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  1. Article ; Online: Emergency cardiac computed tomography.

    Greer, Charlotte / Newby, David E / Adamson, Philip D

    Heart (British Cardiac Society)

    2022  Volume 108, Issue 24, Page(s) 1928–1929

    MeSH term(s) Humans ; Coronary Angiography/methods ; Chest Pain ; Tomography ; Emergency Service, Hospital ; Acute Coronary Syndrome ; Coronary Artery Disease ; Computed Tomography Angiography
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-321378
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  2. Article ; Online: Role of computed tomography cardiac angiography in acute chest pain syndromes.

    Greer, Charlotte / Williams, Michelle C / Newby, David E / Adamson, Philip D

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 18, Page(s) 1350–1356

    Abstract: Use of CT coronary angiography (CTCA) to evaluate chest pain has rapidly increased over the recent years. While its utility in the diagnosis of coronary artery disease in stable chest pain syndromes is clear and is strongly endorsed by international ... ...

    Abstract Use of CT coronary angiography (CTCA) to evaluate chest pain has rapidly increased over the recent years. While its utility in the diagnosis of coronary artery disease in stable chest pain syndromes is clear and is strongly endorsed by international guidelines, the role of CTCA in the acute setting is less certain. In the low-risk setting, CTCA has been shown to be accurate, safe and efficient but inherent low rates of adverse events in this population and the advent of high-sensitivity troponin testing have left little room for CTCA to show any short-term clinical benefit.In higher-risk populations, CTCA has potential to fulfil a gatekeeper role to invasive angiography. The high negative predictive value of CTCA is maintained while also identifying non-obstructive coronary disease and alternative diagnoses in the substantial group of patients presenting with chest pain who do not have type 1 myocardial infarction. For those with obstructive coronary disease, CTCA provides accurate assessment of stenosis severity, characterisation of high-risk plaque and findings associated with perivascular inflammation. This may allow more appropriate selection of patients to proceed to invasive management with no disadvantage in outcomes and can provide a more comprehensive risk stratification to guide both acute and long-term management than routine invasive angiography.
    MeSH term(s) Humans ; Syndrome ; Chest Pain/diagnostic imaging ; Chest Pain/etiology ; Coronary Artery Disease/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Computed Tomography Angiography ; Coronary Angiography/methods ; Predictive Value of Tests
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-321360
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  3. Article ; Online: Moderna COVID-19 vaccine was linked to myocarditis or myopericarditis at 28 d (4.2 events/100 000 persons).

    Krychtiuk, Konstantin A / Newby, L Kristin

    Annals of internal medicine

    2022  Volume 175, Issue 5, Page(s) JC58

    Abstract: Source citation: Husby A, Hansen JV, Fosbøl E, et al. ...

    Abstract Source citation: Husby A, Hansen JV, Fosbøl E, et al.
    MeSH term(s) 2019-nCoV Vaccine mRNA-1273/adverse effects ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cohort Studies ; Humans ; Myocarditis/chemically induced ; Myocarditis/epidemiology ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0021
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  4. Article ; Online: The SCOT-HEART Trial. What we observed and what we learned.

    Adamson, Philip D / Newby, David E

    Journal of cardiovascular computed tomography

    2019  Volume 13, Issue 3, Page(s) 54–58

    MeSH term(s) Adolescent ; Adult ; Aged ; Angina Pectoris/diagnostic imaging ; Angina Pectoris/mortality ; Angina Pectoris/therapy ; Computed Tomography Angiography ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/mortality ; Coronary Artery Disease/therapy ; Female ; Humans ; Male ; Middle Aged ; Multicenter Studies as Topic ; Predictive Value of Tests ; Prognosis ; Randomized Controlled Trials as Topic ; Research Design ; Risk Factors ; Scotland ; Young Adult
    Language English
    Publishing date 2019-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394360-9
    ISSN 1876-861X ; 1934-5925
    ISSN (online) 1876-861X
    ISSN 1934-5925
    DOI 10.1016/j.jcct.2019.01.006
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  5. Article ; Online: Cardiovascular computed tomography imaging for coronary artery disease risk: plaque, flow and fat.

    Channon, Keith M / Newby, David E / Nicol, Edward D / Deanfield, John

    Heart (British Cardiac Society)

    2022  Volume 108, Issue 19, Page(s) 1510–1515

    Abstract: Cardiac imaging is central to the diagnosis and risk stratification of coronary artery disease, beyond symptoms and clinical risk factors, by providing objective evidence of myocardial ischaemia and characterisation of coronary artery plaque. CT coronary ...

    Abstract Cardiac imaging is central to the diagnosis and risk stratification of coronary artery disease, beyond symptoms and clinical risk factors, by providing objective evidence of myocardial ischaemia and characterisation of coronary artery plaque. CT coronary angiography can detect coronary plaque with high resolution, estimate the degree of functional stenosis and characterise plaque features. However, coronary artery disease risk is also driven by biological processes, such as inflammation, that are not fully reflected by severity of stenosis, myocardial ischaemia or by coronary plaque features. New cardiac CT techniques can assess coronary artery inflammation by imaging perivascular fat, and this may represent an important step forward in identifying the 'residual risk' that is not detected by plaque or ischaemia imaging. Coronary artery disease risk assessment that incorporates clinical factors, plaque characteristics and perivascular inflammation offers a more comprehensive individualised approach to quantify and stratify coronary artery disease risk, with potential healthcare benefits for prevention, diagnosis and treatment recommendations. Furthermore, identifying new biomarkers of cardiovascular risk has the potential to refine early-life prevention strategies, before atherosclerosis becomes established.
    MeSH term(s) Computed Tomography Angiography/methods ; Constriction, Pathologic ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/etiology ; Coronary Stenosis/therapy ; Coronary Vessels/diagnostic imaging ; Humans ; Inflammation ; Myocardial Ischemia ; Plaque, Atherosclerotic/diagnostic imaging ; Predictive Value of Tests
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2021-320265
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  6. Article ; Online: Consistency and Generalizability of Trials for Coronary Computed Tomography Angiography.

