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  1. Article: Status epilepticus: current treatment strategies.

    Manno, Edward M

    The Neurohospitalist

    2013  Volume 1, Issue 1, Page(s) 23–31

    Abstract: Status epilepticus is a neurological emergency that is commonly encountered by the neurohospitalist. Successful treatment depends upon the recognition of prolonged seizure activity and the acute mobilization of available resources. Pharmacologic ... ...

    Abstract Status epilepticus is a neurological emergency that is commonly encountered by the neurohospitalist. Successful treatment depends upon the recognition of prolonged seizure activity and the acute mobilization of available resources. Pharmacologic treatment regimens have been shown to decrease the time needed for successful control of seizures and have provided for the rapid administration of anticonvulsant medications. Treatment strategies have evolved so that clinicians can administer effective doses of medication by whatever routes of administration are immediately available. Traditional algorithms for the treatment of status epilepticus have used a stepwise approach to the administration of first-, second-, and third-order medications. More recent options have included aggressive anesthetic doses of medications while second-line medications are being titrated.
    Language English
    Publishing date 2013-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2629083-2
    ISSN 1941-8752 ; 1941-8744
    ISSN (online) 1941-8752
    ISSN 1941-8744
    DOI 10.1177/1941875210383176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Update on intracerebral hemorrhage.

    Manno, Edward M

    Continuum (Minneapolis, Minn.)

    2012  Volume 18, Issue 3, Page(s) 598–610

    Abstract: Purpose of review: This article provides an update on the latest diagnostic and therapeutic trials relating to the management of intracerebral hemorrhage (ICH).: Recent findings: Early hematoma expansion and worsening cerebral edema may account for ... ...

    Abstract Purpose of review: This article provides an update on the latest diagnostic and therapeutic trials relating to the management of intracerebral hemorrhage (ICH).
    Recent findings: Early hematoma expansion and worsening cerebral edema may account for delayed neurologic deterioration after ICH.
    Summary: Despite advances in other areas of stroke, there has been no significant improvement in the morbidity and mortality after ICH. The cause of ICH has been shifting from chronic hypertension to other etiologies. Current understanding of the pathophysiologic processes involved with hematoma expansion and the development of secondary injury after ICH has focused the treatment strategies on prevention of these potential complications. Care for the patient after ICH includes basic medical care, prevention of hematoma expansion, and treatment of potential secondary complications. Trials are underway to evaluate the effect of acute blood pressure control on hematoma expansion and the development of cerebral edema. Similarly, new surgical techniques are being explored for clot removal, and medical therapies are being developed to prevent secondary neurotoxic damage.
    MeSH term(s) Anticoagulants/adverse effects ; Antihypertensive Agents/therapeutic use ; Brain Damage, Chronic/etiology ; Brain Damage, Chronic/prevention & control ; Brain Edema/drug therapy ; Brain Edema/etiology ; Brain Edema/prevention & control ; Cerebral Amyloid Angiopathy/complications ; Cerebral Hemorrhage/diagnosis ; Cerebral Hemorrhage/epidemiology ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/surgery ; Cerebral Hemorrhage/therapy ; Clinical Trials as Topic ; Combined Modality Therapy ; Critical Care/methods ; Emergencies ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Intracranial Hypertension/etiology ; Intracranial Hypertension/prevention & control ; Life Support Care ; Multicenter Studies as Topic ; Neuroimaging ; Risk Factors ; Severity of Illness Index ; Thrombolytic Therapy
    Chemical Substances Anticoagulants ; Antihypertensive Agents
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1080-2371
    ISSN 1080-2371
    DOI 10.1212/01.CON.0000415430.99394.3e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Neurohospitalists: Challenges for the Integration of a New Field: A Neurointensivist's Perspective.

    Manno, Edward M

    Frontiers in neurology

    2010  Volume 1, Page(s) 154

    Language English
    Publishing date 2010-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295 ; 1664-2295
    ISSN (online) 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2010.00154
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  4. Article ; Online: Society of Critical Care Medicine Clinical Practice Guidelines for Rapid Sequence Intubation in the Critically Ill Adult Patient: Executive Summary.

    Acquisto, Nicole M / Mosier, Jarrod M / Bittner, Edward A / Patanwala, Asad E / Hirsch, Karen G / Hargwood, Pamela / Oropello, John M / Bodkin, Ryan P / Groth, Christine M / Kaucher, Kevin A / Slampak-Cindric, Angela A / Manno, Edward M / Mayer, Stephen A / Peterson, Lars-Kristofer N / Fulmer, Jeremy / Galton, Christopher / Bleck, Thomas P / Chase, Karin / Heffner, Alan C /
    Gunnerson, Kyle J / Boling, Bryan / Murray, Michael J

    Critical care medicine

    2023  Volume 51, Issue 10, Page(s) 1407–1410

    MeSH term(s) Adult ; Humans ; Critical Illness/therapy ; Rapid Sequence Induction and Intubation
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article ; Practice Guideline
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Treatment of malignant brain edema and increased intracranial pressure after stroke.

