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Article ; Online: [No title information]

Øymar, Knut

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2017 Volume 137, Issue 22

Title translation	Fyldig bok for småbarnsforeldre.
Language	Norwegian
Publishing date	2017--28
Publishing country	Norway
Document type	Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.17.0758
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Article ; Online: Blood eosinophils during bronchiolitis were not associated with adult asthma in a Norwegian cohort study.

Sørensen, Karen Galta / Øymar, Knut / Halvorsen, Thomas / Mikalsen, Ingvild Bruun

Acta paediatrica (Oslo, Norway : 1992)

2023 Volume 112, Issue 5, Page(s) 1124–1125

MeSH term(s)	Humans ; Adult ; Infant ; Eosinophils ; Cohort Studies ; Bronchiolitis/complications ; Asthma/epidemiology ; Asthma/complications
Language	English
Publishing date	2023-02-23
Publishing country	Norway
Document type	Letter
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.16710
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Article ; Online: Regionale forskjeller i bruk av protonpumpehemmere hos barn.

Closs, Emilie Raaum / Lyamouri, Miriam / Øymar, Knut / Størdal, Ketil

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2023 Volume 143, Issue 9

Abstract: Background: Physiological gastroesophageal reflux in infancy is difficult to distinguish from reflux disease. International guidelines recommend restrictive use of acid suppression therapy for infants due to the lack of documented effect, but its use in ...

Title translation	Regional differences in the use of proton pump inhibitors in children.
Abstract	Background: Physiological gastroesophageal reflux in infancy is difficult to distinguish from reflux disease. International guidelines recommend restrictive use of acid suppression therapy for infants due to the lack of documented effect, but its use in infants and older children has increased in recent years. This study aims to describe change over time and geographic variation in the investigation and treatment of suspected gastroesophageal reflux disease. Material and method: In aggregated data from the Norwegian Prescribed Drug Registry for the period 1.1.2007-31.12.2020, we examined regional differences in the number of proton pump inhibitors dispensed for children and adolescents. Data from the Norwegian Patient Registry were analysed to identify the use of 24-hour pH measurement and gastroscopy, which can support the suspicion of gastroesophageal reflux disease. Results: The number of proton pump inhibitors dispensed in the first year of life increased and was highest in South-Eastern Norway Regional Health Authority, with 10.1 per 1000 children in 2007 and 54.7 per 1000 children in 2020 (relative risk 5.4, 95 % confidence interval 4.6 to 6.4). The number dispensed in 2020 was 64 % higher in South-Eastern Norway Regional Health Authority compared to Northern Norway Regional Health Authority and Central Norway Regional Health Authority. There was little change in the number of gastroscopies, but use of 24-hour pH measurement fell by 52 % from 2016 to 2020. Interpretation: Use of proton pump inhibitors in infants has increased considerably despite the guidelines. Together with geographic variation, this may point towards overtreatment of physiological reflux in infants. Few investigations indicate that an increasing proportion are treated without supporting diagnostics.
MeSH term(s)	Adolescent ; Infant ; Humans ; Child ; Proton Pump Inhibitors/therapeutic use ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/drug therapy ; Gastroesophageal Reflux/epidemiology ; Group Processes ; Norway/epidemiology
Chemical Substances	Proton Pump Inhibitors
Language	Norwegian
Publishing date	2023-06-12
Publishing country	Norway
Document type	English Abstract ; Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.22.0771
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Article: Early-Onset Sepsis in Neonates - A Population-Based Study in South-West Norway From 1996 to 2018.

Vatne, Anlaug / Klingenberg, Claus / Rettedal, Siren / Øymar, Knut

Frontiers in pediatrics

2021 Volume 9, Page(s) 634798

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.634798
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Article ; Online: Have recommendations on change of treatment had any effect?

Øymar, Knut / Karlstad, Øystein / Størdal, Ketil

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2021 Volume 141

Title translation	Har anbefalinger om endring av behandling effekt?
Language	Norwegian
Publishing date	2021-08-24
Publishing country	Norway
Document type	Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.21.0437
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Article ; Online: Blood eosinophils during bronchiolitis: Associations with atopy, asthma and lung function in young adults.

Sørensen, Karen Galta / Øymar, Knut / Dalen, Ingvild / Halvorsen, Thomas / Bruun Mikalsen, Ingvild

Acta paediatrica (Oslo, Norway : 1992)

2023 Volume 112, Issue 4, Page(s) 820–829

Abstract: Aim: To study if blood eosinophils during bronchiolitis were associated with atopy, asthma and lung function in young adults and if these associations differed between respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis.: Methods! ...

