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Article ; Online: Vaccination, Acute Myocardial Infarction, and Ischemic Stroke After COVID-19 Infection-Reply.

Huh, Kyungmin / Kim, Young-Eun / Jung, Jaehun

2023 Volume 329, Issue 5, Page(s) 426–427

MeSH term(s)	Humans ; Brain Ischemia/etiology ; COVID-19/complications ; COVID-19/prevention & control ; Ischemic Stroke/etiology ; Myocardial Infarction/etiology ; Risk Factors ; Vaccination ; COVID-19 Vaccines/therapeutic use
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2022.21627
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Article ; Online: Impact of National Public-Private Mix and Medical Expense Support Program for Control Tuberculosis in South Korea: An Interrupted Time Series Analysis.

Oh, In-Sun / Kim, Ju Hwan / Huh, Kyungmin / Jang, Seung Hun / Shin, Ju-Young

The Journal of infectious diseases

2024

Abstract: Tuberculosis (TB) remains a major threat to global public health, various measures at national level have been implemented to control TB and no evidence with long-term effectiveness has yet been evaluated on TB control programs. We confirmed the long- ... ...

Abstract	Tuberculosis (TB) remains a major threat to global public health, various measures at national level have been implemented to control TB and no evidence with long-term effectiveness has yet been evaluated on TB control programs. We confirmed the long-term effectiveness of the TB control programs in reducing overall burden in South Korea using interrupted time series analysis. Along with the Public-Private Mix, our finding suggests that relieving the economic burden of people with TB may further complement in achieving the End TB strategy. For countries currently developing strategies for TB control, results may provide important insights in effective TB control.
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiae059
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Article ; Online: Lack of association between fluoroquinolone and aortic aneurysm or dissection.

Huh, Kyungmin / Kang, Minsun / Jung, Jaehun

European heart journal

2023 Volume 44, Issue 42, Page(s) 4476–4484

Abstract: Background and aims: An increased risk of aortic aneurysm and aortic dissection (AA/AD) has been reported with fluoroquinolone (FQ) use. However, recent studies suggested confounding factors by indication. This study aimed to investigate the risk of AA/ ... ...

Abstract	Background and aims: An increased risk of aortic aneurysm and aortic dissection (AA/AD) has been reported with fluoroquinolone (FQ) use. However, recent studies suggested confounding factors by indication. This study aimed to investigate the risk of AA/AD associated with FQ use. Methods: This nationwide population-based study included adults aged ≥20 years who received a prescription of oral FQ or third-generation cephalosporins (3GC) during outpatient visits from 2005 to 2016. Data source was the National Health Insurance Service reimbursement database. The primary outcome was hospitalization or in-hospital death with a primary diagnosis of AA/AD. A self-controlled case series (SCCS) and Cox proportional hazards model were used. Self-controlled case series compared the incidence of the primary outcome in the risk period vs. the control periods. Results: A total of 954 308 patients (777 109 with FQ and 177 199 with 3GC use) were included. The incidence rate ratios for AA/AD between the risk period and the pre-risk period were higher in the 3GC group [11.000; 95% confidence interval (CI) 1.420-85.200] compared to the FQ group (2.000; 95% CI 0.970-4.124). The overall incidence of AA/AD among the patients who received FQ and 3GC was 5.40 and 8.47 per 100 000 person-years. There was no significant difference in the risk between the two groups (adjusted hazard ratio 0.752; 95% CI 0.515-1.100) in the inverse probability of treatment-weighted Cox proportional hazards model. Subgroup and sensitivity analysis showed consistent results. Conclusions: There was no significant difference in the risk of AA/AD in patients who were administered oral FQ compared to those administered 3GC. The study findings suggest that the use of FQ should not be deterred when clinically indicated.
MeSH term(s)	Adult ; Humans ; Fluoroquinolones/adverse effects ; Anti-Bacterial Agents/adverse effects ; Hospital Mortality ; Risk Factors ; Aortic Aneurysm/chemically induced ; Aortic Aneurysm/epidemiology ; Aortic Aneurysm/diagnosis ; Aortic Dissection/chemically induced ; Aortic Dissection/epidemiology
Chemical Substances	Fluoroquinolones ; Anti-Bacterial Agents
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehad627
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Article: Emergent Strategies for the Next Phase of COVID-19.

