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  1. Article ; Online: Standard precautions should include 'safe ventilation' to minimise far-afield airborne transmission in health and social care settings.

    Martinot, Martin

    Infection, disease & health

    2022  Volume 28, Issue 2, Page(s) 135–137

    MeSH term(s) Humans ; Respiratory Aerosols and Droplets ; Infection Control
    Language English
    Publishing date 2022-11-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2902143-1
    ISSN 2468-0869 ; 2468-0451
    ISSN (online) 2468-0869
    ISSN 2468-0451
    DOI 10.1016/j.idh.2022.11.001
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  2. Article ; Online: Should remdesivir be recommended in France in the early stage of COVID-19.

    Martin, Martinot

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 116, Page(s) 281–282

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; COVID-19/drug therapy ; France ; Humans ; SARS-CoV-2
    Chemical Substances remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2022-01-02
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.12.359
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  3. Article ; Online: HHV8-Positive Multicentric Castleman's Disease and Thrombotic Thrombocytopenic Purpura among HIV-Positive Patients.

    Pasquer, Roxane / Dieudonné, Yannick / Decours, Pauline / Hinschberger, Olivier / Nicolae, Alina / Martinot, Martin

    European journal of case reports in internal medicine

    2024  Volume 11, Issue 3, Page(s) 4361

    Abstract: Castleman's disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases that can affect the general population, especially those with HIV. Owing to their rarity, the association between CD and TTP remains insufficiently understood. In ... ...

    Abstract Castleman's disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases that can affect the general population, especially those with HIV. Owing to their rarity, the association between CD and TTP remains insufficiently understood. In this study, we present a case of a 53-year-old patient with controlled HIV infection who presented with fever, lymphadenopathy, severe anaemia, and thrombocytopenia. After a series of tests, the diagnosis was concurrent human herpesvirus 8 (HHV8)-related multicentric CD (MCD) and TTP. Only four male patients were previously reported having this association, with HHV8 present in four and HIV in three patients, suggesting that coinfection with HHV8 and HIV is a pivotal factor in MCD with TTP occurrence.
    Learning points: Castleman's disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases, and their association remains extremely uncommon.We report a case of multicentric CD (MCD) with TTP in a 53-year-old male patient with HIV.Only five patients, including ours, have been reported as having both MCD and TTP, with all five having HHV8 and four having HIV. Thus, coinfection with HHV8 and HIV may be a potential pivotal factor in the occurrence of MCD with TTP.
    Language English
    Publishing date 2024-02-28
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2024_004361
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  4. Article ; Online: COVID-19 vaccine: missed opportunities and hospital vaccine implementation.

    Martinot, Martin / Mohseni-Zadeh, Mahsa / Marion, Laurent / Roncalez, Daniel

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 28, Issue 8, Page(s) 1174–1175

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Hospitals ; Humans ; Vaccination ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-04-01
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.03.036
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  5. Article ; Online: Hip resurfacing for small-sized osteonecrosis: 73 cases at a median 8years' follow-up.

    Martinot, Pierre / Martin, Théo / Dartus, Julien / Cailliau, Emeline / Putman, Sophie / Migaud, Henri / Girard, Julien

    Orthopaedics & traumatology, surgery & research : OTSR

    2022  Volume 109, Issue 1, Page(s) 103471

    Abstract: Introduction: Total hip resurfacing arthroplasty (THRA) is an alternative to conventional total hip replacement (THR) in young patients with osteonecrosis of the femoral head. Series have been small, without criteria regarding extent of necrosis, thus ... ...

