LIVIVO - Search results -

Search results

Result 1 - 10 of total 367

Search options

Article ; Online: Advances and Highlights of miRNAs in Asthma: Biomarkers for Diagnosis and Treatment.

Gil-Martínez, Marta / Lorente-Sorolla, Clara / Naharro, Sara / Rodrigo-Muñoz, José M / Del Pozo, Victoria

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Asthma is a heterogeneous inflammatory disease of the airways that causes breathing difficulties, episodes of cough and wheezing, and in more severe cases can greatly diminish quality of life. Epigenetic regulation, including post-transcriptional ... ...

Abstract	Asthma is a heterogeneous inflammatory disease of the airways that causes breathing difficulties, episodes of cough and wheezing, and in more severe cases can greatly diminish quality of life. Epigenetic regulation, including post-transcriptional mediation of microRNAs (miRNAs), is one of the mechanisms behind the development of the range of asthma phenotypes and endotypes. As in every other immune-mediated disease, miRNAs regulate the behavior of cells that shape the airway structure as well as those in charge of the defense mechanisms in the bronchi and lungs, controlling cell survival, growth, proliferation, and the ability of cells to synthesize and secrete chemokines and immune mediators. More importantly, miRNAs are molecules with chemical and biological properties that make them appropriate biomarkers for disease, enabling stratification of patients for optimal drug selection and thereby simplifying clinical management and reducing both the economic burden and need for critical care associated with the disease. In this review, we summarize the roles of miRNAs in asthma and describe how they regulate the mechanisms of the disease. We further describe the current state of miRNAs as biomarkers for asthma phenotyping, endotyping, and treatment selection.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Epigenesis, Genetic ; Quality of Life ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/genetics ; Biomarkers
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021628
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Exosomes: A Key Piece in Asthmatic Inflammation.

Cañas, José A / Rodrigo-Muñoz, José M / Gil-Martínez, Marta / Sastre, Beatriz / del Pozo, Victoria

International journal of molecular sciences

2021 Volume 22, Issue 2

Abstract: Asthma is a chronic disease of the airways that has an important inflammatory component. Multiple cells are implicated in asthma pathogenesis (lymphocytes, eosinophils, mast cells, basophils, neutrophils), releasing a wide variety of cytokines. These ... ...

Abstract	Asthma is a chronic disease of the airways that has an important inflammatory component. Multiple cells are implicated in asthma pathogenesis (lymphocytes, eosinophils, mast cells, basophils, neutrophils), releasing a wide variety of cytokines. These cells can exert their inflammatory functions throughout extracellular vesicles (EVs), which are small vesicles released by donor cells into the extracellular microenvironment that can be taken up by recipient cells. Depending on their size, EVs can be classified as microvesicles, exosomes, or apoptotic bodies. EVs are heterogeneous spherical structures secreted by almost all cell types. One of their main functions is to act as transporters of a wide range of molecules, such as proteins, lipids, and microRNAs (miRNAs), which are single-stranded RNAs of approximately 22 nucleotides in length. Therefore, exosomes could influence several physiological and pathological processes, including those involved in asthma. They can be detected in multiple cell types and biofluids, providing a wealth of information about the processes that take account in a pathological scenario. This review thus summarizes the most recent insights concerning the role of exosomes from different sources (several cell populations and biofluids) in one of the most prevalent respiratory diseases, asthma.
MeSH term(s)	Animals ; Asthma/etiology ; Asthma/pathology ; Cell Communication/physiology ; Cell-Derived Microparticles/metabolism ; Exosomes/pathology ; Exosomes/physiology ; Humans ; Inflammation/etiology ; Inflammation/pathology ; Secretory Vesicles/pathology ; Secretory Vesicles/physiology
Language	English
Publishing date	2021-01-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22020963
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Corrigendum: MicroRNAs as potential regulators of immune response networks in asthma and chronic obstructive pulmonary disease.

Cañas, José A / Rodrigo-Muñoz, José M / Sastre, Beatriz / Gil-Martinez, Marta / Redondo, Natalia / Del Pozo, Victoria

Frontiers in immunology

2022 Volume 13, Page(s) 1051260

Abstract: This corrects the article DOI: 10.3389/fimmu.2020.608666.]. ...

Abstract	[This corrects the article DOI: 10.3389/fimmu.2020.608666.].
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1051260
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Emerging Evidence for Pleiotropism of Eosinophils.

Rodrigo-Muñoz, José M / Gil-Martínez, Marta / Sastre, Beatriz / Del Pozo, Victoria

International journal of molecular sciences

2021 Volume 22, Issue 13

Abstract: Eosinophils are complex granulocytes with the capacity to react upon diverse stimuli due to their numerous and variable surface receptors, which allows them to respond in very different manners. Traditionally believed to be only part of parasitic and ... ...

