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Article: Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial.

Li, Xue / Zheng, Sisi / Feng, Sitong / Ma, Rui / Jia, Yuan / Zhao, Anquan / Wei, Dan / Guo, Hua / Duan, Na / Ding, Ying / Chen, Jindong / Zhu, Hong / Jia, Hongxiao

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9951693

Abstract: Objective: To systematically assess the clinical efficacy of the : Methods: A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three ... ...

Abstract	Objective: To systematically assess the clinical efficacy of the Methods: A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less than or equal to 25% after one week. The primary outcome was a change in total score on the HAMA. The secondary outcomes included the Hamilton Depression Scale (HAMD), Clinical Global Impression (CGI) scale, and TCM Syndrome Scale. Adverse events were recorded using the Treatment Emergent Symptom Scale (TESS). Assessments were conducted at the baseline and 1, 2, 4, and 8 weeks. Results: A total of one hundred thirty-three participants were randomly assigned to the JYW group ( Conclusions: The conclusion of this study supports that JYW and Buspirone can effectively alleviate the anxiety symptoms of GAD patients, which are both effective and safe for treatment of mild to moderate GAD. Besides, high-dose JYW or Buspirone are more effective than low-dose, which is of great importance in assisting clinical medication choice.
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9951693
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Jie Yu Wan on Generalized Anxiety Disorder

Xue Li / Sisi Zheng / Sitong Feng / Rui Ma / Yuan Jia / Anquan Zhao / Dan Wei / Hua Guo / Na Duan / Ying Ding / Jindong Chen / Hong Zhu / Hongxiao Jia

Evidence-Based Complementary and Alternative Medicine, Vol

A Randomized Clinical Trial

2022 Volume 2022

Abstract: Objective. To systematically assess the clinical efficacy of the Jie Yu Wan (JYW) formula ...

Abstract	Objective. To systematically assess the clinical efficacy of the Jie Yu Wan (JYW) formula in treating generalized anxiety disorder (GAD). Methods. A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less than or equal to 25% after one week. The primary outcome was a change in total score on the HAMA. The secondary outcomes included the Hamilton Depression Scale (HAMD), Clinical Global Impression (CGI) scale, and TCM Syndrome Scale. Adverse events were recorded using the Treatment Emergent Symptom Scale (TESS). Assessments were conducted at the baseline and 1, 2, 4, and 8 weeks. Results. A total of one hundred thirty-three participants were randomly assigned to the JYW group (n = 66) and the Buspirone group (n = 67). One hundred twenty-one patients (91%) completed at least one follow-up session. There were no significant differences between the two groups in terms of gender, age, disease course, HAMA, HAMD, CGI, and TCM Syndrome Scale scores at baseline (all P>0.05). Repeated-measures analysis of variance revealed statistically significant time effects for the HAMA (P=0.002), HAMD (P = 0.018), and CGI (P=0.001) in both groups. Sensitivity analyses supported the credibility of the main results (P>0.05). The group effect was not significant for the HAMA (P=0.43), HAMD (P=0.27), CGI (P=0.37), and TCM Syndrome Scale (P=0.86). Furthermore, there were no significant interaction effects between time and group in terms of the HAMA (P=0.47), HAMD ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Record-breaking Mei-yu in 2020 and Associated Atmospheric Circulation and Tropical SST Anomalies.

Ding, Yihui / Liu, Yunyun / Hu, Zeng-Zhen

Advances in atmospheric sciences

2021 Volume 38, Issue 12, Page(s) 1980–1993

Abstract: The record-breaking mei-yu in the Yangtze-Huaihe River valley (YHRV) in 2020 was characterized ... a significant quasi-biweekly oscillation (QBWO) during the mei-yu season of 2020 that was associated ... with the onset and retreat of mei-yu, a northward shift and stagnation of the rainbelt, and the occurrence and ...

