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  1. Article: Synthesis of a novel photochemical and thermoresponsive diblock biomaterial with end-functionalized zinc porphyrin.

    Qiu, Nannan / Pan, Xinyuan / Hu, Ruizhang / Hui, Zhenzhen

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1268458

    Abstract: Porphyrin compound-based photochemical molecules and biomaterials have been synthesized for photosensitivity and bioimaging experiments. However, most porphyrin photosensitizers have limited application in biological environments owing to severe ... ...

    Abstract Porphyrin compound-based photochemical molecules and biomaterials have been synthesized for photosensitivity and bioimaging experiments. However, most porphyrin photosensitizers have limited application in biological environments owing to severe aggregation in aqueous solutions. In the present study, we prepared amphipathic and photosensitive copolymers using zinc porphyrin via consecutive atom transfer-free radical polymerizations (ATRPs) comprising photoresponsive and thermosensitive chain segments. Furthermore, we evaluated the photocatalytic activity of the copolymer for methylene blue (MB) in water.
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1268458
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  2. Article ; Online: Sr

    Hu, Yan / Zhu, Jiahui / Chen, Nannan / Zheng, Xinyue / Zhang, Xingyue / Chen, Zheng / Wu, Zhengcui

    Inorganic chemistry

    2023  Volume 62, Issue 41, Page(s) 16986–16993

    Abstract: Electrochemical reduction of carbon dioxide to value-added multicarbon ( ... ...

    Abstract Electrochemical reduction of carbon dioxide to value-added multicarbon (C
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c02746
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  3. Article ; Online: A novel metabolism-related gene signature in patients with hepatocellular carcinoma.

    Ru, Bin / Hu, Jiaqi / Zhang, Nannan / Wan, Quan

    PeerJ

    2023  Volume 11, Page(s) e16335

    Abstract: Hepatocellular carcinoma (HCC) remains a global challenge as it is the sixth most common neoplasm worldwide and the third leading cause of cancer-related death. A key feature of HCC is abnormal metabolism, which promotes cancer cell proliferation, ... ...

    Abstract Hepatocellular carcinoma (HCC) remains a global challenge as it is the sixth most common neoplasm worldwide and the third leading cause of cancer-related death. A key feature of HCC is abnormal metabolism, which promotes cancer cell proliferation, survival, invasion, and metastasis. However, the significance of metabolism-related genes (MRGs) in HCC remains to be elucidated. Here, we aim to establish a novel metabolism-related prognostic signature for the prediction of patient outcomes and to investigate the value of MRG expression in the prognostic prediction of HCC. In our research, a Metabolism-Related Risk Score (MRRS) model was constructed using 14 MRGs (DLAT, SEPHS1, ACADS, UCK2, GOT2, ADH4, LDHA, ME1, TXNRD1, B4GALT2, AK2, PTDSS2, CSAD, and AMD1). The Kaplan-Meier curve confirmed that the MRRS has a high accuracy in predicting the prognosis of HCC patients (
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/genetics ; Area Under Curve ; B-Lymphocytes ; Butyryl-CoA Dehydrogenase
    Chemical Substances Butyryl-CoA Dehydrogenase (EC 1.3.8.1)
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.16335
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  4. Article ; Online: Synthesis and Properties of Cobalt/Nickel-Iron-Antimony(III, V)-Oxo Tartrate Cluster-Based Compounds.

    Wen, Weiyang / Wang, Yanqi / Pan, Tianyu / Hu, Qianqian / Xiao, Huiping / Wang, Nannan / Li, Xiaoqi / Li, Xinxiong / Hu, Bing / Huang, Xiaoying

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 3

    Abstract: Two types of isostructural iron-cobalt/nickel-antimony-oxo tartrate cluster-based compounds, namely ( ... ...

