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Book ; Online ; E-Book: Emerging Drug Delivery and Biomedical Engineering Technologies

Lamprou, Dimitrios

Transforming Therapy

(Drugs and the Pharmaceutical Sciences Series)

2023

Abstract: This book highlights the advances in drug discovery and delivery and the need for emerging technologies. The text describes new micro and nanofabrication techniques, including methods like electrohydrodynamic processes, additive manufacturing, and ... ...

Author's details	edited by Dimitrios Lamprou
Series title	Drugs and the Pharmaceutical Sciences Series
Abstract	This book highlights the advances in drug discovery and delivery and the need for emerging technologies. The text describes new micro and nanofabrication techniques, including methods like electrohydrodynamic processes, additive manufacturing, and microfluidics, which have potential to produce drug delivery systems that were not possible before.
Keywords	Pharmaceutical technology ; Drug delivery systems ; Drugs/Design
Subject code	615.19
Language	English
Size	1 online resource (269 pages)
Publisher	CRC Press
Publishing place	Boca Raton, FL
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-00-322446-6 ; 1-003-22446-6 ; 1-000-85714-X ; 1-000-85733-6 ; 9781032122717 ; 978-1-00-322446-4 ; 978-1-003-22446-4 ; 978-1-000-85714-6 ; 978-1-000-85733-7 ; 1032122714
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: 3D Printing of Pharmaceuticals and Drug Delivery Devices

Lamprou, Dimitrios A.

2020

Keywords	Medicine ; digital pharmacy ; fused deposition modeling 3D printing ; modified drug release ; personalized medicines ; telemedicine ; three dimensional printing ; additive manufacturing ; 3D printed drug products ; printlets ; personalised medicines ; personalized pharmaceuticals ; multiple units ; spheroids ; beads ; acetaminophen ; 3D printing ; fused filament fabrication ; lignin ; antioxidant materials ; wound dressing ; modified release ; filament extrusion ; fused layer modeling ; theophylline ; high API load ; three-dimensional printing ; fixed-dose combinations ; tablets ; multiple-layer dosage forms ; stereolithography ; vat polymerisation ; fused deposition modeling ; polylactic acid ; chemical modification ; MTT assay ; biofilm formation ; warfarin ; semisolid extrusion 3D printing ; inkjet printing ; orodispersible film ; oral powder ; pediatric ; hospital pharmacy ; personalized medicine ; on-demand manufacturing ; drug delivery ; micromedicine ; drug development ; micro-swimmer ; micro-implant ; oral dosages ; microneedle ; high-precision targeting ; controlled release ; geometry ; resolution ; feature size ; release profile ; vascularization ; digital light processing technology ; neural networks ; optimization ; prediction ; FMD ; pregabalin ; gastric floating ; complex structures ; patient-specific ; structural design ; gums ; Fused Deposition Modeling 3D Printing ; processing parameters ; pharmaceutical quality control ; hot-melt extrusion ; solid dosage forms ; 3D printed oral dosage forms ; sustained drug release tablets ; photopolymerization ; paracetamol (acetaminophen) ; aspirin (acetylsalicylic acid) ; amorphous solid dispersion ; poor solubility ; fixed dose combination ; stencil printing ; pharmacoprinting ; orodispersible discs ; orodisperible films ; floating systems ; pulsatile release ; chronotherapeutic delivery ; wound-healing ; 3D bio-printing ; pectin ; propolis ; cyclodextrin ; 3D bio-inks ; fused deposition modelling ; extrusion ; vaginal meshes ; mechanical properties ; drug release ; anti-infective devices ; pelvic organ prolapse ; stress urinary incontinence ; gastro-retentive floating system ; dissolution kinetics ; implantable devices ; subcutaneous ; biodegradable ; prolonged drug delivery ; polymers ; pharmaceuticals ; extrusion-based 3D printing ; fused deposition modeling (FDM) ; pressure-assisted microsyringe (PAM) ; materials ; process ; 3D bioprinting ; polymeric ink ; pseudo-bone ; implantable scaffold ; computer-aided design (CAD) design ; bioprinting ; computer-aided design (CAD) ; pharmaceutics
Size	1 electronic resource (436 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021044181
ISBN	9783039364244 ; 3039364243
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Recent Development of Electrospinning for Drug Delivery

Zelkó, Romána / Lamprou, Dimitrios A. / Sebe, István

2020

Abstract: Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning ... ...

