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  1. Book ; Thesis: Diagnostik und Therapie von Prionerkrankungen

    Korth, Carsten

    2003  

    Author's details vorgelegt von Carsten Korth
    Language English
    Size Getr. Zählung
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Habil.-Schr., 2003
    Note Ursprünglich als Zeitschriftenaufsätze erschienen
    HBZ-ID HT014214050
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 E 957 order to use in reading room Magazin

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  2. Article ; Online: Tools as "petrified memes": A duality.

    Korth, Carsten

    The Behavioral and brain sciences

    2020  Volume 43, Page(s) e169

    Abstract: Tools are generated by defined steps, fulfill distinct uses, and elicit affordances or mental representations. When the latter are recombined, they are perceived as "technical reasoning," resulting in novel tools when executed. They can be exchanged, ... ...

    Abstract Tools are generated by defined steps, fulfill distinct uses, and elicit affordances or mental representations. When the latter are recombined, they are perceived as "technical reasoning," resulting in novel tools when executed. They can be exchanged, varied, and selected between individuals in a cumulative social process. Tools are materialized, "petrified" memes forming a duality within the framework of active externalism.
    MeSH term(s) Humans ; Problem Solving
    Language English
    Publishing date 2020-08-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X20000205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Thesis: Der Einfluß von Endotoxin auf den Tagschlaf und die unspezifische Immunantwort gesunder Probanden

    Korth, Carsten

    1995  

    Author's details vorgelegt von Carsten Korth
    Language German
    Size VIII, 115 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1995
    HBZ-ID HT006771392
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    95 D 3834 order for loan Magazin

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  4. Article ; Online: Microbial electricity-driven anaerobic phenol degradation in bioelectrochemical systems

    Shixiang Dai / Falk Harnisch / Micjel Chávez Morejón / Nina Sophie Keller / Benjamin Korth / Carsten Vogt

    Environmental Science and Ecotechnology, Vol 17, Iss , Pp 100307- (2024)

    1481  

    Abstract: Microbial electrochemical technologies have been extensively employed for phenol removal. Yet, previous research has yielded inconsistent results, leaving uncertainties regarding the feasibility of phenol degradation under strictly anaerobic conditions ... ...

    Abstract Microbial electrochemical technologies have been extensively employed for phenol removal. Yet, previous research has yielded inconsistent results, leaving uncertainties regarding the feasibility of phenol degradation under strictly anaerobic conditions using anodes as sole terminal electron acceptors. In this study, we employed high-performance liquid chromatography and gas chromatography-mass spectrometry to investigate the anaerobic phenol degradation pathway. Our findings provide robust evidence for the purely anaerobic degradation of phenol, as we identified benzoic acid, 4-hydroxybenzoic acid, glutaric acid, and other metabolites of this pathway. Notably, no typical intermediates of the aerobic phenol degradation pathway were detected. One-chamber reactors (+0.4 V vs. SHE) exhibited a phenol removal rate of 3.5 ± 0.2 mg L−1 d−1, while two-chamber reactors showed 3.6 ± 0.1 and 2.6 ± 0.9 mg L−1 d−1 at anode potentials of +0.4 and + 0.2 V, respectively. Our results also suggest that the reactor configuration certainly influenced the microbial community, presumably leading to different ratios of phenol consumers and microorganisms feeding on degradation products.
    Keywords Microbial electroremediation ; Geobacter ; Extracellular electron transfer ; Anaerobic phenol degradation ; Microbial syntrophy ; Environmental sciences ; GE1-350 ; Environmental technology. Sanitary engineering ; TD1-1066
    Subject code 660 ; 500
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online ; Thesis: Generierung und Charakterisierung von Alzheimer-Antikörpern gegen Amyloid-β im Rahmen der Alzheimer-Erkrankung

    Zittlau, Aaron Raphael [Verfasser] / Korth, Carsten [Gutachter] / Sabel, Michael [Gutachter]

    2022  

    Author's details Aaron Raphael Zittlau ; Gutachter: Carsten Korth, Michael Sabel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Blood tests to diagnose schizophrenia: self-imposed limits in psychiatry.

    Korth, Carsten / Fangerau, Heiner

    The lancet. Psychiatry

    2020  Volume 7, Issue 10, Page(s) 911–914

    Abstract: The naturalisation of mental disorders-ie, their translation into measurable and preferably molecular variables-has not progressed despite breath-taking discoveries in the neurosciences. We ask whether self-inflicted limits exist among psychiatrists that ...