    Abstract Introduction: Total hip resurfacing arthroplasty (THRA) is an alternative to conventional total hip replacement (THR) in young patients with osteonecrosis of the femoral head. Series have been small, without criteria regarding extent of necrosis, thus vitiating results. We therefore conducted a retrospective assessment of THRA for small necrosis, to determine (1) implant survival, (2) functional scores, and (3) systemic chromium, cobalt and titanium ion concentrations.
    Hypothesis: The study hypothesis was that the revision rate is low, meeting the National Institute for Health and Care Excellence (NICE) criterion of<0.5% revision per year.
    Material and method: A single-center single-surgeon retrospective study included 62 patients, for 73 RTHAs, with a mean age of 45.6years (range: 23-68years) presenting Ficat stage 3 or 4 osteonecrosis of the femoral head with<330° total Kerboul angle (frontal+lateral angles) on simple preoperative X-ray. Study data comprised implant survival and preoperative and last follow-up functional scores (Postel-Merle-d'Aubigné, Oxford-12, Harris, and Devane) and titanium, chromium and cobalt blood concentrations. Necrosis size was assessed on preoperative Kerboul angle.
    Results: At a median 8years' follow-up (IQR: 5.9-9.3years), implant survival was 98.6% (95% CI: 97.22-99.98%). Only 1 implant was exchanged, for femoral loosening. Three other patients underwent revision surgery: 2 cases of lavage for infection, and 1 muscle hernia repair. Postel-Merle-d'Aubigné, Oxford-12 and Harris functional scores and Devane activity scores were significantly improved at follow-up, by a median +5 (IQR: 5 to 7), -26 (IQR: -29 to -23), +55 (IQR: 49 to 61) and +1 (IQR: 1 to 2), respectively (all p<0.001). Ion concentrations at last follow-up for titanium, chromium and cobalt were respectively 4.0μg/L (range: 3.6-4.1), 1.1μg/L (range: 0.8-1.9) and 1.1μg/L (range: 0.6-1.8).
    Conclusion: THRA is a useful option in the long-term for young patients with osteonecrosis with Kerboul angle<330°.
    Level of evidence: IV, retrospective study.
    MeSH term(s) Humans ; Middle Aged ; Arthroplasty, Replacement, Hip/methods ; Retrospective Studies ; Hip Prosthesis ; Follow-Up Studies ; Titanium ; Osteonecrosis/diagnostic imaging ; Osteonecrosis/surgery ; Reoperation ; Chromium ; Cobalt ; Treatment Outcome ; Prosthesis Design
    Chemical Substances Titanium (D1JT611TNE) ; Chromium (0R0008Q3JB) ; Cobalt (3G0H8C9362)
    Language English
    Publishing date 2022-11-03
    Publishing country France
    Document type Journal Article
    ISSN 1877-0568
    ISSN (online) 1877-0568
    DOI 10.1016/j.otsr.2022.103471
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  6. Article ; Online: Accuracy of the GeneXpert® MRSA/SA SSTI test to diagnose methicillin-resistant Staphylococcus spp. infection in bone fixation and fusion and management of infected non-unions.

    Martin, Théo / Martinot, Pierre / Leclerc, Jean-Thomas / Titécat, Marie / Loïez, Caroline / Dartus, Julien / Duhamel, Alain / Migaud, Henri / Chantelot, Christophe / Desmurs, Barthélémy Lafon / Amouyel, Thomas / Senneville, Eric

    Orthopaedics & traumatology, surgery & research : OTSR

    2024  , Page(s) 103820

    Abstract: Introduction: The GeneXpert® MRSA/SA SSTI (Methicillin Resistant Staphylococcus aureus / S. aureus skin and soft tissue infection) PCR test allows early detection of methicillin resistance in staphylococci. This test was developed for skin infections ... ...

