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Article ; Online: Self-oriented anisotropic structure of G-hydrogels as a delicate balance between attractive and repulsive forces.

Pepe, Alessia / Moretti, Paolo / Yoneda, Juliana S / Carducci, Federica / Itri, Rosangela / Mariani, Paolo

2023 Volume 15, Issue 37, Page(s) 15196–15205

Abstract: Guanine (G) hydrogels are very attractive materials made by the supramolecular organization of G ... that make long, flexible and knotted G-quadruplexes, were investigated by small- and wide-angle X-ray ...

Abstract	Guanine (G) hydrogels are very attractive materials made by the supramolecular organization of G-derivatives in water. In this paper, hydrogels composed of guanosine 5'-monophosphate (GMP) and guanosine (Gua), that make long, flexible and knotted G-quadruplexes, were investigated by small- and wide-angle X-ray scattering (SAXS and WAXS) to comprehend the origin of their unique orientational properties. The SAXS intensity, analysed at a fixed scattering vector modulus
Language	English
Publishing date	2023-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr01348k
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Article ; Online: SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase.

Martone, Julie / Mariani, Davide / Santini, Tiziana / Setti, Adriano / Shamloo, Sama / Colantoni, Alessio / Capparelli, Francesca / Paiardini, Alessandro / Dimartino, Dacia / Morlando, Mariangela / Bozzoni, Irene

EMBO reports

2020 Volume 21, Issue 6, Page(s) e49942

Abstract: Guanine-quadruplexes (G4) included in RNA molecules exert several functions in controlling gene expression at post-transcriptional level; however, the molecular mechanisms of G4-mediated regulation are still poorly understood. Here, we describe a ... ...

Abstract	Guanine-quadruplexes (G4) included in RNA molecules exert several functions in controlling gene expression at post-transcriptional level; however, the molecular mechanisms of G4-mediated regulation are still poorly understood. Here, we describe a regulatory circuitry operating in the early phases of murine muscle differentiation in which a long non-coding RNA (SMaRT) base pairs with a G4-containing mRNA (Mlx-γ) and represses its translation by counteracting the activity of the DHX36 RNA helicase. The time-restricted, specific effect of lnc-SMaRT on the translation of Mlx-γ isoform modulates the general subcellular localization of total MLX proteins, impacting on their transcriptional output and promoting proper myogenesis and mature myotube formation. Therefore, the circuitry made of lnc-SMaRT, Mlx-γ, and DHX36 not only plays an important role in the control of myogenesis but also unravels a molecular mechanism where G4 structures and G4 unwinding activities are regulated in living cells.
MeSH term(s)	Animals ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; DNA Helicases ; G-Quadruplexes ; Mice ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics
Chemical Substances	RNA, Long Noncoding ; RNA, Messenger ; Dhx36 protein, mouse (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-) ; DEAD-box RNA Helicases (EC 3.6.4.13)
Keywords	covid19
Language	English
Publishing date	2020-04-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.201949942
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Zs.A 5433: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Association among 1267 A/G HSP70-2, -308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population.

Giacconi, R / Costarelli, L / Malavolta, M / Piacenza, F / Galeazzi, R / Gasparini, N / Basso, A / Mariani, E / Fulop, T / Rink, L / Dedoussis, G / Kanoni, S / Herbein, G / Jajte, J / Busco, F / Mocchegiani, E

Biogerontology

2014 Volume 15, Issue 1, Page(s) 65–79

Abstract: ... of inflammatory diseases. We investigated whether Hsp70 1267 A/G and TNF-α -308 G/A polymorphisms are associated ... Hsp70 1267 A/G genotype and allele distribution were similar among various European countries ... laboratory parameters, metallothioneins and zinc status. Hsp70 1267 A/G SNP, but not TNF-α -308 G/A SNP ...