Abstract	Eosinophils are complex granulocytes with the capacity to react upon diverse stimuli due to their numerous and variable surface receptors, which allows them to respond in very different manners. Traditionally believed to be only part of parasitic and allergic/asthmatic immune responses, as scientific studies arise, the paradigm about these cells is continuously changing, adding layers of complexity to their roles in homeostasis and disease. Developing principally in the bone marrow by the action of IL-5 and granulocyte macrophage colony-stimulating factor GM-CSF, eosinophils migrate from the blood to very different organs, performing multiple functions in tissue homeostasis as in the gastrointestinal tract, thymus, uterus, mammary glands, liver, and skeletal muscle. In organs such as the lungs and gastrointestinal tract, eosinophils are able to act as immune regulatory cells and also to perform direct actions against parasites, and bacteria, where novel mechanisms of immune defense as extracellular DNA traps are key factors. Besides, eosinophils, are of importance in an effective response against viral pathogens by their nuclease enzymatic activity and have been lately described as involved in severe acute respiratory syndrome coronavirus SARS-CoV-2 immunity. The pleiotropic role of eosinophils is sustained because eosinophils can be also detrimental to human physiology, for example, in diseases like allergies, asthma, and eosinophilic esophagitis, where exosomes can be significant pathophysiologic units. These eosinophilic pathologies, require specific treatments by eosinophils control, such as new monoclonal antibodies like mepolizumab, reslizumab, and benralizumab. In this review, we describe the roles of eosinophils as effectors and regulatory cells and their involvement in pathological disorders and treatment.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Asthma/drug therapy ; Asthma/immunology ; Asthma/pathology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Eosinophilic Esophagitis/drug therapy ; Eosinophilic Esophagitis/immunology ; Eosinophilic Esophagitis/pathology ; Eosinophils/cytology ; Eosinophils/immunology ; Eosinophils/physiology ; Exosomes/metabolism ; Extracellular Traps/metabolism ; Humans ; Plasma Cells/cytology ; Plasma Cells/metabolism ; SARS-CoV-2/isolation & purification
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2021-06-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22137075
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis.

Gil-Martínez, Marta / Lorente-Sorolla, Clara / Rodrigo-Muñoz, José M / Naharro, Sara / García-de Castro, Zahara / Sastre, Joaquín / Valverde-Monge, Marcela / Quirce, Santiago / Caballero, María L / Olaguibel, José M / Del Pozo, Victoria

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We previously ... ...

Abstract	Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We previously demonstrated that hsa-miR-26a-1-3p and hsa-miR-376a-3p, biomarkers related to an inflammatory profile, discriminate eosinophilic from non-eosinophilic asthmatics. We aimed to study hsa-miR-26a-1-3p, hsa-miR-376a-3p, and their target genes in asthmatic subjects with or without obesity to find biomarkers and comprehend obese asthma mechanisms. Lung tissue samples were obtained from asthmatic patients (n = 16) and healthy subjects (n = 20). We measured miRNA expression using RT-qPCR and protein levels (IGF axis) by ELISA in confirmation samples from eosinophilic (n = 38) and non-eosinophilic (n = 39) obese (n = 26) and non-obese (n = 51) asthma patients. Asthmatic lungs showed higher hsa-miR-26a-1-3p and hsa-miR-376a-3p expression than healthy lungs. A study of seven genes regulated by these miRNAs revealed differential expression of
MeSH term(s)	Humans ; Asthma/complications ; Asthma/genetics ; Biomarkers ; Insulin-Like Growth Factor Binding Protein 3/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Obesity/complications ; Obesity/genetics ; Phenotype ; Quality of Life
Chemical Substances	Biomarkers ; Insulin-Like Growth Factor Binding Protein 3 ; MicroRNAs ; MIRN376A1 microRNA, human
Language	English
Publishing date	2023-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411620
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: MicroRNAs as Potential Regulators of Immune Response Networks in Asthma and Chronic Obstructive Pulmonary Disease.

Cañas, José A / Rodrigo-Muñoz, José M / Sastre, Beatriz / Gil-Martinez, Marta / Redondo, Natalia / Del Pozo, Victoria

Frontiers in immunology

2021 Volume 11, Page(s) 608666

Abstract: Chronic respiratory diseases (CRDs) are an important factor of morbidity and mortality, accounting for approximately 6% of total deaths worldwide. The main CRDs are asthma and chronic obstructive pulmonary disease (COPD). These complex diseases have ... ...

