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  1. Book: The genius of Robert Adam

    Adam, Robert / Harris, Eileen

    his interiors

    2001  

    Author's details Eileen Harris
    Language English
    Size 378 S, zahlr. Ill
    Publisher Yale Univ. Press
    Publishing place New Haven, Conn. u.a.
    Document type Book
    Note Includes bibliographical references (S. [367] - 370) and index ; Publ. for the Paul Mellon Centre for Studies in British Art
    ISBN 0300081294 ; 9780300081299
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book: The genius of Robert Adam

    Adam, Robert / Harris, Eileen

    his interiors

    2001  

    Author's details Eileen Harris
    Language English
    Size 378 S, zahlr. Ill
    Publisher Yale Univ. Press
    Publishing place New Haven, Conn. u.a.
    Document type Book
    Note Includes bibliographical references (S. [367] - 370) and index ; Publ. for the Paul Mellon Centre for Studies in British Art
    ISBN 0300081294 ; 9780300081299
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10.

    Parkin, Edward / Harris, Benjamin

    Journal of neurochemistry

    2009  Volume 108, Issue 6, Page(s) 1464–1479

    Abstract: A disintegrin and metalloproteinase (ADAM) 10 is a type I transmembrane glycoprotein responsible ... in conditioned medium. Shedding of the ADAM10 ectodomain was inhibited by a known ADAM inhibitor with a reciprocal ... in Alzheimer's disease. In this study we demonstrate that ADAM10 itself is subject to shedding by one or more ADAMs ...

    Abstract A disintegrin and metalloproteinase (ADAM) 10 is a type I transmembrane glycoprotein responsible for the ectodomain shedding of a range of proteins including the amyloid precursor protein implicated in Alzheimer's disease. In this study we demonstrate that ADAM10 itself is subject to shedding by one or more ADAMs. Expression of epitope-tagged wild-type ADAM10 in SH-SY5Y cells enabled the detection of a soluble ectodomain in conditioned medium. Shedding of the ADAM10 ectodomain was inhibited by a known ADAM inhibitor with a reciprocal accumulation of the full-length mature protein in both cell lysates and extracellular membrane vesicles. Shedding was also stimulated by phorbol ester treatment of cells. A glycosylphosphatidylinositol-anchored form of ADAM10 lacking the cytosolic, transmembrane and alpha-helical juxtamembrane regions of the wild-type protein was shed in a similar manner. Furthermore, a truncated soluble ADAM10 construct, although correctly post-translationally processed and catalytically active against a synthetic peptide substrate, was incapable of shedding cell-associated amyloid precursor protein. Finally, we show that ADAM9 is, at least in part, responsible for the ectodomain shedding of ADAM10. In conclusion, this is a new mechanism by which levels of ADAM10 are regulated and may have implications in a range of human diseases including Alzheimer's disease.
    MeSH term(s) ADAM Proteins/genetics ; ADAM Proteins/physiology ; ADAM10 Protein ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/physiology ; Amyloid beta-Protein Precursor/metabolism ; Arginine/genetics ; Cell Line ; Disintegrins/physiology ; Enzyme Inhibitors/pharmacology ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Metalloproteases/physiology ; Mutation ; Neuroblastoma ; Peptides/metabolism ; Phosphoinositide Phospholipase C/pharmacology ; Protein Structure, Tertiary/physiology ; Protein Transport/drug effects ; RNA, Small Interfering/genetics ; Tetradecanoylphorbol Acetate/pharmacology ; Transfection/methods
    Chemical Substances Amyloid beta-Protein Precursor ; Disintegrins ; Enzyme Inhibitors ; Membrane Proteins ; Peptides ; RNA, Small Interfering ; Arginine (94ZLA3W45F) ; Phosphoinositide Phospholipase C (EC 3.1.4.11) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Metalloproteases (EC 3.4.-) ; ADAM Proteins (EC 3.4.24.-) ; ADAM10 Protein (EC 3.4.24.81) ; ADAM10 protein, human (EC 3.4.24.81) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
    Language English
    Publishing date 2009-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/j.1471-4159.2009.05907.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.170: Show issues Location:
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  4. Book: Robert Adam and Kedleston

    Harris, Leslie / Adam, Robert / Jackson-Stops, Gervase

    the making of a neo-classical masterpiece

    1987  

    Author's details by Leslie Harris. With a forew. by Gervase Jackson-Stops
    Language English
    Size 96 S., zahlr. Ill., Kt., 21 x 30 cm
    Publisher National Trust
    Publishing place London
    Document type Book
    Note Includes bibliographical references (p. 96)
    ISBN 0707800870 ; 9780707800875
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article: A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10

    Parkin, Edward / Harris, Benjamin

    Journal of neurochemistry. 2009 Mar., v. 108, no. 6

    2009  

    Abstract: A disintegrin and metalloproteinase (ADAM) 10 is a type I transmembrane glycoprotein responsible ... in conditioned medium. Shedding of the ADAM10 ectodomain was inhibited by a known ADAM inhibitor with a reciprocal ... in Alzheimer's disease. In this study we demonstrate that ADAM10 itself is subject to shedding by one or more ADAMs ...

    Abstract A disintegrin and metalloproteinase (ADAM) 10 is a type I transmembrane glycoprotein responsible for the ectodomain shedding of a range of proteins including the amyloid precursor protein implicated in Alzheimer's disease. In this study we demonstrate that ADAM10 itself is subject to shedding by one or more ADAMs. Expression of epitope-tagged wild-type ADAM10 in SH-SY5Y cells enabled the detection of a soluble ectodomain in conditioned medium. Shedding of the ADAM10 ectodomain was inhibited by a known ADAM inhibitor with a reciprocal accumulation of the full-length mature protein in both cell lysates and extracellular membrane vesicles. Shedding was also stimulated by phorbol ester treatment of cells. A glycosylphosphatidylinositol-anchored form of ADAM10 lacking the cytosolic, transmembrane and α-helical juxtamembrane regions of the wild-type protein was shed in a similar manner. Furthermore, a truncated soluble ADAM10 construct, although correctly post-translationally processed and catalytically active against a synthetic peptide substrate, was incapable of shedding cell-associated amyloid precursor protein. Finally, we show that ADAM9 is, at least in part, responsible for the ectodomain shedding of ADAM10. In conclusion, this is a new mechanism by which levels of ADAM10 are regulated and may have implications in a range of human diseases including Alzheimer's disease.
    Keywords Alzheimer disease ; shedding
    Language English
    Dates of publication 2009-03
    Size p. 1464-1479.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/j.1471-4159.2009.05907.x
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Altered cell-matrix associated ADAM proteins in Alzheimer disease.

    Gerst, J L / Raina, A K / Pirim, I / McShea, A / Harris, P L / Siedlak, S L / Takeda, A / Petersen, R B / Smith, M A

    Journal of neuroscience research

    2000  Volume 59, Issue 5, Page(s) 680–684

    Abstract: ... in Alzheimer disease, we undertook a study of ADAM-1 and 2 (A Disintegrin And Metalloprotease), developmentally ... regulated, integrin-binding, membrane-bound metalloproteases. Our results show that whereas ADAM-1 and 2 are ... related neurofibrillary alterations. This increase in both ADAM-1 and 2 in cases of Alzheimer disease was ...

    Abstract Alterations in cell-matrix 'contact' are often related to a disruption of cell cycle regulation and, as such, occur variously in neoplasia. Given the recent findings showing cell cycle alterations in Alzheimer disease, we undertook a study of ADAM-1 and 2 (A Disintegrin And Metalloprotease), developmentally-regulated, integrin-binding, membrane-bound metalloproteases. Our results show that whereas ADAM-1 and 2 are found in susceptible hippocampal neurons in Alzheimer disease, these proteins were not generally increased in similar neuronal populations in younger or age-matched controls except in association with age-related neurofibrillary alterations. This increase in both ADAM-1 and 2 in cases of Alzheimer disease was verified by immunoblot analysis (P < 0.05). An ADAM-induced loss of matrix integration would effectively "reset" the mitotic clock and thereby stimulate re-entry into the cell cycle in neurons in Alzheimer disease. Furthermore, given the importance of integrins in maintaining short-term memory, alterations in ADAM proteins or their proteolytic activity could also play a proximal role in the clinico-pathological manifestations of Alzheimer disease.
    MeSH term(s) ADAM Proteins ; Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Brain/metabolism ; Extracellular Matrix/metabolism ; Fertilins ; Humans ; Immunoblotting ; Immunohistochemistry ; Membrane Glycoproteins/metabolism ; Metalloendopeptidases/metabolism ; Middle Aged
    Chemical Substances Membrane Glycoproteins ; ADAM Proteins (EC 3.4.24.-) ; Fertilins (EC 3.4.24.-) ; Metalloendopeptidases (EC 3.4.24.-)
    Language English
    Publishing date 2000-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/(SICI)1097-4547(20000301)59:5<680::AID-JNR11>3.0.CO;2-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1232: Show issues Location:
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  7. Book: The furniture of Robert Adam

    Harris, Eileen

    (Chapters in art series ; 38)

    1963  

    Author's details Eileen Harris
    Series title Chapters in art series ; 38
    Language English
    Size viii, 110 p, illus., plates, 19 cm
    Publisher A. Tiranti
    Publishing place London
    Document type Book
    Note Bibliography: p. 45-46
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book ; Online: (Table 1) Depth and revised depth from ODP Sites 169-1033 and 169-1034, supplementary data to: Verosub, Kenneth Lee; Harris, Adam H; Karlin, R (2001): Ultrahigh-resolution paleomagnetic record from ODP Leg 169S, Saanich Inlet, British Columbia: initial results. Marine Geology, 174(1-4), 79-93

    Verosub, Kenneth Lee / Harris, Adam H / Karlin, R

    2001  

    Abstract: The Holocene section in Saanich Inlet, Vancouver Island, British Columbia, is 50-70 m thick. Cores from Saanich Inlet obtained during Leg 169S of the Ocean Drilling Program afford an excellent opportunity to obtain an ultrahigh-resolution paleomagnetic ... ...