Abstract	Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (id est, high specific surface area, porosity, and the possibility of controlling the crystalline-amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical-chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included
Keywords	Medicine (General) ; Therapeutics. Pharmacology
Size	1 electronic resource (206 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020480989
ISBN	9783039281404 ; 9783039281411 ; 3039281402 ; 3039281410
DOI	10.3390/books978-3-03928-141-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Conventional vs PEGylated loaded liposomal formulations by microfluidics for delivering hydrophilic chemotherapy.

Jaradat, Eman / Meziane, Adam / Lamprou, Dimitrios A

International journal of pharmaceutics

2024 Volume 655, Page(s) 124077

Abstract: Developing drug delivery systems (DDSs) is one of the approaches used to improve cancer treatment, with the main goal of loading cancer drugs into a carrier targeting a specific organ and avoiding the distribution to healthy tissues. Nanoparticles (NPs) ... ...

Abstract	Developing drug delivery systems (DDSs) is one of the approaches used to improve cancer treatment, with the main goal of loading cancer drugs into a carrier targeting a specific organ and avoiding the distribution to healthy tissues. Nanoparticles (NPs) have been shown to be one of the optimum carriers that can be used as DDSs. Lipid-based NPs, such as liposomes, have been investigated in the current study due to their low toxicity and ability to carry hydrophilic and hydrophobic molecules. In the current studies, conventional liposomes composed of DPPC, and cholesterol and PEGylated liposomes composed of DPPC, cholesterol, and DSPE-PEG2000 are manufactured and loaded with Carboplatin. The study focused on investigating and comparing the impact of modifying the carboplatin-loaded liposomes with different concentrations of DSPE-PEG2000 on the NP diameter, polydispersity, ζ-potential, encapsulation efficiency (EE%), and drug release. The hydrodynamic microfluidic system was used to investigate any possible improvement in the EE% over other conventional methods. The results showed the microfluidic system's promising effect in enhancing the EE% of the Carboplatin. Moreover, the results showed a smaller diameter and higher stability of the PEGylated liposome. However, conventional liposomes represent better homogeneity and higher encapsulation efficiency for hydrophilic molecules.
MeSH term(s)	Liposomes/chemistry ; Carboplatin ; Microfluidics ; Polyethylene Glycols/chemistry ; Cholesterol/chemistry ; Phosphatidylethanolamines
Chemical Substances	Liposomes ; 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000) ; Carboplatin (BG3F62OND5) ; Polyethylene Glycols (3WJQ0SDW1A) ; Cholesterol (97C5T2UQ7J) ; Phosphatidylethanolamines
Language	English
Publishing date	2024-04-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.124077
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Article ; Online: Emerging technologies for diagnostics and drug delivery in the fight against COVID-19 and other pandemics.

Lamprou, Dimitrios A

Expert review of medical devices

2020 Volume 17, Issue 10, Page(s) 1007–1012

Abstract: Introduction: A pandemic is the worst-case scenario in the field of infectious diseases. Innovative technologies have the potential to address the challenges associated with the manufacture of personalized drug delivery systems, biosensors, and medical ... ...

