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Article ; Online: Immature neutrophils and myeloid-derived suppressor cells in sepsis: differences in occurrence kinetics.

Coudereau, Rémy / Haem Rahimi, Muzhda / Lukaszewicz, Anne-Claire / Cour, Martin / Bidar, Frank / Argaud, Laurent / Venet, Fabienne / Monneret, Guillaume

Critical care (London, England)

2024 Volume 28, Issue 1, Page(s) 7

MeSH term(s)	Humans ; Neutrophils ; Myeloid-Derived Suppressor Cells ; Sepsis
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-023-04781-3
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Article ; Online: Altered Ex Vivo NLRP3 Inflammasome Activation Is Associated with 28-Day Mortality in Septic Patients.

Coudereau, Rémy / Monneret, Guillaume / Lukaszewicz, Anne-Claire / Py, Bénédicte F / Argaud, Laurent / Cour, Martin / Bidar, Frank / Gossez, Morgane / Venet, Fabienne

Viruses

2023 Volume 15, Issue 12

Abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated response to infection. In this context, the aberrant activation of the NLRP3 inflammasome has been documented mostly through the measurement of increased plasmatic concentrations of ... ...

Abstract	Sepsis is a life-threatening organ dysfunction caused by a dysregulated response to infection. In this context, the aberrant activation of the NLRP3 inflammasome has been documented mostly through the measurement of increased plasmatic concentrations of IL-1β and IL-18. At the cellular level, contradictory results have been published. However, no study has comprehensively monitored NLRP3 inflammasome activation at the basal level and after ex vivo reactivation of whole blood monocytes and neutrophils focusing on ICU patients with bacterial and viral sepsis, including a longitudinal analysis. Thus, we conducted a prospective longitudinal study, examining NLRP3 inflammasome functionality in COVID-19 ICU patients (
MeSH term(s)	Humans ; Caspase 1/metabolism ; Inflammasomes/metabolism ; Longitudinal Studies ; Nigericin ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Prospective Studies ; Sepsis/mortality
Chemical Substances	Caspase 1 (EC 3.4.22.36) ; Inflammasomes ; Nigericin (RRU6GY95IS) ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	English
Publishing date	2023-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15122419
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Article ; Online: Persistent NLRP3 inflammasome activation is associated with delayed immunosuppression in septic patients.

Coudereau, Rémy / Bodinier, Maxime / Lukaszewicz, Anne-Claire / Py, Bénédicte F / Argaud, Laurent / Cour, Martin / Bidar, Frank / Cerrato, Elisabeth / Garnier, Lorna / Gossez, Morgane / Venet, Fabienne / Monneret, Guillaume

Journal of leukocyte biology

2024 Volume 115, Issue 4, Page(s) 706–713

Abstract: Sepsis triggers a complex response marked by the simultaneous presence of proinflammatory and immunosuppressive elements, disrupting the mechanisms intended to maintain homeostasis. While the NLRP3 inflammasome has been demonstrated to contribute to the ... ...

Abstract	Sepsis triggers a complex response marked by the simultaneous presence of proinflammatory and immunosuppressive elements, disrupting the mechanisms intended to maintain homeostasis. While the NLRP3 inflammasome has been demonstrated to contribute to the inflammatory side, its connection with delayed sepsis-induced immunosuppression remains unexplored. The present objective was to concomitantly and prospectively assess NLRP3 activation (IL-1β, IL-18, and soluble receptors) and features of immune failure (IL-10, mHLA-DR, myeloid-derived suppressor cells) in septic patients. To validate our findings, we conducted a transcriptomic analysis of mRNA of NLRP3-related genes (IL-18R1, IL-1R2) on an additional cohort of 107 patients. Two distinct endotypes were identified. One cluster displayed moderate inflammation rapidly returning to normal values, while the other exhibited a higher inflammatory response persisting until day 28, which was associated with persistent marked immunosuppression and higher 28-d mortality. Identifying endotypes with different pro/anti-inflammatory trajectories could hold important clinical implications for the management of sepsis.
MeSH term(s)	Humans ; Immunosuppression Therapy ; Inflammasomes/genetics ; Interleukin-1beta/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Sepsis/genetics
Chemical Substances	Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1093/jleuko/qiad161
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Article ; Online: Monocyte HLA-DR Measurement by Flow Cytometry in COVID-19 Patients: An Interim Review.

Benlyamani, Ihsane / Venet, Fabienne / Coudereau, Rémy / Gossez, Morgane / Monneret, Guillaume

Cytometry. Part A : the journal of the International Society for Analytical Cytology

2020 Volume 97, Issue 12, Page(s) 1217–1221

Abstract: Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 ... ...

