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  1. Article: John Benjamin Murphy.

    George, Isaac / Hardy, Mark A / Widmann, Warren D

    Current surgery

    2004  Volume 61, Issue 5, Page(s) 439–441

    MeSH term(s) Chicago ; General Surgery/history ; History, 19th Century ; History, 20th Century ; Wisconsin
    Language English
    Publishing date 2004-09
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 428044-1
    ISSN 0149-7944
    ISSN 0149-7944
    DOI 10.1016/j.cursur.2003.12.009
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  2. Article ; Online: PINK1: From Parkinson's disease to mitophagy and back again.

    O'Callaghan, Benjamin / Hardy, John / Plun-Favreau, Helene

    PLoS biology

    2023  Volume 21, Issue 6, Page(s) e3002196

    Abstract: The genetics of Parkinson's disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade. ...

    Abstract The genetics of Parkinson's disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade.
    MeSH term(s) Humans ; Mitophagy ; Protein Kinases/genetics ; Parkinson Disease/genetics ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances Protein Kinases (EC 2.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002196
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  3. Article: Genetic diversity assessment of

    Van Rossum, Fabienne / Godé, Cécile / Baruca Arbeiter, Alenka / Raspé, Olivier / Simsek, Melike / Barigand, Benjamin / Hardy, Olivier J / Bandelj, Dunja

    Ecology and evolution

    2024  Volume 14, Issue 2, Page(s) e10953

    Abstract: Helichrysum ... ...

    Abstract Helichrysum arenarium
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10953
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  4. Article ; Online: Long-term functional outcomes in polytrauma: a fundamentally new approach is needed in prediction.

    Meakes, Simone / Enninghorst, Natalie / Weaver, Natasha / Hardy, Benjamin M / Balogh, Zsolt J

    European journal of trauma and emergency surgery : official publication of the European Trauma Society

    2024  

    Abstract: Purpose: Modern trauma care has reduced mortality but poor long-term outcomes with low follow-up rates are common with limited recommendations for improvements. The aim of this study was to describe the impact of severe injury on the health-related ... ...

    Abstract Purpose: Modern trauma care has reduced mortality but poor long-term outcomes with low follow-up rates are common with limited recommendations for improvements. The aim of this study was to describe the impact of severe injury on the health-related quality of life, specifically characterise the non-responder population and to identify modifiable predictors of poorer outcomes.
    Methods: Five-year (2012-2016) prospective cohort study was performed at a level 1 trauma centre. Baseline Short-Form Health Survey (SF36) was collected at admission, and at 6 and 12 months postinjury together with demographics, injury mechanism and severity, psychosocial wellbeing, and return to work capacity.
    Results: Of the 306 consecutive patients [age 52 ± 17 years, male 72%, ISS 21 (17, 29), mortality 5%], 195 (64%) completed questionnaires at baseline, and at 12 months. Preinjury physical health scores were above the general population (53.1 vs. 50.3, p < 0.001) and mental health component was consistent with the population norms (51.7 vs. 52.9, p = 0.065). One year following injury, both physical health (13.2, 95% CI 14.8, 11.6) and mental health scores (6.0, 95% CI 8.1, 3.8) were significantly below age- and sex-adjusted preinjury baselines. Non-responders had similar ISS but with a lower admission GCS, and were more likely to be younger, and without comorbidities, employment, or university education.
    Conclusion: Contrary to their better than population norm preinjury health status, polytrauma patients remain functionally impaired at least 1 year after injury. The identified high risk for non-responding group needs more focused efforts for follow-up. A fundamentally different approach is required in polytrauma research which identify modifiable predictors of poor long-term outcomes.
    Language English
    Publishing date 2024-02-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2275480-5
    ISSN 1863-9941 ; 1863-9933
    ISSN (online) 1863-9941
    ISSN 1863-9933
    DOI 10.1007/s00068-023-02430-6
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    Zs.MO 607: Show issues

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  5. Article ; Online: Emergency schedule management for COVID-19.

    Hardy, Benjamin / Marshall, Chris

    British journal of anaesthesia

    2020  Volume 125, Issue 5, Page(s) e428–e429

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Critical Care/organization & administration ; Health Resources/organization & administration ; Hospital Administration/methods ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.07.020
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  6. Article ; Online: Sexual and Reproductive Health Care Visits as a Venue for Preexposure Prophylaxis Service Delivery Among Women in the United States: Results From a Nationally Representative Survey.

    Weigel, Gabriela / Theva, Meena / Hardy, Erica / Wagner, Stephen / Brown, Benjamin

    Sexually transmitted diseases

    2023  Volume 50, Issue 11, Page(s) 726–730

    Abstract: Background: Preexposure prophylaxis (PrEP) for HIV is disproportionately underprescribed to women. Centers for Disease Control and Prevention guidelines identify a group of women at risk of HIV acquisition who should be offered PrEP, but opportunities ... ...