    Newby, David E / Adamson, Philip D / Shaw, Leslee J

    JAMA cardiology

    2020  

    Language English
    Publishing date 2020-12-23
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2020.6124
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  7. Article ; Online: Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

    Shek, Naomi / Choy, Anna-Maria / Lang, Chim C / Miller, Bruce E / Tal-Singer, Ruth / Bolton, Charlotte E / Thomson, Neil C / Chalmers, James D / Bown, Matt J / Newby, David E / Khan, Faisel / Huang, Jeffrey T J

    npj aging

    2024  Volume 10, Issue 1, Page(s) 15

    Abstract: Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several ... ...

    Abstract Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ISSN 2731-6068
    ISSN (online) 2731-6068
    DOI 10.1038/s41514-024-00143-7
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  8. Article ; Online: Cellular and molecular imaging of the arteries in the age of precision medicine.

    Forsythe, R O / Newby, D E

    The British journal of surgery

    2018  Volume 105, Issue 4, Page(s) 311–312

    MeSH term(s) Arteries/diagnostic imaging ; Humans ; Magnetic Resonance Angiography/methods ; Molecular Imaging/methods ; Positron Emission Tomography Computed Tomography/methods ; Precision Medicine/methods ; Vascular Diseases/diagnostic imaging
    Language English
    Publishing date 2018-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.10841
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  9. Article ; Online: Non-invasive imaging of the coronary arteries.

    Adamson, Philip D / Newby, David E

    European heart journal

    2018  Volume 40, Issue 29, Page(s) 2444–2454

    Abstract: Non-invasive imaging of the coronary arteries is an enterprise in rapid development. From the research perspective, there is great demand for in vivo techniques that can reliably identify features of high-risk plaque that may offer insight into ... ...

    Abstract Non-invasive imaging of the coronary arteries is an enterprise in rapid development. From the research perspective, there is great demand for in vivo techniques that can reliably identify features of high-risk plaque that may offer insight into pathophysiological processes and act as surrogate indicators of response to therapeutic intervention. Meanwhile, there is clear clinical need for greater accuracy in diagnosis and prognostic stratification. Fortunately, ongoing technological improvements and emerging data from randomized clinical trials are helping make these elusive goals a reality. This review provides an update on the current status of non-invasive coronary imaging with computed tomography, magnetic resonance, and positron emission tomography with a focus on current clinical applications and future research directions.
    MeSH term(s) Computed Tomography Angiography ; Coronary Disease/diagnostic imaging ; Coronary Stenosis/diagnostic imaging ; Coronary Vessels/diagnostic imaging ; Humans ; Magnetic Resonance Angiography ; Plaque, Atherosclerotic/diagnostic imaging ; Positron-Emission Tomography
    Language English
    Publishing date 2018-10-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehy670
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    Zs.MO 640: Show issues

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  10. Article ; Online: Aortic valve perivascular adipose tissue computed tomography attenuation in patients with aortic stenosis.

    Botezatu, Simona B / Yu, Xinming / Meah, Mohammed N / Williams, Michelle C / Dey, Damini / Newby, David E / Tzolos, Evangelos / Dweck, Marc R

    Heart (British Cardiac Society)

    2024  Volume 110, Issue 9, Page(s) 657–665

    Abstract: Objective: Aortic stenosis (AS) shares pathophysiological similarities with atherosclerosis including active inflammation. CT attenuation of perivascular adipose tissue provides a measure of vascular inflammation that is linked to prognosis and has the ... ...

    Abstract Objective: Aortic stenosis (AS) shares pathophysiological similarities with atherosclerosis including active inflammation. CT attenuation of perivascular adipose tissue provides a measure of vascular inflammation that is linked to prognosis and has the potential to be applied to the aortic valve. We investigated perivascular adipose tissue attenuation around the aortic valve in patients with AS.
    Methods: CT attenuation was measured in the perivascular adipose tissue extending 3 mm radially and 10 mm longitudinally around the aortic valve in patients with and without AS. Associations between perivascular adipose tissue attenuation and AS disease severity, activity and progression were investigated.
    Results: Perivascular adipose tissue attenuation around the aortic valve demonstrated good intraobserver and interobserver repeatability (interobserver: intraclass correlation coefficient 0.977 (95% CI: 0.94, 0.99)) but was similar between patients with AS (n=120) and control subjects (n=80) (-62.4 (-68.7, -56.5) Hounsfield units (HU) vs -61.2 (-65.3, -55.6) HU, p=0.099). There were no differences between perivascular adipose tissue attenuation in patients with mild (-60.2 (-66.9, -55.1) HU), moderate (-62.8 (-69.6, -56.80) HU) or severe (-62.3 (-69.3, -55.4) HU) AS (all p>0.05), and perivascular adipose tissue attenuation did not demonstrate an association with AS severity as assessed by echocardiography or CT calcium scoring, nor with disease activity assessed by
    Conclusions: CT-derived aortic valve perivascular adipose tissue attenuation is not associated with AS disease severity, activity or progression suggesting that it has no value in the investigation and management of patients with AS.
    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aortic Valve Stenosis/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Adipose Tissue/diagnostic imaging ; Inflammation ; Computed Tomography Angiography/methods
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2023-323217
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