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Article: A Retrospective Study on the Status of Working Equids Admitted to an Equine Clinic in Cairo: Disease Prevalence and Associations between Physical Parameters and Outcome.

Benedetti, Beatrice / Freccero, Francesca / Barton, Jill / Elmallah, Farah / Refat, Sandy / Padalino, Barbara

Animals : an open access journal from MDPI

2024 Volume 14, Issue 5

Abstract: Working equids are often used to exhaustion, living and dying in conditions below minimal welfare standards. Due to their poor welfare status, euthanasia should be considered in certain conditions. The study aimed to describe the population and the ... ...

Abstract	Working equids are often used to exhaustion, living and dying in conditions below minimal welfare standards. Due to their poor welfare status, euthanasia should be considered in certain conditions. The study aimed to describe the population and the disease frequency of the working equids admitted at an equine clinic in Cairo (i.e., Egypt Equine Aid (EEA)) from 2019 to 2022 and identify possible associations between physical parameters at admission and the outcome. Records of 1360 equids admitted at EEA were reviewed. The majority of the admitted equids were horses (65.6%), followed by donkeys (33%), in particular stallions (68.7%), from 1 to 15 years old (74.8%). Hospitalisation was mainly due to wounds (28.9%), orthopaedic problems (27.4%), colic (8.5%), or infectious diseases (7.4%). The majority of the equids were discharged, but 5.1% died on their own, without human intervention, and 23% were euthanised. Text mining revealed the anamnesis's most frequent words were 'accident', 'lameness', and 'wound'. In addition, owners sometimes reported using inappropriate remedies (e.g., firing) before hospitalisation. Multivariable ordinal regression analysis performed between physical parameters and the outcome (ordered based on severity: discharged, euthanasia, and dead) revealed that sex (male vs. female: OR = 1.33;
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14050817
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Article ; Online: Anti-Melanoma Effects of Miconazole: Investigating the Mitochondria Involvement.

Scatozza, Francesca / Giardina, Maria Miriam / Valente, Carola / Vigiano Benedetti, Virginia / Facchiano, Antonio

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Miconazole is an antimycotic drug showing anti-cancer effects in several cancers. However, little is known on its effects in melanoma. A375 and SK-MEL-28 human melanoma cell lines were exposed to miconazole and clotrimazole (up to 100 mM). Proliferation, ...

Abstract	Miconazole is an antimycotic drug showing anti-cancer effects in several cancers. However, little is known on its effects in melanoma. A375 and SK-MEL-28 human melanoma cell lines were exposed to miconazole and clotrimazole (up to 100 mM). Proliferation, viability with MTT assay and vascular mimicry were assayed at 24 h treatment. Molecular effects were measured at 6 h, namely, ATP-, ROS-release and mitochondria-related cytofluorescence. A metabolomic profile was also investigated at 6 h treatment. Carnitine was one of the most affected metabolites; therefore, the expression of 29 genes involved in carnitine metabolism was investigated in the public platform GEPIA2 on 461 melanoma patients and 558 controls. After 24 h treatments, miconazole and clotrimazole strongly and significantly inhibited proliferation in the presence of 10% serum on either melanoma cell lines; they also strongly reduced viability and vascular mimicry. After 6 h treatment, ATP reduction and ROS increase were observed, as well as a significant reduction in mitochondria-related fluorescence. Further, in A375, miconazole strongly and significantly altered expression of several metabolites including carnitines, phosphatidyl-cholines, all amino acids and several other small molecules, mostly metabolized in mitochondria. The expression of 12 genes involved in carnitine metabolism was found significantly modified in melanoma patients, 6 showing a significant impact on patients' survival. Finally, miconazole antiproliferation activity on A375 was found completely abrogated in the presence of carnitine, supporting a specific role of carnitine in melanoma protection toward miconazole effect, and was significantly reversed in the presence of caspases inhibitors such as ZVAD-FMK and Ac-DEVD-CHO, and a clear pro-apoptotic effect was observed in miconazole-treated cells, by FACS analysis of Annexin V-FITC stained cells. Miconazole strongly affects proliferation and other biological features in two human melanoma cell lines, as well as mitochondria-related functions such as ATP- and ROS-release, and the expression of several metabolites is largely dependent on mitochondria function. Miconazole, likely acting via carnitine and mitochondria-dependent apoptosis, is therefore suggested as a candidate for further investigations in melanoma treatments.
MeSH term(s)	Humans ; Melanoma/drug therapy ; Miconazole/pharmacology ; Clotrimazole ; Reactive Oxygen Species ; Mitochondria ; Carnitine/pharmacology ; Adenosine Triphosphate
Chemical Substances	Miconazole (7NNO0D7S5M) ; Clotrimazole (G07GZ97H65) ; Reactive Oxygen Species ; Carnitine (S7UI8SM58A) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073589
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Article ; Online: New insights into the cytotoxic effects of Thymus vulgaris essential oil on the human triple-negative breast cancer cell line MDA-MB-231.

