Article: [Effects of Chinese herbal medicine Shenxiong Yujing Granule on regeneration of neural cells in rats with diabetes-associated cerebral ischemia].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
2012 Volume 10, Issue 10, Page(s) 1140–1148
Abstract: ... Polygonati Odorati and Rhizoma Polygonati Sibirici Granule (Shenxiong Yujing Granule), which has the function ... operation, diabetes plus ischemia reperfusion injury model, Shenxiong Yujing Granule and Radix Ginseng and ... in the model group, but there was no significant difference compared with 7 day treatment with Shenxiong Yujing ...
| Abstract | Objective: To establish a rat model of diabetes-associated cerebral ischemia due to qi and yin deficiency and blood stasis, and to investigate the effects of Radix Ginseng, Rhizoma Chuanxiong, Rhizoma Polygonati Odorati and Rhizoma Polygonati Sibirici Granule (Shenxiong Yujing Granule), which has the function of strengthening qi, nourishing yin, and activating blood, on proliferation, differentiation and survival of neural cells in rats with diabetes-associated cerebral ischemia. Methods: Rats were divided into sham-operation, diabetes plus ischemia reperfusion injury model, Shenxiong Yujing Granule and Radix Ginseng and Rhizoma Chuanxiong Granule (Shenxiong Granule) groups with 20 rats in each. The 5-bromo-2'-deoxyuridine (BrdU) incorporation assay and immunohistochemical method were used to investigate the proliferation, differentiation and survival of neural cells in dentate gyrus of rats with diabetes-associated cerebral ischemia. Results: The number of newly proliferating cells in subgranular zone of dentate gyrus was increased in the model group, but there was no significant difference compared with 7 day treatment with Shenxiong Yujing Granule. Shenxiong Yujing Granule significantly increased the survival rate and promoted the differentiation of newly proliferating neurons after 21-day treatment (P<0.01). In addition, the beneficial effect of Shenxiong Yujing Granule was considerably greater than that of the Shenxiong Granule (P<0.01). Conclusion: Shenxiong Yujing Granule can increase the survival rate and promote the differentiation of newly proliferating neurons in rats with diabetes-associated cerebral ischemia of dual deficiency of qi and yin and blood stasis obstructing the collaterals. The effect is greater than that of Shenxiong Granule. |
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| MeSH term(s) | Animals ; Astrocytes/drug effects ; Brain Ischemia/complications ; Brain Ischemia/drug therapy ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Hippocampus/drug effects ; Hippocampus/physiology ; Male ; Nerve Regeneration/drug effects ; Phytotherapy ; Rats ; Rats, Sprague-Dawley |
| Chemical Substances | Drugs, Chinese Herbal |
| Language | Chinese |
| Publishing date | 2012-09-27 |
| Publishing country | China |
| Document type | English Abstract ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. |
| ZDB-ID | 2229154-4 |
| ISSN | 1672-1977 |
| ISSN | 1672-1977 |
| DOI | 10.3736/jcim20121011 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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