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  1. Article ; Online: Integrated organ immunity: a path to a universal vaccine.

    Pulendran, Bali

    Nature reviews. Immunology

    2024  Volume 24, Issue 2, Page(s) 81–82

    MeSH term(s) Humans ; Influenza, Human ; Influenza Vaccines
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-024-00990-1
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  2. Book: From innate immunity to immunological memory

    Pulendran, Bali

    (Current topics in microbiology and immunology ; 311)

    2006  

    Author's details B. Pulendran ... (ed.)
    Series title Current topics in microbiology and immunology ; 311
    Collection
    Keywords Angeborene Immunität
    Language English
    Size VI, 182 S. : Ill.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014856356
    ISBN 9783540326357 ; 3-540-32635-9 ; 978-3-540-32635-9
    Database Catalogue ZB MED Medicine, Health

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    Ud II Zs 24 -311- verfügbar in Königswinter Königswinter

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  3. Book ; Conference proceedings: Crossroads between innate and adaptive immunity III

    Katsikis, Peter D. / Pulendran, Bali

    (Advances in experimental medicine and biology ; 780 ; Biomedicine)

    2011  

    Event/congress Crossroads Between Innate and Adaptive Immunity Conference (3, 2009, Chania)
    Author's details Bali Pulendran, Peter D. Katsikis ... (ed.)
    Series title Advances in experimental medicine and biology ; 780
    Biomedicine
    Collection
    Language English
    Size X, 174 S. : Ill., graf. Darst., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016946912
    ISBN 978-1-441-95631-6 ; 1-441-95631-X ; 9781441956323 ; 1441956328
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3192 -780- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Immunology taught by vaccines.

    Pulendran, Bali

    Science (New York, N.Y.)

    2019  Volume 366, Issue 6469, Page(s) 1074–1075

    MeSH term(s) Animals ; Gastrointestinal Microbiome/immunology ; Humans ; Immunity ; Immunogenicity, Vaccine ; Mice ; Mice, Mutant Strains ; Toll-Like Receptor 5/genetics ; Vaccination ; Vaccines/immunology
    Chemical Substances Tlr5 protein, mouse ; Toll-Like Receptor 5 ; Vaccines
    Language English
    Publishing date 2019-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aau6975
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  5. Article ; Online: Editorial overview: Vaccines 2020.

    Pulendran, Bali / Rappuoli, Rino

    Current opinion in immunology

    2020  Volume 65, Page(s) iii

    MeSH term(s) Antigens/immunology ; Humans ; Vaccination ; Viral Vaccines/immunology
    Chemical Substances Antigens ; Viral Vaccines
    Language English
    Publishing date 2020-12-07
    Publishing country England
    Document type Editorial
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.11.002
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  6. Article ; Online: Epigenetic adjuvants: durable reprogramming of the innate immune system with adjuvants.

    Lee, Audrey / Wimmers, Florian / Pulendran, Bali

    Current opinion in immunology

    2022  Volume 77, Page(s) 102189

    Abstract: Development of effective vaccines is a critical global health priority. Stimulating antigen-specific B and T cells to elicit long-lasting protection remains the central paradigm of vaccinology. Adjuvants are components that enhance vaccine immunogenicity ...

    Abstract Development of effective vaccines is a critical global health priority. Stimulating antigen-specific B and T cells to elicit long-lasting protection remains the central paradigm of vaccinology. Adjuvants are components that enhance vaccine immunogenicity by targeting specific innate immune receptors and pathways. Recent data highlight the capacity of adjuvants to induce durable epigenetic reprogramming of the innate immune system to engender heightened resistance against pathogens. This raises the prospect of developing epigenetic adjuvants that, in addition to stimulating robust T and B cell responses, convey broad protection against diverse pathogens by training the innate immune system. In this review, we discuss our emerging understanding of the various vaccines and adjuvants and their effects on durable reprogramming of the innate immune response, their putative mechanisms of action, and the promise and challenges of developing epigenetic adjuvants as a universal vaccine strategy.
    MeSH term(s) Adjuvants, Immunologic/pharmacology ; Epigenesis, Genetic ; Humans ; Immune System ; Immunity, Innate ; Vaccines
    Chemical Substances Adjuvants, Immunologic ; Vaccines
    Language English
    Publishing date 2022-05-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2022.102189
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  7. Article ; Online: Emerging technologies for systems vaccinology - multi-omics integration and single-cell (epi)genomic profiling.

    Wimmers, Florian / Pulendran, Bali

    Current opinion in immunology

    2020  Volume 65, Page(s) 57–64

    Abstract: Systems vaccinology leverages high-throughput 'omics' technologies, such as transcriptomics, metabolomics, and mass cytometry, coupled with computational approaches to construct a global map of the complex processes that occur during an immune response ... ...