Huh, Kyungmin / Shin, Hyoung Shik / Peck, Kyong Ran

Infection & chemotherapy

2020 Volume 52, Issue 1, Page(s) 105–109

Keywords	covid19
Language	English
Publishing date	2020-02-25
Publishing country	Korea (South)
Document type	Editorial
ZDB-ID	2573798-3
ISSN	2093-2340
ISSN	2093-2340
DOI	10.3947/ic.2020.52.1.105
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Article: Correction: Candidemia Risk Prediction (CanDETEC) Model for Patients With Malignancy: Model Development and Validation in a Single-Center Retrospective Study.

Yoo, Junsang / Kim, Si-Ho / Hur, Sujeong / Ha, Juhyung / Huh, Kyungmin / Cha, Won Chul

JMIR medical informatics

2022 Volume 10, Issue 1, Page(s) e36385

Abstract: This corrects the article DOI: 10.2196/24651.]. ...

Abstract	[This corrects the article DOI: 10.2196/24651.].
Language	English
Publishing date	2022-01-19
Publishing country	Canada
Document type	Published Erratum
ZDB-ID	2798261-0
ISSN	2291-9694
ISSN	2291-9694
DOI	10.2196/36385
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Article ; Online: Correction: Clinical efficacy and safety of interferon (Type I and Type III) therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials.

Ryoo, Seungeun / Koh, Dae-Hyup / Yu, Su-Yeon / Choi, Miyoung / Huh, Kyungmin / Yeom, Joon-Sup / Heo, Jung Yeon

PloS one

2023 Volume 18, Issue 12, Page(s) e0296219

Abstract: This corrects the article DOI: 10.1371/journal.pone.0272826.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0272826.].
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0296219
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Article ; Online: Risk of mortality and clinical outcomes associated with healthcare delay among patients with tuberculosis.

Bea, Sungho / Lee, Hyesung / Choi, Won Suk / Huh, Kyungmin / Jung, Jaehun / Shin, Ju-Young

Journal of infection and public health

2023 Volume 16, Issue 8, Page(s) 1313–1321

Abstract: Background: To eliminate tuberculosis (TB), World Health Organization (WHO) initiated "The End TB Strategy" with the goal of a 95% reduction in deaths. While many resources are contributed to eradicating TB, a substantial number of TB patients are still ...

Abstract	Background: To eliminate tuberculosis (TB), World Health Organization (WHO) initiated "The End TB Strategy" with the goal of a 95% reduction in deaths. While many resources are contributed to eradicating TB, a substantial number of TB patients are still unlikely to receive timely treatment. Thus, we aimed to measure healthcare delay and its association with clinical outcomes from 2013 to 2018. Methods: We conducted a retrospective cohort study using linked data of the National Tuberculosis Surveillance Registry and the health insurance claims data of South Korea. We included incident TB patients, and healthcare delay was defined as the period between the first medical visit with TB-related symptoms and the initiation of an anti-TB regimen. We described the distribution of healthcare delay, and the study population was classified into two groups with mean as a cutoff. The association between healthcare delay and clinical outcomes (all-cause mortality, pneumonia, progression to multi/extensively drug-resistant, intensive care unit admission, and mechanical ventilation use) was evaluated using the Cox proportional hazard model. Several stratified and sensitivity analyses were also conducted. Results: Among 39,747 patients with pulmonary TB, mean healthcare delay was 42.3 days and delayed and non-delayed groups, classified by mean (or average), were 10,680 (26.9%) and 29,067 (73.1%), respectively. Healthcare delay was associated with an increased risk of all-cause mortality (HR 1.10, 95% CI 1.03-1.17), pneumonia (HR 1.13, 95% CI 1.09-1.18), and mechanical ventilation use (HR 1.15, 95% CI 1.01-1.32). We also observed the duration-response of healthcare delay. Stratified analyses showed patients with respiratory diseases were at higher risk, and consistent results were observed in sensitivity analyses. Conclusions: We observed a substantial number of patients experiencing healthcare delays, and it was associated with the deterioration of clinical outcomes. Our findings suggest that attention from authorities and healthcare professionals is needed to attenuate the preventable burden caused by TB through timely treatment.
MeSH term(s)	Humans ; Retrospective Studies ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Tuberculosis/diagnosis ; Delivery of Health Care ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/epidemiology ; Health Facilities
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2023.05.038
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Article ; Online: The effects of remdesivir on mortality and the requirement for mechanical ventilation in patients with COVID-19: a systematic review stratified by disease severity.

