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  1. Article ; Online: Forest waste composting-operational management, environmental impacts, and application.

    Silva, Maria Elisabete Ferreira / Saetta, Raffaella / Raimondo, Roberta / Costa, José Manuel / Ferreira, José Vicente / Brás, Isabel

    Environmental science and pollution research international

    2024  

    Abstract: In Portugal, the number of fires and the size of burnt areas are rising dramatically every year, increasing with improper management of agroforestry wastes (AFRs). This work aims to study the composting of these wastes with minimal operational costs and ... ...

    Abstract In Portugal, the number of fires and the size of burnt areas are rising dramatically every year, increasing with improper management of agroforestry wastes (AFRs). This work aims to study the composting of these wastes with minimal operational costs and understand the environmental impact and the compost application on burnt soil. Thus, a study of life cycle assessment (LCA) was carried out based on windrow composting processes, considering the avoided environmental impacts associated with the end-product quality and its application as an organic amendment. Three composting piles were made with AFRs from the Residual Biomass Collection Centre (RBCC) in Bodiosa (Portugal). Sewage sludges (SS) from an urban wastewater treatment plant were used as conditioning agent. One pile with AFRs (MC) and another with AFRs and SS (MCS) were managed according to good composting practices. Another pile with the AFRs was developed without management (NMC), thus with a minimal operational cost. Periodically, it was measured several physical and chemical parameters according to standard methodologies. Eleven environmental impacts of compost production, MC and MCS, were analyzed by a LCA tool, and their effect on the growth of Pinus pinea was evaluated, using peat as reference. Composting evolution was expected for both piles. Final composts, MC and MCS, were similar, complying with organic amendment quality parameters. Compost NMC, with no operational management, showed the highest germination index. Piles MC and MCS showed similar environmental impacts, contributing to a negative impact on global warming, acidification, and eutrophication. Greater growth was obtained with application of MCS, followed by MC, and finally, peat. Composting is a sustainable way to valorize AFRs wastes, producing compost that could restore burnt soils and promote plant growth and circular economy.
    Language English
    Publishing date 2024-02-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32279-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply to: Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates.

    Guerreiro, Rita / Bras, Jose

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 4264

    MeSH term(s) Humans ; Genome-Wide Association Study ; Phenotype ; Multifactorial Inheritance/genetics ; Risk Factors ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29953-7
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  3. Article ; Online: Popeye Deformity: A Red Flag for Wild-Type Transthyretin Amyloidosis.

    Viegas, José Miguel / Brás, Pedro Garcia / Cardoso, Isabel / Rosa, Sílvia Aguiar

    The American journal of medicine

    2023  Volume 136, Issue 5, Page(s) e90–e91

    MeSH term(s) Humans ; Amyloid Neuropathies, Familial/complications ; Amyloid Neuropathies, Familial/diagnosis ; Prealbumin/genetics
    Chemical Substances Prealbumin
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2023.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.289: Show issues Location:
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  4. Article: Validation of an analytical methodology to determine humic substances using low-volume toxic reagents

    Brás, Isabel / Tavares, Ana / Pereira, José / Silva, Elisabete

    Open Agriculture. 2022 Sept. 12, v. 7, no. 1

    2022  

    Abstract: The 12 principles of green chemistry were stated to pursue good practices and techniques that minimize the use of hazardous substances in the production and application of chemicals. To minimize the risks and the pollution generated using chemicals, new ... ...

