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Article ; Online: Emergency myelopoiesis in critical illness: lessons from the COVID-19 pandemic.

O'Driscoll, David N

2022 Volume 192, Issue 2, Page(s) 831–832

MeSH term(s)	Humans ; Myelopoiesis ; COVID-19 ; Critical Illness ; Pandemics
Language	English
Publishing date	2022-06-16
Publishing country	Ireland
Document type	Letter ; Comment
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-022-03068-w
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Article ; Online: Cannabidiol modulation of oxidative stress and signalling.

Pereira, Sónia R / Hackett, Becky / O'Driscoll, David N / Sun, Melody Cui / Downer, Eric J

Neuronal signaling

2021 Volume 5, Issue 3, Page(s) NS20200080

Abstract: Cannabidiol (CBD), one of the primary non-euphoric components in ... ...

Abstract	Cannabidiol (CBD), one of the primary non-euphoric components in the
Language	English
Publishing date	2021-08-24
Publishing country	England
Document type	Journal Article ; Review
ISSN	2059-6553
ISSN (online)	2059-6553
DOI	10.1042/NS20200080
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Article ; Online: Antipsychotic prescribing: national findings of children and adolescents attending mental health services in Ireland.

Driscoll, David J O / McCarthy, Suzanne

European child & adolescent psychiatry

2024

Abstract: ... 17-years of age (n = 3528). Each service provided anonymised data. We described the frequency ... prescribed an antipsychotic medication. Twelve percentage (n = 437) were prescribed an antipsychotic and 16 ... 17-years (n = 211, 48.3%) was the most common age category. The commonest reason for prescribing ...

Abstract	Antipsychotic prescribing trends vary internationally, albeit off-label use remains high (i.e., target symptoms). We aim to describe antipsychotic use, target conditions, target symptoms and dosing regimens in children and adolescents in Ireland. We used a sampled cohort from a national audit of children and adolescents attending mental health services with predefined inclusion and exclusion criteria from Jul-2021 to Dec-2021 who were prescribed at least one psychotropic medication and up to and including 17-years of age (n = 3528). Each service provided anonymised data. We described the frequency of antipsychotic medication, medication type, target condition, target symptom and medication doses. We used multivariable logistic regression, adjusted with available co-variates to assess the association of being prescribed an antipsychotic medication. Twelve percentage (n = 437) were prescribed an antipsychotic and 16-17-years (n = 211, 48.3%) was the most common age category. The commonest reason for prescribing an antipsychotic was target symptoms (i.e., off-label use) (n = 329; 75.%) and of these symptoms, agitation (n = 77/329; 25%) and irritability (56/239; 25%) were the most common. Quetiapine (n = 127; 29%) was the most common antipsychotic, followed by risperidone (n = 125; 28.6%), aripiprazole (n = 107; 24.5%), and olanzapine (n = 66; 15.1%). In adjusted analysis, having a psychotic disorder ((adjusted-odds-ratio) aOR: 39.63, CI 95%, 13.40-117.22), bipolar disorder (aOR: 16.96, CI 95%, 3.60-80.00), autism spectrum disorder (aOR: 3.24, CI 95%, 2.45-4.28) or aggression symptoms (aOR: 16.75, CI 95%, 7.22-38.89) was associated with prescribing an antipsychotic medication. This is the first study in children and adolescents that describes the target conditions and target symptoms for antipsychotic use in Ireland. Our results show a high proportion of antipsychotic prescribing based on target symptoms rather than target condition or diagnosis.
Language	English
Publishing date	2024-04-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1118299-4
ISSN	1435-165X ; 1018-8827 ; 1433-5719
ISSN (online)	1435-165X
ISSN	1018-8827 ; 1433-5719
DOI	10.1007/s00787-024-02428-4
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Article ; Online: Quantifying the Kinase Activities of MST1/2.

O'Driscoll, Niamh A / Matallanas, David

Methods in molecular biology (Clifton, N.J.)

2018 Volume 1893, Page(s) 289–304

Abstract: The functions of the kinases MST1 and MST2 rely heavily on their ability to phosphorylate and become phosphorylated themselves. Hence, it is important to precisely measure the kinase activities of both isoforms in a reproducible manner. Here, we describe ...

