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  1. Article ; Online: A family of olfactory receptors uniquely expanded in marsupial and monotreme genomes are expressed by a T cell subset also unique to marsupials and monotremes.

    Sampson, Jordan M / Morrissey, Kimberly A / Douek, Daniel C / Miller, Robert D

    Developmental and comparative immunology

    2024  Volume 154, Page(s) 105149

    Abstract: Olfactory receptors (OR), expressed on olfactory neurons, mediate the sense of smell. Recently, OR have also been shown to be expressed in non-olfactory tissues, including cells of the immune system. An analysis of single-cell transcriptomes of ... ...

    Abstract Olfactory receptors (OR), expressed on olfactory neurons, mediate the sense of smell. Recently, OR have also been shown to be expressed in non-olfactory tissues, including cells of the immune system. An analysis of single-cell transcriptomes of splenocytes of the grey short-tailed opossum (Monodelphis domestica) found OR are expressed on a subset of T cells, the γμ T cells, that are unique to marsupials and monotremes. A majority of opossum γμ T cells transcriptomes contain OR family 14 transcripts, specifically, from the OR14C subfamily. Amongst the mammals, the OR14 gene family is expanded in the genomes of marsupials and monotremes, and rarer or absent in placental mammals. In summary, here we demonstrate the intriguing correlation that a family of OR genes, abundant in the genomes of marsupials and monotremes, are ectopically expressed in a particular subset of T cells unique to the marsupials and monotremes.
    MeSH term(s) Female ; Pregnancy ; Animals ; Marsupialia/genetics ; Receptors, Odorant/genetics ; Placenta ; Genome/genetics ; Mammals/genetics ; T-Lymphocyte Subsets
    Chemical Substances Receptors, Odorant
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2024.105149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1327: Show issues Location:
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  2. Article ; Online: Harnessing the power of IFN for therapeutic approaches to COVID-19.

    Viox, Elise G / Bosinger, Steven E / Douek, Daniel C / Schreiber, Gideon / Paiardini, Mirko

    Journal of virology

    2024  , Page(s) e0120423

    Abstract: Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the ... ...

    Abstract Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01204-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
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  3. Article ; Online: HIV Infection: Advances Toward a Cure.

    Douek, Daniel C

    Topics in antiviral medicine

    2018  Volume 25, Issue 4, Page(s) 121–125

    Abstract: ... likely to require a combination of approaches. This article summarizes a presentation by Daniel C. Douek ...

    Abstract Achieving cure of HIV infection requires eliminating all replication-competent virus from the reservoir of latently infected cells or completely inhibiting infected cells from emerging from latency. Strategies include very early use of antiretroviral therapy; hematopoietic stem cell transplantation; "shock-and-kill" approaches; immune therapy with immune checkpoint inhibitors; gene therapy, including use of CC chemokine receptor 5-modified CD4+ T cells; and broadly neutralizing antibody therapy. Success is likely to require a combination of approaches. This article summarizes a presentation by Daniel C. Douek, MD, PhD, at the IAS-USA continuing education program held in Berkeley, California, in May 2017.
    MeSH term(s) AIDS Vaccines/administration & dosage ; Anti-HIV Agents/therapeutic use ; Antibodies, Neutralizing/therapeutic use ; CD4-Positive T-Lymphocytes/immunology ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Humans ; Receptors, CCR5/immunology ; Virus Activation/drug effects ; Virus Latency/drug effects
    Chemical Substances AIDS Vaccines ; Anti-HIV Agents ; Antibodies, Neutralizing ; Receptors, CCR5
    Language English
    Publishing date 2018-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5861
    ISSN (online) 2161-5853
    ISSN 2161-5861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants.

    Johnston, Timothy S / Li, Shuk Hang / Painter, Mark M / Atkinson, Reilly K / Douek, Naomi R / Reeg, David B / Douek, Daniel C / Wherry, E John / Hensley, Scott E

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to accumulate substitutions, leading to breakthrough infections of vaccinated individuals and prompting the development of updated booster vaccines. Here, we ...