    Abstract Two types of isostructural iron-cobalt/nickel-antimony-oxo tartrate cluster-based compounds, namely (H
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29030591
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Role of hypoxia in promoting migration and cell fusion of urine-derived stem cells

    ZHANG Nannan / HU Chaoqun / HE Yun

    陆军军医大学学报, Vol 45, Iss 23, Pp 2467-

    2023  Volume 2475

    Abstract: Objective To explore the effect of hypoxia on cell migration and fusion of urine-derived stem cells (USCs) in vitro, and observe the changes in cytoskeleton and cell polarity during the process. Methods After USCs were cultured under normoxia (20%) or ... ...

    Abstract Objective To explore the effect of hypoxia on cell migration and fusion of urine-derived stem cells (USCs) in vitro, and observe the changes in cytoskeleton and cell polarity during the process. Methods After USCs were cultured under normoxia (20%) or hypoxia (3%) for 48 h, cell migration were detected by cell scratch test and Transwell assay, USCs' fusion with hepatic HP14-19 and HepG2 cells were observed and determined using confocal microscopy and flow cytometry, and structure of cytoskeleton was observed with transmission electron microscopy (TEM) and phalloidin fluorescence probe. The expression of cell polarity related proteins, RhoA, Cdc42 and Rac1 was measured with immunofluorescence staining, flow cytometry and real-time PCR. Results The USCs from the hypoxia group showed stronger migration capacity and cell fusion with hepatocytes when compared with the cells from the normoxia group. The results of TEM and phalloidin fluorescence staining revealed that hypoxia induced remodeling of cytoskeleton, and regularly and well-arranged microfilament and microtubule. The results of immunofluorescence staining, flow cytometry and real-time PCR indicated that the expression levels of cell polarity related proteins RhoA, Cdc42 and Rac1 were much higher in the hypoxia group than in the normoxia group. Conclusion Hypoxia preconditioning promotes cell migration and fusion in USCs, which may be associated with cytoskeleton remodeling and up-regulation of cell polarity.
    Keywords urine-derived stem cells ; cell migration ; cell fusion ; cell polarity ; cytoskeleton ; Medicine (General) ; R5-920
    Subject code 571
    Language Chinese
    Publishing date 2023-12-01T00:00:00Z
    Publisher Editorial Office of Journal of Army Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A novel metabolism-related gene signature in patients with hepatocellular carcinoma

    Bin Ru / Jiaqi Hu / Nannan Zhang / Quan Wan

    PeerJ, Vol 11, p e

    2023  Volume 16335

    Abstract: Hepatocellular carcinoma (HCC) remains a global challenge as it is the sixth most common neoplasm worldwide and the third leading cause of cancer-related death. A key feature of HCC is abnormal metabolism, which promotes cancer cell proliferation, ... ...

    Abstract Hepatocellular carcinoma (HCC) remains a global challenge as it is the sixth most common neoplasm worldwide and the third leading cause of cancer-related death. A key feature of HCC is abnormal metabolism, which promotes cancer cell proliferation, survival, invasion, and metastasis. However, the significance of metabolism-related genes (MRGs) in HCC remains to be elucidated. Here, we aim to establish a novel metabolism-related prognostic signature for the prediction of patient outcomes and to investigate the value of MRG expression in the prognostic prediction of HCC. In our research, a Metabolism-Related Risk Score (MRRS) model was constructed using 14 MRGs (DLAT, SEPHS1, ACADS, UCK2, GOT2, ADH4, LDHA, ME1, TXNRD1, B4GALT2, AK2, PTDSS2, CSAD, and AMD1). The Kaplan-Meier curve confirmed that the MRRS has a high accuracy in predicting the prognosis of HCC patients (p < 0.001). According to the MRRS model, the area under the curve (AUC) values for predicting the prognosis of patients with hepatocellular carcinoma at 1, 3, and 5 years reached 0.829, 0.760, and 0.739, respectively. Functional analyses revealed that signaling pathways associated with the cell cycle were largely enriched by differential genes between high and low-risk groups. In addition, dendritic cells (DCs) (p < 0.001), CD4+ T cells (p < 0.01), CD8+ T cells (p < 0.001), B cells (p < 0.001), neutrophils (p < 0.001), macrophages (p < 0.001) had a higher proportion of infiltrates in high-risk populations. Low GOT2 expression is associated with poor prognosis in patients with hepatocellular carcinoma. Knockdown of GOT2 significantly increased the migration capacity of the Huh7 and MHCC97H hepatocellular carcinoma lines. Our research reveals that GOT2 is negatively related to the survival of patients with hepatocellular carcinoma and GOT2 may contribute to tumor progression by inhibiting the ability of tumor cells to migrate.
    Keywords Hepatocellular carcinoma (HCC) ; Lipid metabolism ; Biomarkers ; Risk model ; ICGC ; GOT2 ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A fractal structural feature related to dynamic crossover in metallic glass-forming liquids.

    Chu, Wei / Yu, Jinhua / Ren, Nannan / Wang, Zheng / Hu, Lina

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 5, Page(s) 4151–4160

    Abstract: The dynamic crossover in supercooled liquids initially predicted by model coupling theory has been widely accepted, but its underlying structural origin is still an open issue for glass-forming liquids. By molecular dynamics simulations of binary CuZr ... ...

    Abstract The dynamic crossover in supercooled liquids initially predicted by model coupling theory has been widely accepted, but its underlying structural origin is still an open issue for glass-forming liquids. By molecular dynamics simulations of binary CuZr liquids, the present work verifies that high pressure could enhance this crossover, facilitating the studies on the structural features at the crossover temperature
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp04840j
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  8. Article ; Online: Lake shrinkage-induced terrestrial ecological environmental quality degradation in a semiarid lake basin.

    Cheng, Nannan / Yang, Tengteng / Wu, Tingfeng / Hu, Runtao / He, Xiangyu

    Environmental science and pollution research international

    2023  Volume 30, Issue 57, Page(s) 120892–120902

    Abstract: Lake water environmental problems caused by lake shrinkage in semiarid zones have attracted widespread attention, but few studies have quantified the impact of lake shrinkage on the terrestrial ecological environmental quality of watersheds. In this ... ...

    Abstract Lake water environmental problems caused by lake shrinkage in semiarid zones have attracted widespread attention, but few studies have quantified the impact of lake shrinkage on the terrestrial ecological environmental quality of watersheds. In this study, remote sensing image inversion, digital elevation modeling, and statistical analysis were applied to explore the impact of Lake Daihai shrinkage on the terrestrial ecological environmental quality of its receding water areas from 1986 to 2019. The results showed that the area of Lake Daihai shrank from 170.7 km
    MeSH term(s) Humans ; Ecosystem ; Environmental Monitoring/methods ; Lakes ; Remote Sensing Technology ; Water ; China
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-11-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-30421-y
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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  9. Article: Emergency Management of Mental Hospitals during the Outbreak of COVID-19.

    Hu, Nannan / Mao, Hongjing

    Psychiatry investigation

    2020  Volume 17, Issue 5, Page(s) 489–490

    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2414364-9
    ISSN 1976-3026 ; 1738-3684
    ISSN (online) 1976-3026
    ISSN 1738-3684
    DOI 10.30773/pi.2020.0086
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6598: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Mitofusin2 Promotes

    Lu, Li / Zhitao, Li / Nannan, Cui / Mingzhu, Huang / Xiaoping, Hu / Dongsheng, Hong / Zongfu, Pan / Xiaoyang, Lu

    Stem cells international

    2022  Volume 2022, Page(s) 1172795

    Abstract: ... ...

    Abstract β
    Language English
    Publishing date 2022-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573856-2
    ISSN 1687-9678 ; 1687-966X
    ISSN (online) 1687-9678
    ISSN 1687-966X
    DOI 10.1155/2022/1172795
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