers and investigated their binding to wheat germ agglutinin (WGA). The glycodendrimers were prepared by the conjugation of 3-mercaptopropyl, 4-mercaptobutyl, or 5‑mercaptopentyl glycosides to maleimide-terminated hexavalent carbosilane dendrimers. Titration of WGA with the glycodendrimers yielded quenching of tryptophan fluorescence. All of the glycodendrimers exhibited high affinity with nanomolar dissociation constants (K
    MeSH term(s) Dendrimers ; Glycosides ; Ligands ; Maleimides ; Sulfhydryl Compounds ; Wheat Germ Agglutinins
    Chemical Substances Dendrimers ; Glycosides ; Ligands ; Maleimides ; Sulfhydryl Compounds ; Wheat Germ Agglutinins
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2022.106061
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    Zs.A 4207: Show issues Location:
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  8. Article ; Online: Modification of Fab Fragments by Dibromopyridazinediones Carrying Mono- and Double-Biotin Functionalities.

    Matsushita, Takahiko / Maruyama, Naoto / Koyama, Tetsuo / Hatano, Ken / Matsuoka, Koji

    ACS omega

    2022  Volume 7, Issue 38, Page(s) 34554–34562

    Abstract: To verify the potencies of dibromopyridazinediones with mono- and double-biotin groups, the functions as cysteine-selective biotinylation reagents were evaluated through conjugation with a goat anti-mouse IgG Fab fragment as a functional protein model. ... ...

    Abstract To verify the potencies of dibromopyridazinediones with mono- and double-biotin groups, the functions as cysteine-selective biotinylation reagents were evaluated through conjugation with a goat anti-mouse IgG Fab fragment as a functional protein model. The starting Fab was reduced with tris(2-carboxyethyl)phosphine to cleave the disulfide bond and then treated with the reagents. These reagents simultaneously introduced biotin groups into the reduced Fab and re-bridged the disulfide moiety. Furthermore, we demonstrated that the biotin-labeled Fabs were reactive to an antigen and streptavidin.
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c04379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Preparation of a Water-Soluble Glycopolymer Bearing Porphyrin Skeletons and Its Biological Properties.

    Ishimaru, Yoshihiro / Moteki, Tomohide / Suzuki, Miho / Koyama, Tetsuo / Matsushita, Takahiko / Hatano, Ken / Matsuoka, Koji

    ACS omega

    2023  Volume 8, Issue 40, Page(s) 37451–37460

    Abstract: A known tetraphenyl porphyrin (TPP) having an amino functional group [5-(4-aminophenyl)-10,15,20-(triphenyl)porphyrin] was converted into the corresponding monomer by means of condensation with acryloyl chloride. Simple radical polymerization of the ... ...

    Abstract A known tetraphenyl porphyrin (TPP) having an amino functional group [5-(4-aminophenyl)-10,15,20-(triphenyl)porphyrin] was converted into the corresponding monomer by means of condensation with acryloyl chloride. Simple radical polymerization of the porphyrin monomer and a glycosyl monomer in the presence of acrylamide as a regulator monomer in order to avoid steric interference gave a water-soluble glycopolymer bearing porphyrin moieties. Spectroscopic analyses suggested incorporation of porphyrin moieties in the glycopolymer. The physical properties of the water-soluble glycopolymer bearing porphyrin moieties were examined in aqueous media, and the results also indicated the incorporation of TPP moieties in the polymer. Uptake of the polymer into HeLa cells was observed, and the cytotoxicity of the polymer was confirmed by microscopic analyses. The glycopolymer bearing porphyrin moieties is promising not only for photodynamic therapy but also as an anti-cancer reagent.
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Proteolytic polymer: polyacrylamides functionalized with amino acids cleave bovine and human serum albumins.

    Matsushita, Takahiko / Yamochi, Hinako / Omiya, Shinzo / Koyama, Tetsuo / Hatano, Ken / Matsuoka, Koji

    Bioorganic & medicinal chemistry

    2023  Volume 92, Page(s) 117422

    Abstract: Polyacrylamides with various compositions of serine, aspartic acid, and histidine, which are the amino acids involved in the catalytic triad of natural serine protease chymotrypsin, were synthesized and their protein cleavage activity was investigated. ... ...

    Abstract Polyacrylamides with various compositions of serine, aspartic acid, and histidine, which are the amino acids involved in the catalytic triad of natural serine protease chymotrypsin, were synthesized and their protein cleavage activity was investigated. SDS-PAGE analysis showed that some of the synthesized ternary copolymers showed cleavage activity against bovine and human serum albumins. Polyacrylamides incorporating a single type of amino acid were also able to cleave the protein substrates. These homopolymers exhibited unique cleavage profiles and pH and temperature sensitivities that differed from those of α-chymotrypsin. The results indicate the potential of polymers functionalized with amino acids as proteolytic artificial enzymes.
    MeSH term(s) Animals ; Cattle ; Humans ; Amino Acids/pharmacology ; Amino Acids/chemistry ; Amino Acid Sequence ; Serum Albumin, Human ; Proteins ; Peptide Hydrolases ; Substrate Specificity
    Chemical Substances Amino Acids ; polyacrylamide (9003-05-8) ; Serum Albumin, Human (ZIF514RVZR) ; Proteins ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2023.117422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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