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  1. Article ; Online: Exploring the role of TRPM4 in calcium-dependent triggered activity and cardiac arrhythmias.

    Pironet, Andy / Vandewiele, Frone / Vennekens, Rudi

    The Journal of physiology

    2023  Volume 602, Issue 8, Page(s) 1605–1621

    Abstract: Cardiac arrhythmias pose a major threat to a patient's health, yet prove to be often difficult to predict, prevent and treat. A key mechanism in the occurrence of arrhythmias is disturbed ... ...

    Abstract Cardiac arrhythmias pose a major threat to a patient's health, yet prove to be often difficult to predict, prevent and treat. A key mechanism in the occurrence of arrhythmias is disturbed Ca
    MeSH term(s) Humans ; Mice ; Animals ; Calcium/metabolism ; Arrhythmias, Cardiac/genetics ; Myocytes, Cardiac/metabolism ; Calcium, Dietary ; TRPM Cation Channels/genetics
    Chemical Substances Calcium (SY7Q814VUP) ; Calcium, Dietary ; TRPM Cation Channels ; TRPM4 protein, human ; TRPM4 protein, mouse
    Language English
    Publishing date 2023-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP283831
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  2. Article ; Online: Putting the pressure on endocytosis in the kidney.

    Van Giel, Dorien / Vennekens, Rudi

    Cell calcium

    2020  Volume 94, Page(s) 102338

    Abstract: In Science Signaling, Gualdani and colleagues provide evidence that the ion channel TRPV4 functions as a mechanosensor in the renal proximal tubules and show that TRPV4 activity modulates protein reabsorption. ...

    Abstract In Science Signaling, Gualdani and colleagues provide evidence that the ion channel TRPV4 functions as a mechanosensor in the renal proximal tubules and show that TRPV4 activity modulates protein reabsorption.
    MeSH term(s) Albumins ; Endocytosis ; Kidney Tubules, Proximal ; TRPV Cation Channels
    Chemical Substances Albumins ; TRPV Cation Channels
    Language English
    Publishing date 2020-12-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2020.102338
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  3. Article ; Online: Correction to: Is autosomal dominant polycystic kidney disease an early sweet disease?

    Dachy, Angélique / Decuypere, Jean-Paul / Vennekens, Rudi / Jouret, François / Mekahli, Djalila

    Pediatric nephrology (Berlin, Germany)

    2022  Volume 37, Issue 9, Page(s) 2223–2224

    Language English
    Publishing date 2022-06-21
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-022-05624-z
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  4. Article ; Online: A TRiP to heart failure.

    Vennekens, Rudi

    Cardiovascular research

    2013  Volume 99, Issue 4, Page(s) 590–591

    MeSH term(s) Animals ; Calcium Channels/physiology ; Cardiomyopathy, Dilated/etiology ; Humans ; Sarcolemma/metabolism ; TRPV Cation Channels/physiology
    Chemical Substances Calcium Channels ; TRPV Cation Channels ; TRPV2 protein, human ; Trpv2 protein, mouse
    Language English
    Publishing date 2013-09-01
    Publishing country England
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvt186
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  5. Article ; Online: TRPM4 regulates hilar mossy cell loss in temporal lobe epilepsy.

    Mundrucz, Laura / Kecskés, Angéla / Henn-Mike, Nóra / Kóbor, Péter / Buzás, Péter / Vennekens, Rudi / Kecskés, Miklós

    BMC biology

    2023  Volume 21, Issue 1, Page(s) 96

    Abstract: Background: Mossy cells comprise a large fraction of excitatory neurons in the hippocampal dentate gyrus, and their loss is one of the major hallmarks of temporal lobe epilepsy (TLE). The vulnerability of mossy cells in TLE is well known in animal ... ...

    Abstract Background: Mossy cells comprise a large fraction of excitatory neurons in the hippocampal dentate gyrus, and their loss is one of the major hallmarks of temporal lobe epilepsy (TLE). The vulnerability of mossy cells in TLE is well known in animal models as well as in patients; however, the mechanisms leading to cellular death is unclear.
    Results: Transient receptor potential melastatin 4 (TRPM4) is a Ca
    Conclusions: Our results provide evidence for the role of TRPM4 in MC excitability both in physiological and pathological conditions.
    MeSH term(s) Animals ; Action Potentials ; Epilepsy, Temporal Lobe/metabolism ; Epilepsy, Temporal Lobe/pathology ; Mossy Fibers, Hippocampal/metabolism ; Mossy Fibers, Hippocampal/pathology ; TRPM Cation Channels/metabolism
    Chemical Substances TRPM Cation Channels
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2133020-7
    ISSN 1741-7007 ; 1741-7007
    ISSN (online) 1741-7007
    ISSN 1741-7007
    DOI 10.1186/s12915-023-01604-3
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  6. Article ; Online: Continuous glucose monitoring during pregnancy in healthy mice.