Benedetti, Serena / Nasoni, Maria Gemma / Luchetti, Francesca / Palma, Francesco

Toxicology in vitro : an international journal published in association with BIBRA

2023 Volume 93, Page(s) 105705

Abstract: Essential oils (EOs) are natural products that have gained wide interest due to their biological activities and anticancer properties through various mechanisms. The present study aimed to test the cytotoxicity of Thymus vulgaris L. (thyme) EO of Italian ...

Abstract	Essential oils (EOs) are natural products that have gained wide interest due to their biological activities and anticancer properties through various mechanisms. The present study aimed to test the cytotoxicity of Thymus vulgaris L. (thyme) EO of Italian origin, rich in thymol (49.6%) and p-cymene (18.8%), towards the triple-negative breast cancer cell line MDA-MB-231 and to investigate the biochemical mechanisms underlying its antitumor activity. Thyme EO reduced cancer cell viability in a dose-dependent manner after 24 h treatment, with an IC
MeSH term(s)	Humans ; Female ; Thymus Plant/chemistry ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Breast Neoplasms ; NF-E2-Related Factor 2 ; Oils, Volatile/pharmacology ; Apoptosis ; Antineoplastic Agents/pharmacology ; Apoptosis Regulatory Proteins/genetics ; Cell Line, Tumor
Chemical Substances	thyme oil (2UK410MY6B) ; NF-E2-Related Factor 2 ; Oils, Volatile ; Antineoplastic Agents ; Apoptosis Regulatory Proteins
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2023.105705
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Article: Occurrence of Terrifying Nightmares after Few Days of Mirtazapine Use in Elderly Patients.

Dell'Osso, Liliana / Lorenzi, Primo / Nardi, Benedetta / Carpita, Barbara / Benedetti, Francesca / Cremone, Ivan Mirko

Case reports in psychiatry

2023 Volume 2023, Page(s) 8843206

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2629914-8
ISSN	2090-6838 ; 2090-682X
ISSN (online)	2090-6838
ISSN	2090-682X
DOI	10.1155/2023/8843206
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Article ; Online: A STEM Training Approach Focused on Microscopy at Morgan State University.

Denaro, Frank J / Nyaga, Simon / Zella, Davide / Bryant, J / Benedetti, Francesca

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2023 Volume 29, Issue 29 Suppl 1, Page(s) 2111–2112

Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1093/micmic/ozad067.1095
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Article ; Online: Ultrasound features of a bilineal inheritance of autosomal dominant polycystic kidney disease.

Montaguti, Elisa / Montanari, Francesca / Bernardi, Vito / Luppi, Elena / De Benedetti, Pierandrea / Lanzoni, Giulia / Seri, Marco / Pilu, Gianluigi

European journal of obstetrics, gynecology, and reproductive biology

2024 Volume 296, Page(s) 382–383

MeSH term(s)	Humans ; Polycystic Kidney, Autosomal Dominant ; Ultrasonography ; Pedigree ; Kidney/diagnostic imaging
Language	English
Publishing date	2024-03-19
Publishing country	Ireland
Document type	Letter
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2024.03.026
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Article ; Online: Resting-state functional connectivity in multiple sclerosis patients receiving nabiximols for spasticity.

Gajofatto, Alberto / Cardobi, Nicolò / Gobbin, Francesca / Calabrese, Massimiliano / Turatti, Marco / Benedetti, Maria Donata

BMC neurology

2023 Volume 23, Issue 1, Page(s) 128

Abstract: Background: Nabiximols (Sativex®) is a cannabinoid approved for multiple sclerosis (MS)-related spasticity. Its mechanism of action is partially understood, and efficacy is variable.: Objective: To conduct an exploratory analysis of brain networks ... ...