Abstract	The functions of the kinases MST1 and MST2 rely heavily on their ability to phosphorylate and become phosphorylated themselves. Hence, it is important to precisely measure the kinase activities of both isoforms in a reproducible manner. Here, we describe in detail the protocol for an in-gel kinase assay for the quantification of the kinase activity of MST1/2, which involves immunoprecipitation of MST1/2 and the incorporation of radiolabeled phosphate from [γ-
MeSH term(s)	Biological Assay ; Blotting, Western ; Enzyme Activation ; Enzyme Assays ; Protein-Serine-Threonine Kinases/metabolism
Chemical Substances	Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2018-12-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-8910-2_22
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Article ; Online: Immune function? A missing link in the gender disparity in preterm neonatal outcomes.

O'Driscoll, David N / Greene, Catherine M / Molloy, Eleanor J

Expert review of clinical immunology

2017 Volume 13, Issue 11, Page(s) 1061–1071

Abstract: Introduction: In neonatology, males exhibit a more severe disease course and poorer prognosis in many pathological states when compared to females. Perinatal brain injury, respiratory morbidity, and sepsis, among other complications, preferentially ... ...

Abstract	Introduction: In neonatology, males exhibit a more severe disease course and poorer prognosis in many pathological states when compared to females. Perinatal brain injury, respiratory morbidity, and sepsis, among other complications, preferentially affect males. Preterm neonates (born <37 weeks gestation) display a particularly marked sexual disparity in pathology, especially at the borders of viability. The sex biases in preterm neonatal outcomes and underlying multifactorial mechanisms have been incompletely explored. Sex-specific clinical phenomena may be partially explained by intrinsic differences in immune function. The distinct immune system of preterm neonates renders this patient population vulnerable, and it is increasingly important to consider biological sex in disease processes and to strive for improved outcomes for both sexes. Areas covered: We discuss the cellular responses and molecular intermediates in immune function which are strongly dependent on sex-specific factors such as the genetic and hormonal milieu of premature birth and consider novel findings in a clinical context. Expert commentary: The role of immune function in the manifestation of sex-specific disease manifestations and outcomes in preterm neonates is a critical prognostic variable. Further mechanistic elucidation will yield valuable translational and clinical information of disease processes in preterm neonates which may be harnessed for modulation.
Language	English
Publishing date	2017-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2274260-8
ISSN	1744-8409 ; 1744-666X
ISSN (online)	1744-8409
ISSN	1744-666X
DOI	10.1080/1744666X.2017.1386555
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Article ; Online: Marine pollution in fledged Leach's storm-petrels (Hydrobates leucorhous) from Baccalieu Island, Newfoundland and Labrador, Canada.

Krug, David M / Frith, Rhyl / Wong, Sarah N P / Ronconi, Robert A / Wilhelm, Sabina I / O'Driscoll, Nelson J / Mallory, Mark L

Marine pollution bulletin

2020 Volume 162, Page(s) 111842

Abstract: The Leach's storm-petrel (Hydrobates leucorhous) is one of the most abundant and widely distributed marine birds in the North Atlantic but is under global population decline, possibly linked to marine pollution. We determined levels of ingested plastic ... ...

Abstract	The Leach's storm-petrel (Hydrobates leucorhous) is one of the most abundant and widely distributed marine birds in the North Atlantic but is under global population decline, possibly linked to marine pollution. We determined levels of ingested plastic and hepatic total mercury (THg) in recently fledged juveniles that stranded in Newfoundland and Labrador, Canada, and assessed the relationship to body condition, size and diet. Plastic prevalence was high (87.5%) but hepatic THg was relatively low (mean 486.7 ng/g dry weight) compared to other studies. Levels of neither pollutant were significantly related to body metrics of health. Our data confirm that plastic and mercury are pervasive in the western North Atlantic Ocean, prominent even in young birds.
MeSH term(s)	Animals ; Atlantic Ocean ; Birds ; Canada ; Environmental Monitoring ; Islands ; Newfoundland and Labrador
Language	English
Publishing date	2020-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2020.111842
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Article ; Online: Gender disparities in preterm neonatal outcomes.

O'Driscoll, David N / McGovern, Matthew / Greene, Catherine M / Molloy, Eleanor J

Acta paediatrica (Oslo, Norway : 1992)

2018

Abstract: Aim: From birth to old age, males generally have poorer disease outcomes compared to females. Preterm infants display a marked gender disparity in disease outcomes, and the underlying mechanisms are not well delineated. Our aim was to review the ... ...

