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  1. Article ; Online: Evaluation of a Summer Medical Student Research Program during a Pandemic.

    Hardie, William D

    ATS scholar

    2021  Volume 2, Issue 2, Page(s) 172–175

    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Journal Article
    ISSN 2690-7097
    ISSN (online) 2690-7097
    DOI 10.34197/ats-scholar.2021-0014BR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exercise-induced laryngeal obstruction: A step in the right direction.

    Hardie, William D / Kercsmar, Carolyn M

    The Journal of allergy and clinical immunology

    2021  Volume 149, Issue 4, Page(s) 1216–1217

    MeSH term(s) Airway Obstruction/etiology ; Humans ; Laryngeal Diseases/etiology ; Respiratory Sounds
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.12.773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF.

    Yombo, Dan Jk / Ghandikota, Sudhir / Vemulapalli, Chanukya P / Singh, Priyanka / Jegga, Anil G / Hardie, William D / Madala, Sathish K

    American journal of physiology. Cell physiology

    2024  

    Abstract: Idiopathic pulmonary fibrosis (IPF) is marked by the activation of fibroblasts, leading to excessive production and deposition of extracellular matrix (ECM) within the lung parenchyma. Despite the pivotal role of ECM overexpression in IPF, potential ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) is marked by the activation of fibroblasts, leading to excessive production and deposition of extracellular matrix (ECM) within the lung parenchyma. Despite the pivotal role of ECM overexpression in IPF, potential negative regulators of ECM production in fibroblasts have yet to be identified. Semaphorin class 3B (SEMA3B), a secreted protein highly expressed in lung tissues, has established roles in axonal guidance and tumor suppression. However, the role of SEMA3B in ECM production by fibroblasts in the pathogenesis of IPF remains unexplored. Here, we show the downregulation of
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00681.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Introducing trainees to research using an online, asynchronous course.

    Blackard, Jason T / Knapke, Jacqueline M / Schuckman, Stephanie / Veevers, Jennifer / Hardie, William D / Ryan, Patrick H

    Journal of clinical and translational science

    2023  Volume 7, Issue 1, Page(s) e155

    Abstract: Introduction: Research is an important aspect of many students' training. However, formal research training is rarely included in curricula. Thus, we developed an online, asynchronous series of modules to introduce trainees to multiple topics that are ... ...

    Abstract Introduction: Research is an important aspect of many students' training. However, formal research training is rarely included in curricula. Thus, we developed an online, asynchronous series of modules to introduce trainees to multiple topics that are relevant to the conduct of research.
    Methods: Research 101
    Results: Pre-module survey results showed that learners felt most confident with the
    Conclusions: These data demonstrate that significant learning resulted from completion of
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Journal Article
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2023.579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pulmonary fibroelastosis - A review.

    Yombo, Dan J K / Madala, Satish K / Vemulapalli, Chanukya P / Ediga, Harshavardhana H / Hardie, William D

    Matrix biology : journal of the International Society for Matrix Biology

    2023  Volume 124, Page(s) 1–7

    Abstract: Elastin is a long-lived fibrous protein that is abundant in the extracellular matrix of the lung. Elastic fibers provide the lung the characteristic elasticity during inhalation with recoil during exhalation thereby ensuring efficient gas exchange. ... ...

    Abstract Elastin is a long-lived fibrous protein that is abundant in the extracellular matrix of the lung. Elastic fibers provide the lung the characteristic elasticity during inhalation with recoil during exhalation thereby ensuring efficient gas exchange. Excessive deposition of elastin and other extracellular matrix proteins reduces lung compliance by impairing ventilation and compromising gas exchange. Notably, the degree of elastosis is associated with the progressive decline in lung function and survival in patients with interstitial lung diseases. Currently there are no proven therapies which effectively reduce the elastin burden in the lung nor prevent dysregulated elastosis. This review describes elastin's role in the healthy lung, summarizes elastosis in pulmonary diseases, and evaluates the current understanding of elastin regulation and dysregulation with the goal of guiding future research efforts to develop novel and effective therapies.
    MeSH term(s) Humans ; Lung/metabolism ; Lung Diseases, Interstitial/metabolism ; Fibrosis ; Elastin ; Elastic Tissue/metabolism
    Chemical Substances Elastin (9007-58-3)
    Language English
    Publishing date 2023-11-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2023.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: (F)utility of preoperative pulmonary function testing in pectus excavatum to assess severity.

    Gonzalez, Gabriel C / Berazaluce, Alejandra M Casar / Jenkins, Todd M / Hardie, William D / Foster, Karla E / Moore, Ryan A / Powell, Adam W / Garcia, Victor F / Brown, Rebeccah L

    Pediatric surgery international

    2024  Volume 40, Issue 1, Page(s) 102

    Abstract: Purpose: The utility of pulmonary function testing (PFT) in pectus excavatum (PE) has been subject to debate. Although some evidence shows improvement from preoperative to postoperative values, the clinical significance is uncertain. A high failure-to- ... ...