Abstract	Aim: To study if blood eosinophils during bronchiolitis were associated with atopy, asthma and lung function in young adults and if these associations differed between respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis. Methods: This historical cohort enrolled 225 subjects. Blood eosinophils were measured during bronchiolitis in infancy, and the subjects were invited to a follow-up at 17-20 years of age including questionnaires for asthma and examinations of lung function and atopy. Results: The level of eosinophils was positively associated with subsequent atopy in the unadjusted analysis, but not in the adjusted analysis, and not with asthma. There was a negative association between the level of eosinophils and forced vital capacity (FVC) (-0.11; -0.19, -0.02) and forced expiratory volume in first second (FEV Conclusions: The level of eosinophils during bronchiolitis was negatively associated with lung function in young adult age, but we found no associations with atopy or asthma. These associations were not different after RSV bronchiolitis compared to non-RSV bronchiolitis.
MeSH term(s)	Young Adult ; Humans ; Infant ; Eosinophils ; Bronchiolitis/complications ; Asthma/complications ; Respiratory Syncytial Virus Infections/complications ; Tidal Volume ; Lung
Language	English
Publishing date	2023-01-20
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.16666
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Article ; Online: Are BMI and adipokines associated with asthma, atopy and lung function in young adults previously hospitalized for bronchiolitis?

Sørensen, Karen Galta / Øymar, Knut / Jonsson, Grete / Dalen, Ingvild / Halvorsen, Thomas / Mikalsen, Ingvild Bruun

Respiratory medicine

2023 Volume 209, Page(s) 107149

Abstract: Background: Children hospitalized for bronchiolitis have increased risk of asthma and low lung function persisting into adulthood, but the underlying mechanisms are poorly understood. Body mass index (BMI) and adipokines are associated with respiratory ... ...

Abstract	Background: Children hospitalized for bronchiolitis have increased risk of asthma and low lung function persisting into adulthood, but the underlying mechanisms are poorly understood. Body mass index (BMI) and adipokines are associated with respiratory morbidity. We aimed to investigate if associations between BMI and adipokines and the outcomes asthma, atopy, and lung function differed between young adults previously hospitalized for bronchiolitis and control subjects. Methods: This sub study of a historical cohort enrolled 185 young adults previously hospitalized for bronchiolitis and 146 matched control subjects. Exposures (BMI and the adipokines: adiponectin, leptin, resistin, and ghrelin) and outcomes (asthma, atopy, and lung function) were measured cross-sectionally at 17-20 years of age. Associations were tested in regression models, and differences between the post-bronchiolitis- and control group were tested by including interaction terms. Results: BMI was associated with asthma and lung function, but we did not find that the associations differed between the post-bronchiolitis- and control group. We also found some associations between adipokines and outcomes, but only associations between adiponectin and forced vital capacity (FVC) and between resistin and current asthma differed between the groups (p-value interaction term 0.027 and 0.040 respectively). Adiponectin tended to be positively associated with FVC in the post-bronchiolitis group, with an opposite tendency in the control group. Resistin was positively associated with current asthma only in the control group. Conclusion: The increased prevalence of asthma and impaired lung function observed in young adults previously hospitalized for bronchiolitis do not seem to be related to growth and fat metabolism.
MeSH term(s)	Humans ; Young Adult ; Adipokines ; Adiponectin ; Asthma/complications ; Asthma/epidemiology ; Body Mass Index ; Bronchiolitis/complications ; Leptin ; Lung ; Resistin ; Respiratory Function Tests
Chemical Substances	Adipokines ; Adiponectin ; Leptin ; Resistin
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2023.107149
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Article ; Online: Bruk av inhalasjonssteroider hos førskolebarn.

Øymar, Knut

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2012 Volume 132, Issue 2, Page(s) 160–162

Abstract: Due to the large variation in symptoms presented, diagnosing wheezing or asthma and deciding on treatment for preschool children may be difficult. Inhaled corticosteroids may be effective for controlling asthma symptoms and recurrent wheezing also in ... ...

Title translation	The use of inhaled corticosteroids in preschool children.
Abstract	Due to the large variation in symptoms presented, diagnosing wheezing or asthma and deciding on treatment for preschool children may be difficult. Inhaled corticosteroids may be effective for controlling asthma symptoms and recurrent wheezing also in this age group, but due to the heterogeneity of the disease and lack of diagnostic tools, both over- and under-treatment may occur. The author discusses current guidelines and recommendations for the use of inhaled corticosteroids in the preschool group. Inhaled corticosteroids are frequently prescribed in Norway for children in the first two years of life, whereas the guidelines recommend restrictive use of inhaled corticosteroids in this age group.
MeSH term(s)	Administration, Inhalation ; Anti-Asthmatic Agents/administration & dosage ; Anti-Asthmatic Agents/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/therapeutic use ; Child, Preschool ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Humans ; Infant ; Practice Guidelines as Topic ; Respiratory Sounds/diagnosis
Chemical Substances	Anti-Asthmatic Agents ; Bronchodilator Agents ; Glucocorticoids
Language	Norwegian
Publishing date	2012-01-24
Publishing country	Norway
Document type	English Abstract ; Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.10.0742
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Article: The role of tonsillectomy in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome; a literature review.