    Abstract The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to accumulate substitutions, leading to breakthrough infections of vaccinated individuals and prompting the development of updated booster vaccines. Here, we determined the specificity and functionality of antibody and B cell responses following exposure to BA.5 and XBB variants in individuals who received ancestral SARS-CoV-2 mRNA vaccines. BA.5 exposures elicited antibody responses that primarily targeted epitopes conserved between the BA.5 and ancestral spike, with poor reactivity to the XBB.1.5 variant. XBB exposures also elicited antibody responses that targeted epitopes conserved between the XBB.1.5 and ancestral spike. However, unlike BA.5, a single XBB exposure elicited low levels of XBB.1.5-specific antibodies and B cells in some individuals. Pre-existing cross-reactive B cells and antibodies were correlated with stronger overall responses to XBB but weaker XBB-specific responses, suggesting that baseline immunity influences the activation of variant-specific SARS-CoV-2 responses.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.08.24301002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants.

    Johnston, Timothy S / Li, Shuk Hang / Painter, Mark M / Atkinson, Reilly K / Douek, Naomi R / Reeg, David B / Douek, Daniel C / Wherry, E John / Hensley, Scott E

    Immunity

    2024  Volume 57, Issue 4, Page(s) 912–925.e4

    Abstract: The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to accumulate substitutions, leading to breakthrough infections of vaccinated individuals. It remains unclear if exposures to antigenically distant SARS-CoV- ... ...

    Abstract The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to accumulate substitutions, leading to breakthrough infections of vaccinated individuals. It remains unclear if exposures to antigenically distant SARS-CoV-2 variants can overcome memory B cell biases established by initial SARS-CoV-2 encounters. We determined the specificity and functionality of antibody and B cell responses following exposure to BA.5 and XBB variants in individuals who received ancestral SARS-CoV-2 mRNA vaccines. BA.5 exposures elicited antibody responses that targeted epitopes conserved between the BA.5 and ancestral spike. XBB exposures also elicited antibody responses that primarily targeted epitopes conserved between the XBB.1.5 and ancestral spike. However, unlike BA.5, a single XBB exposure elicited low frequencies of XBB.1.5-specific antibodies and B cells in some individuals. Pre-existing cross-reactive B cells and antibodies were correlated with stronger overall responses to XBB but weaker XBB-specific responses, suggesting that baseline immunity influences the activation of variant-specific SARS-CoV-2 responses.
    MeSH term(s) Humans ; SARS-CoV-2 ; Antibody Formation ; COVID-19 ; Antibodies ; Epitopes ; Antibodies, Neutralizing ; Antibodies, Viral
    Chemical Substances Antibodies ; Epitopes ; Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2024.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  6. Article ; Online: What policy makers need to know about COVID-19 protective immunity.

    Altmann, Daniel M / Douek, Daniel C / Boyton, Rosemary J

    Lancet (London, England)

    2020  Volume 395, Issue 10236, Page(s) 1527–1529

    MeSH term(s) Administrative Personnel ; Antibodies, Viral/blood ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Humans ; Immunity, Herd ; Mass Vaccination ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30985-5
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
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  7. Article ; Online: Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design.

    Schramm, Chaim A / Douek, Daniel C

    Frontiers in immunology

    2018  Volume 9, Page(s) 1876

    Abstract: The evolution of antibodies in an individual during an immune response by somatic hypermutation (SHM) is essential for the ability of the immune system to recognize and remove the diverse spectrum of antigens that may be encountered. These mutations are ... ...

    Abstract The evolution of antibodies in an individual during an immune response by somatic hypermutation (SHM) is essential for the ability of the immune system to recognize and remove the diverse spectrum of antigens that may be encountered. These mutations are not produced at random; nucleotide motifs that result in increased or decreased rates of mutation were first reported in 1992. Newer models that estimate the propensity for mutation for every possible 5- or 7-nucleotide motif have emphasized the complexity of SHM targeting and suggested possible new hot spot motifs. Even with these fine-grained approaches, however, non-local context matters, and the mutations observed at a specific nucleotide motif varies between species and even by locus, gene segment, and position along the gene segment within a single species. An alternative method has been provided to further abstract away the molecular mechanisms underpinning SHM, prompted by evidence that certain stereotypical amino acid substitutions are favored at each position of a particular
    MeSH term(s) Amino Acid Sequence ; Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Base Sequence ; Evolution, Molecular ; Humans ; Immunity ; Immunogenicity, Vaccine ; Nucleotide Motifs ; Somatic Hypermutation, Immunoglobulin ; Vaccine Potency ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2018-08-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.01876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Predicting the impact of COVID-19 non-pharmaceutical intervention on short- and medium-term dynamics of enterovirus D68 in the US.

