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Article ; Online: The impact of colonialism on head and neck cancer in Brazil: a historical essay focussing on tobacco, alcohol and slavery.

Figueiredo Lebre Martins, Beatriz Nascimento / Dos Santos, Erison Santana / Fonseca, Felipe Paiva / William, William Nassib / Bueno de Oliveira, Thiago / Marta, Gustavo Nader / Freitas Chaves, Aline Lauda / Prado-Ribeiro, Ana Carolina / Ayo-Yusuf, Olalekan / Curado, Maria Paula / Saes, Alexandre Macchione / Kowalski, Luiz Paulo / Santos-Silva, Alan Roger

Lancet regional health. Americas

2024 Volume 31, Page(s) 100690

Abstract: Colonialism's enduring impact on Brazil has had significant implications for health and oncology outcomes. This historical essay delves into the profound changes brought about by the transatlantic slave trade from Africa to the Americas, particularly in ... ...

Abstract	Colonialism's enduring impact on Brazil has had significant implications for health and oncology outcomes. This historical essay delves into the profound changes brought about by the transatlantic slave trade from Africa to the Americas, particularly in terms of its influence on the economy, sociocultural habits, and health outcomes. This essay explores the enduring connections between the colonial period's operational dynamics in Brazil and the current epidemiological panorama of head and neck cancer (HNC). The examination provides original insights on the role of tobacco and alcohol production and consumption, alongside the investigation of structural racism, which contributes to disparities in access to diagnosis, treatment, and prognosis for patients with HNC. This article presents novel visions and an analysis of evidence-based strategies to disrupt the adverse impact of colonialism's legacy on the epidemiology of HNC in Brazil.
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article ; Review
ISSN	2667-193X
ISSN (online)	2667-193X
DOI	10.1016/j.lana.2024.100690
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differentiated thyroid carcinoma: what the nonspecialists needs to know.

Hoff, Ana O / Chaves, Aline Lauda Freitas / de Oliveira, Thiago Bueno / Ramos, Helton Estrela / Penna, Gustavo Cancela / Dos Santos, Lucas Vieira / Maia, Ana Luiza / Brito, Daniel Oliveira / Vizzotto, Franco Pelissari

Archives of endocrinology and metabolism

2024 Volume 68, Page(s) e230375

Abstract: Differentiated thyroid carcinoma (DTC) accounts for most cases of thyroid cancer, and the heterogeneity of DTC requires that management decisions be taken by a multidisciplinary team involving endocrinologists, head and neck surgeons, nuclear medicine ... ...

Abstract	Differentiated thyroid carcinoma (DTC) accounts for most cases of thyroid cancer, and the heterogeneity of DTC requires that management decisions be taken by a multidisciplinary team involving endocrinologists, head and neck surgeons, nuclear medicine physicians, pathologists, radiologists, radiation oncologists, and medical oncologists. It is important for nonspecialists to recognize and refer patients with DTC who will benefit from a specialized approach. Recent advances in knowledge and changes in management of DTC call for the need to raise awareness on the part of these nonspecialist physicians, including general endocrinologists and medical oncologists at large. We provide an overview of diagnostic and therapeutic principles in DTC, especially those that bear direct implication on day-to-day management of these patients by generalists. Patients with DTC may be broadly categorized as having localized, locally persistent/recurrent, or metastatic disease. Current recommendations for DTC include a three-tiered system that classifies patients with localized disease into low, intermediate, or high risk of persistent or recurrent disease. Risk stratification should be performed at baseline and repeated on an ongoing basis, depending on clinical evolution. One of the overarching goals in the management of DTC is the need to personalize treatment by tailoring its modality and intensity according to ongoing prognostic stratification, evolving knowledge about the disease, and patient characteristics and preference. In metastatic disease that is refractory to radioactive iodine, thyroid tumors are being reclassified into molecular subtypes that better reflect their biological properties and for which molecular alterations can be targeted with specific agents.
MeSH term(s)	Humans ; Thyroid Neoplasms/pathology ; Iodine Radioisotopes/therapeutic use ; Phenylurea Compounds ; Adenocarcinoma ; Prognosis
Chemical Substances	Iodine Radioisotopes ; Phenylurea Compounds
Language	English
Publishing date	2024-03-01
Publishing country	Brazil
Document type	Journal Article ; Review
ISSN	2359-4292
ISSN (online)	2359-4292
DOI	10.20945/2359-4292-2023-0375
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Article: Effect of the COVID-19 Pandemic on the Activity of Physicians Working in the Areas of Head and Neck Surgery and Otorhinolaryngology.