Abstract	Proinflammatory cytokines and heat shock proteins play relevant roles in the pathogenesis of inflammatory diseases. We investigated whether Hsp70 1267 A/G and TNF-α -308 G/A polymorphisms are associated with proinflammatory mediators, zinc status and laboratory parameters in 1,078 healthy elderly from ZincAge study. Hsp70 1267 A/G genotype and allele distribution were similar among various European countries, while a TNF-α genetic heterogeneity was observed between the Northern and the Southern European populations, with a major frequency of the -308 A variant in France, Germany and Poland. We used linear regression models to test additive, dominant or recessive associations of each SNP with proinflammatory mediators, laboratory parameters, metallothioneins and zinc status. Hsp70 1267 A/G SNP, but not TNF-α -308 G/A SNP, influences TNF-α and IL-6 plasma levels under additive, dominant and recessive models (for TNF-α only). An association between Hsp70 1267 A/G SNP and zinc plasma levels was observed in the dominant model. In particular, G allele carriers showed increased circulating pro-inflammatory cytokines and zinc. Moreover, both these SNPs affect creatinine levels suggesting a possible influence on renal function. In conclusion, Hsp70 1267 A/G SNP is associated with pro-inflammatory cytokine production in healthy elderly and might represent a possible determinant of individual susceptibility to inflammatory diseases.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/genetics ; Aging/metabolism ; C-Reactive Protein/metabolism ; Cytokines/blood ; Europe ; Female ; Gene Frequency/genetics ; Genotype ; HSP70 Heat-Shock Proteins/genetics ; Homeostasis/physiology ; Humans ; Inflammation/blood ; Inflammation/genetics ; Male ; Metallothionein/metabolism ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Tumor Necrosis Factor-alpha/genetics ; Zinc/metabolism
Chemical Substances	Cytokines ; HSP70 Heat-Shock Proteins ; Tumor Necrosis Factor-alpha ; C-Reactive Protein (9007-41-4) ; Metallothionein (9038-94-2) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2014-02
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2047160-9
ISSN	1573-6768 ; 1389-5729
ISSN (online)	1573-6768
ISSN	1389-5729
DOI	10.1007/s10522-013-9480-1
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Article ; Online: Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures.

Percivalle, Claudia / Sissi, Claudia / Greco, Maria Laura / Musetti, Caterina / Mariani, Angelica / Artese, Anna / Costa, Giosuè / Perrore, Maria Lucia / Alcaro, Stefano / Freccero, Mauro

Organic & biomolecular chemistry

2014 Volume 12, Issue 22, Page(s) 3744–3754

Abstract: ... as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest ... assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are ...

Abstract	Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties.
MeSH term(s)	Anthraquinones/chemistry ; Circular Dichroism ; DNA/chemistry ; Fluorescence ; G-Quadruplexes ; Ligands ; Models, Molecular ; Taq Polymerase/metabolism ; Telomere/chemistry ; Transition Temperature
Chemical Substances	Anthraquinones ; Ligands ; DNA (9007-49-2) ; Taq Polymerase (EC 2.7.7.-)
Language	English
Publishing date	2014-06-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/c4ob00220b
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Article ; Online: Playing supramolecular dominoes with light: building and breaking a photoreversible G-quadruplex made from guanosine, boric acid and an azobenzene.

Pieraccini, Silvia / Campitiello, Marilena / Carducci, Federica / Davis, Jeffery T / Mariani, Paolo / Masiero, Stefano

Organic & biomolecular chemistry

2019 Volume 17, Issue 10, Page(s) 2759–2769

Abstract: ... various guanosine borate esters induces a helical G-quartet based self-organization, stabilized ... This inclusion complex templates the formation of G-quartets. The quartets, in turn, pile up to form ... a supramolecular G-quadruplex structure, in which other G species present in solution are progressively included ...

Abstract	Addition of azobenzene-derivative 1 in its E configuration to an aqueous solution containing various guanosine borate esters induces a helical G-quartet based self-organization, stabilized by intercalation of the dye. The process is driven, in a domino fashion, by the initial host-guest interaction between the dye and a specific guanosine borate diester, whose structure can be thus assigned. This inclusion complex templates the formation of G-quartets. The quartets, in turn, pile up to form a supramolecular G-quadruplex structure, in which other G species present in solution are progressively included. The G-quadruplex can be reversibly broken and reformed by photoisomerization of the dye. This hierarchical and photosensitive self-assembly is unprecedented for simple guanosine derivatives.
MeSH term(s)	Azo Compounds/chemistry ; Boric Acids/chemistry ; G-Quadruplexes ; Guanosine/chemistry ; Models, Molecular ; Photochemical Processes
Chemical Substances	Azo Compounds ; Boric Acids ; Guanosine (12133JR80S) ; azobenzene (F0U1H6UG5C) ; boric acid (R57ZHV85D4)
Language	English
Publishing date	2019-02-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/c9ob00193j
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Article ; Online: Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.

