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  1. Book ; Online ; E-Book: Paediatric infectious diseases

    Lee, Ping-Ing / Huang, Yhu-Chering / Chen, Po-Yen

    a practical guide and cases

    2023  

    Abstract: This book aims to provide readers updated information on diagnosis and management of infectious diseases in children, especially those prevailing in Asian countries. Each chapter presents with one to two typical clinical cases first and then introduces ... ...

    Author's details edited by Yhu-Chering Huang, Ping-Ing Lee, Po-Yen Chen
    Abstract This book aims to provide readers updated information on diagnosis and management of infectious diseases in children, especially those prevailing in Asian countries. Each chapter presents with one to two typical clinical cases first and then introduces the epidemiology, and the pearls of clinical skills in diagnosis and treatment of most frequent infectious pediatric diseases occurred in respiratory tract, gastrointestinal tract, central nervous system, bone/joint, skin and soft tissue. Infectious diseases in neonates, vaccine-associated adverse effects, and specific syndromes prevailing in Asian countries are also discussed with details. Written by experts in the field, this case-based book will be a useful reference for infectious disease researchers and paediatricians, as well as those who are interested in related field. .
    Keywords Communicable diseases in children
    Subject code 929.605
    Language English
    Size 1 online resource (239 pages)
    Edition 1st ed. 2023.
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-19-7276-1 ; 9789811972751 ; 978-981-19-7276-8 ; 9811972753
    DOI 10.1007/978-981-19-7276-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Multisystem inflammatory syndrome in children: A dysregulated autoimmune disorder following COVID-19.

    Lee, Ping-Ing / Hsueh, Po-Ren

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2023  Volume 56, Issue 2, Page(s) 236–245

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a dysregulated autoimmune-mediated illness in genetically susceptible patients following COVID-19 with an interval of 2-6 weeks. The median age of patients with MIS-C is 6-11 years. Most common ... ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) is a dysregulated autoimmune-mediated illness in genetically susceptible patients following COVID-19 with an interval of 2-6 weeks. The median age of patients with MIS-C is 6-11 years. Most common manifestations are involvement of gastrointestinal tract, cardiovascular system, hematological system, and mucocutaneous system. Respiratory tract, neurological system, musculoskeletal system, and kidney are less frequently affected. Mucocutaneous manifestations and coronary artery abnormalities characteristic for Kawasaki disease (KD) may be observed in a significant proportion of MIS-C patients that may make the differential diagnosis be difficult for some patients, especially in the post-pandemic era. The mortality rate is 1-3%. Management and prognosis of MIS-C are similar to that of KD. MIS-C and KD may share a common pathogenic process. Based on the observation of MIS-C-like illness in uninfected neonates, i.e. multisystem inflammatory syndrome in neonates, both MIS-C and KD may be a consequence of dysregulated, over-exaggerated humoral immune responses triggered by a specific infectious agent.
    MeSH term(s) Child ; Infant, Newborn ; Humans ; COVID-19/complications ; Systemic Inflammatory Response Syndrome/diagnosis ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Diagnosis, Differential ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis
    Language English
    Publishing date 2023-01-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2023.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How Taiwan has responded to COVID-19 and how COVID-19 has affected Taiwan, 2020-2022.

    Lai, Chih-Cheng / Lee, Ping-Ing / Hsueh, Po-Ren

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2023  Volume 56, Issue 3, Page(s) 433–441

    Abstract: From January 2020 to December 2022, there was a total of 8,872,955 confirmed COVID-19 cases in Taiwan. In addition, a total of 15,253 COVID-19 related deaths were reported. During these three years, the government and health authority did many efforts to ...

