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  1. Article ; Online: A drug delivery strategy emerges that has the potential to transform cancer therapy.

    Theobald, Nigel / Templeton, David

    Drug discovery today

    2024  Volume 29, Issue 4, Page(s) 103923

    Abstract: The shortcomings of current approaches to treating cancer are driving the need for novel, innovative strategies that reduce the toxicity associated with chemotherapy and improve on the limited efficacy of immunotherapy. We believe that dual delivery of ... ...

    Abstract The shortcomings of current approaches to treating cancer are driving the need for novel, innovative strategies that reduce the toxicity associated with chemotherapy and improve on the limited efficacy of immunotherapy. We believe that dual delivery of small interfering RNA (siRNA) via a suitable delivery system, with or without a relevant, additional, small-molecule therapeutic agent, will herald new era of treatment efficiency in cancer.
    MeSH term(s) Humans ; Nanoparticles ; Drug Delivery Systems ; Neoplasms/therapy ; RNA, Small Interfering ; Immunotherapy
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Editorial
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2024.103923
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    Zs.A 4725: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Emerging vaccine delivery systems for COVID-19: Functionalised silica nanoparticles offer a potentially safe and effective alternative delivery system for DNA/RNA vaccines and may be useful in the hunt for a COVID-19 vaccine.

    Theobald, Nigel

    Drug discovery today

    2020  Volume 25, Issue 9, Page(s) 1556–1558

    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/prevention & control ; Drug Carriers/pharmacology ; Drug Delivery Systems/methods ; Drug Development ; Drug Discovery/methods ; Humans ; Nanoparticles/therapeutic use ; Oligonucleotides/pharmacology ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Silicon Dioxide/pharmacology ; Vaccines, DNA/pharmacology ; Viral Vaccines/pharmacology
    Chemical Substances COVID-19 Vaccines ; Drug Carriers ; Oligonucleotides ; Vaccines, DNA ; Viral Vaccines ; Silicon Dioxide (7631-86-9)
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Editorial
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2020.06.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Emerging vaccine delivery systems for COVID-19

    Theobald, Nigel

    Drug Discovery Today

    2020  Volume 25, Issue 9, Page(s) 1556–1558

    Keywords Pharmacology ; Drug Discovery ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2020.06.020
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Emerging vaccine delivery systems for COVID-19: Functionalised silica nanoparticles offer a potentially safe and effective alternative delivery system for DNA/RNA vaccines and may be useful in the hunt for a COVID-19 vaccine

    Theobald, Nigel

    Drug Discov Today

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #613094
    Database COVID19

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  5. Book: Packaging closures and sealing systems

    Theobald, Nigel / Winder, Belinda

    (Packaging technology series)

    2006  

    Author's details ed. by Nigel Theobald; Belinda Winder
    Series title Packaging technology series
    Language English
    Size XVIII, 264 S, Ill., graph. Darst, 24 cm
    Publisher CRC Press ; Blackwell
    Publishing place Boca Raton, Fla ; Oxford
    Document type Book
    Note Includes bibliographical references and index
    ISBN 1841273376 ; 9781841273372
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book: Packaging closures and sealing systems

    Theobald, Nigel / Winder, Belinda

    (Packaging technology series)

    2006  

    Author's details edited by Nigel Theobald, Belinda Winder
    Series title Packaging technology series
    Keywords Packaging. ; Seals (Closures)
    Language English
    Size xviii, 264 p. :, ill. ;, 24 cm.
    Publisher Blackwell Pub ; CRC Press
    Publishing place Oxford ; Boca Raton, FL
    Document type Book
    Note Includes index.
    ISBN 1841273376 ; 9781841273372 ; 0849328071 ; 9780849328077
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Effects of chicory/perennial ryegrass swards compared with perennial ryegrass swards on the performance and carcass quality of grazing beef steers.

    Marley, Christina L / Fychan, Rhun / Davies, John W / Scollan, Nigel D / Richardson, R Ian / Theobald, Vince J / Genever, Elizabeth / Forbes, Andy B / Sanderson, Ruth

    PloS one

    2014  Volume 9, Issue 1, Page(s) e86259

    Abstract: An experiment investigated whether the inclusion of chicory (Cichorium intybus) in swards grazed by beef steers altered their performance, carcass characteristics or parasitism when compared to steers grazing perennial ryegrass (Lolium perenne). ... ...