    Abstract The naturalisation of mental disorders-ie, their translation into measurable and preferably molecular variables-has not progressed despite breath-taking discoveries in the neurosciences. We ask whether self-inflicted limits exist among psychiatrists that would prevent them from supporting an imaginary perfect blood test with diagnostic specificity, sensitivity, and validity, which was able to replace clinical diagnosis completely. Although relevant for many mental disorders, we use the clinical disease category schizophrenia here as an example to discuss factors that oppose the naturalisation of clinical disease categories. We defend the provocative position that a complete substitution of the clinical diagnosis by a blood test is generally not desired among clinicians because various factors perpetuate the current diagnostic culture. These are (1) methodological problems, such as a falsely presumed homogeneity of biological causes under the umbrella of one clinical diagnosis that prevents efficient subset identification, (2) professional fears, such as loss of importance of interview-diagnostic expert skills, and (3) conceptual problems, such as a dualistic mindset. We posit that doubts regarding the possibility of a blood test for diagnosing schizophrenia can subtly result in a negative self-fulfilling prophecy, discouraging serious scientific efforts to develop one. We give historical examples of how some of these problems have been solved in other medical disciplines. We predict that only blood tests that improve diagnostic accuracy but do not displace the primacy of clinical diagnosis will be successful. In the future, novel professional expertise for orchestrating various biological variables together with clinical criteria will be needed.
    MeSH term(s) Biomarkers/blood ; Hematologic Tests ; Humans ; Psychiatry/trends ; Schizophrenia/blood ; Schizophrenia/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-03-23
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(20)30058-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Microbial electricity-driven anaerobic phenol degradation in bioelectrochemical systems.

    Dai, Shixiang / Harnisch, Falk / Morejón, Micjel Chávez / Keller, Nina Sophie / Korth, Benjamin / Vogt, Carsten

    Environmental science and ecotechnology

    2023  Volume 17, Page(s) 100307

    Abstract: Microbial electrochemical technologies have been extensively employed for phenol removal. Yet, previous research has yielded inconsistent results, leaving uncertainties regarding the feasibility of phenol degradation under strictly anaerobic conditions ... ...

    Abstract Microbial electrochemical technologies have been extensively employed for phenol removal. Yet, previous research has yielded inconsistent results, leaving uncertainties regarding the feasibility of phenol degradation under strictly anaerobic conditions using anodes as sole terminal electron acceptors. In this study, we employed high-performance liquid chromatography and gas chromatography-mass spectrometry to investigate the anaerobic phenol degradation pathway. Our findings provide robust evidence for the purely anaerobic degradation of phenol, as we identified benzoic acid, 4-hydroxybenzoic acid, glutaric acid, and other metabolites of this pathway. Notably, no typical intermediates of the aerobic phenol degradation pathway were detected. One-chamber reactors (+0.4 V vs. SHE) exhibited a phenol removal rate of 3.5 ± 0.2 mg L
    Language English
    Publishing date 2023-07-26
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-4984
    ISSN (online) 2666-4984
    DOI 10.1016/j.ese.2023.100307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 50-kHz ultrasonic vocalizations do not signal social anhedonia in transgenic DISC1 rats.

    Seidisarouei, Mohammad / Schäble, Sandra / van Wingerden, Marijn / Trossbach, Svenja V / Korth, Carsten / Kalenscher, Tobias

    Brain and behavior

    2023  Volume 13, Issue 5, Page(s) e2984

    Abstract: Patients diagnosed with neuropsychiatric disorders, such as autism and schizophrenia, suffer from disorganized speech. The disrupted-in-schizophrenia 1 (DISC1) protein pathway is considered a risk factor for the development of several psychiatric ... ...

    Abstract Patients diagnosed with neuropsychiatric disorders, such as autism and schizophrenia, suffer from disorganized speech. The disrupted-in-schizophrenia 1 (DISC1) protein pathway is considered a risk factor for the development of several psychiatric disorders and plays an important role in the dysregulation of dopamine (DA), which in turn plays an important role in the regulation of ultrasonic vocalizations (USVs) in rats. Moreover, the DISC1 protein pathway has been identified as a cause of social anhedonia, that is, a decrease in the drive for social interactions. USVs transmit specific affective information to other rats, with 50-kHz calls indicating a positive affective state in rats. Dysregulation of the dopaminergic system impacts the qualitative and quantitative features of USVs, such as duration, peak frequency, and the call rate. In this study, we thus used a well-established transgenic DISC1 (tgDISC1) rat line to investigate whether the neural (decreased DA levels in the dorsal striatum, amygdala, and hippocampus (HPC)) and behavioral (social anhedonia) features of tgDISC1 rats could be manifested through the modulation of their 50-kHz USVs. Analyses of three features (call rate, duration, and peak frequency) of all 50-kHz revealed no significant differences between groups, suggesting decreased DA levels in the dorsal striatum and amygdala, and HPC may affect social interaction but leave 50-kHz USV production intact.
    MeSH term(s) Rats ; Animals ; Rats, Transgenic ; Vocalization, Animal/physiology ; Ultrasonics ; Anhedonia ; Emotions ; Dopamine/metabolism ; Nerve Tissue Proteins
    Chemical Substances Dopamine (VTD58H1Z2X) ; Disc1 protein, rat ; Nerve Tissue Proteins
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.2984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Generierung und Charakterisierung muriner und kamelider Antikörper gegen Reelin

    Köber, Sabrina [Verfasser] / Korth, Carsten [Gutachter] / Lang, Philipp [Gutachter]

    2021  

    Author's details Sabrina Köber ; Gutachter: Carsten Korth, Philipp Lang
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Book ; Online ; Thesis: Axonale Regeneration in adulten retinalen Ganglienzellen bei konstitutiver Aktivität von GSK3α/β

    Golla, Renate [Verfasser] / Fischer, Dietmar [Gutachter] / Korth, Carsten [Gutachter]

    2021  

    Author's details Renate Golla ; Gutachter: Dietmar Fischer, Carsten Korth
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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