    Abstract From January 2020 to December 2022, there was a total of 8,872,955 confirmed COVID-19 cases in Taiwan. In addition, a total of 15,253 COVID-19 related deaths were reported. During these three years, the government and health authority did many efforts to response this pandemic. In the early pandemic, Taiwan Central Epidemic Command Center was established in the early 2020 to organize associated resource, develop effective policy and implement strict intervention. In response to COVID-19 pandemic, many infection control policy and interventions, including universal mask wearing with increasing production of face mask, hand hygiene, border control, introduce of digital technology incorporating big data, quarantine of COVID-19 cases, travel and gathering restriction, were implemented. In the meanwhile, two COVID-19 vaccines, namely MVC-COV1901 and UB-612, have been developed under the support of government. Furthermore, MVC-COV1901 was taken into clinical practice after received emergency use approval. In addition, two traditional Chinese medicines, including NRICM101 and NRICM102 showed their promising effect against SARS-CoV-2 infection and were recommended as potential therapeutic options for COVID-19. During the pandemic, the nonpharmacologic intervention help reduce many infectious diseases, especially for airborne/droplet-transmitted diseases. However, COVID-19 exhibited some adverse impacts on the healthcare systems, such as emergency medical service on out of hospital cardiac arrest, cancer screening, HIV screening and prevention services, and public health, namely the psychosocial status of healthcare workers. Although the outbreak of SARS-CoV-2 infections may gradually subsided, we should keep monitoring its associated impact and appropriately response to this pandemic.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19 Vaccines ; SARS-CoV-2 ; Pandemics/prevention & control ; Taiwan/epidemiology
    Chemical Substances UB-612 COVID-19 vaccine ; COVID-19 Vaccines
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2023.04.001
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  4. Article ; Online: Safety of Japanese encephalitis vaccines.

    Hu, Ya-Li / Lee, Ping-Ing

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 11, Page(s) 4259–4264

    Abstract: Japanese encephalitis (JE) is an endemic disease dominantly in the Asia-Pacific region with mortality rate varying between 3% and 30%. Long-term neuropsychiatric sequelae developed in 30-50% of the survivors. There is no available antiviral therapy for ... ...

    Abstract Japanese encephalitis (JE) is an endemic disease dominantly in the Asia-Pacific region with mortality rate varying between 3% and 30%. Long-term neuropsychiatric sequelae developed in 30-50% of the survivors. There is no available antiviral therapy for JE. JE vaccines play a major role in preventing this devastating disease. The incidence of JE declined over years and the age distribution shifted toward adults in countries where JE immunization program exists. Mouse brain-JE vaccine is currently replaced by inactivated Vero cell-derived vaccine and live-attenuated vaccine using SA14-14-2 strain, and live chimeric JE vaccines. These three types of JE vaccines are associated with favorable efficacy and safety profiles. Common adverse reactions include injection site reactions and fever, and severe adverse reactions are rare.
    MeSH term(s) Animals ; Chlorocebus aethiops ; Encephalitis Virus, Japanese ; Encephalitis, Japanese/epidemiology ; Encephalitis, Japanese/prevention & control ; Japanese Encephalitis Vaccines/adverse effects ; Mice ; Vaccines, Attenuated/adverse effects ; Vaccines, Inactivated/adverse effects ; Vero Cells
    Chemical Substances Japanese Encephalitis Vaccines ; Vaccines, Attenuated ; Vaccines, Inactivated
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.1969852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Seasonality and risk factor analysis of respiratory syncytial virus infection in children in Taiwan-A retrospective study from 1995 to 2005.

    Lee, Ping-Ing / Liu, Ching-Chuan / Hu, Ya-Li / Chen, Jong-Min

    Journal of medical virology

    2023  Volume 95, Issue 10, Page(s) e29116

    Abstract: Respiratory syncytial virus (RSV) is one of the important pathogens leading to acute respiratory tract infection in infants and young children. We aimed to investigate the seasonality of RSV infection in different parts of Taiwan and to delineate the ... ...

    Abstract Respiratory syncytial virus (RSV) is one of the important pathogens leading to acute respiratory tract infection in infants and young children. We aimed to investigate the seasonality of RSV infection in different parts of Taiwan and to delineate the risk factors for severe RSV infections. We collected RSV-infected patients' data by retrospective chart review. A total of 1740 RSV-infected children aged under 18 years were enrolled. The infection was acquired during hospitalization in 103 (7.1%) children, while none of them required ventilator support or needed intensive care before RSV infection. The need for intensive care or ventilator support was significantly associated with congenital heart disease (CHD), chronic lung disease, and neuromuscular diseases. Age <1 year and nosocomially acquired infection are also significant predictors for the need of intensive care. Only the presence of CHD, especially acyanotic CHD, was significantly associated with a fatal outcome. RSV infection occurs all year round. Monthly distribution of RSV infections in Northern Taiwan showed a bimodal pattern, with one peak from March to May, and another from August to October. The distribution in Southern Taiwan showed a single peak from April to July. The occurrence of RSV correlates positively with temperature and rain. The bimodal seasonal distribution pattern in Northern Taiwan may be a transitional pattern shifting from a single high winter peak in temperate areas to a wider summer peak in tropical areas. Continuous surveillance is needed to explore the possible effect of global warming on the seasonality of RSV infection.
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29116
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  6. Article ; Online: An Unusual Case With a Huge Hepatic Cystic Mass.