    Abstract Introduction: The GeneXpert® MRSA/SA SSTI (Methicillin Resistant Staphylococcus aureus / S. aureus skin and soft tissue infection) PCR test allows early detection of methicillin resistance in staphylococci. This test was developed for skin infections and has been evaluated for prosthetic joint infections but, to our knowledge, has not been evaluated for hardware infections outside of arthroplasties. Furthermore, we conducted a retrospective study in patients with non-prosthetic osteosynthesis hardware aiming: 1) to identify the diagnostic values of the PCR test compared to conventional cultures and the resulting rate of appropriate antibiotic therapy. 2) to identify the rate of false negative (FN) results, 3) to identify and compare the rates of failure of infectious treatment (FN versus others) 4) to search for risk factors for FN of the PCR test.
    Hypothesis: The PCR test allowed early and appropriate targeting of antibiotic therapy.
    Material and methods: The results of PCR tests and conventional cultures for osteoarticular infections of non-prosthetic hardware over four years (2012-2016) were compared to identify the diagnostic values of using the results of conventional culture as a reference and the rate of appropriate antibiotic therapies. Infectious management failures between the results of the FN group and the others were compared, and variables associated with a FN of the PCR test were identified.
    Results: The analysis of 419 PCR tests allowed us to establish a sensitivity of 42.86%, a specificity of 96.82%, a positive predictive value of 60% and a negative predictive value of 93.83%. Using the results of the PCR test for the targeting of postoperative antibiotic therapy, it was suitable for staphylococcal coverage in 90.94% (381/419). The rates of patients for whom infectious treatment failed were not significantly different between the FN group and the other patients (20.8% versus 17.7%, respectively; Hazard Ratio = 1.12 (95%CI 0.47-2.69, p = 0.79)). A skin opening during the initial trauma (p = 0.005) and a polymicrobial infection were significantly associated with a risk of FN from the PCR test (p < 0.001).
    Conclusion: The PCR test makes it possible to reduce the duration of empirical broad-spectrum antibiotic therapy during the treatment of an infection of osteosynthesis hardware but causes a lack of antibiotic coverage in 9.06% of cases.
    Level of evidence: III; Diagnostic case control study.
    Language English
    Publishing date 2024-01-22
    Publishing country France
    Document type Journal Article
    ISSN 1877-0568
    ISSN (online) 1877-0568
    DOI 10.1016/j.otsr.2024.103820
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  7. Article ; Online: Severe acute herpes virus type 2 primo-infection and its association with anti-type 1 interferon autoantibodies.

    Martinot, Martin / Gravier, Simon / Mohseni-Zadeh, Mahsa / Fabien, Nicole / Casanova, Jean-Laurent / Puel, Anne / Goncalves, David

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2023  Volume 42, Issue 12, Page(s) 1531–1535

    Abstract: Herpes simplex virus type 2 (HSV-2) is a common cause of infection, which is usually self-limited and asymptomatic. A 71-year-old patient with HSV-2 primo-infection developed acute hepatitis and secondary hemophagocytic lymphohistiocytosis. The patient ... ...

    Abstract Herpes simplex virus type 2 (HSV-2) is a common cause of infection, which is usually self-limited and asymptomatic. A 71-year-old patient with HSV-2 primo-infection developed acute hepatitis and secondary hemophagocytic lymphohistiocytosis. The patient had high levels of autoantibodies against type I interferon (IFN) (> 1000 ng/mL), neutralizing high concentration (10 ng/mL) of both IFN-α and IFN-ω but not IFN-β. Anti-IFN-I auto-antibodies are rarely observed in healthy individuals; however, their prevalence increases in individuals over 70 years of age and have been identified as a cause of some severe viral diseases, including critical COVID-19. Considering the function of IFN-I in innate immunity, the pathological role of these autoantibodies in severe viral diseases following primo-infections in elderly patient appears crucial.
    MeSH term(s) Aged ; Humans ; Autoantibodies ; Herpes Simplex ; Herpesvirus 2, Human ; Interferon Type I ; Interferon-alpha
    Chemical Substances Autoantibodies ; Interferon Type I ; Interferon-alpha
    Language English
    Publishing date 2023-10-23
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-023-04688-5
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    Zs.A 1732: Show issues Location:
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  8. Article ; Online: Positive intrathecal anti-Borrelia antibody synthesis: what are the implications for clinical practice? Clinical features and outcomes of 138 patients in a French multicenter cohort study.