    Abstract The 12 principles of green chemistry were stated to pursue good practices and techniques that minimize the use of hazardous substances in the production and application of chemicals. To minimize the risks and the pollution generated using chemicals, new methodologies must be developed that avoid the application of dangerous products or its amount. Considering the principle of pollution prevention, this work proposes the development and application of a different methodology for the quantification of humic substances (HS), applying a spectrophotometric methodology that reduces the quantity of hazardous reagents (sodium dichromate and sulfuric acid) and minimizes the waste production. To deeply acknowledge the method, a validation of the methodology was done to allow the evaluation of its effectiveness to report reliable results. It was done by the evaluation of the parameters often used for this purpose (analytical limits, precision, accuracy, selectivity, robustness, and method working range). The detection limit attained was 0.03 g glucose/L and the quantification limit was 0.09 g glucose/L. The precision and accuracy were also evaluated using the repeatability limit and through performance testing, respectively, with a repeatability limit of 0.045 g/L and a Z-score less than 2. For selectivity and robustness, differences in variances were not significant, and the working range is well adjusted, with no differences regarding the precision of the lower and higher standard. The results obtained showed that the method under study, adapted to the green chemistry principles, can be applied to quantify HS in impure and complex samples.
    Keywords agriculture ; detection limit ; glucose ; green chemistry ; pollution ; pollution control ; sodium dichromate ; sulfuric acid ; toxicity
    Language English
    Dates of publication 2022-0912
    Size p. 679-687.
    Publishing place De Gruyter
    Document type Article
    ISSN 2391-9531
    DOI 10.1515/opag-2022-0120
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Remote Emotion Recognition Using Continuous-Wave Bio-Radar System.

    Gouveia, Carolina / Soares, Beatriz / Albuquerque, Daniel / Barros, Filipa / Soares, Sandra C / Pinho, Pedro / Vieira, José / Brás, Susana

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 5

    Abstract: The Bio-Radar is herein presented as a non-contact radar system able to capture vital signs remotely without requiring any physical contact with the subject. In this work, the ability to use the proposed system for emotion recognition is verified by ... ...

    Abstract The Bio-Radar is herein presented as a non-contact radar system able to capture vital signs remotely without requiring any physical contact with the subject. In this work, the ability to use the proposed system for emotion recognition is verified by comparing its performance on identifying fear, happiness and a neutral condition, with certified measuring equipment. For this purpose, machine learning algorithms were applied to the respiratory and cardiac signals captured simultaneously by the radar and the referenced contact-based system. Following a multiclass identification strategy, one could conclude that both systems present a comparable performance, where the radar might even outperform under specific conditions. Emotion recognition is possible using a radar system, with an accuracy equal to 99.7% and an F1-score of 99.9%. Thus, we demonstrated that it is perfectly possible to use the Bio-Radar system for this purpose, which is able to be operated remotely, avoiding the subject awareness of being monitored and thus providing more authentic reactions.
    MeSH term(s) Radar ; Vital Signs ; Respiratory Rate ; Algorithms ; Emotions ; Signal Processing, Computer-Assisted
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24051420
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  6. Article ; Online: Not All Left Ventricular Hypertrophy Is Hypertrophic Cardiomyopathy: MYL2-Associated Double-Chambered Left Ventricle.

    Garcia Brás, Pedro / Cardoso, Isabel / Viegas, José Miguel / Antunes, Diana / Thomas, Boban / Rosa, Sílvia Aguiar

    The Canadian journal of cardiology

    2023  Volume 39, Issue 10, Page(s) 1332–1334

    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Case Reports
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.05.013
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2150: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Correction: Challenge accepted: Uncovering the role of rare genetic variants in Alzheimer's disease.

    Khani, Marzieh / Gibbons, Elizabeth / Bras, Jose / Guerreiro, Rita

    Molecular neurodegeneration

    2022  Volume 17, Issue 1, Page(s) 70

    Language English
    Publishing date 2022-11-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2244557-2
    ISSN 1750-1326 ; 1750-1326
    ISSN (online) 1750-1326
    ISSN 1750-1326
    DOI 10.1186/s13024-022-00575-3
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  8. Article ; Online: Genetics of synucleins in neurodegenerative diseases.

    Brás, José / Gibbons, Elizabeth / Guerreiro, Rita

    Acta neuropathologica

    2020  Volume 141, Issue 4, Page(s) 471–490

    Abstract: The SNCA locus currently has an indisputable role in Parkinson's disease and other synucleinopathies. The role of genetic variability in the other members of the synuclein family (SNCB and SNCG) in disease is far less clear. In this review, we critically ...