Abstract	Aim: From birth to old age, males generally have poorer disease outcomes compared to females. Preterm infants display a marked gender disparity in disease outcomes, and the underlying mechanisms are not well delineated. Our aim was to review the literature on clinical outcomes between preterm infants of different genders and discuss the potential mechanisms underlying the differences observed. Methods: A literature review was undertaken for experimental and clinical research related to gender differences in preterm outcomes. Results: Preterm male infants appear to have consistently worse outcomes compared to females, and the aetiology of these differences, while mostly undetermined, is likely multifactorial. Conclusion: The male disadvantage in preterm outcomes is likely multifactorial with hormonal, genetic and immunological differences likely playing key roles. Gender is an important variable in preterm outcome and should be considered when designing clinical and experimental research.
Language	English
Publishing date	2018-05-11
Publishing country	Norway
Document type	Journal Article ; Review
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.14390
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Article ; Online: Nursing students' views of using virtual reality in healthcare: A qualitative study.

Saab, Mohamad M / Landers, Margaret / Murphy, David / O'Mahony, Billy / Cooke, Eoghan / O'Driscoll, Michelle / Hegarty, Josephine

Journal of clinical nursing

2021 Volume 31, Issue 9-10, Page(s) 1228–1242

Abstract: ... for Reporting Qualitative Research checklist.: Methods: Nursing students (n = 26) were recruited using ...

Abstract	Aims and objectives: This study explored nursing students' views of using virtual reality in healthcare. Background: The popularity and use of virtual reality in healthcare delivery and education is on the rise. Yet, the views of future nurses regarding this technology remain underexplored. Design: This is a qualitative descriptive study guided by a naturalistic inquiry and reported using the Standards for Reporting Qualitative Research checklist. Methods: Nursing students (n = 26) were recruited using convenience and snowball sampling. They were first exposed to a virtual reality intervention aimed to enhance men's awareness of testicular diseases. This was attempted to familiarise participants with the technology and initiate conversations around its use in healthcare. Participants were then interviewed face-to-face, either individually or within focus groups. Data were analysed using thematic analysis. Results: Four themes were identified: (i) positive experiences of virtual reality; (ii) challenges to using virtual reality; (iii) settings where virtual reality can be implemented; and (iv) blue-sky and future applications of virtual reality. Participants described this technology as novel, enjoyable, immersive, memorable and inclusive. They questioned, however, the suitability of virtual reality for older adults, reported minor technical difficulties and stressed the importance of prior preparation in the use of the technology. Virtual reality was recommended for use in outpatient healthcare settings, schools and the community. Participants suggested using virtual reality in health promotion, disease prevention and management, and to promote nurses' empathy towards patients. Conclusions: Findings highlight the potential role of virtual reality in assisting nurses in promoting health and managing disease. Future research is needed to establish the long-term effect of virtual reality interventions among more diverse participants. Relevance to clinical practice: Virtual reality can be implemented in outpatient, educational and community settings in order to promote health, prevent disease, enhance disease and self-management, and increase nurses' empathy towards patients.
MeSH term(s)	Aged ; Delivery of Health Care ; Health Promotion ; Humans ; Male ; Qualitative Research ; Students, Nursing ; Virtual Reality
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1159483-4
ISSN	1365-2702 ; 0962-1067 ; 1752-9816
ISSN (online)	1365-2702
ISSN	0962-1067 ; 1752-9816
DOI	10.1111/jocn.15978
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Article ; Online: Household energy poverty and trajectories of emotional and behavioural difficulties in children and adolescents: findings from two prospective cohort studies.

O Driscoll, David J / Kiely, Elizabeth / O'Keeffe, Linda M / Khashan, Ali S

Social psychiatry and psychiatric epidemiology

2024

Abstract: ... Cohort (n = 11,134) were recruited at age 9 months (9 m) and followed up at 3, 5, 7 and 9 years (y ... The Child Cohort (n = 8,538) were recruited at age 9 y and followed up at 13 y and 17/18 y. EP was ...