    Brogan, Michael E / Manno, Edward M

    Current treatment options in neurology

    2014  Volume 17, Issue 1, Page(s) 327

    Abstract: Opinion statement: The management of patients with large territory ischemic strokes and the subsequent development of malignant brain edema and increased intracranial pressure is a significant challenge in modern neurology and neurocritical care. These ... ...

    Abstract Opinion statement: The management of patients with large territory ischemic strokes and the subsequent development of malignant brain edema and increased intracranial pressure is a significant challenge in modern neurology and neurocritical care. These patients are at high risk of subsequent neurologic decline and are best cared for in an intensive care unit or a comprehensive stroke center with access to neurosurgical support. Risks include hemorrhagic conversion, herniation, poor functional outcome, and death. This review discusses recent advances in understanding the pathophysiology of edema formation, identifying patients at risk, current management strategies, and emerging therapies.
    Language English
    Publishing date 2014-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2057342-X
    ISSN 1534-3138 ; 1092-8480
    ISSN (online) 1534-3138
    ISSN 1092-8480
    DOI 10.1007/s11940-014-0327-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5535: Show issues Location:
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  6. Article: Neurotoxicity of commonly used hepatic drugs.

    Ahrens, Christine L / Manno, Edward M

    Handbook of clinical neurology

    2014  Volume 120, Page(s) 675–682

    Abstract: Neurologic complications are common side-effects of immunosuppressive medications used in the prevention of graft rejection after organ transplantation. The medications most commonly encountered include the calcineurin inhibitors and mycophenolate ... ...

    Abstract Neurologic complications are common side-effects of immunosuppressive medications used in the prevention of graft rejection after organ transplantation. The medications most commonly encountered include the calcineurin inhibitors and mycophenolate mofetil. Depression is the most commonly encountered neurotoxicity; however, severe but rare adverse neurological effects related to these therapies have been reported. Interferons, ribavirin, and protease inhibitors are therapeutic options commonly encountered in the treatment of hepatitis. Nucleoside analogs such as adefovir dipivoxil and entecavir carry significant risks for the development of lactic acidosis and hepatic dysfunction; however, most common adverse effects to these therapies in general are mild. While the mechanisms of action are poorly elucidated, they are discussed along with treatment strategies.
    MeSH term(s) Hepatitis/drug therapy ; Hepatitis/surgery ; Humans ; Immunosuppressive Agents/adverse effects ; Liver Transplantation/methods ; Neurotoxicity Syndromes/etiology
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2014
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-7020-4087-0.00046-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Safety issues and concerns for the neurological patient in the emergency department.

    Manno, Edward M

    Neurocritical care

    2008  Volume 9, Issue 2, Page(s) 259–264

    Abstract: Introduction: Patient safety in our medical system has been an increasing national concern. Neurological patient safety in the emergency department (ED) has not been studied. The purpose of this article is thus to describe the issues relevant to ... ...

    Abstract Introduction: Patient safety in our medical system has been an increasing national concern. Neurological patient safety in the emergency department (ED) has not been studied. The purpose of this article is thus to describe the issues relevant to neurological patient safety in the ED, review the current status of the literature, identify specific patient populations at risk, and suggest applicable solutions.
    Methods: Medline and PubMed literature review of key words associated with patient safety, neurological diseases, and EDs.
    Results: Little data can be found on overall neurological patient safety in the ED, however data for specific neurological emergencies including subarachnoid hemorrhage, stroke, status epilepticus, and head and spine trauma does exist and is reviewed.
    Conclusions: Limitations in ED education and access to neurological expertise may place some patients at risk. Recommendations for improving neurological patient safety in the EDs are suggested and include a discussion on barriers to implementation.
    MeSH term(s) Diagnostic Errors ; Emergency Service, Hospital/standards ; Emergency Service, Hospital/statistics & numerical data ; Humans ; Nervous System Diseases/diagnosis ; Nervous System Diseases/epidemiology ; Nervous System Diseases/therapy ; Quality of Health Care ; Risk Factors ; Safety
    Language English
    Publishing date 2008-06-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-008-9111-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6538: Show issues Location:
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  8. Article ; Online: Society of Critical Care Medicine Clinical Practice Guidelines for Rapid Sequence Intubation in the Critically Ill Adult Patient.