    Abstract The SNCA locus currently has an indisputable role in Parkinson's disease and other synucleinopathies. The role of genetic variability in the other members of the synuclein family (SNCB and SNCG) in disease is far less clear. In this review, we critically assess the pathogenicity, main characteristics, and roles of genetic variants in these genes reported to be causative of synucleinopathies. We also summarize the different association signals identified in the SNCA locus that have been associated with risk for disease. We take a bird's eye view of the variability currently reported in the general population for the three genes and use these data to infer on the potential relationship between each of the genes and human disease.
    MeSH term(s) Animals ; Humans ; Neurodegenerative Diseases/genetics ; Synucleinopathies/genetics ; Synucleins/genetics
    Chemical Substances Synucleins
    Language English
    Publishing date 2020-08-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-020-02202-1
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    Ui II Zs.188: Show issues Location:
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  9. Article: Copy number variations and constitutional chromothripsis (Review).

    Brás, Aldina / Rodrigues, António Sebastião / Rueff, José

    Biomedical reports

    2020  Volume 13, Issue 3, Page(s) 11

    Abstract: Both copy number variations (CNVs) and chromothripsis are phenomena that involve complex genomic rearrangements. Chromothripsis results in CNVs and other structural changes. CNVs are frequently observed in the human genome. Studies on CNVs have been ... ...

    Abstract Both copy number variations (CNVs) and chromothripsis are phenomena that involve complex genomic rearrangements. Chromothripsis results in CNVs and other structural changes. CNVs are frequently observed in the human genome. Studies on CNVs have been increasing exponentially; the Database of Genomic Variants shows an increase in the number of data published on structural variations added to the database in the last 15 years. CNVs may be a result of replicative and non-replicative mechanisms, and are hypothesized to serve important roles in human health and disease. Chromothripsis is a phenomena of chromosomal rearrangement following chromosomal breaks at multiple locations and involves impaired DNA repair. In 2011, Stephens
    Language English
    Publishing date 2020-06-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2020.1318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity.

    Araújo-Martins, José / Brás-Geraldes, Carlos / Neuparth, Nuno

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 12674

    Abstract: Although the pathophysiology of nasal polyposis is incompletely understood, rhinologists have seldom studied it with rhinomanometry or peak nasal inspiratory flow (PNIF) due to technical limitations and the perception that polyp size might impair ... ...

    Abstract Although the pathophysiology of nasal polyposis is incompletely understood, rhinologists have seldom studied it with rhinomanometry or peak nasal inspiratory flow (PNIF) due to technical limitations and the perception that polyp size might impair reproducibility and the usefulness of recordings. The objective of this study is to assess how measures of rhinomanometry and PNIF relate to disease activity. Nineteen patients with polyps, 15 patients with chronic sinusitis without polyps and 11 negative controls were evaluated with active anterior rhinomanometry and PNIF. Sinusitis and polyp patients were re-evaluated after medical treatment. Polyp patients had the highest median Lund-Mackay score (14) and a median Johansen score of 1. PNIF and its variation after treatment were also lowest in this group (median 90 L/min before and after treatment; median variation of 0 L/min). Nasal resistance was similar between groups, and only correlated with Johansen score (Spearman = 0.517, p = 0.048) after treatment. Our study suggests that evaluating polyp patients using rhinomanometry and PNIF may provide useful and reproducible data. Several findings considered together suggest that polyp size is not the main determinant of nasal functional changes in these patients, warranting further studies to verify whether PNIF changes reflect sinus inflammation or merely airway obstruction.
    MeSH term(s) Administration, Intranasal ; Administration, Topical ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Case-Control Studies ; Clarithromycin/administration & dosage ; Clarithromycin/therapeutic use ; Cross-Sectional Studies ; Female ; Humans ; Leukotriene Antagonists/administration & dosage ; Leukotriene Antagonists/therapeutic use ; Male ; Middle Aged ; Nasal Obstruction/diagnosis ; Nasal Obstruction/drug therapy ; Nasal Polyps/drug therapy ; Nasal Polyps/pathology ; Prospective Studies ; Reproducibility of Results ; Rhinomanometry/instrumentation ; Rhinomanometry/methods ; Severity of Illness Index ; Sinusitis/drug therapy ; Sinusitis/pathology ; Treatment Outcome
    Chemical Substances Adrenal Cortex Hormones ; Leukotriene Antagonists ; Clarithromycin (H1250JIK0A)
    Language English
    Publishing date 2020-07-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-69693-6
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