Abstract	Chronic respiratory diseases (CRDs) are an important factor of morbidity and mortality, accounting for approximately 6% of total deaths worldwide. The main CRDs are asthma and chronic obstructive pulmonary disease (COPD). These complex diseases have different triggers including allergens, pollutants, tobacco smoke, and other risk factors. It is important to highlight that although CRDs are incurable, various forms of treatment improve shortness of breath and quality of life. The search for tools that can ensure accurate diagnosis and treatment is crucial. MicroRNAs (miRNAs) are small non-coding RNAs and have been described as promising diagnostic and therapeutic biomarkers for CRDs. They are implicated in multiple processes of asthma and COPD, regulating pathways associated with inflammation, thereby showing that miRNAs are critical regulators of the immune response. Indeed, miRNAs have been found to be deregulated in several biofluids (sputum, bronchoalveolar lavage, and serum) and in both structural lung and immune cells of patients in comparison to healthy subjects, showing their potential role as biomarkers. Also, miRNAs play a part in the development or termination of histopathological changes and comorbidities, revealing the complexity of miRNA regulation and opening up new treatment possibilities. Finally, miRNAs have been proposed as prognostic tools in response to both conventional and biologic treatments for asthma or COPD, and miRNA-based treatment has emerged as a potential approach for clinical intervention in these respiratory diseases; however, this field is still in development. The present review applies a systems biology approach to the understanding of miRNA regulatory networks in asthma and COPD, summarizing their roles in pathophysiology, diagnosis, and treatment.
MeSH term(s)	Animals ; Asthma/immunology ; Humans ; Immunity/immunology ; Inflammation/immunology ; Lung/immunology ; MicroRNAs/immunology ; Pulmonary Disease, Chronic Obstructive/immunology ; Sputum/immunology
Chemical Substances	MicroRNAs
Language	English
Publishing date	2021-01-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.608666
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Changes in Serum MicroRNAs after Anti-IL-5 Biological Treatment of Severe Asthma.

Rial, Manuel J / Cañas, José A / Rodrigo-Muñoz, José M / Valverde-Monge, Marcela / Sastre, Beatriz / Sastre, Joaquín / Del Pozo, Victoria

International journal of molecular sciences

2021 Volume 22, Issue 7

Abstract: There is currently enough evidence to think that miRNAs play a role in several key points in asthma, including diagnosis, severity of the disease, and response to treatment. Cells release different types of lipid double-membrane vesicles into the ... ...

Abstract	There is currently enough evidence to think that miRNAs play a role in several key points in asthma, including diagnosis, severity of the disease, and response to treatment. Cells release different types of lipid double-membrane vesicles into the extracellular microenvironment, including exosomes, which function as very important elements in intercellular communication. They are capable of distributing genetic material, mRNA, mitochondrial DNA, and microRNAs (miRNAs). Serum miRNA screening was performed in order to analyze possible changes in serum miRNAs in 10 patients treated with reslizumab and 6 patients with mepolizumab after 8 weeks of treatment. The expression of miR-338-3p was altered after treatment (
MeSH term(s)	Adult ; Anti-Asthmatic Agents/pharmacology ; Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Asthma/genetics ; Biomarkers/blood ; Female ; Gene Expression Regulation/drug effects ; Humans ; Interleukin-5/antagonists & inhibitors ; Male ; MicroRNAs/blood ; Middle Aged ; Treatment Outcome
Chemical Substances	Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; Biomarkers ; IL5 protein, human ; Interleukin-5 ; MIRN338 microRNA, human ; MicroRNAs ; reslizumab (35A26E427H) ; mepolizumab (90Z2UF0E52)
Language	English
Publishing date	2021-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22073558
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Role of miR-185-5p as modulator of periostin synthesis and smooth muscle contraction in asthma.

Rodrigo-Muñoz, José M / Cañas, José A / Sastre, Beatriz / Gil-Martínez, Marta / García Latorre, Raquel / Sastre, Joaquín / Del Pozo, Victoria

Journal of cellular physiology

2021 Volume 237, Issue 2, Page(s) 1498–1508

Abstract: Asthma is a chronic respiratory disease produced by an aberrant immune response that originates with breathing difficulties and cough, through airway remodeling. The above pathophysiological events of asthma emerge the regulators of effectors, like ... ...