    Tai, Chi-San / Ni, Yen-Hsuan / Lee, Ping-Ing

    Gastroenterology

    2021  Volume 162, Issue 4, Page(s) e7–e8

    MeSH term(s) Brain ; Digestive System Abnormalities ; Humans ; Liver/diagnostic imaging ; Liver/surgery
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.08.011
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  7. Article ; Online: Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV.

    Lee, Ping-Ing / Hsueh, Po-Ren

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2020  Volume 53, Issue 3, Page(s) 365–367

    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Betacoronavirus/pathogenicity ; COVID-19 ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/therapy ; Communicable Diseases, Emerging/transmission ; Communicable Diseases, Emerging/virology ; Coronavirus/pathogenicity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Host Specificity ; Humans ; Pandemics/veterinary ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/veterinary ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/therapy ; Severe Acute Respiratory Syndrome/veterinary ; Severe Acute Respiratory Syndrome/virology ; Zoonoses/therapy ; Zoonoses/transmission ; Zoonoses/virology
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-02-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2020.02.001
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  8. Article ; Online: Cost-effectiveness analysis of cell-based versus egg-based quadrivalent influenza vaccines in the pediatric population in Taiwan.

    Chi, Chia-Yu / Cheng, Ming-Fang / Ko, Karam / Mould, Joaquin F / Chen, Chih-Jung / Huang, Yhu-Chering / Lee, Ping-Ing

    Journal of medical virology

    2024  Volume 96, Issue 1, Page(s) e29279

    Abstract: Cell-based influenza vaccines avoid egg-adaptive mutations, potentially improving vaccine effectiveness. We assessed the one-season cost-effectiveness of cell-based quadrivalent influenza vaccine (QIVc) against that of egg-derived quadrivalent influenza ... ...

    Abstract Cell-based influenza vaccines avoid egg-adaptive mutations, potentially improving vaccine effectiveness. We assessed the one-season cost-effectiveness of cell-based quadrivalent influenza vaccine (QIVc) against that of egg-derived quadrivalent influenza vaccines (QIVe) in children (6 months to 17 years of age) from payer and societal perspectives in Taiwan using an age-stratified static model. Base case and high egg adaptation scenarios were assessed. Deterministic and probabilistic sensitivity analyses were performed. The incremental cost-effectiveness ratio (ICER) threshold in Taiwan was assumed to be USD 99 177/quality-adjusted life year (QALY). Compared to QIVe, QIVc would prevent 15 665 influenza cases, 2244 complicated cases, and 259 hospitalizations per year. The base case ICER was USD 68 298/QALY and USD 40 085/QALY from the payer and societal perspective, respectively. In the high egg adaptation scenario, the ICER was USD 45 782/QALY from the payer's perspective and USD 17 489/QALY from the societal perspective. Deterministic sensitivity analyses indicated that infection incidence rate, vaccination coverage, and prevalence of the A/H3N2 strain were the main drivers of ICER. In conclusion, switching the immunization strategy from QIVe to QIVc is predicted to reduce the influenza-associated disease burden and be cost-effective for the pediatric population in Taiwan. The potential benefits of QIVc would be even higher during influenza seasons with high levels of egg adaptation.
    MeSH term(s) Child ; Humans ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Cost-Effectiveness Analysis ; Taiwan/epidemiology ; Influenza A Virus, H3N2 Subtype ; Vaccines, Combined
    Chemical Substances Influenza Vaccines ; Vaccines, Combined
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29279
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  10. Article ; Online: Evolving reporting criteria of COVID-19 in Taiwan during the epidemic.

    Huang, Yhu-Chering / Lee, Ping-Ing / Hsueh, Po-Ren

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2020  Volume 53, Issue 3, Page(s) 413–418

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Centers for Disease Control and Prevention, U.S. ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Disease Notification/statistics & numerical data ; Health Resources ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Taiwan/epidemiology ; United States ; World Health Organization
    Keywords covid19
    Language English
    Publishing date 2020-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2020.03.014
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