Di Antonio, Marco / Biffi, Giulia / Mariani, Angelica / Raiber, Eun-Ang / Rodriguez, Raphaël / Balasubramanian, Shankar

Angewandte Chemie (International ed. in English)

2012 Volume 51, Issue 44, Page(s) 11073–11078

Abstract: It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see ... ...

Abstract	It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA.
MeSH term(s)	Alkynes/chemistry ; Azides/chemistry ; Click Chemistry ; DNA/chemistry ; Fibroblasts/cytology ; G-Quadruplexes ; Humans ; Microscopy, Fluorescence ; Molecular Structure ; RNA/chemistry ; Telomere/chemistry
Chemical Substances	Alkynes ; Azides ; RNA (63231-63-0) ; DNA (9007-49-2)
Language	English
Publishing date	2012-10-04
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201206281
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Article ; Online: Impact of the volume of blood collected by phlebotomy on transfusion requirements in preterm infants with birth weight of less than 1500 g. A quasi-experimental study.

Brener Dik, Pablo H / Galletti, María F / Carrascal, María P / De Gregorio, Alejandra / Burgos Pratx, Leandro / Gómez Saldaño, Ana M / Mariani, Gonzalo L

Archivos argentinos de pediatria

2020 Volume 118, Issue 2, Page(s) 109–116

Abstract: ... of 1145 g (875-1345). The baseline red series profile was similar between both groups. The number ...

Title translation	Impacto del volumen de sangre extraído por flebotomía sobre el requerimiento transfusional en prematuros menores de 1500 g. Estudio cuasiexperimental.
Abstract	Introduction: Anemia is a complication in very low birth weight (VLBW) infants, and lab tests are a predominant risk factor. At least one red blood cell transfusion is given in more than 50 % of cases. Transfusions are associated with a higher risk for infections, intracranial hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia. In 2012, Hospital Italiano de Buenos Aires implemented a strategy to collect a lower blood volume by phlebotomy. The objective of this study was to assess its association with the number of transfusions. Methods: Before-and-after, quasi-experimental study. The number of transfusions was compared between two groups of VLBW preterm infants with different blood collection volumes. The correlation between the collection volume and the number of transfusions was assessed estimating Spearman's coefficient. A logistic regression model was used to adjust for confounders. Results: The study included 178 patients with a mean gestational age of 29.4 weeks (standard deviation: 2.7) and a birth weight of 1145 g (875-1345). The baseline red series profile was similar between both groups. The number of transfusions (p = 0.017) and the transfusion volume (p = 0.048) decreased significantly. The correlation coefficient was 0.83. In the multivariate analysis, collection volume and birth weight were associated with a requirement of more than three transfusions. Conclusion: A lower blood collection volume in VLBW preterm infants is independently associated with fewer transfusion requirements.
MeSH term(s)	Anemia/etiology ; Anemia/therapy ; Erythrocyte Transfusion/statistics & numerical data ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/etiology ; Infant, Premature, Diseases/therapy ; Infant, Very Low Birth Weight ; Logistic Models ; Male ; Phlebotomy/adverse effects ; Phlebotomy/methods ; Risk Factors ; Treatment Outcome
Language	Spanish
Publishing date	2020-03-21
Publishing country	Argentina
Document type	Journal Article ; Observational Study
ZDB-ID	424449-7
ISSN	1668-3501 ; 0325-0075 ; 0004-0487
ISSN (online)	1668-3501
ISSN	0325-0075 ; 0004-0487
DOI	10.5546/aap.2020.eng.109
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Article: Mutation of Respiratory Syncytial Virus G Protein's CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells.

Ha, Binh / Chirkova, Tatiana / Boukhvalova, Marina S / Sun, He Ying / Walsh, Edward E / Anderson, Christopher S / Mariani, Thomas J / Anderson, Larry J

Vaccines

2019 Volume 7, Issue 3

Abstract: ... using an RSV r19F with a mutation in the CX3C chemokine motif in the RSV G protein (CX4C ...