Abstract	Asthma is a chronic respiratory disease produced by an aberrant immune response that originates with breathing difficulties and cough, through airway remodeling. The above pathophysiological events of asthma emerge the regulators of effectors, like epigenetics, which include microRNAs (miRNAs) who perform post-transcriptional regulation, controlling diverse pathways in respiratory diseases. The objective of the study was to determine how miR-185-5p regulates the secretion of periostin by airway structural cells, and smooth muscle cells contraction, both related to airway remodeling in asthma. We used miR-185-5p mimic and inhibitors in bronchial smooth muscle cells (BSMCs) and small airway epithelial cells (SAECs) from healthy subjects. Gene expression and protein levels of periostin (POSTN), CDC42, and RHOA were analyzed by RT-PCR and ELISA/Western blot, respectively. BSMC contractility was analyzed using cell-embedded collagen gels and measurement of intracellular calcium was performed using Fura-2. Additionally, miR-185-5p and periostin expression were evaluated in sputum from healthy and asthmatics. From these experiments, we observed that miR-185-5p modulation regulates periostin mRNA and protein in BSMCs and SAECs. A tendency for diminished miR-185-5p expression and higher periostin levels was seen in sputum cells from asthmatics compared to healthy, with an inverse correlation observed between POSTN and miR-185-5p. Inhibition of miR-185-5p produced higher BSMCs contraction induced by histamine. Calcium mobilization was not modified by miR-185-5p, showing that miR-185-5p role in BSMC contractility is performed by regulating CDC42 and RhoA pro-contractile factors instead. In conclusion, miR-185-5p is a modulator of periostin secretion by airway structural cells and of smooth muscle contraction, which can be related to asthma pathophysiology, and thus, might be a promising therapeutic target.
MeSH term(s)	Airway Remodeling/genetics ; Asthma/metabolism ; Calcium/metabolism ; Cell Proliferation/genetics ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Muscle Contraction/genetics ; Myocytes, Smooth Muscle/metabolism
Chemical Substances	MIRN185 microRNA, human ; MicroRNAs ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.30620
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uc I Zs.212: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Exosomes: A new approach to asthma pathology.

Cañas, José A / Sastre, Beatriz / Rodrigo-Muñoz, José M / Del Pozo, Victoria

Clinica chimica acta; international journal of clinical chemistry

2019 Volume 495, Page(s) 139–147

Abstract: Asthma is a chronic inflammatory disease of the airways with a complex pathophysiology, making the development of diagnostic and therapeutic tools a challenge. Exosomes are extracellular membranous nanovesicles implicated in intercellular communication. ... ...

Abstract	Asthma is a chronic inflammatory disease of the airways with a complex pathophysiology, making the development of diagnostic and therapeutic tools a challenge. Exosomes are extracellular membranous nanovesicles implicated in intercellular communication. Exosome composition and cargo are highly heterogeneous depending on their cellular origin and physiological state. They contain proteins (tetraspanins, heat-shock proteins), nucleic acids (RNA, microRNA), and lipids (ceramides, cholesterol, sphingolipids). Current scientific advances show that exosomes play a pivotal role in the pathology of asthma as well as other inflammatory diseases, and all types of inflammatory cells (neutrophils, dendritic cells, lymphocytes, eosinophils) release exosomes. Also, structural lung cells such as airway epithelial cells and airway smooth muscle cells produce and secrete these nanovesicles. Exosomes influence and modify the functionality of these inflammatory and structural cells, triggering the characteristic processes of asthma disease. Additionally, exosomes are used as biomarkers in several disorders because they are easier to collect from different biofluids, making them a non-invasive method for screening human pathologies. Also, due to their special molecular characteristics, they can be loaded with different molecules and employed as a drug-delivery vehicle. This review focuses on recent advances related to the role of exosomes in asthma disease.
MeSH term(s)	Animals ; Asthma/immunology ; Asthma/pathology ; Asthma/therapy ; Exosomes/pathology ; Humans
Language	English
Publishing date	2019-04-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2019.04.055
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.173: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The excellent biocompatibility and negligible immune response of the titanium heterometallic MOF MUV-10.

Lázaro, Isabel Abánades / Rodrigo-Muñoz, Jose M / Sastre, Beatriz / Ángel, María Romero / Martí-Gastaldo, Carlos / Del Pozo, Victoria

Journal of materials chemistry. B

2021 Volume 9, Issue 31, Page(s) 6144–6148

Abstract: The Ti-Ca heterometallic MOF MUV-10 exhibits good dispersibility in phosphate buffer and low phosphate-induced degradation in comparison to other MOF systems. It induces no cytotoxicity towards cells of the immune system and no inmune response, making it ...

Abstract	The Ti-Ca heterometallic MOF MUV-10 exhibits good dispersibility in phosphate buffer and low phosphate-induced degradation in comparison to other MOF systems. It induces no cytotoxicity towards cells of the immune system and no inmune response, making it an attractive candidate for biomedical applications and demonstrating its safe use for other applications.
MeSH term(s)	Animals ; Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Calcium/chemistry ; Humans ; Immunity ; Materials Testing ; Metal-Organic Frameworks/chemical synthesis ; Metal-Organic Frameworks/chemistry ; Mice ; Particle Size ; Titanium/chemistry
Chemical Substances	Biocompatible Materials ; Metal-Organic Frameworks ; Titanium (D1JT611TNE) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-07-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb00981h
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito