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Article: Perfecting the venerable SSC.

Angelos, George Mitchell

The Journal of clinical pediatric dentistry

2023 Volume 47, Issue 5, Page(s) 1–3

Abstract: Stainless steel crowns (SSCs) are the preferred restoration of pediatric dentists for children requiring a pediatric dental rehabilitation due to their low cost and durability. Despite low technique sensitivity SSC placement can be challenging in some ... ...

Abstract	Stainless steel crowns (SSCs) are the preferred restoration of pediatric dentists for children requiring a pediatric dental rehabilitation due to their low cost and durability. Despite low technique sensitivity SSC placement can be challenging in some clinical situations including when placed on primary canines. Primary canines restored with SSCs often result in premature contacts and posterior open bite making acquiring an "as the patient presented" (ATPP) occlusion difficult when providing a pediatric dental rehabilitation. Opening of the posterior occlusion due to premature canine contact in a dental rehabilitation is often viewed as unavoidable. This technique article describes a simple method to address this clinical situation and reviews basic principles and techniques for placing SSCs.
MeSH term(s)	Child ; Humans ; Dentists ; Open Bite
Language	English
Publishing date	2023-09-03
Publishing country	Singapore
Document type	Editorial
ZDB-ID	1062408-9
ISSN	1053-4628 ; 0145-5508
ISSN	1053-4628 ; 0145-5508
DOI	10.22514/jocpd.2023.047
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Article ; Online: Bipedalism and the dawn of uterine fibroids.

Vilos, George A / Vilos, Angelos G / Burbank, Fred

Human reproduction (Oxford, England)

2024 Volume 39, Issue 3, Page(s) 454–463

Abstract: The high prevalence and burden of uterine fibroids in women raises questions about the origin of these benign growths. Here, we propose that fibroids should be understood in the context of human evolution, specifically the advent of bipedal locomotion in ...

Abstract	The high prevalence and burden of uterine fibroids in women raises questions about the origin of these benign growths. Here, we propose that fibroids should be understood in the context of human evolution, specifically the advent of bipedal locomotion in the hominin lineage. Over the ≥7 million years since our arboreal ancestors left their trees, skeletal adaptations ensued, affecting the pelvis, limbs, hands, and feet. By 3.2 million years ago, our ancestors were fully bipedal. A key evolutionary advantage of bipedalism was the freedom to use hands to carry and prepare food and create and use tools which, in turn, led to further evolutionary changes such as brain enlargement (encephalization), including a dramatic increase in the size of the neocortex. Pelvic realignment resulted in narrowing and transformation of the birth canal from a simple cylinder to a convoluted structure with misaligned pelvic inlet, mid-pelvis, and pelvic outlet planes. Neonatal head circumference has increased, greatly complicating parturition in early and modern humans, up to and including our own species. To overcome the so-called obstetric dilemma provoked by bipedal locomotion and encephalization, various compensatory adaptations have occurred affecting human neonatal development. These include adaptations limiting neonatal size, namely altricial birth (delivery of infants at an early neurodevelopmental stage, relative to other primates) and mid-gestation skeletal growth deceleration. Another key adaptation was hyperplasia of the myometrium, specifically the neomyometrium (the outer two-thirds of the myometrium, corresponding to 90% of the uterine musculature), allowing the uterus to more forcefully push the baby through the pelvis during a lengthy parturition. We propose that this hyperplasia of smooth muscle tissue set the stage for highly prevalent uterine fibroids. These fibroids are therefore a consequence of the obstetric dilemma and, ultimately, of the evolution of bipedalism in our hominin ancestors.
MeSH term(s)	Infant ; Infant, Newborn ; Pregnancy ; Animals ; Humans ; Female ; Hyperplasia ; Leiomyoma ; Muscle, Smooth ; Myometrium ; Hominidae
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	632776-x
ISSN	1460-2350 ; 0268-1161 ; 1477-741X
ISSN (online)	1460-2350
ISSN	0268-1161 ; 1477-741X
DOI	10.1093/humrep/deae005
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Article ; Online: Response to Guest Editorial.