    Acquisto, Nicole M / Mosier, Jarrod M / Bittner, Edward A / Patanwala, Asad E / Hirsch, Karen G / Hargwood, Pamela / Oropello, John M / Bodkin, Ryan P / Groth, Christine M / Kaucher, Kevin A / Slampak-Cindric, Angela A / Manno, Edward M / Mayer, Stephen A / Peterson, Lars-Kristofer N / Fulmer, Jeremy / Galton, Christopher / Bleck, Thomas P / Chase, Karin / Heffner, Alan C /
    Gunnerson, Kyle J / Boling, Bryan / Murray, Michael J

    Critical care medicine

    2023  Volume 51, Issue 10, Page(s) 1411–1430

    Abstract: Rationale: Controversies and practice variations exist related to the pharmacologic and nonpharmacologic management of the airway during rapid sequence intubation (RSI).: Objectives: To develop evidence-based recommendations on pharmacologic and ... ...

    Abstract Rationale: Controversies and practice variations exist related to the pharmacologic and nonpharmacologic management of the airway during rapid sequence intubation (RSI).
    Objectives: To develop evidence-based recommendations on pharmacologic and nonpharmacologic topics related to RSI.
    Design: A guideline panel of 20 Society of Critical Care Medicine members with experience with RSI and emergency airway management met virtually at least monthly from the panel's inception in 2018 through 2020 and face-to-face at the 2020 Critical Care Congress. The guideline panel included pharmacists, physicians, a nurse practitioner, and a respiratory therapist with experience in emergency medicine, critical care medicine, anesthesiology, and prehospital medicine; consultation with a methodologist and librarian was available. A formal conflict of interest policy was followed and enforced throughout the guidelines-development process.
    Methods: Panelists created Population, Intervention, Comparison, and Outcome (PICO) questions and voted to select the most clinically relevant questions for inclusion in the guideline. Each question was assigned to a pair of panelists, who refined the PICO wording and reviewed the best available evidence using predetermined search terms. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework was used throughout and recommendations of "strong" or "conditional" were made for each PICO question based on quality of evidence and panel consensus. Recommendations were provided when evidence was actionable; suggestions, when evidence was equivocal; and best practice statements, when the benefits of the intervention outweighed the risks, but direct evidence to support the intervention did not exist.
    Results: From the original 35 proposed PICO questions, 10 were selected. The RSI guideline panel issued one recommendation (strong, low-quality evidence), seven suggestions (all conditional recommendations with moderate-, low-, or very low-quality evidence), and two best practice statements. The panel made two suggestions for a single PICO question and did not make any suggestions for one PICO question due to lack of evidence.
    Conclusions: Using GRADE principles, the interdisciplinary panel found substantial agreement with respect to the evidence supporting recommendations for RSI. The panel also identified literature gaps that might be addressed by future research.
    MeSH term(s) Adult ; Humans ; Airway Management ; Consensus ; Critical Care ; Critical Illness/therapy ; Rapid Sequence Induction and Intubation
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article ; Practice Guideline ; Research Support, Non-U.S. Gov't
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Ventilatory management and extubation criteria of the neurological/neurosurgical patient.

    Souter, M J / Manno, Edward M

    The Neurohospitalist

    2013  Volume 3, Issue 1, Page(s) 39–45

    Abstract: Approximately 200 000 patients per year will require mechanical ventilation secondary to neurological injury or disease. The associated mortality, morbidity, and costs are significant. The neurological patient presents a unique set of challenges to ... ...

    Abstract Approximately 200 000 patients per year will require mechanical ventilation secondary to neurological injury or disease. The associated mortality, morbidity, and costs are significant. The neurological patient presents a unique set of challenges to airway management, mechanical ventilation, and defining extubation readiness. Neurological injury and disease can directly or indirectly involve the process involved with respiration or airway control. This article will review the basics of airway management and mechanical ventilation in the neurological patient. The current state of the literature evaluating extubation criteria in the neurological patient will also be reviewed.
    Language English
    Publishing date 2013-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2629083-2
    ISSN 1941-8752 ; 1941-8744
    ISSN (online) 1941-8752
    ISSN 1941-8744
    DOI 10.1177/1941874412463944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Emergency management in neurocritical care

    Manno, Edward M

    (Neurology in practice.)

    2012  

    Author's details edited by Edward M. Manno
    Series title Neurology in practice.
    MeSH term(s) Central Nervous System Diseases/therapy ; Emergencies ; Critical Care/methods ; Intensive Care Units
    Language English
    Size ix, 244 p. :, ill.
    Publisher Wiley-Blackwell
    Publishing place Chichester, West Sussex
    Document type Book
    ISBN 9780470654736 ; 0470654732
    Database Catalogue of the US National Library of Medicine (NLM)

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