    Abstract Purpose: The utility of pulmonary function testing (PFT) in pectus excavatum (PE) has been subject to debate. Although some evidence shows improvement from preoperative to postoperative values, the clinical significance is uncertain. A high failure-to-completion rate for operative PFT (48%) was identified in our large institutional cohort. With such a high non-completion rate, we questioned the overall utility of PFT in the preoperative assessment of PE and sought to evaluate if other measures of PE severity or cardiopulmonary function could explain this finding.
    Methods: Demographics, clinical findings, and results from cardiac MRI, PFT (spirometry and plethysmography), and cardiopulmonary exercise tests (CPET) were reviewed in 270 patients with PE evaluated preoperatively between 2015 and 2018. Regression modeling was used to measure associations between PFT completion and cardiopulmonary function.
    Results: There were no differences in demographics, symptoms, connective tissue disorders, or multiple indices of pectus severity and cardiac deformation in PFT completers versus non-completers. While regression analysis revealed higher RVEF, LVEF, and LVEF-Z scores, lower RV-ESV/BSA, LV-ESV/BSA, and LV-ESV/BSA-Z scores, and abnormal breathing reserve in PFT completers vs. non-completers, these findings were not consistent across continuous and binary analyses.
    Conclusions: We found that PFT completers were not significantly different from non-completers in most structural and functional measures of pectus deformity and cardiopulmonary function. Inability to complete PFT is not an indicator of pectus severity.
    MeSH term(s) Humans ; Funnel Chest/surgery ; Spirometry
    Language English
    Publishing date 2024-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-024-05675-3
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    Zs.A 2138: Show issues Location:
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  7. Article: Added value of iodine-specific imaging and virtual non-contrast imaging for gastrointestinal assessment using dual-energy computed tomography.

    Kocher, Madison R / Kovacs, Mark D / Stewart, William / Flemming, Brian P / Hinen, Shaun / Hardie, Andrew D

    Journal of clinical imaging science

    2021  Volume 11, Page(s) 68

    Abstract: Dual-energy computed tomography (DECT) has become increasingly available and can be readily incorporated into clinical practice. Although DECT can provide a wide variety of spectral imaging reconstructions, most clinically valuable information is ... ...

    Abstract Dual-energy computed tomography (DECT) has become increasingly available and can be readily incorporated into clinical practice. Although DECT can provide a wide variety of spectral imaging reconstructions, most clinically valuable information is available from a limited number of standard image reconstructions including virtual non-contrast and iodine overlay. The combination of these standard reconstructions can be used for specific diagnostic tasks that provide added value over traditional CT protocols. In this pictorial essay, the added value of these standard reconstructed images will be demonstrated by case examples for diseases specifically related to the gastrointestinal system.
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601233-9
    ISSN 2156-5597 ; 2156-7514
    ISSN (online) 2156-5597
    ISSN 2156-7514
    DOI 10.25259/JCIS_199_2021
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  8. Article ; Online: Research 101:

    Blackard, Jason T / Knapke, Jacqueline M / Ryan, Patrick H / Schuckman, Stephanie / Veevers, Jennifer / Hardie, William D / Heubi, James E

    Journal of clinical and translational science

    2022  Volume 6, Issue 1, Page(s) e102

    Abstract: Introduction: Research is an important aspect of many medical students' training. However, many medical students are not required to complete a scholarly project, and formal research training is often fragmented across the medical school curriculum. ... ...

    Abstract Introduction: Research is an important aspect of many medical students' training. However, many medical students are not required to complete a scholarly project, and formal research training is often fragmented across the medical school curriculum. Thus, we developed an online, structured, asynchronous set of modules to introduce trainees to multiple topics relevant to the conduct of research.
    Methods: Research 101
    Results: Pre-module survey results showed that learners felt most confident in
    Conclusions: Comparison of post-module to pre-module survey scores provided clear evidence of improved learning across all topics. The modules developed were responsive to the students' needs, and students provided additional improvements for subsequent iterations of
    Language English
    Publishing date 2022-08-01
    Publishing country England
    Document type Journal Article
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2022.435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Introducing trainees to research using an online, asynchronous course

    Jason T. Blackard / Jacqueline M. Knapke / Stephanie Schuckman / Jennifer Veevers / William D. Hardie / Patrick H. Ryan

    Journal of Clinical and Translational Science, Vol

    2023  Volume 7

    Abstract: Abstract Introduction: Research is an important aspect of many students’ training. However, formal research training is rarely included in curricula. Thus, we developed an online, asynchronous series of modules to introduce trainees to multiple topics ... ...

    Abstract Abstract Introduction: Research is an important aspect of many students’ training. However, formal research training is rarely included in curricula. Thus, we developed an online, asynchronous series of modules to introduce trainees to multiple topics that are relevant to the conduct of research. Methods: Research 101 was utilized by first-year medical students and undergraduate students conducting mentored research projects. Students’ knowledge, confidence, and satisfaction were assessed using pre- and post-module surveys with five-point Likert scaled questions, open-ended text responses, and a final quiz. Results: Pre-module survey results showed that learners felt most confident with the Conducting a literature search and Race and racism in medicine modules and least confident with the Submitting an Institutional Review Board protocol at UC module. Post-module survey responses were significantly increased compared to pre-module results for all modules and questions (p < 0.0001). The response to “The content of this module met my needs” was endorsed across all modules (84.9% “yes” responses). A final quiz of 25 multiple-choice questions was completed by 92 participants who received a median score of 21. Content analysis of open-ended post-module survey responses identified several strengths and opportunities for improvement in course content and instructional methods. Conclusions: These data demonstrate that significant learning resulted from completion of Research 101, as post-module survey scores were significantly higher than pre-module survey scores for all modules and questions. Final quiz scores were positive but also highlighted opportunity for additional trainee learning and will guide evolution of future modules.
    Keywords Research training ; medical student ; scholarly activity ; Medicine ; R
    Subject code 370
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Black walnut tree syrup is not allergenic in individuals with a documented walnut allergy.

    Lierl, Michelle / Assa'ad, Amal / Jennings, Jennifer / Farrell, Michael / Hardie, William D

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 6, Page(s) 2096–2097

    MeSH term(s) Allergens ; Humans ; Hypersensitivity ; Juglans ; Nuts ; Trees
    Chemical Substances Allergens
    Language English
    Publishing date 2020-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.01.061
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