Abstract	Background: Nabiximols (Sativex®) is a cannabinoid approved for multiple sclerosis (MS)-related spasticity. Its mechanism of action is partially understood, and efficacy is variable. Objective: To conduct an exploratory analysis of brain networks connectivity changes on resting state (RS) functional MRI (fMRI) of MS patients treated with nabiximols. Methods: We identified a group of MS patients treated with Sativex® at Verona University Hospital, who underwent RS brain fMRI in the 4 weeks before (T0) and 4-8 weeks after (T1) treatment start. Sativex® response was defined as ≥ 20% spasticity Numerical Rating Scale score reduction at T1 vs. T0. Connectivity changes on fMRI were compared between T0 and T1 in the whole group and according to response status. ROI-to-ROI and seed-to-voxel connectivity were evaluated. Results: Twelve MS patients (7 males) were eligible for the study. Seven patients (58.3%) resulted Sativex® responders at T1. On fMRI analysis, Sativex® exposure was associated with global brain connectivity increase (particularly in responders), decreased connectivity of motor areas, and bidirectional connectivity changes of the left cerebellum with a number of cortical areas. Conclusions: Nabiximols administration is associated with brain connectivity increase of MS patients with spasticity. Modulation of sensorimotor cortical areas and cerebellum connectivity could play a role in nabiximols effect.
MeSH term(s)	Male ; Humans ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/drug therapy ; Cannabidiol/therapeutic use ; Dronabinol/therapeutic use ; Cannabinoids ; Drug Combinations ; Muscle Spasticity/diagnostic imaging ; Muscle Spasticity/drug therapy
Chemical Substances	nabiximols (K4H93P747O) ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S) ; Cannabinoids ; Drug Combinations
Language	English
Publishing date	2023-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041347-6
ISSN	1471-2377 ; 1471-2377
ISSN (online)	1471-2377
ISSN	1471-2377
DOI	10.1186/s12883-023-03171-0
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Article ; Online: Generation of human gastric assembloids from primary fetal organoids.

Benedetti, Giada / Jones, Brendan C / Sgualdino, Francesca / De Coppi, Paolo / Giobbe, Giovanni Giuseppe

Pediatric surgery international

2023 Volume 40, Issue 1, Page(s) 6

Abstract: Purpose: Understanding human gastric epithelium homeostasis remains partial, motivating the exploration of innovative in vitro models. Recent literature showcases the potential of fetal stem cell-derived organoids in developmental and disease modelling ... ...

Abstract	Purpose: Understanding human gastric epithelium homeostasis remains partial, motivating the exploration of innovative in vitro models. Recent literature showcases the potential of fetal stem cell-derived organoids in developmental and disease modelling and translational therapies. To scale the complexity of the model, we propose to generate assembloids, aiming to increase gastric maturation to provide new structural and functional insights. Methods: Human fetal gastric organoids (fGOs) were expanded in 3D Matrigel cultures. Confluent organoid cultures were released from the Matrigel dome and resuspended in a collagen I hydrogel. Subsequently, the organoid mixture was seeded in a ring shape within a 24-well plate and allowed to gelate. The structure was lifted in the medium and cultured in floating conditions, allowing for organoid self-assembling into a gastric assembloid. After 10 days of maturation, the assembloids were characterized by immunostaining and RT-PCR, comparing different fetal developmental stages. Results: Successful generation of human fetal gastric assembloids (fGAs) was achieved using spontaneous self-aggregation within the collagen I hydrogel. Immunostaining analysis of early and late fGAs showed the establishment of apico-basal cell polarity, secretion of gastric mucins, and the presence of chromogranin A in both samples. Transcriptional markers analysis revealed distinct disparities in markers associated with mature cell types between late and early fetal stages. Conclusions: fGOs can reliably be generated from human fetal samples. This pioneering assembloid approach paves the way for advancing our comprehension of human gastric epithelium homeostasis and its perturbation, offering a better in vitro platform for the study of gastric epithelial development and therapeutic translation.
MeSH term(s)	Humans ; Stomach ; Organoids/metabolism ; Gastric Mucosa ; Collagen ; Hydrogels/metabolism
Chemical Substances	Collagen (9007-34-5) ; Hydrogels
Language	English
Publishing date	2023-11-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	632773-4
ISSN	1437-9813 ; 0179-0358
ISSN (online)	1437-9813
ISSN	0179-0358
DOI	10.1007/s00383-023-05586-9
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Article: Old Drug, New Pain. Roles and Challenges of Methadone Therapy in Pediatric Palliative Care: A Systematic Review.

