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  1. Article ; Online: Parameterization of General Organic Polymers within the Open Force Field Framework.

    Davel, Connor M / Bernat, Timotej / Wagner, Jeffrey R / Shirts, Michael R

    Journal of chemical information and modeling

    2024  Volume 64, Issue 4, Page(s) 1290–1305

    Abstract: Polymer and chemically modified biopolymer systems present unique challenges to traditional molecular simulation preparation workflows. First, typical polymer and biomolecular input formats, such as Protein Data Bank (PDB) files, lack adequate chemical ... ...

    Abstract Polymer and chemically modified biopolymer systems present unique challenges to traditional molecular simulation preparation workflows. First, typical polymer and biomolecular input formats, such as Protein Data Bank (PDB) files, lack adequate chemical information needed for the parameterization of new chemistries. Second, polymers are typically too large for accurate partial charge generation methods. In this work, we employ direct chemical perception through the Open Force Field toolkit to create a flexible polymer simulation workflow for organic polymers, encompassing everything from biopolymers to soft materials. We propose and test a new input specification for monomer information that can, along with a 3D conformational geometry, parametrize and simulate most soft-material systems within the same workflow used for smaller ligands. The monomer format encompasses a subset of the SMIRKS substructure query language to uniquely identify chemical information and repeating charges in underspecified systems through matching atomic connectivity. This workflow is combined with several different approaches for automatic partial-charge generation for larger systems. As an initial proof of concept, a variety of diverse polymeric systems were parametrized with the Open Force Field toolkit, including functionalized proteins, DNA, homopolymers, cross-linked systems, and sugars. Additionally, shape properties and radial distribution functions were computed from molecular dynamics simulations of poly(ethylene glycol), polyacrylamide, and poly(
    MeSH term(s) Polymers/chemistry ; Molecular Dynamics Simulation ; Biopolymers ; Proteins/chemistry ; Molecular Conformation
    Chemical Substances Polymers ; Biopolymers ; Proteins
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.3c01691
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1230: Show issues Location:
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  2. Article ; Online: Hospitalizations for heart failure and mortality risk during the evolving coronavirus disease 2019 pandemic - the wave may break but a dangerous undertow persists.

    Wagner, Jeffrey R / Ambrosy, Andrew P

    European journal of heart failure

    2020  Volume 22, Issue 12, Page(s) 2225–2227

    MeSH term(s) COVID-19 ; Heart Failure/epidemiology ; Hospitalization ; Humans ; London ; Pandemics ; Referral and Consultation ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-16
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2043
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    Zs.A 5299: Show issues Location:
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  3. Book ; Article ; Online: Financial access and digital services within agri-food value chains in Uganda

    Adong, Annet / Ambler, Kate / Bloem, Jeffrey R. / de Brauw, Alan / Wagner, Julia / Bloem, Jeffrey

    2023  

    Abstract: Agri-food value chains represent an important element of food systems and economies around the world. For example, intermediary agri-food value chain actors—those operating enterprises that transport and transform food from the farmgate to retailers— ... ...

    Abstract Agri-food value chains represent an important element of food systems and economies around the world. For example, intermediary agri-food value chain actors—those operating enterprises that transport and transform food from the farmgate to retailers—account for a substantial share, often between 60 and 75 percent, of value-added produced by the entire agricultural sector of an economy.

    Non-PR

    IFPRI1; DCA; 1 Fostering Climate-Resilient and Sustainable Food Supply; 3 Building Inclusive and Efficient Markets, Trade Systems, and Food Industry; 4 Transforming Agricultural and Rural Economies; Digital Financial Services Adoption

    Markets, Trade, and Institutions (MTI); Food and Nutrition Policy
    Keywords UGANDA ; EAST AFRICA ; AFRICA SOUTH OF SAHARA ; AFRICA ; arabica coffee ; data collection ; finances ; food systems ; production ; soybeans ; surveys ; survey design ; value chains ; digital finance services
    Language English
    Publisher International Food Policy Research Institute (IFPRI)
    Publishing country us
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Article ; Online: Financial access and digital services within agri-food value chains in Bangladesh

    Ambler, Kate / Bloem, Jeffrey R. / de Brauw, Alan / Islam, Saiful / Wagner, Julia / Bloem, Jeffrey

    2023  

    Abstract: Agri-food value chains are a crucial element of food systems and local economies around the world. Existing estimates show that intermediary agri-food value chain actors—the operating enterprises that transport and transform food from the farmgate to ... ...