Abstract	Introduction: A pandemic is the worst-case scenario in the field of infectious diseases. Innovative technologies have the potential to address the challenges associated with the manufacture of personalized drug delivery systems, biosensors, and medical devices during a pandemic. 3D-Printing, microfluidics, and Microelectromechanical systems (MEMS) can provide an important part on this fight, as are cheap, easy to be operated, capable to provide rapid detection and monitoring of a disease, and deliver medicines. Areas covered: This manuscript answers the question of how these emerging technologies can save lives during a pandemic by avoiding supply chain delays and also by providing rapid diagnostics, disease monitoring, or by offering personalized treatments. The manuscript covers recent approaches in the topic with a focus in manuscripts published in the last year and by emphasising recent regulatory considerations by regulatory agencies in the manufacturing of 3DP systems or other medical devices during COVID. Expert opinion: New manufacturing techniques are emerging with the ability to address the challenges associated with the development of medical devices or diagnostics, during a pandemic. Are many challenges in order to achieve this and especially in short times that are required under a pandemic attack, which will also be covered in this manuscript.
MeSH term(s)	COVID-19/drug therapy ; COVID-19/epidemiology ; Drug Delivery Systems/methods ; Humans ; Micro-Electrical-Mechanical Systems ; Microfluidics ; Pandemics ; SARS-CoV-2/physiology
Keywords	covid19
Language	English
Publishing date	2020-07-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2250857-0
ISSN	1745-2422 ; 1743-4440
ISSN (online)	1745-2422
ISSN	1743-4440
DOI	10.1080/17434440.2020.1792287
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Article ; Online: Application of 3D printing in early phase development of pharmaceutical solid dosage forms.

Milliken, Rachel L / Quinten, Thomas / Andersen, Sune K / Lamprou, Dimitrios A

International journal of pharmaceutics

2024 Volume 653, Page(s) 123902

Abstract: Three-dimensional printing (3DP) is an emerging technology, offering the possibility for the development of dose-customized, effective, and safe solid oral dosage forms (SODFs). Although 3DP has great potential, it does come with certain limitations, and ...

Abstract	Three-dimensional printing (3DP) is an emerging technology, offering the possibility for the development of dose-customized, effective, and safe solid oral dosage forms (SODFs). Although 3DP has great potential, it does come with certain limitations, and the traditional drug manufacturing platforms remain the industry standard. The consensus appears to be that 3DP technology is expected to benefit personalized medicine the most, but that it is unlikely to replace conventional manufacturing for mass production. The 3DP method, on the other hand, could prove well-suited for producing small batches as an adaptive manufacturing technique for enabling adaptive clinical trial design for early clinical studies. The purpose of this review is to discuss recent advancements in 3DP technologies for SODFs and to focus on the applications for SODFs in the early clinical development stages, including a discussion of current regulatory challenges and quality controls.
MeSH term(s)	Printing, Three-Dimensional ; Precision Medicine/methods ; Industry ; Quality Control ; Pharmaceutical Preparations ; Technology, Pharmaceutical/methods ; Dosage Forms
Chemical Substances	Pharmaceutical Preparations ; Dosage Forms
Language	English
Publishing date	2024-02-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.123902
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Article: 3D Bioprinted Chitosan-Based Hydrogel Scaffolds in Tissue Engineering and Localised Drug Delivery.

Lazaridou, Maria / Bikiaris, Dimitrios N / Lamprou, Dimitrios A

Pharmaceutics

2022 Volume 14, Issue 9

Abstract: Bioprinting is an emerging technology with various applications in developing functional tissue constructs for the replacement of harmed or damaged tissues and simultaneously controlled drug delivery systems (DDSs) for the administration of several ... ...

Abstract	Bioprinting is an emerging technology with various applications in developing functional tissue constructs for the replacement of harmed or damaged tissues and simultaneously controlled drug delivery systems (DDSs) for the administration of several active substances, such as growth factors, proteins, and drug molecules. It is a novel approach that provides high reproducibility and precise control over the fabricated constructs in an automated way. An ideal bioink should possess proper mechanical, rheological, and biological properties essential to ensure proper function. Chitosan is a promising natural-derived polysaccharide to be used as ink because of its attractive properties, such as biodegradability, biocompatibility, low cost, and non-immunogenicity. This review focuses on 3D bioprinting technology for the preparation of chitosan-based hydrogel scaffolds for the regeneration of tissues delivering either cells or active substances to promote restoration.
Language	English
Publishing date	2022-09-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14091978
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Combining 3D Printing and Microfluidic Techniques: A Powerful Synergy for Nanomedicine.