    Abstract Background: Preexposure prophylaxis (PrEP) for HIV is disproportionately underprescribed to women. Centers for Disease Control and Prevention guidelines identify a group of women at risk of HIV acquisition who should be offered PrEP, but opportunities remain to improve patient awareness of and provider counseling about PrEP and to expand service delivery of PrEP.
    Methods: Using nationally representative data from the 2017-2019 National Survey of Family Growth, we compared women with (n = 689) and without (n = 5,452) Centers for Disease Control and Prevention indications for PrEP on measures of PrEP awareness, counseling by a provider, and interaction with the health care system.
    Results: Women with PrEP indications were no more likely to report awareness of PrEP (odds ratio [OR], 1.03; 95% confidence interval [CI], 0.82-1.29) or PrEP counseling by a provider (OR, 1.32; 95% CI, 0.77-2.27), compared with those without PrEP indications. However, women with PrEP indications were more likely than those without to report a birth control visit (OR, 1.82; 95% CI, 1.39-2.38) or an abortion within the last 12 months (OR, 5.93; 95% CI, 1.48-23.73), and to currently use prescription contraception (OR, 1.45; 95% CI, 1.19-1.78). A majority of both groups reported accessing prenatal care within the last 12 months.
    Conclusions: There remains a gap in PrEP awareness and counseling among women at highest risk for HIV acquisition. Sexual and reproductive health visits represent a logical and feasible venue for PrEP provision. Obstetrician-gynecologists and other family planning providers may be able to aid in service delivery innovations by providing PrEP alongside other sexual and reproductive health care.
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000001805
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  8. Article ; Online: Emergency schedule management for COVID-19

    Hardy, Benjamin / Marshall, Chris

    British Journal of Anaesthesia

    2020  Volume 125, Issue 5, Page(s) e428–e429

    Keywords Anesthesiology and Pain Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.07.020
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The outcomes of the most severe polytrauma patients: a systematic review of the use of high ISS cutoffs for performance measurement.

    Hardy, Benjamin M / Varghese, Adrian / Adams, Megan J / Enninghorst, Natalie / Balogh, Zsolt J

    European journal of trauma and emergency surgery : official publication of the European Trauma Society

    2023  

    Abstract: Background: This systematic review aimed to describe the outcomes of the most severely injured polytrauma patients and identify the consistent Injury Severity Score based definition of utilised for their definition. This could provide a global standard ... ...

    Abstract Background: This systematic review aimed to describe the outcomes of the most severely injured polytrauma patients and identify the consistent Injury Severity Score based definition of utilised for their definition. This could provide a global standard for trauma system benchmarking.
    Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist was applied to this review. We searched Medline, Embase, Cochrane Reviews, CINAHL, CENTRAL from inception until July 2022. Case reports were excluded. Studies in all languages that reported the outcomes of adult and paediatric patients with an ISS 40 and above were included. Abstracts were screened by two authors and ties adjudicated by the senior author.
    Results: 7500 abstracts were screened after excluding 13 duplicates. 56 Full texts were reviewed and 37 were excluded. Reported ISS groups varied widely between the years 1986 and 2022. ISS groups reported ranged from 40-75 up to 51-75. Mortality varied between 27 and 100%. The numbers of patients in the highest ISS group ranged between 15 and 1451.
    Conclusions: There are very few critically injured patients reported during the last 48 years. The most critically injured polytrauma patients still have at least a 50% risk of death. There is no consistent inclusion and exclusion criteria for this high-risk cohort. The current approach to reporting is not suitable for monitoring the epidemiology and outcomes of the critically injured polytrauma patients.
    Level of evidence: Level 4-systematic review of level 4 studies.
    Language English
    Publishing date 2023-12-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2275480-5
    ISSN 1863-9941 ; 1863-9933
    ISSN (online) 1863-9941
    ISSN 1863-9933
    DOI 10.1007/s00068-023-02409-3
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  10. Article ; Online: The most critically injured polytrauma patient mortality: should it be a measurement of trauma system performance?

    Hardy, Benjamin Maurice / Enninghorst, Natalie / King, Kate Louise / Balogh, Zsolt Janos

    European journal of trauma and emergency surgery : official publication of the European Trauma Society

    2022  Volume 50, Issue 1, Page(s) 115–119

    Abstract: Purpose: The risk of death after traumatic injury in developed trauma systems is at an all-time low. Among 'major trauma' patients (injury severity score, ISS > 15), the risk of dying is less than 10%. This group contains critical polytrauma patients ( ... ...

    Abstract Purpose: The risk of death after traumatic injury in developed trauma systems is at an all-time low. Among 'major trauma' patients (injury severity score, ISS > 15), the risk of dying is less than 10%. This group contains critical polytrauma patients (ISS 50-75), with high risks of death. We hypothesized that the reduction in trauma mortality was driven by reduction in moderate injury severity and that death from critical polytrauma remained persistently high.
    Methods: A 20-year retrospective analysis ending December 2021 of a Level-1 trauma center's registry was performed on all trauma patients admitted with ISS > 15. Patients' demographics, injury severity and outcomes were collected. Multivariate logistic regression analysis was performed. Mortality was examined for the entire study group and separately for the subset of critical polytrauma patients (ISS 50-75).
    Results: A total of 8462 severely injured (ISS > 15) trauma patients were identified during the 20-year period. Of these 238 (2.8%) were critical polytrauma patients (ISS 50-75). ISS > 15 mortality decreased from 11.3 to 9.4% over the study period (Adjusted OR 0.98, 0.97-0.99). ISS 50-75 mortality did not change significantly (46.2-60.0%), adjusted OR 0.96, 0.92-1.00).
    Conclusion: The improvement in trauma mortality over the past 20 years has not been experienced equally. The ISS50-75 critical polytrauma mortality is a practical group to capture. It could be a group for deeper study and reporting to drive improvement.
    MeSH term(s) Humans ; Retrospective Studies ; Multiple Trauma ; Injury Severity Score ; Hospitalization ; Registries ; Trauma Centers
    Language English
    Publishing date 2022-08-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2275480-5
    ISSN 1863-9941 ; 1863-9933
    ISSN (online) 1863-9941
    ISSN 1863-9933
    DOI 10.1007/s00068-022-02073-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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