    Abstract Agri-food value chains are a crucial element of food systems and local economies around the world. Existing estimates show that intermediary agri-food value chain actors—the operating enterprises that transport and transform food from the farmgate to retailers—account for 60 to 75 percent of value-added produced by the entire agricultural sector of an economy.

    Non-PR

    IFPRI1; 3 Building Inclusive and Efficient Markets, Trade Systems, and Food Industry; 4 Transforming Agricultural and Rural Economies; DCA; Digital Financial Services Adoption

    Markets, Trade, and Institutions (MTI); Food and Nutrition Policy
    Keywords agrifood systems ; digital technology ; access to finance ; value chains ; economic activities ; value added ; agricultural sector
    Language English
    Publisher International Food Policy Research Institute (IFPRI)
    Publishing country us
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Hospitalizations for heart failure and mortality risk during the evolving coronavirus disease 2019 pandemic - the wave may break but a dangerous undertow persists

    Wagner, Jeffrey R / Ambrosy, Andrew P

    Eur. j. heart fail

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #893221
    Database COVID19

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  6. Article ; Online: Recognizing Suicidal Risk in Very Young Children.

    Wagner, Elizabeth / Gottipaty, Anjali / Hunt, Jeffrey I / Boekamp, John R

    Rhode Island medical journal (2013)

    2022  Volume 105, Issue 4, Page(s) 36–39

    Abstract: Suicidal thought and behavior (STB) in preschool and kindergarten-age children is an alarming event. Until recently, these young children's experiences have been under recognized, in part due to an under appreciation for their awareness of the finality ... ...

    Abstract Suicidal thought and behavior (STB) in preschool and kindergarten-age children is an alarming event. Until recently, these young children's experiences have been under recognized, in part due to an under appreciation for their awareness of the finality of death. Although rare, serious suicide attempts and death by suicide among preschool and kindergarten-age children are well documented. There is limited research on the risk factors that contribute to STB in very young children. We present de-identified case descriptions of very young children seen for psychiatric treatment at a day hospital program who presented with self-injurious behavior and suicidal ideation (SI). The patients described have common risk factors, including exposure to trauma, family conflict and family history of suicidal behavior. It is critical that children presenting with STB be assessed and offered services to mitigate these risks.
    MeSH term(s) Child ; Child, Preschool ; Humans ; Risk Factors ; Suicidal Ideation ; Suicide, Attempted
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 419430-5
    ISSN 2327-2228 ; 0363-7913
    ISSN (online) 2327-2228
    ISSN 0363-7913
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    Zs.A 222: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Thriving from Work Questionnaire: Dimensionality, reliability, and validity of the long and short form questionnaires.

    Peters, Susan E / Gundersen, Daniel A / Katz, Jeffrey N / Sorensen, Glorian / Wagner, Gregory R

    American journal of industrial medicine

    2023  Volume 66, Issue 4, Page(s) 281–296

    Abstract: Introduction: Thriving from Work is defined as the state of positive mental, physical, and social functioning in which workers' experiences of their work and working conditions enable them to thrive in their overall lives, contributing to their ability ... ...