    Abstract Systems vaccinology leverages high-throughput 'omics' technologies, such as transcriptomics, metabolomics, and mass cytometry, coupled with computational approaches to construct a global map of the complex processes that occur during an immune response to vaccination. Its goal is to define the mechanisms of protective immunity and to identify cellular and molecular correlates of vaccine efficacy. Emerging technological advances including integration of multi-omics datasets, and single-cell genomic and epigenomic profiling of immune responses, have invigorated systems vaccinology, and provide new insights into the mechanisms by which the cellular and molecular information underlying immune memory is stored in the innate and adaptive immune systems. Here, we will review these emerging directions in systems vaccinology, with a particular focus on the epigenome, and its impact on modulating vaccination induced memory in the innate and adaptive immune systems.
    MeSH term(s) Epigenesis, Genetic/genetics ; Epigenesis, Genetic/immunology ; Humans ; Immune System/immunology ; Systems Biology ; Vaccinology
    Language English
    Publishing date 2020-06-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.05.001
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  8. Article ; Online: The science and medicine of human immunology.

    Pulendran, Bali / Davis, Mark M

    Science (New York, N.Y.)

    2020  Volume 369, Issue 6511

    Abstract: Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of ... ...

    Abstract Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of immunity. More recently, new strategies and technologies have been developed to directly explore the human immune system with unprecedented precision. We discuss how these approaches are advancing our mechanistic understanding of human immunology and are facilitating the development of vaccines and therapeutics for infection, autoimmune diseases, and cancer.
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Communicable Disease Control ; Disease Models, Animal ; Genetic Variation ; Humans ; Immune System ; Immunity/genetics ; Immunogenicity, Vaccine/genetics ; Infections/immunology ; Infections/therapy ; Mice ; Mice, Inbred Strains ; Neoplasms/immunology ; Neoplasms/therapy ; Translational Research, Biomedical/trends ; Vaccination ; Vaccines/immunology ; Vaccines/therapeutic use
    Chemical Substances Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aay4014
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  9. Article ; Online: The varieties of immunological experience: of pathogens, stress, and dendritic cells.

    Pulendran, Bali

    Annual review of immunology

    2015  Volume 33, Page(s) 563–606

    Abstract: In the 40 years since their discovery, dendritic cells (DCs) have been recognized as central players in immune regulation. DCs sense microbial stimuli through pathogen-recognition receptors (PRRs) and decode, integrate, and present information derived ... ...

    Abstract In the 40 years since their discovery, dendritic cells (DCs) have been recognized as central players in immune regulation. DCs sense microbial stimuli through pathogen-recognition receptors (PRRs) and decode, integrate, and present information derived from such stimuli to T cells, thus stimulating immune responses. DCs can also regulate the quality of immune responses. Several functionally specialized subsets of DCs exist, but DCs also display functional plasticity in response to diverse stimuli. In addition to sensing pathogens via PRRs, emerging evidence suggests that DCs can also sense stress signals, such as amino acid starvation, through ancient stress and nutrient sensing pathways, to stimulate adaptive immunity. Here, I discuss these exciting advances in the context of a historic perspective on the discovery of DCs and their role in immune regulation. I conclude with a discussion of emerging areas in DC biology in the systems immunology era and suggest that the impact of DCs on immunity can be usefully contextualized in a hierarchy-of-organization model in which DCs, their receptors and signaling networks, cell-cell interactions, tissue microenvironment, and the host macroenvironment represent different levels of the hierarchy. Immunity or tolerance can then be represented as a complex function of each of these hierarchies.
    MeSH term(s) Animals ; Cell Communication/immunology ; Cell Differentiation/immunology ; Clonal Selection, Antigen-Mediated ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Disease Resistance ; Disease Susceptibility ; Host-Pathogen Interactions/immunology ; Humans ; Lymphocytes/cytology ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Stress, Physiological
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-020711-075049
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  10. Article ; Online: The immunology of SARS-CoV-2 infections and vaccines.

    Grigoryan, Lilit / Pulendran, Bali

    Seminars in immunology

    2020  Volume 50, Page(s) 101422

    Abstract: SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million deaths around the world, to date, this pandemic represents the gravest global health ... ...

    Abstract SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million deaths around the world, to date, this pandemic represents the gravest global health crisis of our times. Thus, the race to develop a COVID-19 vaccine is an urgent global imperative. At the time of writing, there are over 165 vaccine candidates being developed, with 33 in various stages of clinical testing. In this review, we discuss emerging insights about the human immune response to SARS-CoV-2, and their implications for vaccine design. We then review emerging knowledge of the immunogenicity of the numerous vaccine candidates that are currently being tested in the clinic and discuss the range of immune defense mechanisms that can be harnessed to develop novel vaccines that confer durable protection against SARS-CoV-2. Finally, we conclude with a discussion of the potential role of a systems vaccinology approach in accelerating the clinical testing of vaccines, to meet the urgent needs posed by the pandemic.
    MeSH term(s) Adjuvants, Immunologic/therapeutic use ; Adult ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Disease Models, Animal ; Drug Design ; Humans ; Middle Aged ; SARS-CoV-2/immunology ; Systems Biology/methods ; T-Lymphocytes/immunology ; Vaccinology/methods ; Young Adult
    Chemical Substances Adjuvants, Immunologic ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2020.101422
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