    Naudion, Pauline / Raffetin, Alice / Zayet, Souheil / Klopfenstein, Timothée / Baux, Elisabeth / Martinot, Martin / Piroth, Lionel / Caumes, Eric / Chirouze, Catherine / Bouiller, Kevin

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2023  Volume 42, Issue 4, Page(s) 441–452

    Abstract: We aimed to describe the clinical characteristics, management, and residual symptoms (RS) in patients with definite and possible Lyme neuroborreliosis (LNB). We conducted a retrospective French multicenter cohort study (2010-2020). Cases of LNB were ... ...

    Abstract We aimed to describe the clinical characteristics, management, and residual symptoms (RS) in patients with definite and possible Lyme neuroborreliosis (LNB). We conducted a retrospective French multicenter cohort study (2010-2020). Cases of LNB were defined as clinical manifestations attributed to LNB and a positive Borrelia-specific intrathecal antibody index (AI) ("possible" LNB) and with pleocytosis ("definite" LNB). Risk factors of RS were determined using a logistic regression model. We included 138 adult patients with a positive AI. Mean age was 59.5 years (± 14.7). The median duration of symptoms before diagnosis was 1.0 [0.5-4.0] months. The most frequent manifestation was radicular pain (n = 79, 57%). Complete cerebrospinal fluid (CSF) leukocyte analysis was available in 131 patients, of whom 72 (55%) had pleocytosis. Patients with definite LNB had a shorter duration of symptoms (median 1.0 [0.5-2.6] vs. 3.0 [0.6-7.0] months, p < 0.01) and more radicular pain (74% vs 44%, p < 0.01) than patients with possible LNB. At the last visit (median duration of follow-up: 70 [30-175] days), 74/124 patients (59.7%) reported RS, mostly radicular pain (n = 31, 25%). In multivariate analysis, definite LNB (OR = 0.21 [0.05-0.931], p = 0.039) and duration of symptoms less than 3 months (OR = 0.04 [0.01-0.37], p = 0.005) were protective factors against RS at last follow-up. Our study highlights the challenges of LNB management, especially for patients with a positive AI without pleocytosis, questioning whether LB is still ongoing or not. Early diagnosis and treatment are important to improve outcomes and to lower potential RS.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Borrelia ; Retrospective Studies ; Cohort Studies ; Leukocytosis ; Chemokine CXCL13/cerebrospinal fluid ; Lyme Neuroborreliosis/diagnosis ; Lyme Neuroborreliosis/drug therapy ; Pain
    Chemical Substances Chemokine CXCL13
    Language English
    Publishing date 2023-02-21
    Publishing country Germany
    Document type Multicenter Study ; Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-023-04574-0
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  9. Article ; Online: Pulmonary Nocardiosis as an Opportunistic Infection in COVID-19.

    Laplace, Marc / Flamand, Thomas / Ion, Ciprian / Gravier, Simon / Zadeh, Mahsa Mohseni / Debriel, Dominique / Augereau, Olivier / Gregorowicz, Guillaume / Martinot, Martin

    European journal of case reports in internal medicine

    2022  Volume 9, Issue 8, Page(s) 3477

    Abstract: Secondary bacterial pneumonia infection is frequent in COVID-19 patients. : Learning points: ... ...

    Abstract Secondary bacterial pneumonia infection is frequent in COVID-19 patients.
    Learning points: Nocardia
    Language English
    Publishing date 2022-08-22
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2022_003477
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  10. Article ; Online: Outbreak of SARS-CoV-2 infection in a long-term care facility after COVID-19 BNT162b2 mRNA vaccination.

    Martinot, Martin / Carnein, Stéphane / Kempf, Christian / Gantner, Pierre / Gallais, Floriane / Fafi-Kremer, Samira

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 27, Issue 10, Page(s) 1537–1539

    MeSH term(s) Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; BNT162 Vaccine ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Cross Infection/epidemiology ; Cross Infection/virology ; Disease Outbreaks/statistics & numerical data ; Female ; France/epidemiology ; Humans ; Long-Term Care/statistics & numerical data ; Male ; Middle Aged ; Risk Factors ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-07-07
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.06.038
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