    Wuyts, Caroline / Simoens, Caroline / Pinto, Silvia / Philippaert, Koenraad / Vennekens, Rudi

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 4450

    Abstract: During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops. To ... ...

    Abstract During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops. To gain insight in the pregnancy-induced adaptations, we applied continuous glucose monitoring via telemetric transmitters. We show that continuous glucose monitoring in conscious, non-stressed, freely moving mice throughout the full pregnancy is feasible, accurate and safe. We show that healthy mice during a full pregnancy develop adaptations in glucose homeostasis reminiscent of those in pregnant women. Furthermore, continuous glucose monitoring allows the complete analysis of all aspects of glucose excursions associated with spontaneous feeding episodes, and the thorough analysis of glycaemic variability. In conclusion, continuous glucose monitoring allows a detailed description of the glycaemic status during pregnancy, which will help to unravel specific mechanisms for gestational diabetes mellitus.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Blood Glucose Self-Monitoring/methods ; Diabetes, Gestational/blood ; Diabetes, Gestational/metabolism ; Female ; Insulin/metabolism ; Insulin Resistance/physiology ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Pregnancy Outcome ; Pregnancy in Diabetics/blood ; Pregnancy in Diabetics/metabolism
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-83901-x
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  7. Article ; Online: The emerging role of the apelinergic system in kidney physiology and disease.

    Janssens, Peter / Decuypere, Jean-Paul / Bammens, Bert / Llorens-Cortes, Catherine / Vennekens, Rudi / Mekahli, Djalila

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2022  Volume 37, Issue 12, Page(s) 2314–2326

    Abstract: The apelinergic system (AS) is a novel pleiotropic system with an essential role in renal and cardiovascular physiology and disease, including water homeostasis and blood pressure regulation. It consists of two highly conserved peptide ligands, apelin ... ...

    Abstract The apelinergic system (AS) is a novel pleiotropic system with an essential role in renal and cardiovascular physiology and disease, including water homeostasis and blood pressure regulation. It consists of two highly conserved peptide ligands, apelin and apela, and a G-protein-coupled apelin receptor. The two ligands have many isoforms and a short half-life and exert both similar and divergent effects. Vasopressin, apelin and their receptors colocalize in hypothalamic regions essential for body fluid homeostasis and interact at the central and renal levels to regulate water homeostasis and diuresis in inverse directions. In addition, the AS and renin-angiotensin system interact both systemically and in the kidney, with implications for the cardiovascular system. A role for the AS in diverse pathological states, including disorders of sodium and water balance, hypertension, heart failure, pre-eclampsia, acute kidney injury, sepsis and diabetic nephropathy, has recently been reported. Furthermore, several metabolically stable apelin analogues have been developed, with potential applications in diverse diseases. We review here what is currently known about the physiological functions of the AS, focusing on renal, cardiovascular and metabolic homeostasis, and the role of the AS in associated diseases. We also describe several hurdles and research opportunities worthy of the attention of the nephrology community.
    MeSH term(s) Humans ; Apelin/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Kidney/metabolism ; Ligands ; Receptors, G-Protein-Coupled/metabolism ; Water/metabolism ; Kidney Diseases
    Chemical Substances Apelin ; Intercellular Signaling Peptides and Proteins ; Ligands ; Receptors, G-Protein-Coupled ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-11-10
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfab070
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  8. Article ; Online: Is autosomal dominant polycystic kidney disease an early sweet disease?

    Dachy, Angélique / Decuypere, Jean-Paul / Vennekens, Rudi / Jouret, François / Mekahli, Djalila

    Pediatric nephrology (Berlin, Germany)

    2022  Volume 37, Issue 9, Page(s) 1945–1955

    Abstract: The clinical course of autosomal dominant polycystic kidney disease (ADPKD) starts in childhood. Evidence of the beneficial impact of early nephron-protective strategies and lifestyle modifications on ADPKD prognosis is accumulating. Recent studies have ... ...