Angelos, George M

Pediatric dentistry

2017 Volume 39, Issue 4, Page(s) 266–267

Language	English
Publishing date	2017-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	604709-9
ISSN	1942-5473 ; 0164-1263
ISSN (online)	1942-5473
ISSN	0164-1263
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Article ; Online: Evaluating Post-Fire Erosion and Flood Protection Techniques

George Papaioannou / Angelos Alamanos / Fotios Maris

GeoHazards, Vol 4, Iss 4, Pp 380-

A Narrative Review of Applications

2023 Volume 405

Abstract: Wildfires affect and change the burned sites’ condition, functionality, and ecosystem services. Altered hydrologic processes, such as runoff, increased streamflows, and sediment transport, are only a few examples resulting from burned soils, vegetation, ... ...

Abstract	Wildfires affect and change the burned sites’ condition, functionality, and ecosystem services. Altered hydrologic processes, such as runoff, increased streamflows, and sediment transport, are only a few examples resulting from burned soils, vegetation, and land cover. Such areas are flood-prone and face risks of extreme peak flows, reduced infiltration, water pollution affecting habitats, and hydromorphological changes. In this study, we present the different post-fire erosion and flood protection treatments that have been developed to avoid and mitigate the consequences and risks mentioned above. We categorize them into Land, Channel, Barrier, and Road treatments and analyze their types, such as cover-based methods, barriers, mulching, in-channel treatments, such as check dams, seeding, or even chemical treatments. Examples of how such treatments were used in real cases are provided, commenting on their results in flood and erosion protection. We found that cover changes were more effective than barriers, as they provided an immediate ground-cover increase in both Mediterranean and US sites. We explore the factors that play a role in their effectiveness, including storm duration and intensity, topography and slopes, land cover and uses, treatment implementation-installation, as well as fire-related factors such as burn severity. These factors have different effects on different treatments, so we further discuss the suitability of each one depending on the site’s and treatment’s characteristics. The outcomes of this work are expected to improve the understanding of the practical aspects of these treatments, providing for the first time a synthesis of the available knowledge on the multiple complex factors that can determine their efficiency.
Keywords	wildfires ; post-fire ; flood protection ; soil erosion ; sediment ; reforestation ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Transanal Hemorrhoidal Dearterialization With Mucopexy Versus Ferguson Hemorrhoidectomy for Prolapsed Internal Hemorrhoids: A Multicenter Prospective Study.

Gachabayov, Mahir / Angelos, George / Orangio, Guy / Abcarian, Herand / Bergamaschi, Roberto

Annals of surgery

2023 Volume 278, Issue 3, Page(s) 376–382

Abstract: Objective: To compare transanal hemorrhoidal dearterialization (THD) with mucopexy to Ferguson hemorrhoidectomy in terms of recurrence rates and quality of life.: Background: There is uncertainty regarding the durability of the therapeutic effect of ... ...

Abstract	Objective: To compare transanal hemorrhoidal dearterialization (THD) with mucopexy to Ferguson hemorrhoidectomy in terms of recurrence rates and quality of life. Background: There is uncertainty regarding the durability of the therapeutic effect of THD with mucopexy compared with Ferguson hemorrhoidectomy in terms of recurrence rates. Methods: This was a multicenter prospective study. Participating surgeons performed the operation they knew best enrolling 10 patients each. Surgeons' unedited videos were reviewed by an independent expert. Patients with prolapsed internal hemorrhoids in at least 3 columns were eligible. The primary endpoint was recurrence rates defined as prolapsing internal hemorrhoids. Patient-reported outcomes and satisfaction were evaluated with Pain Scale and Brief Pain Inventory, Fecal Incontinence Quality Of Life (FIQOL), Cleveland Clinic Incontinence, Constipation, Short-Form 12 scores, and Patient satisfaction (4-point Likert) scale. Results: Twenty surgeons enrolled 197 patients. THD patients had lower Visual pain scores at postoperative day (POD) 1 (6.2 vs 8.3, P =0.047), POD7 (4.5 vs 7.7, P =0.021), POD14 (2.8 vs 5.3, P <0.001), and medication use at POD14 (23% vs 58%, P <0.001). Median follow-up was 3.1 (1.0-5.5) years. Recurrence rates did not differ between the study arms (5.9% vs 2.4%, P =0.253). Patient satisfaction rate was higher after THD at POD14 (76.4% vs 52.5%, P =0.031) and 3 months (95.1% vs 63.3%, P =0.029), but did not differ at 6 months (91.7% vs 88%, P =0.228) and 1 year (94.2% vs 88%, P =0.836). Conclusion: THD with mucopexy was associated with improved patient-reported outcomes and quality of life as compared with Ferguson hemorrhoidectomy with nonsignificantly different recurrence rates.
MeSH term(s)	Humans ; Hemorrhoids/surgery ; Hemorrhoids/complications ; Hemorrhoidectomy ; Prospective Studies ; Quality of Life ; Treatment Outcome ; Ligation ; Pain
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000005961
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Article ; Online: Reply- letter to the editor: From diet to sleep and psychological state: Insights and future perspectives.

