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Buch ; Konferenzbeitrag: Hannō-kakusan-kei-ni-okeru-patān-keisei-to-zenkin-teki-kika-kōzō-no-kenkyū

Ei, Shin-Ichiro / Sakamoto, Kunimochi

(Sūri-Kaiseki-Kenkyūsho-kōkyūroku ; 1356)

2004

Titelvarianten	Pattern formation and asymptotic geometric structure in reaction-diffusion systems
Veranstaltung/Kongress	Kongress (2003.10.15-17, Kyōto)
Verfasserangabe	Kunimochi Sakamoto; Shin-Ichiro Ei
Serientitel	Sūri-Kaiseki-Kenkyūsho-kōkyūroku ; 1356
Sprache	Japanisch ; Englisch
Umfang	134 S, graph. Darst
Verlag	Kyoto University, Research Institute for Mathematical Sciences
Erscheinungsort	Kyōto
Dokumenttyp	Buch ; Konferenzbeitrag
Anmerkung	Text japan., teilw. engl
Datenquelle	Katalog der Technische Informationsbibliothek Hannover

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Artikel ; Online: PEN2: Metformin's new partner at lysosome.

Sakamoto, Kei / Jessen, Niels

Cell research

2022 Band 32, Heft 6, Seite(n) 507–508

Mesh-Begriff(e)	Lysosomes ; Metformin/pharmacology
Chemische Substanzen	Metformin (9100L32L2N)
Sprache	Englisch
Erscheinungsdatum	2022-04-12
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1319303-x
ISSN	1748-7838 ; 1001-0602
ISSN (online)	1748-7838
ISSN	1001-0602
DOI	10.1038/s41422-022-00661-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Pressure dependence of metal-silicate partitioning explains the mantle phosphorus abundance.

Ikuta, Nagi / Sakamoto, Naoya / Tagawa, Shoh / Hirose, Kei / Tsutsumi, Yutaro / Yokoo, Shunpei / Yurimoto, Hisayoshi

Scientific reports

2024 Band 14, Heft 1, Seite(n) 1194

Abstract: Previous experiments performed below 20 GPa suggested that the metal/silicate partition coefficient of phosphorus (P), ... ...

Abstract	Previous experiments performed below 20 GPa suggested that the metal/silicate partition coefficient of phosphorus (P), D
Sprache	Englisch
Erscheinungsdatum	2024-01-12
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51662-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Borane-Protecting Strategy for Hydrosilylation of Phosphorus-Containing Olefins.

Naganawa, Yuki / Fujita, Akira / Sakamoto, Kei / Tanaka, Shinji / Sato, Kazuhiko / Nakajima, Yumiko

ACS omega

2023 Band 8, Heft 6, Seite(n) 5672–5682

Abstract: Ir-catalyzed hydrosilylation of the alkenyl phosphine borane ... ...

Abstract	Ir-catalyzed hydrosilylation of the alkenyl phosphine borane complex
Sprache	Englisch
Erscheinungsdatum	2023-01-23
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c07161
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Correction to Nanopore Impedance Spectroscopy Reveals Electrical Properties of Single Nanoparticles for Detecting and Identifying Pathogenic Viruses.

Kitta, Kazuki / Sakamoto, Maami / Hayakawa, Kei / Nukazuka, Akira / Kano, Kazuhiko / Yamamoto, Takatoki

ACS omega

2023 Band 8, Heft 28, Seite(n) 25639

Abstract: This corrects the article DOI: 10.1021/acsomega.3c00628.]. ...

Abstract	[This corrects the article DOI: 10.1021/acsomega.3c00628.].
Sprache	Englisch
Erscheinungsdatum	2023-06-30
Erscheinungsland	United States
Dokumenttyp	Published Erratum
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c04155
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Pressure dependence of metal–silicate partitioning explains the mantle phosphorus abundance

Nagi Ikuta / Naoya Sakamoto / Shoh Tagawa / Kei Hirose / Yutaro Tsutsumi / Shunpei Yokoo / Hisayoshi Yurimoto

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Band 8

Abstract: Abstract Previous experiments performed below 20 GPa suggested that the metal/silicate partition coefficient of phosphorus (P), D P, extrapolated to typical high-pressure and -temperature conditions of the Earth’s core formation gives too high P ... ...