Sommonte, Federica / Denora, Nunzio / Lamprou, Dimitrios A

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 1

Abstract: Nanomedicine has grown tremendously in recent years as a responsive strategy to find novel therapies for treating challenging pathological conditions. As a result, there is an urgent need to develop novel formulations capable of providing adequate ... ...

Abstract	Nanomedicine has grown tremendously in recent years as a responsive strategy to find novel therapies for treating challenging pathological conditions. As a result, there is an urgent need to develop novel formulations capable of providing adequate therapeutic treatment while overcoming the limitations of traditional protocols. Lately, microfluidic technology (MF) and additive manufacturing (AM) have both acquired popularity, bringing numerous benefits to a wide range of life science applications. There have been numerous benefits and drawbacks of MF and AM as distinct techniques, with case studies showing how the careful optimization of operational parameters enables them to overcome existing limitations. Therefore, the focus of this review was to highlight the potential of the synergy between MF and AM, emphasizing the significant benefits that this collaboration could entail. The combination of the techniques ensures the full customization of MF-based systems while remaining cost-effective and less time-consuming compared to classical approaches. Furthermore, MF and AM enable highly sustainable procedures suitable for industrial scale-out, leading to one of the most promising innovations of the near future.
Language	English
Publishing date	2023-01-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16010069
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Article ; Online: Machine learning in additive manufacturing & Microfluidics for smarter and safer drug delivery systems.

Dedeloudi, Aikaterini / Weaver, Edward / Lamprou, Dimitrios A

International journal of pharmaceutics

2023 Volume 636, Page(s) 122818

Abstract: A new technological passage has emerged in the pharmaceutical field, concerning the management, application, and transfer of knowledge from humans to machines, as well as the implementation of advanced manufacturing and product optimisation processes. ... ...

Abstract	A new technological passage has emerged in the pharmaceutical field, concerning the management, application, and transfer of knowledge from humans to machines, as well as the implementation of advanced manufacturing and product optimisation processes. Machine Learning (ML) methods have been introduced to Additive Manufacturing (AM) and Microfluidics (MFs) to predict and generate learning patterns for precise fabrication of tailor-made pharmaceutical treatments. Moreover, regarding the diversity and complexity of personalised medicine, ML has been part of quality by design strategy, targeting towards the development of safe and effective drug delivery systems. The utilisation of different and novel ML techniques along with Internet of Things sensors in AM and MFs, have shown promising aspects regarding the development of well-defined automated procedures towards the production of sustainable and quality-based therapeutic systems. Thus, the effective data utilisation, prospects on a flexible and broader production of "on demand" treatments. In this study, a thorough overview has been achieved, concerning scientific achievements of the past decade, which aims to trigger the research interest on incorporating different types of ML in AM and MFs, as essential techniques for the enhancement of quality standards of customised medicinal applications, as well as the reduction of variability potency, throughout a pharmaceutical process.
MeSH term(s)	Humans ; Microfluidics ; Drug Delivery Systems ; Pharmaceutical Preparations ; Precision Medicine ; Printing, Three-Dimensional
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2023-03-11
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.122818
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Article ; Online: Emerging technologies for diagnostics and drug delivery in the fight against COVID-19 and other pandemics

Lamprou, Dimitrios A.

Expert Review of Medical Devices

2020 , Page(s) 1–6

Keywords	Surgery ; Biomedical Engineering ; General Medicine ; covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2250857-0
ISSN	1745-2422 ; 1743-4440
ISSN (online)	1745-2422
ISSN	1743-4440
DOI	10.1080/17434440.2020.1792287
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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