Ryoo, Seungeun / Choi, Miyoung / Yu, Su-Yeon / Yoon, Young Kyung / Huh, Kyungmin / Joo, Eun-Jeong

The Korean journal of internal medicine

2023 Volume 39, Issue 1, Page(s) 160–171

Abstract: Background/aims: The effectiveness of remdesivir treatment in reducing mortality and the requirement for mechanical ventilation (MV) remains uncertain, as randomized controlled trials (RCTs) have produced conflicting results.: Methods: We searched ... ...

Abstract	Background/aims: The effectiveness of remdesivir treatment in reducing mortality and the requirement for mechanical ventilation (MV) remains uncertain, as randomized controlled trials (RCTs) have produced conflicting results. Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and other data resources to find RCTs published prior to April 10, 2023. The selection of studies, assessment of risk of bias, and meta-analysis were conducted according to PRISMA guidelines. The primary outcomes were all-cause mortality and the need to initiate MV. Results: A total of 5,068 articles were screened, from eight RCTs comprising 11,945 patients. The meta-analysis found that, compared to standard care or placebo, remdesivir treatment provided no significant all-cause mortality benefit (pooled risk ratio [RR], 0.93; 95% confidence interval [CI], 0.85-1.02; 8 studies; high certainty evidence), while subgroup analyses revealed a trend towards reduced mortality among patients requiring oxygen but not MV (pooled RR, 0.88; 95% CI, 0.77-1.00; 6 studies; I2 = 4%). The need to initiate MV (pooled RR, 0.74; 95% CI, 0.59-0.94; 7 studies; moderate certainty evidence) in remdesivir-treated patients was also reduced compared to controls. Remdesivir significantly increased clinical improvement and discharge and significantly reduced serious adverse events. Conclusion: In this systematic review and meta-analysis of RCTs, it was found that remdesivir treatment did not show a substantial decrease in the risk of mortality. However, it was linked to a reduction in the necessity for additional ventilatory support, suggesting remdesivir could be beneficial for COVID-19 patients, particularly those who are not on MV.
MeSH term(s)	Humans ; COVID-19 ; Respiration, Artificial ; COVID-19 Drug Treatment ; Patient Acuity ; Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives
Chemical Substances	remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2023-12-28
Publishing country	Korea (South)
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639023-7
ISSN	2005-6648 ; 1226-3303
ISSN (online)	2005-6648
ISSN	1226-3303
DOI	10.3904/kjim.2023.357
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Article ; Online: Model-informed COVID-19 exit strategy with projections of SARS-CoV-2 infections generated by variants in the Republic of Korea.

Jung, Sung-Mok / Huh, Kyungmin / Radnaabaatar, Munkhzul / Jung, Jaehun

BMC public health

2022 Volume 22, Issue 1, Page(s) 2098

Abstract: Background: With the prompt administration of coronavirus disease 2019 (COVID-19) vaccines, highly vaccinated countries have begun to lift their stringent control measures. However, considering the spread of highly transmissible new variants, resuming ... ...