Abstract	Abstract Previous experiments performed below 20 GPa suggested that the metal/silicate partition coefficient of phosphorus (P), D P, extrapolated to typical high-pressure and -temperature conditions of the Earth’s core formation gives too high P concentration in the core unless a large amount of silicon was included in metals. Here we examined D P between liquid metal and coexisting molten silicate at 27–61 GPa and 3820–4760 K, corresponding to conditions of core-forming metal segregation from silicate, by measuring recovered samples using a high-resolution imaging technique coupled with secondary ion mass spectrometry. The results demonstrate that the pressure dependence of D P changes from positive to negative above 15 GPa, likely because of an increase in the coordination number of P5+ in silicate melt. With the present new partitioning data, the observed mantle P abundance may indicate ~ 0.2 wt% P in the core, consistent with the cosmo-/geochemical estimates, based on both single-stage and multi-stage core formation models without involving high amounts of silicon in metals.
Schlagwörter	Medicine ; R ; Science ; Q
Thema/Rubrik (Code)	550
Sprache	Englisch
Erscheinungsdatum	2024-01-01T00:00:00Z
Verlag	Nature Portfolio
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Real-World Safety and Effectiveness of Benralizumab in Japanese Patients with Severe Asthma: A Multicenter Prospective Observational Study.

Yamaguchi, Masao / Nishimura, Yoshihiro / Takumi, Yuko / Hayashi, Nobuya / Sakamoto, Kei / Tohda, Yuji

Journal of asthma and allergy

2024 Band 17, Seite(n) 45–60

Abstract: Introduction: This study aimed to demonstrate whether benralizumab maintained the safety and effectiveness profiles established in randomized controlled trials among all patients with severe uncontrolled asthma initially prescribed benralizumab in the ... ...

Abstract	Introduction: This study aimed to demonstrate whether benralizumab maintained the safety and effectiveness profiles established in randomized controlled trials among all patients with severe uncontrolled asthma initially prescribed benralizumab in the real-world setting in Japan. Methods: This was a prospective, observational, multicenter post-marketing study (ClinicalTrial.gov, NCT03588546). The safety and tolerability of benralizumab over 1 year were assessed by the incidence of adverse events (AEs), serious AEs, adverse drug reactions (ADRs), and serious ADRs. Patient background characteristics indicating a more frequent onset of ADRs with benralizumab were explored. The main effectiveness assessment was the change in Asthma Control Questionnaire-5 (ACQ-5) score from baseline. Patients with baseline ACQ-5 scores ≥1.5 were defined as having severe uncontrolled asthma. Results: In total, 632 patients were evaluated for safety and 274 for effectiveness; 139 patients were included in the severe uncontrolled asthma subgroup. ADRs were reported in 12.7% and serious AEs in 13.0% of patients. Serious infections occurred in 3.8%, serious hypersensitivity in 0.3%, and malignancy in 0.3% of patients. No helminthic infections occurred. In the effectiveness population, benralizumab improved the mean (standard deviation [95% confidence interval]) ACQ-5 score by -1.16 (1.40 [-1.36, -0.96]) from baseline; forced expiratory volume in 1 second by 0.151 (0.440 [0.09, 0.21]) L; and Mini-Asthma Quality of Life questionnaire score by 1.16 (1.29 [0.94, 1.38]) at the last observation. The annual asthma exacerbation rate was 0.42. A greater ACQ-5 score improvement was observed among patients with eosinophilic asthma characteristics. Conclusion: No new safety concerns were raised, and patients experienced benefits consistent with previous studies of benralizumab, thus supporting the use of benralizumab for the add-on maintenance treatment of patients with eosinophilic severe uncontrolled asthma.
Sprache	Englisch
Erscheinungsdatum	2024-01-20
Erscheinungsland	New Zealand
Dokumenttyp	Journal Article
ZDB-ID	2494877-9
ISSN	1178-6965
ISSN	1178-6965
DOI	10.2147/JAA.S432695
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: A Rare Presentation of Lymph Node Metastasis of VIPoma After Three Years of Resection: A Case Report.

Şal, Oğuzhan / Sakamoto, Katsunori / Tamura, Kei / Honjo, Masahiko / Nishi, Yusuke / Hikida, Takahiro / Sakamoto, Akimasa / Funamizu, Naotake / Ogawa, Kohei / Takada, Yasutsugu

Cureus

2024 Band 16, Heft 4, Seite(n) e57628

Abstract: Vasoactive intestinal peptide-producing tumor of the pancreas (VIPoma) is one of the rarer subtypes of neuroendocrine tumor (NET) of the pancreas. It usually represents intractable diarrhea, weight loss, and electrolyte abnormalities secondary to ... ...