Kowalski, Luiz Paulo / Imamura, Rui / Castro Junior, Gilberto de / Marta, Gustavo Nader / Chaves, Aline Lauda Freitas / Matos, Leandro Luongo / Bento, Ricardo Ferreira

International archives of otorhinolaryngology

2020 Volume 24, Issue 3, Page(s) e258–e266

Abstract: ... ...

Abstract	Introduction
Keywords	covid19
Language	English
Publishing date	2020-05-22
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777
ISSN (online)	1809-4864
ISSN	1809-9777
DOI	10.1055/s-0040-1712169
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Article ; Online: Latin American Consensus on the Treatment of Head and Neck Cancer.

Matos, Leandro Luongo / Kowalski, Luiz Paulo / Chaves, Aline Lauda Freitas / de Oliveira, Thiago Bueno / Marta, Gustavo Nader / Curado, Maria Paula / de Castro Junior, Gilberto / Farias, Terence P / Bardales, Gustavo Sarria / Cabrera, Mario Avila / Capuzzo, Renato de Castro / de Carvalho, Genival Barbosa / Cernea, Claudio Roberto / Dedivitis, Rogério Aparecido / Dias, Fernando Luiz / Estefan, Andrés Munyo / Falco, Agustin Horacio / Ferraris, Gustavo Alberto / Gonzalez-Motta, Alejandro /

Gouveia, Andre Guimarães / Jacinto, Alexandre Arthur / Kulcsar, Marco Aurelio Vamondes / Leite, Ana Kober / Lira, Renan Bezerra / Mak, Milena Perez / De Marchi, Pedro / de Mello, Evandro Sobroza / de Matos, Fátima Cristina Mendes / Montero, Pablo H / de Moraes, Eduardo Dias / de Moraes, Fabio Ynoe / Morais, Diego Chaves Rezende / Poenitz, Fernando Miguel / Poitevin, Adela / Riveros, Hernán Ortiz / Sanabria, Álvaro / Ticona-Castro, Miguel / Vartanian, José Guilherme / Viani, Gustavo / Vines, Eugenio F / William Junior, William Nassib / Conway, David / Virani, Shama / Brennan, Paul

JCO global oncology

2024 Volume 10, Page(s) e2300343

Abstract: Head and neck squamous cell carcinoma (HNSCC) is well known as a serious health problem worldwide, especially in low-income countries or those with limited resources, such as most countries in Latin America. International guidelines cannot always be ... ...

Abstract	Head and neck squamous cell carcinoma (HNSCC) is well known as a serious health problem worldwide, especially in low-income countries or those with limited resources, such as most countries in Latin America. International guidelines cannot always be applied to a population from a large region with specific conditions. This study established a Latin American guideline for care of patients with head and neck cancer and presented evidence of HNSCC management considering availability and oncologic benefit. A panel composed of 41 head and neck cancer experts systematically worked according to a modified Delphi process on (1) document compilation of evidence-based answers to different questions contextualized by resource availability and oncologic benefit regarding Latin America (region of limited resources and/or without access to all necessary health care system infrastructure), (2) revision of the answers and the classification of levels of evidence and degrees of recommendations of all recommendations, (3) validation of the consensus through two rounds of online surveys, and (4) manuscript composition. The consensus consists of 12 sections: Head and neck cancer staging, Histopathologic evaluation of head and neck cancer, Head and neck surgery-oral cavity, Clinical oncology-oral cavity, Head and neck surgery-oropharynx, Clinical oncology-oropharynx, Head and neck surgery-larynx, Head and neck surgery-larynx/hypopharynx, Clinical oncology-larynx/hypopharynx, Clinical oncology-recurrent and metastatic head and neck cancer, Head and neck surgery-reconstruction and rehabilitation, and Radiation therapy. The present consensus established 48 recommendations on HNSCC patient care considering the availability of resources and focusing on oncologic benefit. These recommendations could also be used to formulate strategies in other regions like Latin America countries.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/therapy ; Latin America/epidemiology ; Consensus ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms/therapy
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.23.00343
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Article ; Online: Tumor Tissue Oxidative Stress Changes and Na, K-ATPase Evaluation in Head and Neck Squamous Cell Carcinoma.

Toledo, Marina Marques / De Souza Gonçalves, Bruno / Colodette, Natalie Mounteer / Chaves, Aline Lauda Freitas / Muniz, Luciana Vieira / De A Ribeiro, Rosy Iara Maciel / Dos Santos, Hélio Batista / Cortes, Vanessa F / Soares, Joao Marcos Arantes / De Lima Santos, Hérica / Barbosa, Leandro A

The Journal of membrane biology

2021 Volume 254, Issue 5-6, Page(s) 475–486

Abstract: Changes in metabolism are mechanisms that are largely implicated in the development, progression, and metastasis of head and neck squamous cell carcinoma (HNSCC) and also in resistance to different anticancer therapies. Identification of biomarkers for ... ...

Abstract	Changes in metabolism are mechanisms that are largely implicated in the development, progression, and metastasis of head and neck squamous cell carcinoma (HNSCC) and also in resistance to different anticancer therapies. Identification of biomarkers for differentiation between cancerous and normal epithelium, treatment design and prognosis remain a vital issue in the field of head and neck cancer. The present study analyzed the main biochemical changes that occur in HNSCC tumors by through mechanisms involving oxidative stress. The release of substances reactive to thiobarbituric acid was significantly lower in HNSCC tumor tissue as compared to healthy tissue. The assays related to the lipid profile assays showed changes in membrane biophysics of tumor cells due to an increase in total phospholipids and total cholesterol, as well as an increased activity and expression of the α1 subunit of Na, K-ATPase, which is fundamental in the process of carcinogenesis. The modulation of the antioxidant system was also affected, with a decrease in the catalytic activity of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), as well as a reduction of glutathione (GSH) content and an increase in H
MeSH term(s)	Adenosine Triphosphatases ; Head and Neck Neoplasms ; Humans ; Hydrogen Peroxide ; Oxidative Stress ; Squamous Cell Carcinoma of Head and Neck
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Adenosine Triphosphatases (EC 3.6.1.-)
Language	English
Publishing date	2021-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3082-x
ISSN	1432-1424 ; 0022-2631
ISSN (online)	1432-1424
ISSN	0022-2631
DOI	10.1007/s00232-021-00185-y
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Article ; Online: Effect of the COVID-19 Pandemic on the Activity of Physicians Working in the Areas of Head and Neck Surgery and Otorhinolaryngology

Kowalski, Luiz Paulo / Imamura, Rui / Castro Junior, Gilberto de / Marta, Gustavo Nader / Chaves, Aline Lauda Freitas / Matos, Leandro Luongo / Bento, Ricardo Ferreira

International Archives of Otorhinolaryngology v.24 n.3 2020

2020

Abstract: Abstract Introduction Coronavirus disease 2019 (COVID-19) is an acute infection caused by the new coronavirus (SARS-CoV-2) and it is highly transmissible, especially through respiratory droplets. To prepare the health system for the care of these ... ...

Abstract	Abstract Introduction Coronavirus disease 2019 (COVID-19) is an acute infection caused by the new coronavirus (SARS-CoV-2) and it is highly transmissible, especially through respiratory droplets. To prepare the health system for the care of these patients also led to a restriction in the activity of several medical specialties. Physicians who work with patients affected by diseases of the head and neck region constitute one of the populations most vulnerable to COVID-19 and also most affected by the interruption of their professional activities. Objective The aim of the present study was to assess the impact of the COVID-19 pandemic on the practice of head and neck surgeons and otorhinolaryngologists in Brazil. Methods An anonymous online survey of voluntary participation was applied, containing 30 questions regarding demographic aspects, availability of personal protective equipment (PPE), and impact on the routine of head and neck surgeons and otorhinolaryngologists, as well as clinical oncologists and radiation oncologists who work with head and neck diseases. Results Seven hundred and twenty-nine answers were received in a period of 4 days, ∼ 40 days after the 1st confirmed case in Brazil. With professionals working in public and private services, there was a high level of concerns with the disease and its consequences, limited availability of PPE and a significant decrease in the volume of specialized medical care. Conclusion The study demonstrated a direct impact of the COVID-19 pandemic on the clinical practice of specialties related to the treatment of patients with diseases of the head and neck region already in the beginning of the illness management in Brazil.
Keywords	COVID-19 ; pandemics ; occupational groups ; health personnel ; work ; covid19
Subject code	630
Language	English
Publishing date	2020-09-01
Publisher	Fundação Otorrinolaringologia
Publishing country	br
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of the COVID-19 Pandemic on the Activity of Physicians Working in the Areas of Head and Neck Surgery and Otorhinolaryngology

Luiz Paulo Kowalski / Rui Imamura / Gilberto de Castro Junior / Gustavo Nader Marta / Aline Lauda Freitas Chaves / Leandro Luongo Matos / Ricardo Ferreira Bento

International Archives of Otorhinolaryngology, Vol 24, Iss 03, Pp e258-e

2020 Volume 266

Abstract: Introduction Coronavirus disease 2019 (COVID-19) is an acute infection caused by the new coronavirus (SARS-CoV-2) and it is highly transmissible, especially through respiratory droplets. To prepare the health system for the care of these patients also ... ...

Abstract	Introduction Coronavirus disease 2019 (COVID-19) is an acute infection caused by the new coronavirus (SARS-CoV-2) and it is highly transmissible, especially through respiratory droplets. To prepare the health system for the care of these patients also led to a restriction in the activity of several medical specialties. Physicians who work with patients affected by diseases of the head and neck region constitute one of the populations most vulnerable to COVID-19 and also most affected by the interruption of their professional activities. Objective The aim of the present study was to assess the impact of the COVID-19 pandemic on the practice of head and neck surgeons and otorhinolaryngologists in Brazil. Methods An anonymous online survey of voluntary participation was applied, containing 30 questions regarding demographic aspects, availability of personal protective equipment (PPE), and impact on the routine of head and neck surgeons and otorhinolaryngologists, as well as clinical oncologists and radiation oncologists who work with head and neck diseases. Results Seven hundred and twenty-nine answers were received in a period of 4 days, ∼ 40 days after the 1st confirmed case in Brazil. With professionals working in public and private services, there was a high level of concerns with the disease and its consequences, limited availability of PPE and a significant decrease in the volume of specialized medical care. Conclusion The study demonstrated a direct impact of the COVID-19 pandemic on the clinical practice of specialties related to the treatment of patients with diseases of the head and neck region already in the beginning of the illness management in Brazil.
Keywords	covid-19 ; pandemics ; occupational groups ; health personnel ; work ; Medicine ; R ; Otorhinolaryngology ; RF1-547 ; covid19
Subject code	630
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Thieme Revinter Publicações Ltda.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Oral leukoplakia and erythroplakia in young patients: a systematic review.

Roza, Ana Luiza Oliveira Corrêa / Kowalski, Luiz Paulo / William, William Nassib / de Castro, Gilberto / Chaves, Aline Lauda Freitas / Araújo, Anna Luiza Damaceno / Ribeiro, Ana Carolina Prado / Brandão, Thaís Bianca / Lopes, Marcio Ajudarte / Vargas, Pablo Agustin / Santos-Silva, Alan Roger

Oral surgery, oral medicine, oral pathology and oral radiology

2020 Volume 131, Issue 1, Page(s) 73–84

Abstract: Objective: The aim of this study was to estimate the frequency of oral leukoplakia and oral erythroplakia in young patients.: Study design: The systematic review was based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta- ... ...

Abstract	Objective: The aim of this study was to estimate the frequency of oral leukoplakia and oral erythroplakia in young patients. Study design: The systematic review was based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and performed in the following electronic databases: PubMed, Scopus, and Embase. The studies included were cross-sectional, cohort, and diagnostic, which provided with clinical and microscopic data of patients younger than 40 years. The Critical Appraisal Checklist for Prevalence Studies from the Joanna Briggs Institute and the Quality Assessment Tool for Diagnostic Accuracy Studies were used to assess the risk of bias. Results: Five studies met eligibility criteria and were included. The total number of patients from the studies was 1246, of which 115 were young patients (9.2%) with oral leukoplakia as the only oral potentially malignant disorder reported. Oral epithelial dysplasia was identified in 40 cases (34.7%), of which 8 (6.9%) presented malignant transformation. Conclusions: The frequency of oral leukoplakia is low in young patients. Observational studies are necessary for understanding oral leukoplakia and other oral potentially malignant disorders in younger patients.
MeSH term(s)	Carcinoma in Situ ; Cell Transformation, Neoplastic ; Cross-Sectional Studies ; Erythroplasia/epidemiology ; Humans ; Leukoplakia, Oral/epidemiology
Language	English
Publishing date	2020-09-14
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2650843-6
ISSN	2212-4411 ; 2212-4403
ISSN (online)	2212-4411
ISSN	2212-4403
DOI	10.1016/j.oooo.2020.09.002
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Article: Effect of the COVID-19 Pandemic on the Activity of Physicians Working in the Areas of Head and Neck Surgery and Otorhinolaryngology