Vlahoyiannis, Angelos / Andreou, Eleni / Bargiotas, Panagiotis / Aphamis, George / Sakkas, Giorgos K / Giannaki, Christoforos D

Clinical nutrition (Edinburgh, Scotland)

2024

Language	English
Publishing date	2024-04-21
Publishing country	England
Document type	Letter
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2024.04.028
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Article: Molecular-based Alternatives for Colorectal Cancer Screening during the COVID-19 Pandemic.

Dockter, Andrew G / Angelos, George C

Surgical technology international

2020 Volume 36, Page(s) 143–147

Abstract: Due to the COVID-19 pandemic, important elective procedures, such as screening colonoscopy, have been delayed or cancelled, and there may be a very long waitlist for rescheduling once the moratorium is lifted. However, DNA-based stool sample tests may be ...

Abstract	Due to the COVID-19 pandemic, important elective procedures, such as screening colonoscopy, have been delayed or cancelled, and there may be a very long waitlist for rescheduling once the moratorium is lifted. However, DNA-based stool sample tests may be useful for colorectal cancer screening when colonoscopy is not available. The aim of this review is to demonstrate the potential utility of enhanced DNA-based stool testing for colorectal cancer screening and diagnosis during crises that strain available healthcare resources, such as the current COVID-19 pandemic. This review shows that DNA-based stool sample tests have the potential to enable colorectal cancer screening to prioritize patients to elective colonoscopy procedures, the continued delay of which during the COVID-19 pandemic has already placed a burden on future elective procedures.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Colorectal Neoplasms/diagnosis ; Coronavirus Infections ; Early Detection of Cancer ; Humans ; Mass Screening ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1225512-9
ISSN	1090-3941
ISSN	1090-3941
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Article ; Online: Direct interaction between mortalin and HIF-1α at the mitochondria inhibits apoptosis by blocking recruitment of Bax.

Yfantis, Angelos / Mylonis, Ilias / Simos, George

The FEBS journal

2023 Volume 290, Issue 15, Page(s) 3764–3780

Abstract: Hypoxia-inducible factor-1, a heterodimer of alpha (HIF-1α) and beta (HIF-1β or ARNT) subunits, is a major regulator of the transcriptional response to hypoxia. However, HIF-1α, the oxygen-regulated subunit, also exerts nontranscriptional functions ... ...

Abstract	Hypoxia-inducible factor-1, a heterodimer of alpha (HIF-1α) and beta (HIF-1β or ARNT) subunits, is a major regulator of the transcriptional response to hypoxia. However, HIF-1α, the oxygen-regulated subunit, also exerts nontranscriptional functions through interaction with proteins other than ARNT. We have previously shown that the subcellular localization and protein interactions of HIF-1α are controlled by ERK-mediated phosphorylation at Ser641/643. When HIF-1α is modified at these sites, it is nuclear, binds to ARNT, interacts with nucleophosmin 1 (NPM1) and activates transcription of hypoxia-target genes. On the contrary, unmodified HIF-1α is bound by chromosomal region maintenance 1 (CRM1), exits the nucleus and, via its association with mortalin, is targeted to the mitochondria to form an antiapoptotic complex. To further characterize the latter function, recombinant fragments of HIF-1α and mortalin were used for in vitro binding assays and immunoprecipitation experiments to map the respective binding sites and show that their interaction is direct and functional. We could also show that embelin, a natural product and known inhibitor of the mortalin-p53 interaction, also disrupts the mortalin-HIF-1α association and, furthermore, removes unmodified HIF-1α from mitochondria. Mitochondrial dissociation of HIF-1α, either by embelin or overexpression of a HIF-1α peptide harbouring the mortalin binding site, under stress conditions leads to mitochondrial localization of the pro-apoptotic protein B-cell lymphoma 2-associated X protein (Bax) and induction of apoptosis. We suggest that when ERK activity is low under hypoxia, binding of HIF-1α to mortalin inhibits mitochondrial recruitment of Bax and protects cells from apoptotic cell death.
MeSH term(s)	Humans ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; Cell Hypoxia/physiology ; Mitochondria/metabolism ; Hypoxia/metabolism ; Apoptosis ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
Chemical Substances	embelin (SHC6U8F5ER) ; bcl-2-Associated X Protein ; mortalin ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16762
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Article ; Online: Direct interaction between mortalin and HIF‐1α at the mitochondria inhibits apoptosis by blocking recruitment of Bax