    Park, Sang Woo / Messacar, Kevin / Douek, Daniel C / Spaulding, Alicen B / Metcalf, C Jessica E / Grenfell, Bryan T

    Epidemics

    2023  Volume 46, Page(s) 100736

    Abstract: Recent outbreaks of enterovirus D68 (EV-D68) infections, and their causal linkage with acute flaccid myelitis (AFM), continue to pose a serious public health concern. During 2020 and 2021, the dynamics of EV-D68 and other pathogens have been ... ...

    Abstract Recent outbreaks of enterovirus D68 (EV-D68) infections, and their causal linkage with acute flaccid myelitis (AFM), continue to pose a serious public health concern. During 2020 and 2021, the dynamics of EV-D68 and other pathogens have been significantly perturbed by non-pharmaceutical interventions against COVID-19; this perturbation presents a powerful natural experiment for exploring the dynamics of these endemic infections. In this study, we analyzed publicly available data on EV-D68 infections, originally collected through the New Vaccine Surveillance Network, to predict their short- and long-term dynamics following the COVID-19 interventions. Although long-term predictions are sensitive to our assumptions about underlying dynamics and changes in contact rates during the NPI periods, the likelihood of a large outbreak in 2023 appears to be low. Comprehensive surveillance data are needed to accurately characterize future dynamics of EV-D68. The limited incidence of AFM cases in 2022, despite large EV-D68 outbreaks, poses further questions for the timing of the next AFM outbreaks.
    MeSH term(s) Humans ; Enterovirus D, Human ; COVID-19/epidemiology ; Neuromuscular Diseases/epidemiology ; Myelitis/epidemiology ; Disease Outbreaks ; Enterovirus Infections/epidemiology ; Enterovirus Infections/prevention & control ; Central Nervous System Viral Diseases
    Language English
    Publishing date 2023-12-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2467993-8
    ISSN 1878-0067 ; 1755-4365
    ISSN (online) 1878-0067
    ISSN 1755-4365
    DOI 10.1016/j.epidem.2023.100736
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  10. Article ; Online: Immune activation, HIV persistence, and the cure.

    Douek, Daniel C

    Topics in antiviral medicine

    2013  Volume 21, Issue 4, Page(s) 128–132

    Abstract: ... by Daniel C. Douek, MD, PhD, at the IAS-USA continuing education program held in San Francisco, California ...

    Abstract HIV infection is characterized by persistent immune activation, even in the context of suppressive antiretroviral therapy. This persistent activation, which appears to be fueled by microbial translocation from the gut resulting from HIV-related damage, is associated with deficits in immune function that in turn contribute to persistent activation. The presence of latent HIV reservoirs in lymphoid tissues also provokes immune activation in the context of immune suppression, resulting in expansion of the viral reservoir and potential viral replication, even with suppressive antiretroviral therapy. Therapeutic strategies are being devised to reduce persistent immune activation and limit the size of the HIV reservoir. This article summarizes a presentation by Daniel C. Douek, MD, PhD, at the IAS-USA continuing education program held in San Francisco, California, in March 2013.
    MeSH term(s) Anti-HIV Agents/therapeutic use ; Bacterial Translocation/immunology ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/microbiology ; Gastrointestinal Tract/virology ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/immunology ; HIV-1/physiology ; Humans ; Immunity, Cellular/immunology ; Pyrrolidinones/therapeutic use ; Raltegravir Potassium ; Viral Load ; Virus Latency ; Virus Replication
    Chemical Substances Anti-HIV Agents ; Pyrrolidinones ; Raltegravir Potassium (43Y000U234)
    Language English
    Publishing date 2013-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5853
    ISSN (online) 2161-5853
    ISSN 2161-5853
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