Abstract	The record-breaking mei-yu in the Yangtze-Huaihe River valley (YHRV) in 2020 was characterized by an early onset, a delayed retreat, a long duration, a wide meridional rainbelt, abundant precipitation, and frequent heavy rainstorm processes. It is noted that the East Asian monsoon circulation system presented a significant quasi-biweekly oscillation (QBWO) during the mei-yu season of 2020 that was associated with the onset and retreat of mei-yu, a northward shift and stagnation of the rainbelt, and the occurrence and persistence of heavy rainstorm processes. Correspondingly, during the mei-yu season, the monsoon circulation subsystems, including the western Pacific subtropical high (WPSH), the upper-level East Asian westerly jet, and the low-level southwesterly jet, experienced periodic oscillations linked with the QBWO. Most notably, the repeated establishment of a large southerly center, with relatively stable latitude, led to moisture convergence and ascent which was observed to develop repeatedly. This was accompanied by a long-term duration of the mei-yu rainfall in the YHRV and frequent occurrences of rainstorm processes. Moreover, two blocking highs were present in the middle to high latitudes over Eurasia, and a trough along the East Asian coast was also active, which allowed cold air intrusions to move southward through the northwestern and/or northeastern paths. The cold air frequently merged with the warm and moist air from the low latitudes resulting in low-level convergence over the YHRV. The persistent warming in the tropical Indian Ocean is found to be an important external contributor to an EAP/PJ-like teleconnection pattern over East Asia along with an intensified and southerly displaced WPSH, which was observed to be favorable for excessive rainfall over YHRV.
Language	English
Publishing date	2021-04-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2228064-9
ISSN	1861-9533 ; 0256-1530
ISSN (online)	1861-9533
ISSN	0256-1530
DOI	10.1007/s00376-021-0361-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Identification of the Biomarkers of Sheng-Ji Hua-Yu Formula Treated Diabetic Wound Healing Using Modular Pharmacology.

Jiang, Jing-Si / Zhang, Ying / Luo, Ying / Ru, Yi / Luo, Yue / Fei, Xiao-Ya / Song, Jian-Kun / Ding, Xiao-Jie / Zhang, Zhan / Yang, Dan / Yin, Shuang-Yi / Zhang, Hui-Ping / Liu, Tai-Yi / Li, Bin / Kuai, Le

Frontiers in pharmacology

2021 Volume 12, Page(s) 726158

Abstract: Sheng-Ji Hua-Yu (SJHY) formula has been proved to reduce the severity of diabetic wound healing ...

Abstract	Sheng-Ji Hua-Yu (SJHY) formula has been proved to reduce the severity of diabetic wound healing without significant adverse events in our previous clinical trials. However, based on multi-target characteristics, the regulatory network among herbs, ingredients, and hub genes remains to be elucidated. The current study aims to identify the biomarkers of the SJHY formula for the treatment of diabetic wound healing. First, a network of components and targets for the SJHY formula was constructed using network pharmacology. Second, the ClusterONE algorithm was used to build a modular network and identify hub genes along with kernel pathways. Third, we verified the kernel targets by molecular docking to select hub genes. In addition, the biomarkers of the SJHY formula were validated by animal experiments in a diabetic wound healing mice model. The results revealed that the SJHY formula downregulated the mRNA expression of
Language	English
Publishing date	2021-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.726158
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Book: Shan yu ren tong

Ding, Xinbao

yu Xianggang tong bu cheng zhang de Dong hua san yuan (1897-1997)

2010

Title variant	Yu Xianggang tong bu cheng zhang de Dong hua san yuan (1897-1997)
Institution	Dong hua san yuan (Hong Kong, China)
Author's details	[Ding Xinbao zhu]
MeSH term(s)	Hospitals/history
Keywords	Hong Kong
Language	Chinese
Size	401 p. :, ill. ;, 25 cm.
Edition	Xianggang di 1 ban.
Publisher	San lian shu dian (Xianggang) you xian gong si
Publishing place	Xianggang
Document type	Book
ISBN	9789620429309 ; 9620429303
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Bu dui chen cui hua yu he cheng

Ding, Kuiling

(Hua xue xue bao ; 72.2014,7)

2014

Title variant	Bu-dui-chen cui-hua yu he-cheng
Author's details	Kuiling Ding
Series title	Hua xue xue bao ; 72.2014,7
Language	Chinese
Size	S. 757 - 870, Ill., graph. Darst., Tab.
Publisher	Ke xue chu ban she
Publishing place	Beijing
Document type	Book
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book: Gong si Han yu

Li Li / Ding, Anqi

Business Chinese

(Bei-Da-ban xin yi-dai duiwai Hanyu jiaocai)

2008

Author's details	Li Li; Ding Anqi bianzhu
Series title	Bei-Da-ban xin yi-dai duiwai Hanyu jiaocai
Language	Chinese
Size	2, 208 S., Ill.
Edition	[Nachdr.]
Publisher	Beijing Da xue Chu ban she
Publishing place	Beijing
Document type	Book
Note	In chines. Schr. ; Übers. d. Hauptsacht.: Business-Chinesisch
ISBN	7301057342 ; 9787301057346
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Reply to Yu et al.: Global temperature change as the ultimate driver of the shift in the summer monsoon rain belt in East Asia.