Abstract	Purpose: The aim of this study is to examine the association between household energy poverty (EP) and trajectories of emotional and behavioural difficulties during childhood. Methods: The Growing up in Ireland study is two nationally representative prospective cohorts of children. The Infant Cohort (n = 11,134) were recruited at age 9 months (9 m) and followed up at 3, 5, 7 and 9 years (y). The Child Cohort (n = 8,538) were recruited at age 9 y and followed up at 13 y and 17/18 y. EP was a composite of two relative measures of EP. Emotional and behavioural difficulties were repeatedly measured using the strengths and difficulties questionnaire (SDQ). Linear spline multilevel models were used, adjusted for confounders to examine the association between (1) EP (9 m or 3 y) and trajectories of emotional and behavioural difficulties from 3 to 9 y in the Infant Cohort and (2) EP at 9 y and the same trajectories from 9 to 18 y in the Child Cohort. Results: In adjusted analyses, EP at 9 m or 3 y of age was associated with higher total difficulties score at 3 y (0.66, 95% CI 0.41, 0.91) and 5 y (0.77, 95% CI 0.48, 1.05) but not at 7 y or 9 y. EP at 9 y was associated with higher total difficulties score at 9 y (1.73, 95% CI 1.28, 2.18), with this difference reducing over time leading to 0.68 (95% CI 0.19, 1.17) at 17/18 y. Conclusions: Our study demonstrates a potential association between early life EP and emotional and behavioural difficulties that may be transient and attenuate over time during childhood. Further studies are required to replicate these findings and to better understand if these associations are causal.
Language	English
Publishing date	2024-02-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	623071-4
ISSN	1433-9285 ; 0037-7813 ; 0933-7954
ISSN (online)	1433-9285
ISSN	0037-7813 ; 0933-7954
DOI	10.1007/s00127-024-02616-2
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Article ; Online: Melatonin Alters Innate Immune Function in Infants with Neonatal Encephalopathy.

Aslam, Saima / O'Dea, Mary / Kelly, Lynne A / O'Neill, Amanda / McKenna, Ellen / Hurley, Tim / Branagan, Aoife / O'Driscoll, David / Normile, Caoimhe / Saleemi, Shahid / Sweetman, Deirdre / Vavasseur, Claudine / Murphy, John / Donoghue, Veronica / Watson, William / Molloy, Eleanor J

Neonatology

2023 Volume 120, Issue 3, Page(s) 325–333

Abstract: ... n = 20; NE n = 20) over the first week of life. Melatonin reduced neutrophil CD11b and TLR-4 ...

Abstract	Introduction: Melatonin has been suggested an adjunctive therapy in neonatal encephalopathy (NE). Melatonin reduces oxidative stress and neutrophil activation; however, the immunological effects in NE have not been studied. Methods: Infants with NE and neonatal controls were prospectively recruited. Whole blood was sampled in the first week of life. Following endotoxin and or melatonin treatment, diurnal variation was measured by RT PCR for circadian rhythm genes (brain and Muscle Arnt-Like protein [BMAL1], circadian locomotor output cycles kaput [CLOCK], Nuclear Receptor Subfamily 1 Group D Member 2 [REV Erβ], and cryptochrome circadian clock [CRY]). Neutrophil and monocyte cell surface markers of activation CD11b, reactive oxygen intermediates (ROIs), and Toll-like receptor (TLR)-4 were also examined by flow cytometry in matching samples. Results: Serum and RNA samples from forty infants were included (controls n = 20; NE n = 20) over the first week of life. Melatonin reduced neutrophil CD11b and TLR-4 expression in response to LPS in infants with NE compared to controls. There were no differences in ROIs. BMAL1 and CLOCK baseline gene expression levels were similar. BMAL1 was significantly decreased with LPS stimulation in NE. There was no significant diurnal variation in melatonin, neutrophil, and monocyte function or circadian genes. Conclusions: Melatonin alters immune function ex vivo in infants with NE. Infants with NE have altered immune circadian responses following LPS stimulation, which have potential for modulation.
MeSH term(s)	Infant, Newborn ; Humans ; Infant ; Melatonin ; Lipopolysaccharides ; ARNTL Transcription Factors/genetics ; ARNTL Transcription Factors/metabolism ; Brain Diseases ; Reactive Oxygen Species/metabolism ; Immunity
Chemical Substances	Melatonin (JL5DK93RCL) ; Lipopolysaccharides ; ARNTL Transcription Factors ; Reactive Oxygen Species
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2266911-5
ISSN	1661-7819 ; 1661-7800
ISSN (online)	1661-7819
ISSN	1661-7800
DOI	10.1159/000527714
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