Benedetti, Francesca / Zoletto, Silvia / Salerno, Annalisa / Avagnina, Irene / Benini, Franca

Frontiers in pediatrics

2022 Volume 10, Page(s) 874529

Abstract: Background: Pediatric palliative care (PPC) is defined as the prevention and relief from suffering of families and children with life-limiting (LLDs) or life-threatening diseases (LTDs). These patients often experience pain, with morphine being the most ...

Abstract	Background: Pediatric palliative care (PPC) is defined as the prevention and relief from suffering of families and children with life-limiting (LLDs) or life-threatening diseases (LTDs). These patients often experience pain, with morphine being the most widely used drug to treat it. Few studies investigated the role of methadone in PPC patients, although it is considered among the most effective and underutilized drugs in PPC. Objectives: Our aim was to evaluate the efficacy, safety, and dosage of methadone in PPC. Methods: Between August and October 2021 PubMed, Scopus and the Cochrane Library were searched for studies on the use of methadone in children with LLDs and LTDs. Articles were included if they met the following criteria: published in the last 10 years, English language, patients aged 0-23 years; children enrolled in a PPC center or receiving declared support from a PPC service; reporting of specific data on methadone in interventional trials, observational studies, or case series on >10 patients. The reporting of the article was guided by the PRISMA guidelines, and a critical appraisal of the included studies was performed using the JBI-tool. Results: After duplicates removal and full-text assessment, four studies were included and another one was added after checking the references of the retrieved papers. All were retrospective, and the literature is concordant in documenting the lack of evidence. A total of 116 children received methadone in PPC. From our review emerges the poor quality of data collection: in only one study pain was assessed with standardized scales. All studies documented the effectiveness of methadone in treating complex pain, either nociceptive or neuropathic. No serious adverse events were reported, with no cases of cardiac arrhythmias. Conclusion: Our results suggest that methadone could represent a suitable strategy for treating pain in PPC. However, the evidence base is insufficient, and further research is warranted.
Language	English
Publishing date	2022-05-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.874529
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Article ; Online: Monogenic systemic lupus erythematosus onset in a 13-year-old boy with Noonan like-syndrome: a case report and literature review.

Morán-Álvarez, Patricia / Gianviti, Alessandra / Diomedi-Camassei, Francesca / Ginevrino, Monia / de Benedetti, Fabrizio / Bracaglia, Claudia

Pediatric rheumatology online journal

2024 Volume 22, Issue 1, Page(s) 17

Abstract: Background: Childhood systemic lupus erythematosus (cSLE) has been considered as a polygenic autoimmune disease; however, a monogenic lupus-like phenotype is emerging with the recent recognition of several related novel high-penetrance genetic variants. ...

Abstract	Background: Childhood systemic lupus erythematosus (cSLE) has been considered as a polygenic autoimmune disease; however, a monogenic lupus-like phenotype is emerging with the recent recognition of several related novel high-penetrance genetic variants. RASopathies, a group of disorders caused by mutations in the RAS/MAPK pathway, have been recently described as a cause of monogenic lupus. Case presentation: We present a 13-year-old boy with Noonan-like syndrome with loose anagen hair who developed a monogenic lupus. The renal biopsy confirmed a class III lupus nephritis and identified the presence of zebra bodies. Conclusions: RASopathies represent a cause of monogenic lupus. We report a new case of monogenic lupus in a child with Noonan-like syndrome with loose anagen hair. Lupus nephritis which has never been described in this context, may be part of the presentation. The presence of zebra bodies in SLE or RASopathies in unclear, but no other known conditions (Fabry disease or drugs) were identified as the cause of zebra bodies in our patient.
MeSH term(s)	Adolescent ; Humans ; Male ; Loose Anagen Hair Syndrome ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/genetics ; Lupus Nephritis/diagnosis ; Lupus Nephritis/genetics ; Lupus Nephritis/complications ; Noonan Syndrome/complications ; Noonan Syndrome/diagnosis ; Noonan Syndrome/genetics
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2279468-2
ISSN	1546-0096 ; 1546-0096
ISSN (online)	1546-0096
ISSN	1546-0096
DOI	10.1186/s12969-023-00939-z
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