Abstract	Vasoactive intestinal peptide-producing tumor of the pancreas (VIPoma) is one of the rarer subtypes of neuroendocrine tumor (NET) of the pancreas. It usually represents intractable diarrhea, weight loss, and electrolyte abnormalities secondary to diarrhea. The most common site of metastasis of VIPoma is the liver. Furthermore, lymph node metastasis (LNM) is rare, and no metachronous LNM with a resectable situation has been reported before. A 60-year-old male patient (height: 181 cm, body weight: 74 kg) with a history of operated pancreatic VIPoma three years ago was referred to our department due to the detection of lymphadenomegaly which was suggestive of lymph node metastasis by routine follow-up computed tomography (CT). Preoperative CT showed a lymph node on the left side of the abdominal aorta and caudal side of the left renal vein with a size of 1 cm. Lymphadenectomy was performed without significant complications and blood loss. This is the first report of metachronous LNM in a patient with operated VIPoma. Although much rarer than solid organ metastasis of VIPoma, LNM in these patients can also be seen synchronously and metachronously. Close follow-up and vigilance are key to preventing recurrence-related morbidity and mortality in these patients.
Sprache	Englisch
Erscheinungsdatum	2024-04-04
Erscheinungsland	United States
Dokumenttyp	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.57628
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Notch signaling in oral squamous neoplasia.

Sakamoto, Kei

Pathology international

2016 Band 66, Heft 11, Seite(n) 609–617

Abstract: Notch signaling is involved in cell-cell communication. It is an evolutionarily ancient mechanism and plays a fundamental role in development. The typical function of Notch signaling is the regulation of cell fate segregation at asymmetric division; ... ...

Abstract	Notch signaling is involved in cell-cell communication. It is an evolutionarily ancient mechanism and plays a fundamental role in development. The typical function of Notch signaling is the regulation of cell fate segregation at asymmetric division; however, a role in tumorigenesis has also been suggested. Inactivating mutations of NOTCH1 are present in about 10 % of cases of squamous cell carcinoma of the skin, oral cavity, esophagus, and lung, rendering it one of the most frequently mutated genes in squamous cell carcinoma. Mouse knockout studies have demonstrated that Notch1 is imperative for early development but is dispensable for formation of the squamous epithelium. However, loss of Notch signaling predisposes the epidermis to hyperplasia and increases tumor incidence. This tumor-inducing effect resulting from the loss of Notch signaling is associated with non-cell-autonomous effects that are elicited by subtle alteration of epithelial cell features, generating a wound-like microenvironment in the underlying stroma. We found that Notch1 was expressed specifically in the basal cells of the oral squamous epithelium. In cancer and oral epithelial dysplasia, it was significantly downregulated, suggesting that reduced Notch activity plays a distinct role in oral neoplasia.
Sprache	Englisch
Erscheinungsdatum	2016-11
Erscheinungsland	Australia
Dokumenttyp	Review ; Journal Article
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/pin.12461
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Uniportal VATS combined subsegmentectomy of the left S1+2c+S3a guided by 3D computed tomography simulation.

Sakamoto, Kei / Maitani, Fumio / Horinouchi, Hirohisa

Multimedia manual of cardiothoracic surgery : MMCTS

2022 Band 2022

Abstract: When a tumor to be resected is located close to or extending beyond the intersegmental plane, combined segmentectomy or subsegmentectomy is an option to ensure a sufficient surgical margin. The segmental and subsegmental anatomy of the lungs varies ... ...

Abstract	When a tumor to be resected is located close to or extending beyond the intersegmental plane, combined segmentectomy or subsegmentectomy is an option to ensure a sufficient surgical margin. The segmental and subsegmental anatomy of the lungs varies greatly from case to case. Therefore, there is no standardized procedure for combined subsegmentectomy, and surgical planning based on individual anatomy using three-dimensional computed tomography is essential. This video tutorial presents the surgical technique for uniportal video-assisted thoracic surgery of the left S1+2c+S3a combined subsegmentectomy for tumors located at the border of the S1+2c and S3a segments of the left upper lobes, with preoperative three-dimensional simulation and intraoperative navigation images.
Mesh-Begriff(e)	Humans ; Lung/surgery ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Pneumonectomy/methods ; Thoracic Surgery, Video-Assisted/methods ; Tomography, X-Ray Computed
Sprache	Englisch
Erscheinungsdatum	2022-06-06
Erscheinungsland	England
Dokumenttyp	Video-Audio Media
ZDB-ID	2280156-X
ISSN	1813-9175 ; 1813-9175
ISSN (online)	1813-9175
ISSN	1813-9175
DOI	10.1510/mmcts.2022.029
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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