Abstract	Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 falls in the scope of septic syndromes (organ dysfunction due to dysregulated host response to an infection) in which immunosuppression is a significant driver of mortality. Sepsis-induced immunosuppression is mostly defined and monitored by the measurement of decreased expression of HLA-DR molecules on circulating monocytes (mHLA-DR). In this interim review, we summarize the first mHLA-DR results in COVID-19 patients. In critically ill patients, results homogenously indicate a decreased mHLA-DR expression, which, along with profound lymphopenia and other functional alterations, is indicative of a status of immunosuppression. © 2020 International Society for Advancement of Cytometry.
MeSH term(s)	COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Female ; Flow Cytometry ; HLA-DR Antigens/genetics ; HLA-DR Antigens/immunology ; Humans ; Immune Tolerance/genetics ; Male ; Monocytes/immunology ; SARS-CoV-2/pathogenicity
Chemical Substances	HLA-DR Antigens
Keywords	covid19
Language	English
Publishing date	2020-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2099868-5
ISSN	1552-4930 ; 0196-4763 ; 1552-4922
ISSN (online)	1552-4930
ISSN	0196-4763 ; 1552-4922
DOI	10.1002/cyto.a.24249
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Zs.A 1688: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Monitoring NLRP3 Inflammasome Activation and Exhaustion in Clinical Samples: A Refined Flow Cytometry Protocol for ASC Speck Formation Measurement Directly in Whole Blood after Ex Vivo Stimulation.

Coudereau, Rémy / Gossez, Morgane / Py, Bénédicte F / Henry, Thomas / Lukaszewicz, Anne-Claire / Monneret, Guillaume / Venet, Fabienne

Cells

2022 Volume 11, Issue 20

Abstract: Alteration of NLRP3 inflammasome pathway including hyper-activation or exhaustion has been implicated in the pathophysiology of many diseases. Following cell stimulation, aggregation of the ASC protein into a multiprotein complex, the ASC speck, has been ...

Abstract	Alteration of NLRP3 inflammasome pathway including hyper-activation or exhaustion has been implicated in the pathophysiology of many diseases. Following cell stimulation, aggregation of the ASC protein into a multiprotein complex, the ASC speck, has been proposed as a specific read-out for monitoring NLRP3 inflammasome activation by flow cytometry in clinical samples. So far, only a few papers have described a technique to detect ASC speck formation directly in whole blood without any cell purification, and none included an ex vivo stimulation. The objective of this study was thus to develop a simple and shortened flow cytometry protocol to detect ASC speck formation directly in whole blood including an ex vivo stimulation step. We showed that after red blood cells lysis and removal of the LPS stimulation step, ASC speck formation can be detected in both monocytes and neutrophils from healthy donors directly in nigericin-stimulated whole blood samples. Using samples from four septic shock patients, we showed that this technique allows for the detection of NLRP3 inflammasome exhaustion in clinical samples. This novel shortened and simple whole blood protocol should facilitate day-to-day monitoring of NLRP3 inflammasome activation and exhaustion in both monocytes and neutrophils in clinical studies.
MeSH term(s)	Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Flow Cytometry/methods ; CARD Signaling Adaptor Proteins/metabolism ; Lipopolysaccharides ; Nigericin
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; CARD Signaling Adaptor Proteins ; Lipopolysaccharides ; Nigericin (RRU6GY95IS)
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11203306
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Article ; Online: L’inflammasome NLRP3 dans la physiopathologie des infections virales - Un focus sur la COVID-19.

Chemarin, Marlène / Dufies, Océane / Mazet, Anastassia / Mellan, Eva / Coudereau, Rémy / Py, Bénédicte F / Boyer, Laurent / Venet, Fabienne

Medecine sciences : M/S

2022 Volume 38, Issue 6-7, Page(s) 545–552

Abstract: NLRP3 is one of the best characterized innate immune cytosolic sensor. As part of the innate immune response, the NLRP3 inflammasome detects a wide range of danger signals such as pathogens, tissue damages, cellular stress. The priming and activation of ... ...

Title translation	Role of inflammasome NLRP3 in the pathophysiology of viral infections: A focus on SARS-CoV-2 infection.
Abstract	NLRP3 is one of the best characterized innate immune cytosolic sensor. As part of the innate immune response, the NLRP3 inflammasome detects a wide range of danger signals such as pathogens, tissue damages, cellular stress. The priming and activation of NLRP3 lead to the formation of an oligomeric intracellular complex and to the recruitment and activation of caspase-1. Once activated, not only this inflammasome complex controls the processing and release of pro-inflammatory factors including IL-1β and IL-18, but also the inflammatory cell death pyroptosis mediated by gasdermin D pores. In this review, we describe the role of the NLRP3 inflammasome activation in viral infections with a particular interest on SARS-CoV-2 infection. In addition, we present therapies evaluated or under evaluation targeting the NLRP3 inflammasome pathway as COVID-19 treatment.
MeSH term(s)	COVID-19/drug therapy ; COVID-19/immunology ; Humans ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Interleukin-1beta/immunology ; Interleukin-1beta/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; SARS-CoV-2
Chemical Substances	Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	French
Publishing date	2022-06-29
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2022080
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Zs.B 2872: Show issues

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Article: Assessment of neutrophil subsets and immune checkpoint inhibitor expressions on T lymphocytes in liver transplantation: A preliminary study beyond the neutrophil-lymphocyte ratio.