    Abstract Introduction: Thriving from Work is defined as the state of positive mental, physical, and social functioning in which workers' experiences of their work and working conditions enable them to thrive in their overall lives, contributing to their ability to achieve their full potential at work, at home, and in the community. The purpose of this study was to develop a psychometrically-sound questionnaire measuring the positive contribution that work can have on one's well-being both at, and outside of, their work.
    Methods: We used both a qualitative and quantitative approach of item reduction, domain mapping dimensionality testing, development of "long-" and "short-" versions of the questionnaire, reliability, and construct and criterion validity testing. This was established in two independent online samples of US based workers (n = 1550, n = 500).
    Results: We developed a bi-factor model 30-item long-form and a uni-factorial 8-item short-version. The long-form measures both the latent construct of Thriving from Work and six domains (psychological/emotional; work-life integration; social; experience of work; basic needs; health). Both long- and short- forms were found to have high empirical reliability (0.93  and 0.87 respectively). The short-form captures 94% of variance of the long-form. Construct and criterion validity were supported. Test-retest reliability was high.
    Conclusions: The Thriving from Work Questionnaire appears to be a valid and reliable measure of work-related well-being in United States workers. Further testing is needed to refine and test the instrument in specific industries, unique worker populations, and across geographic regions.
    MeSH term(s) Humans ; Reproducibility of Results ; Psychometrics ; Surveys and Questionnaires ; Quality of Life/psychology
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 604538-8
    ISSN 1097-0274 ; 0271-3586
    ISSN (online) 1097-0274
    ISSN 0271-3586
    DOI 10.1002/ajim.23465
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    Zs.A 1605: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Book ; Online: Financial access and digital services within agri-food value chains in Uganda

    Adong, Annet / Ambler, Kate / Bloem, Jeffrey R. / de Brauw, Alan / Wagner, Julia

    2023  

    Abstract: Agri-food value chains represent an important element of food systems and economies around the world. For example, intermediary agri-food value chain actors—those operating enterprises that transport and transform food from the farmgate to retailers— ... ...

    Abstract Agri-food value chains represent an important element of food systems and economies around the world. For example, intermediary agri-food value chain actors—those operating enterprises that transport and transform food from the farmgate to retailers—account for a substantial share, often between 60 and 75 percent, of value-added produced by the entire agricultural sector of an economy.
    Keywords arabica coffee ; data collection ; food systems ; production ; soybeans ; surveys ; survey design ; value chains
    Language English
    Publishing date 2023-10-27T19:36:01Z
    Publisher International Food Policy Research Institute
    Publishing country fr
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Microdystrophin Expression as a Surrogate Endpoint for Duchenne Muscular Dystrophy Clinical Trials.

    Chamberlain, Jeffrey S / Robb, Melissa / Braun, Serge / Brown, Kristy J / Danos, Olivier / Ganot, Annie / Gonzalez-Alegre, Pedro / Hunter, Nina / McDonald, Craig / Morris, Carl / Tobolowsky, Mark / Wagner, Kathryn R / Ziolkowski, Olivia / Duan, Dongsheng

    Human gene therapy

    2023  Volume 34, Issue 9-10, Page(s) 404–415

    Abstract: Duchenne muscular dystrophy (DMD) is a serious, rare genetic disease, affecting primarily boys. It is caused by mutations in ... ...

    Abstract Duchenne muscular dystrophy (DMD) is a serious, rare genetic disease, affecting primarily boys. It is caused by mutations in the
    MeSH term(s) Male ; Humans ; Muscular Dystrophy, Duchenne/genetics ; Muscle, Skeletal/metabolism ; Genetic Therapy/methods ; Gene Transfer Techniques ; Biomarkers/metabolism
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.2022.190
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2988: Show issues Location:
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  10. Article ; Online: Regulatory T cells: A review of manufacturing and clinical utility.

    Mamo, Tewodros / Hippen, Keli L / MacMillan, Margaret L / Brunstein, Claudio G / Miller, Jeffrey S / Wagner, John E / Blazar, Bruce R / McKenna, David H

    Transfusion

    2022  Volume 62, Issue 4, Page(s) 904–915

    MeSH term(s) Humans ; Quality Control ; T-Lymphocytes, Regulatory
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16797
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    Zs.A 284: Show issues Location:
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