Yang, Shiling / Ding, Zhongli / Li, Yangyang / Wang, Xu / Jiang, Wenying / Huang, Xiaofang

Proceedings of the National Academy of Sciences of the United States of America

2016 Volume 113, Issue 16, Page(s) E2211–2

MeSH term(s)	Far East ; Rain ; Seasons ; Temperature
Language	English
Publishing date	2016-04-19
Publishing country	United States
Document type	Comment ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1601768113
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Zs.A 1148: Show issues

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Article: Relative roles of dry intrusion, latent heat and instabilities in the Mei-yu rainband life cycle: A case study

Luo, Xia / Fei, Jianfang / Huang, Xiaogang / Ding, Juli / Ma, Zhanhong

Atmospheric research. 2018 Dec. 01, v. 214

2018

Abstract: ... of long-lived moist convection into a Mei-yu rainband (091800–101,800 UTC June 2008). This rainband was ... to the northeast with the narrow width.In addition to establishment of the Mei-yu frontal zone, the northwesterly ... This behavior combined with the Mei-yu frontogenesis, leading to successive convection to maintain the rainband ...

Abstract	Simulations using a convection-permitting numerical model (The Weather Research and Forecasting, WRF) are conducted to investigate the mechanisms responsible for the maintenance and organization of long-lived moist convection into a Mei-yu rainband (091800–101,800 UTC June 2008). This rainband was composed of multiple two-dimensional precipitation bandings, being elongated from the southwest to the northeast with the narrow width.In addition to establishment of the Mei-yu frontal zone, the northwesterly flow behind the mid-tropospheric trough also brought about upper-level dry air. The downward transport of the dry air had a high value of potential vorticity and just overrode the low-level moist southwesterly component, inducing the conditional instability (CI) and frontogenesis at the coherent regions. This behavior combined with the Mei-yu frontogenesis, leading to successive convection to maintain the rainband, whereas the latent heat was not directly linked to the rainband longevity. The releases of CI, conditionally symmetric and inertial instabilities were simultaneously present in the bandings, as an indication of the mechanisms for the formation of banded structures. Therefore, the mesoscale circulations in banded convection developed in the form of coexisted upward and slantwise motions. Our attempt to integrate the dry intrusion and multiple instabilities could be a vital significance in discussing the Mei-yu rainband development.
Keywords	case studies ; convection ; latent heat ; mathematical models ; weather
Language	English
Dates of publication	2018-1201
Size	p. 10-20.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0169-8095
DOI	10.1016/j.atmosres.2018.07.007
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway.

Ding, Kang / Wang, Yan / Jiang, Weimin / Zhang, Yu / Yin, Hongping / Fang, Zhuyuan

BMC complementary and alternative medicine

2015 Volume 15, Page(s) 81

Abstract: Background: Qian Yang Yu Yin Granule (QYYYG), a traditional Chinese herbal medicine, has been ...

Abstract	Background: Qian Yang Yu Yin Granule (QYYYG), a traditional Chinese herbal medicine, has been indicated for renal damage in hypertension for decades in China, but little remains known regarding its underlying molecular mechanism. Therefore, we performed the current study in order to investigate the underlying molecular mechanism of QYYYG in the treatment of hypertensive renal damage. Methods: We hypothesize that QYYYG relieves hypertensive renal injury through an angiotensin II (Ang II)-nicotinamide adenine dinucleotide phosphate (NAPDH)-oxidase (NOX)-reactive oxygen species (ROS) pathway. In this study, we investigated the effects of QYYYG-containing serum (QYGS) in human mesangial cells (HMCs) against Ang II-induced cell proliferation, ROS production, and inflammation through the seropharmacological method. Results: We found that QYGS could inhibit cell proliferation in Ang II-treated HMCs. In addition, QYGS considerably suppressed production of ROS, decreased mRNA and protein expression of NAPDH-oxidase 4 (NOX4), p22 (phox) , and activated Ras-related C3 botulinum toxin substrate 1 (GTP-Rac1); as well as counteracted the up-regulation of inflammatory markers including tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB) p65, and interleukin 6 (IL-6). These effects were further confirmed in HMCs transfected with specific small interfering RNA (siRNA) targeting NOX4. Conclusions: Taken together, these results suggest that a NOX4-dependent pathway plays an important role in regulating the inhibitory effect of QYGS. Our findings provide new insights into the molecular mechanisms of QYYYG and their role in the treatment of hypertensive nephropathy.
MeSH term(s)	Angiotensin II/metabolism ; Animals ; Cell Proliferation/drug effects ; China ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Hypertension, Renal/drug therapy ; Hypertension, Renal/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Mesangial Cells/drug effects ; Mesangial Cells/metabolism ; NADPH Oxidases/metabolism ; NF-kappa B/metabolism ; Phytotherapy ; Polygonum ; RNA, Small Interfering/pharmacology ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Up-Regulation/drug effects
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; RNA, Small Interfering ; Reactive Oxygen Species ; TNF protein, human ; Tumor Necrosis Factor-alpha ; Angiotensin II (11128-99-7) ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2015-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-015-0619-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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