Kowalski, Luiz Paulo / Imamura, Rui / Castro Junior, Gilberto de / Marta, Gustavo Nader / Chaves, Aline Lauda Freitas / Matos, Leandro Luongo / Bento, Ricardo Ferreira

International archives of otorhinolaryngology

Abstract: Introduction Coronavirus disease 2019 (COVID-19) is an acute infection caused by the new coronavirus (SARS-CoV-2) and it is highly transmissible, especially through respiratory droplets To prepare the health system for the care of these patients also led ...

Abstract	Introduction Coronavirus disease 2019 (COVID-19) is an acute infection caused by the new coronavirus (SARS-CoV-2) and it is highly transmissible, especially through respiratory droplets To prepare the health system for the care of these patients also led to a restriction in the activity of several medical specialties Physicians who work with patients affected by diseases of the head and neck region constitute one of the populations most vulnerable to COVID-19 and also most affected by the interruption of their professional activities Objective The aim of the present study was to assess the impact of the COVID-19 pandemic on the practice of head and neck surgeons and otorhinolaryngologists in Brazil Methods An anonymous online survey of voluntary participation was applied, containing 30 questions regarding demographic aspects, availability of personal protective equipment (PPE), and impact on the routine of head and neck surgeons and otorhinolaryngologists, as well as clinical oncologists and radiation oncologists who work with head and neck diseases Results Seven hundred and twenty-nine answers were received in a period of 4 days, ∼ 40 days after the 1 (st) confirmed case in Brazil With professionals working in public and private services, there was a high level of concerns with the disease and its consequences, limited availability of PPE and a significant decrease in the volume of specialized medical care Conclusion The study demonstrated a direct impact of the COVID-19 pandemic on the clinical practice of specialties related to the treatment of patients with diseases of the head and neck region already in the beginning of the illness management in Brazil
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #696024
Database	COVID19

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Article: Effect of the COVID-19 Pandemic on the Activity of Physicians Working in the Areas of Head and Neck Surgery and Otorhinolaryngology

Kowalski, Luiz Paulo / Imamura, Rui / Castro Junior, Gilberto de / Marta, Gustavo Nader / Chaves, Aline Lauda Freitas / Matos, Leandro Luongo / Bento, Ricardo Ferreira

International Archives of Otorhinolaryngology

2020 Volume 24, Issue 03, Page(s) e258–e266

Abstract: Introduction: Coronavirus disease 2019 (COVID-19) is an acute infection caused by the new coronavirus (SARS-CoV-2) and it is highly transmissible, especially through respiratory droplets. To prepare the health system for the care of these patients also ... ...

Abstract	Introduction: Coronavirus disease 2019 (COVID-19) is an acute infection caused by the new coronavirus (SARS-CoV-2) and it is highly transmissible, especially through respiratory droplets. To prepare the health system for the care of these patients also led to a restriction in the activity of several medical specialties. Physicians who work with patients affected by diseases of the head and neck region constitute one of the populations most vulnerable to COVID-19 and also most affected by the interruption of their professional activities. Objective: The aim of the present study was to assess the impact of the COVID-19 pandemic on the practice of head and neck surgeons and otorhinolaryngologists in Brazil. Methods: An anonymous online survey of voluntary participation was applied, containing 30 questions regarding demographic aspects, availability of personal protective equipment (PPE), and impact on the routine of head and neck surgeons and otorhinolaryngologists, as well as clinical oncologists and radiation oncologists who work with head and neck diseases. Results: Seven hundred and twenty-nine answers were received in a period of 4 days, ∼ 40 days after the 1 st confirmed case in Brazil. With professionals working in public and private services, there was a high level of concerns with the disease and its consequences, limited availability of PPE and a significant decrease in the volume of specialized medical care. Conclusion: The study demonstrated a direct impact of the COVID-19 pandemic on the clinical practice of specialties related to the treatment of patients with diseases of the head and neck region already in the beginning of the illness management in Brazil.
Keywords	COVID-19 ; pandemics ; occupational groups ; health personnel ; work
Language	English
Publishing date	2020-05-22
Publisher	Thieme Revinter Publicações Ltda
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777
ISSN (online)	1809-4864
ISSN	1809-9777
DOI	10.1055/s-0040-1712169
Database	Thieme publisher's database

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