    Abstract The clinical course of autosomal dominant polycystic kidney disease (ADPKD) starts in childhood. Evidence of the beneficial impact of early nephron-protective strategies and lifestyle modifications on ADPKD prognosis is accumulating. Recent studies have described the association of overweight and obesity with rapid disease progression in adults with ADPKD. Moreover, defective glucose metabolism and metabolic reprogramming have been reported in distinct ADPKD models highlighting these pathways as potential therapeutic targets in ADPKD. Several "metabolic" approaches are currently under evaluation in adults, including ketogenic diet, food restriction, and metformin therapy. No data are available on the impact of these approaches in childhood thus far. Yet, according to World Health Organization (WHO), we are currently facing a childhood obesity crisis with an increased prevalence of overweight/obesity in the pediatric population associated with a cardio-metabolic risk profile. The present review summarizes the knowledge about the role of glucose metabolism in the pathophysiology of ADPKD and underscores the possible harm of overweight and obesity in ADPKD especially in terms of long-term cardiovascular outcomes and renal prognosis.
    MeSH term(s) Adult ; Child ; Disease Progression ; Glucose/therapeutic use ; Humans ; Kidney ; Overweight/complications ; Pediatric Obesity/complications ; Polycystic Kidney, Autosomal Dominant/drug therapy ; Polycystic Kidney, Autosomal Dominant/therapy
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-01-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05406-z
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  9. Article: Leukopenia in autosomal dominant polycystic kidney disease: a single-center cohort of kidney transplant candidates with post-transplantation follow-up.

    Schellekens, Pieter / Van Loon, Elisabet / Coemans, Maarten / Meyts, Isabelle / Vennekens, Rudi / Kuypers, Dirk / Mekahli, Djalila / Bammens, Bert

    Clinical kidney journal

    2023  Volume 16, Issue 12, Page(s) 2578–2586

    Abstract: Background: Autosomal dominant polycystic kidney disease (ADPKD) has occasionally been associated with lower peripheral white blood cell (WBC) counts. This study aimed to investigate the peripheral blood cell counts in a large cohort of kidney ... ...

    Abstract Background: Autosomal dominant polycystic kidney disease (ADPKD) has occasionally been associated with lower peripheral white blood cell (WBC) counts. This study aimed to investigate the peripheral blood cell counts in a large cohort of kidney transplant recipients before and after kidney transplantation and its potential impact on post-transplant outcomes.
    Methods: This was a retrospective study with long-term follow-up data of 2090 patients who underwent a first kidney transplantation in the Leuven University Hospitals, of whom 392 had ADPKD.
    Results: In total, 2090 patients who underwent a first kidney transplantation in the Leuven University Hospitals were included, of whom 392 had ADPKD. Both pre- and post-transplantation, ADPKD patients had significantly lower total WBC counts, and more specifically lower neutrophil, lymphocyte and eosinophil counts compared with the non-ADPKD patients. This observation was independent of potential confounders such as level of inflammation, smoking habit, vitamins and pre-transplant medication. Overall survival and kidney transplant survival were significantly better in ADPKD vs non-ADPKD transplant recipients and a longer time to first infection was observed. However, no association between blood cell counts and outcome differences was found.
    Conclusions: In conclusion, this large single-center study reports a strong and independent association between ADPKD and lower peripheral WBC counts both before and after kidney transplantation. Considering the role of inflammation in disease progression, further investigation into the role of WBC in ADPKD is needed.
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad165
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  10. Article ; Online: Emerging concepts for the role of TRP channels in the cardiovascular system.

    Vennekens, Rudi

    The Journal of physiology

    2010  Volume 589, Issue Pt 7, Page(s) 1527–1534

    Abstract: The transient receptor potential (TRP) family of ion channels is a large family of cation selective ion channels, which are expressed and functional in a variety of tissues. In this review we focus on the most recent results detailing the role of TRP ... ...

    Abstract The transient receptor potential (TRP) family of ion channels is a large family of cation selective ion channels, which are expressed and functional in a variety of tissues. In this review we focus on the most recent results detailing the role of TRP channels in the cardiovascular system. The presented results underscore the role of TRP channels in cardiomyocytes, smooth cells and endothelium, and in disease states such as hypertension, cardiac conduction block and cardiac hypertrophy.
    MeSH term(s) Animals ; Blood Pressure/physiology ; Cardiomegaly/etiology ; Cardiomegaly/physiopathology ; Cardiovascular Physiological Phenomena ; Endothelium, Vascular/physiology ; Humans ; Models, Cardiovascular ; Muscle, Smooth, Vascular/physiology ; Myocardium/metabolism ; Transient Receptor Potential Channels/physiology
    Chemical Substances Transient Receptor Potential Channels
    Language English
    Publishing date 2010-12-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2010.202077
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