Abstract	Despite being a high priority for vaccine development, no vaccine is yet available for respiratory syncytial virus (RSV). A live virus vaccine is the primary type of vaccine being developed for young children. In this report, we describe our studies of infected cotton rats and primary human airway epithelial cells (pHAECs) using an RSV r19F with a mutation in the CX3C chemokine motif in the RSV G protein (CX4C). Through this CX3C motif, RSV binds to the corresponding chemokine receptor, CX3CR1, and this binding contributes to RSV infection of pHAECs and virus induced host responses that contribute to disease. In both the cotton rat and pHAECs, the CX4C mutation decreased virus replication and disease and/or host responses to infection. Thus, this mutation, or other mutations that block binding to CX3CR1, has the potential to improve a live attenuated RSV vaccine by attenuating both infection and disease pathogenesis.
Language	English
Publishing date	2019-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines7030069
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Article ; Online: Small-angle X-ray scattering study of self-assembling lipophilic guanines in organic solvents: G-quadruplex formation and cation effects in cyclohexane.

Gonnelli, A / Ortore, M G / Baldassarri, E J / Spada, G P / Pieraccini, S / Perone, R C / Funari, S S / Mariani, P

The journal of physical chemistry. B

2013 Volume 117, Issue 4, Page(s) 1095–1103

Abstract: ... assembly pathways based on different H-bonded motifs, e.g., the cyclic discrete G-quartet, which forms ... in the presence of alkali-metal ions, and the "infinite" tape-like G-ribbon observed in the absence of ions. Using ... in the presence of different salts. The formation of G-quartet based supramolecular aggregates has been confirmed ...

Abstract	Lipophilic guanilic derivatives (lipoGs) dissolved in organic solvents can undergo different self-assembly pathways based on different H-bonded motifs, e.g., the cyclic discrete G-quartet, which forms in the presence of alkali-metal ions, and the "infinite" tape-like G-ribbon observed in the absence of ions. Using in-solution small-angle X-ray scattering, we analyzed a series of lipoGs dissolved in cyclohexane in the presence of different salts. The formation of G-quartet based supramolecular aggregates has been confirmed, evidencing the coexistence equilibrium of octamers and noncovalent molecular nanowires (the so-called G-quadruplexes). By global fitting the scattering data, the concentration of the two kinds of particles as well as the nanowire length have been derived as a function of temperature for the different compounds and salts. The thermodynamic parameters show that the self-assembly aggregation process is enthalpy driven, while the observed enthalpy-entropy compensation suggests that similar stacking interactions control the self-assembly of the different compounds. However, the strength of the stacking interactions, and then the nanowire stability, depends on the nature of templating cations and on their capacity to fill the central cavity of quadruplexes, with the order Sr(+) < Na(+) ≲ K(+).
MeSH term(s)	Cations/chemistry ; Cyclohexanes/chemistry ; G-Quadruplexes ; Guanine/chemistry ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Salts/chemistry ; Scattering, Small Angle ; Solvents/chemistry ; Thermodynamics ; X-Ray Diffraction
Chemical Substances	Cations ; Cyclohexanes ; Salts ; Solvents ; Cyclohexane (48K5MKG32S) ; Guanine (5Z93L87A1R)
Language	English
Publishing date	2013-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/jp3121929
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Article ; Online: Mutation of Respiratory Syncytial Virus G Protein’s CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells

Binh Ha / Tatiana Chirkova / Marina S. Boukhvalova / He Ying Sun / Edward E. Walsh / Christopher S. Anderson / Thomas J. Mariani / Larry J. Anderson

Vaccines, Vol 7, Iss 3, p

2019 Volume 69

Abstract: ... using an RSV r19F with a mutation in the CX3C chemokine motif in the RSV G protein (CX4C ...

Abstract	Despite being a high priority for vaccine development, no vaccine is yet available for respiratory syncytial virus (RSV). A live virus vaccine is the primary type of vaccine being developed for young children. In this report, we describe our studies of infected cotton rats and primary human airway epithelial cells (pHAECs) using an RSV r19F with a mutation in the CX3C chemokine motif in the RSV G protein (CX4C). Through this CX3C motif, RSV binds to the corresponding chemokine receptor, CX3CR1, and this binding contributes to RSV infection of pHAECs and virus induced host responses that contribute to disease. In both the cotton rat and pHAECs, the CX4C mutation decreased virus replication and disease and/or host responses to infection. Thus, this mutation, or other mutations that block binding to CX3CR1, has the potential to improve a live attenuated RSV vaccine by attenuating both infection and disease pathogenesis.
Keywords	respiratory syncytial virus ; live RSV vaccines ; RSV G protein ; Medicine ; R
Subject code	570
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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