Yfantis, Angelos / Mylonis, Ilias / Simos, George

The FEBS Journal. 2023 Aug., v. 290, no. 15 p.3764-3780

2023

Abstract: Hypoxia‐inducible factor‐1, a heterodimer of alpha (HIF‐1α) and beta (HIF‐1β or ARNT) subunits, is a major regulator of the transcriptional response to hypoxia. However, HIF‐1α, the oxygen‐regulated subunit, also exerts nontranscriptional functions ... ...

Abstract	Hypoxia‐inducible factor‐1, a heterodimer of alpha (HIF‐1α) and beta (HIF‐1β or ARNT) subunits, is a major regulator of the transcriptional response to hypoxia. However, HIF‐1α, the oxygen‐regulated subunit, also exerts nontranscriptional functions through interaction with proteins other than ARNT. We have previously shown that the subcellular localization and protein interactions of HIF‐1α are controlled by ERK‐mediated phosphorylation at Ser641/643. When HIF‐1α is modified at these sites, it is nuclear, binds to ARNT, interacts with nucleophosmin 1 (NPM1) and activates transcription of hypoxia‐target genes. On the contrary, unmodified HIF‐1α is bound by chromosomal region maintenance 1 (CRM1), exits the nucleus and, via its association with mortalin, is targeted to the mitochondria to form an antiapoptotic complex. To further characterize the latter function, recombinant fragments of HIF‐1α and mortalin were used for in vitro binding assays and immunoprecipitation experiments to map the respective binding sites and show that their interaction is direct and functional. We could also show that embelin, a natural product and known inhibitor of the mortalin‐p53 interaction, also disrupts the mortalin‐HIF‐1α association and, furthermore, removes unmodified HIF‐1α from mitochondria. Mitochondrial dissociation of HIF‐1α, either by embelin or overexpression of a HIF‐1α peptide harbouring the mortalin binding site, under stress conditions leads to mitochondrial localization of the pro‐apoptotic protein B‐cell lymphoma 2‐associated X protein (Bax) and induction of apoptosis. We suggest that when ERK activity is low under hypoxia, binding of HIF‐1α to mortalin inhibits mitochondrial recruitment of Bax and protects cells from apoptotic cell death.
Keywords	B-cell lymphoma ; apoptosis ; dissociation ; hypoxia ; hypoxia-inducible factor 1 ; mitochondria ; phosphorylation ; precipitin tests ; pro-apoptotic proteins ; transcription (genetics)
Language	English
Dates of publication	2023-08
Size	p. 3764-3780.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.16762
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Incorporating Quantum Number Characteristics in the Pictorial Representations of the Atomic Structure

Nikolaos Zarkadis / George Papageorgiou / Angelos Markos

Science Education International, Vol 33, Iss 1, Pp 93-

Consistency Issues and Students’ Relevant Profiles

2022 Volume 101

Abstract: The main purpose of this study was to investigate the consistency of pictorial representations of the atomic structure drawn by students on the basis of particular quantum numbers’ characteristics. Participants were 192 students of the 12th grade of ... ...

Abstract	The main purpose of this study was to investigate the consistency of pictorial representations of the atomic structure drawn by students on the basis of particular quantum numbers’ characteristics. Participants were 192 students of the 12th grade of secondary Greek schools. This study’s instrument, a paper-and-pencil assessment tool, included four open-ended tasks. In each one of the four tasks, students were asked to draw representations of the atomic structure under two specific conditions concerning particular quantum numbers’ values. Results indicated the existence of a consistency between pictorial representations, providing indications that this kind of representation could be used as a consistent tool in order to study students’ understanding of the contribution of quantum number characteristics in the configuration of the atomic structure. Furthermore Latent Class Analysis revealed distinct student profiles indicating how this consistency is distributed across the sample and emerging student classes that have problems in conceptualizing the characteristics of the first and fourth quantum numbers. Implications for science education are discussed.
Keywords	quantum numbers ; atomic structure ; consistency ; latent class analysis ; pictorial representations ; Theory and practice of education ; LB5-3640 ; Science ; Q
Subject code	512
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	ICASE
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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