Riff, Arnaud / Haem Rahimi, Muzhda / Delignette, Marie-Charlotte / Gossez, Morgane / Coudereau, Rémy / Pantel, Solène / Antonini, Teresa / Villeret, François / Zoulim, Fabien / Mabrut, Jean-Yves / Dumortier, Jérome / Venet, Fabienne / Lebossé, Fanny / Monneret, Guillaume

Frontiers in physiology

2023 Volume 14, Page(s) 1095723

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1095723
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Article: Monocyte HLA-DR Measurement by Flow Cytometry in COVID-19 Patients: An Interim Review

Benlyamani, Ihsane / Venet, Fabienne / Coudereau, Rémy / Gossez, Morgane / Monneret, Guillaume

Cytometry, Part A

Abstract	Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 falls in the scope of septic syndromes (organ dysfunction due to dysregulated host response to an infection) in which immunosuppression is a significant driver of mortality. Sepsis-induced immunosuppression is mostly defined and monitored by the measurement of decreased expression of HLA-DR molecules on circulating monocytes (mHLA-DR). In this interim review, we summarize the first mHLA-DR results in COVID-19 patients. In critically ill patients, results homogenously indicate a decreased mHLA-DR expression, which, along with profound lymphopenia and other functional alterations, is indicative of a status of immunosuppression. © 2020 International Society for Advancement of Cytometry.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #893217
Database	COVID19

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Article: Correction to: Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients.

Bidar, Frank / Hamada, Sarah / Gossez, Morgane / Coudereau, Remy / Lopez, Jonathan / Cazalis, Marie-Angelique / Tardiveau, Claire / Brengel-Pesce, Karen / Mommert, Marine / Buisson, Marielle / Conti, Filippo / Rimmelé, Thomas / Lukaszewicz, Anne-Claire / Argaud, Laurent / Cour, Martin / Monneret, Guillaume / Venet, Fabienne

Annals of intensive care

2022 Volume 12, Issue 1, Page(s) 30

Language	English
Publishing date	2022-04-01
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-022-01007-7
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Article ; Online: Emergence of immunosuppressive LOX-1+ PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome.

Coudereau, Rémy / Waeckel, Louis / Cour, Martin / Rimmele, Thomas / Pescarmona, Rémi / Fabri, Astrid / Jallades, Laurent / Yonis, Hodane / Gossez, Morgane / Lukaszewicz, Anne-Claire / Argaud, Laurent / Venet, Fabienne / Monneret, Guillaume

Journal of leukocyte biology

2021 Volume 111, Issue 2, Page(s) 489–496

Abstract: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with immunosuppressive properties. In cancer patients, the expression of lectin-type oxidized LDL receptor 1 (LOX-1) on granulocytic MDSC identifies a subset ...

Abstract	Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with immunosuppressive properties. In cancer patients, the expression of lectin-type oxidized LDL receptor 1 (LOX-1) on granulocytic MDSC identifies a subset of MDSC that retains the most potent immunosuppressive properties. The main objective of the present work was to explore the presence of LOX-1+ MDSC in bacterial and viral sepsis. To this end, whole blood LOX-1+ cells were phenotypically, morphologically, and functionally characterized. They were monitored in 39 coronavirus disease-19 (COVID-19, viral sepsis) and 48 septic shock (bacterial sepsis) patients longitudinally sampled five times over a 3 wk period in intensive care units (ICUs). The phenotype, morphology, and immunosuppressive functions of LOX-1+ cells demonstrated that they were polymorphonuclear MDSC. In patients, we observed the significant emergence of LOX-1+ MDSC in both groups. The peak of LOX-1+ MDSC was 1 wk delayed with respect to ICU admission. In COVID-19, their elevation was more pronounced in patients with acute respiratory distress syndrome. The persistence of these cells may contribute to long lasting immunosuppression leaving the patient unable to efficiently resolve infections.
MeSH term(s)	Aged ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Female ; Humans ; Leukocytes, Mononuclear/immunology ; Male ; Middle Aged ; Myeloid-Derived Suppressor Cells/immunology ; Respiratory Distress Syndrome/physiopathology ; SARS-CoV-2/immunology ; Scavenger Receptors, Class E/metabolism ; Shock, Septic/immunology ; Shock, Septic/metabolism ; Shock, Septic/microbiology ; Shock, Septic/pathology
Chemical Substances	OLR1 protein, human ; Scavenger Receptors, Class E
Language	English
Publishing date	2021-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1002/JLB.4COVBCR0321-129R
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