    Abstract The Holocene section in Saanich Inlet, Vancouver Island, British Columbia, is 50-70 m thick. Cores from Saanich Inlet obtained during Leg 169S of the Ocean Drilling Program afford an excellent opportunity to obtain an ultrahigh-resolution paleomagnetic and environmental magnetic record for the Holocene and Late Pleistocene of western Canada. We have used an automated, long-core cryogenic magnetometer to study over 380 m of continuous u-channel samples from ODP Sites 1033 and 1034, the two sites that constitute Leg 169S. Holocene records of paleomagnetic inclination and intensity show excellent intra-site correlation and can be used to fine-tune the lithologic correlation among cores from each site. The Late Pleistocene magnetic records provide a means of intra-site correlation of the otherwise featureless marine clay. Near the Holocene/Late Pleistocene boundary, both sites contain a magnetic intensity feature that is interpreted as a Missoula-type flood event on the Fraser River. The composite Holocene inclination records from the two sites are quite similar and provide a means of comparing current age-models that are based on radiocarbon dating of material from each site. This comparison shows only minor differences in the available age-models. It also provides strong evidence that the sediments of Saanich Inlet represent a reliable record of geomagnetic field behavior.
    Language English
    Dates of publication 2001-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/S0025-3227(00)00143-2
    DOI 10.1594/PANGAEA.744817
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article ; Online: Exploring the usability of the virtual reality module LEAF CAFÉ: a qualitative think-aloud study.

    Siette, Joyce / Campbell, Christopher / Adam, Patrick J / Harris, Celia B

    BMC geriatrics

    2024  Volume 24, Issue 1, Page(s) 162

    Abstract: Background: The global healthcare system faces increasing strain from our ageing population, primarily due to the growing prevalence of age-related health conditions such as dementia. While modern healthcare technology offers potential solutions, it ... ...

    Abstract Background: The global healthcare system faces increasing strain from our ageing population, primarily due to the growing prevalence of age-related health conditions such as dementia. While modern healthcare technology offers potential solutions, it frequently lacks user-friendliness for older adults. Virtual Reality (VR) has emerged as a promising tool for diagnosing cognitive impairment, offering innovative solutions where traditional methods may fall short. This study explores older adults' perspectives on the usability of a newly designed VR module for cognitive assessment.
    Methods: During a 100-min session, participants were asked to engage and complete recall and recognition tasks within the VR module (think-aloud approach) and provide feedback upon completion (semi-structured interviews). Audio materials were transcribed for analysis and recordings of the users' interactions with the module were annotated to provide additional context. These combined textual data were analysed using content coding and thematic analysis to identify themes that reflect how participants used the module's features and what features are desirable to support that process better.
    Results: Participants (N = 10; Mean age = 73.3, SD = 7.53, range = 65-83 years) perceived the VR module as user-friendly and endorsed its potential as a cognitive screener due to its engaging and immersive nature. Older adults highlighted three key aspects of the module: the usefulness of the platform's ability to offer a comprehensive and reliable evaluation of an individual's cognitive abilities; the need to present concise and relevant content to optimise engagement and use; and the importance of overcoming barriers to support implementation. Suggested game improvements centred on food recognition and adjusting difficulty levels. Barriers to implementation included technology challenges for older adults and concerns about the game's suitability for everyday scenarios. Participants stressed the need for reliable implementation strategies, proposing locations such as libraries and advocating for home-based screening.
    Conclusion: Continued improvements in accessibility suggest that VR tools could help with diagnosing cognitive impairment in older adults. Using a simulated environment to assess cognitive status might fill the gap between current diagnostic methods, aiding treatment planning and early intervention. However, these findings should be approached cautiously, as more research is needed to fully grasp the potential impact of VR tools in this context.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Virtual Reality ; Cognition ; Aging ; Cognitive Dysfunction ; Data Collection
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-024-04767-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Evaluation of inflammatory bowel disease

    Shah, Samir A. / Harris, Adam / Feller, Edward

    (Gastroenterology clinics of North America ; 41,2)

    2012  

    Author's details guest ed. Samir A. Shah ; Adam Harris ; Edward Feller
    Series title Gastroenterology clinics of North America ; 41,2
    Collection
    Language English
    Size XIV S., S. 271 - 537 : Ill., graph. Darst.
    Publisher Saunders an imprint of Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT017249876
    ISBN 978-1-4557-4627-9 ; 1-4557-4627-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 123 -41,2- verfügbar in Königswinter Königswinter

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