Abstract	Background: With the prompt administration of coronavirus disease 2019 (COVID-19) vaccines, highly vaccinated countries have begun to lift their stringent control measures. However, considering the spread of highly transmissible new variants, resuming socio-economic activities may lead to the resurgence of incidence, particularly in nations with a low proportion of individuals who have natural immunity. Here, we aimed to quantitatively assess an optimal COVID-19 exit strategy in the Republic of Korea, where only a small number of cumulative incidences have been recorded as of September 2021, comparing epidemiological outcomes via scenario analysis. Methods: A discrete-time deterministic compartmental model structured by age group was used, accounting for the variant-specific transmission dynamics and the currently planned nationwide vaccination. All parameters were calibrated using comprehensive empirical data obtained from the Korea Disease Control and Prevention Agency. Results: Our projection suggests that tapering the level of social distancing countermeasures to the minimum level from November 2021 can efficiently suppress a resurgence of incidence given the currently planned nationwide vaccine roll-out. In addition, considering the spread of the Delta variant, our model suggested that gradual easing of countermeasures for more than 4 months can efficiently withstand the prevalence of severe COVID-19 cases until the end of 2022. Conclusions: Our model-based projections provide evidence-based guidance for an exit strategy that allows society to resume normal life while sustaining the suppression of the COVID-19 epidemic in countries where the spread of COVID-19 has been well controlled.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccination ; Epidemics
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-022-14576-w
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Article ; Online: The effects of remdesivir on mortality and the requirement for mechanical ventilation in patients with COVID-19

Seungeun Ryoo / Miyoung Choi / Su-Yeon Yu / Young Kyung Yoon / Kyungmin Huh / Eun-Jeong Joo

The Korean Journal of Internal Medicine, Vol 39, Iss 1, Pp 160-

a systematic review stratified by disease severity

2024 Volume 171

Abstract: Background/Aims The effectiveness of remdesivir treatment in reducing mortality and the requirement for mechanical ventilation (MV) remains uncertain, as randomized controlled trials (RCTs) have produced conflicting results. Methods We searched MEDLINE, ... ...

Abstract	Background/Aims The effectiveness of remdesivir treatment in reducing mortality and the requirement for mechanical ventilation (MV) remains uncertain, as randomized controlled trials (RCTs) have produced conflicting results. Methods We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and other data resources to find RCTs published prior to April 10, 2023. The selection of studies, assessment of risk of bias, and meta-analysis were conducted according to PRISMA guidelines. The primary outcomes were all-cause mortality and the need to initiate MV. Results A total of 5,068 articles were screened, from eight RCTs comprising 11,945 patients. The meta-analysis found that, compared to standard care or placebo, remdesivir treatment provided no significant all-cause mortality benefit (pooled risk ratio [RR], 0.93; 95% confidence interval [CI], 0.85–1.02; 8 studies; high certainty evidence), while subgroup analyses revealed a trend towards reduced mortality among patients requiring oxygen but not MV (pooled RR, 0.88; 95% CI, 0.77–1.00; 6 studies; I2 = 4%). The need to initiate MV (pooled RR, 0.74; 95% CI, 0.59–0.94; 7 studies; moderate certainty evidence) in remdesivir-treated patients was also reduced compared to controls. Remdesivir significantly increased clinical improvement and discharge and significantly reduced serious adverse events. Conclusions In this systematic review and meta-analysis of RCTs, it was found that remdesivir treatment did not show a substantial decrease in the risk of mortality. However, it was linked to a reduction in the necessity for additional ventilatory support, suggesting remdesivir could be beneficial for COVID-19 patients, particularly those who are not on MV.
Keywords	covid-19 ; covid-19 drug treatment ; systematic review ; mortality ; ventilators ; mechanical ; Medicine ; R
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	The Korean Association of Internal Medicine
Document type	Article ; Online
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