Førsvoll, Jostein / Øymar, Knut

BMC ear, nose, and throat disorders

2018 Volume 18, Page(s) 3

Abstract: Background: Tonsillectomy (TE) or adenotonsillectomy (ATE) may have a beneficial effect on the clinical course in children with the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome. However, an immunological reason ...

Abstract	Background: Tonsillectomy (TE) or adenotonsillectomy (ATE) may have a beneficial effect on the clinical course in children with the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome. However, an immunological reason for this effect remains unknown. This literature review summarizes the current knowledge of the effect of TE or ATE in the PFAPA syndrome. Methods: A search of PubMed, Medline, EMBASE and Cochrane was conducted for papers written in English dated from 1 January 1987 to 31 December 2016. The search included all studies reporting outcomes after TE or ATE from children aged 0 to 18 years with PFAPA. Results: Two randomized controlled trials reported significantly faster resolution of febrile episodes after TE or ATE in children with PFAPA compared to controls (non-surgery groups). We identified 28 case series including 555 children with PFAPA. The diagnosis was set prospectively before surgery in 440 children and retrospectively after surgery in 115 of the children. TE or ATE had a curative effect in 509 of the 555 children with PFAPA (92%), but few studies were of high quality. Conclusion: TE or ATE may have a curative effect on children with PFAPA, but the evidence is of moderate quality. Further high-quality randomized controlled studies are still needed.
Language	English
Publishing date	2018-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2091302-3
ISSN	1472-6815
ISSN	1472-6815
DOI	10.1186/s12901-017-0049-5
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Article ; Online: Asthma, atopy and lung function in young adults after hospitalisation for bronchiolitis in infancy: impact of virus and sex.

Sørensen, Karen Galta / Øymar, Knut / Dalen, Ingvild / Halvorsen, Thomas / Mikalsen, Ingvild Bruun

BMJ open respiratory research

2022 Volume 9, Issue 1

Abstract: Background: Hospitalisation for bronchiolitis is a risk factor for asthma and impaired lung function during childhood, but outcomes in young adults are poorly described. Our primary aim was to study the prevalence of asthma and atopy, and lung function ... ...

Abstract	Background: Hospitalisation for bronchiolitis is a risk factor for asthma and impaired lung function during childhood, but outcomes in young adults are poorly described. Our primary aim was to study the prevalence of asthma and atopy, and lung function at 17-20 years of age after bronchiolitis in infancy and, secondarily, the impact of viral aetiology (respiratory syncytial virus (RSV) vs non-RSV) and sex on these outcomes. Methods: This Norwegian cohort study enrolled 225 young adults hospitalised for bronchiolitis in infancy during 1996-2001 and 167 matched control subjects. The follow-up included questionnaires for asthma and examinations of lung function and atopy. Outcomes were analysed by mixed effects regressions. Results: Current asthma was more frequent in the postbronchiolitis group versus the control group: 25.1% (95% CI 19.0% to 31.2%) vs 13.1% (95% CI 7.9% to 18.2%), but not atopy: 44.3% (95% CI 37.1% to 51.5%) vs 48.2% (95% CI 40.5% to 55.8%), adjusted predicted proportions (95% CIs). Asthma prevalence did not differ between the RSV group and the non-RSV group: 24.0% (95% CI 16.1% to 32.0%) vs 23.8% (95% CI 12.8% to 34.7%) nor between sexes. Forced expiratory volume in 1 s (FEV Conclusion: Young adults hospitalised for bronchiolitis had higher prevalence of asthma, but not atopy, and a more obstructive lung function pattern than control subjects. The asthma prevalence was high after both RSV bronchiolitis and non-RSV bronchiolitis, and there was no difference between sexes. Bronchiolitis in infancy is associated with respiratory morbidity persisting into young adulthood.
MeSH term(s)	Adult ; Asthma ; Bronchiolitis/complications ; Case-Control Studies ; Cohort Studies ; Follow-Up Studies ; Hospitalization ; Humans ; Lung ; Respiratory Sounds ; Young Adult
Language	English
Publishing date	2022-01-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2021-001095
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