    Abstract An experiment investigated whether the inclusion of chicory (Cichorium intybus) in swards grazed by beef steers altered their performance, carcass characteristics or parasitism when compared to steers grazing perennial ryegrass (Lolium perenne). Triplicate 2-ha plots were established with a chicory/ryegrass mix or ryegrass control. Forty-eight Belgian Blue-cross steers were used in the first grazing season and a core group (n = 36) were retained for finishing in the second grazing season. The experiment comprised of a standardisation and measurement period. During standardisation, steers grazed a ryegrass/white clover pasture as one group. Animals were allocated to treatment on the basis of liveweight, body condition and faecal egg counts (FEC) determined 7 days prior to the measurement period. The measurement period ran from 25 May until 28 September 2010 and 12 April until 11 October 2011 in the first and second grazing year. Steers were weighed every 14 days at pasture or 28 days during housing. In the first grazing year, faecal samples were collected for FEC and parasite cultures. At the end of the first grazing year, individual blood samples were taken to determine O. ostertagi antibody and plasma pepsinogen levels. During winter, animals were housed as one group and fed silage. In the second grazing year, steers were slaughtered when deemed to reach fat class 3. Data on steer performance showed no differences in daily live-weight gain which averaged 1.04 kg/day. The conformation, fat grade and killing out proportion of beef steers grazing chicory/ryegrass or ryegrass were not found to differ. No differences in FEC, O. ostertagi antibody or plasma pepsinogen levels of beef steers grazing either chicory/ryegrass or ryegrass were observed. Overall, there were no detrimental effects of including chicory in swards grazed by beef cattle on their performance, carcass characteristics or helminth parasitism, when compared with steers grazing ryegrass.
    MeSH term(s) Animal Feed ; Animal Husbandry ; Animals ; Cattle ; Cichorium intybus ; Lolium ; Meat ; Parasite Egg Count ; Weight Gain
    Language English
    Publishing date 2014-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0086259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effects of chicory/perennial ryegrass swards compared with perennial ryegrass swards on the performance and carcass quality of grazing beef steers.

    Christina L Marley / Rhun Fychan / John W Davies / Nigel D Scollan / R Ian Richardson / Vince J Theobald / Elizabeth Genever / Andy B Forbes / Ruth Sanderson

    PLoS ONE, Vol 9, Iss 1, p e

    2014  Volume 86259

    Abstract: An experiment investigated whether the inclusion of chicory (Cichorium intybus) in swards grazed by beef steers altered their performance, carcass characteristics or parasitism when compared to steers grazing perennial ryegrass (Lolium perenne). ... ...

    Abstract An experiment investigated whether the inclusion of chicory (Cichorium intybus) in swards grazed by beef steers altered their performance, carcass characteristics or parasitism when compared to steers grazing perennial ryegrass (Lolium perenne). Triplicate 2-ha plots were established with a chicory/ryegrass mix or ryegrass control. Forty-eight Belgian Blue-cross steers were used in the first grazing season and a core group (n = 36) were retained for finishing in the second grazing season. The experiment comprised of a standardisation and measurement period. During standardisation, steers grazed a ryegrass/white clover pasture as one group. Animals were allocated to treatment on the basis of liveweight, body condition and faecal egg counts (FEC) determined 7 days prior to the measurement period. The measurement period ran from 25 May until 28 September 2010 and 12 April until 11 October 2011 in the first and second grazing year. Steers were weighed every 14 days at pasture or 28 days during housing. In the first grazing year, faecal samples were collected for FEC and parasite cultures. At the end of the first grazing year, individual blood samples were taken to determine O. ostertagi antibody and plasma pepsinogen levels. During winter, animals were housed as one group and fed silage. In the second grazing year, steers were slaughtered when deemed to reach fat class 3. Data on steer performance showed no differences in daily live-weight gain which averaged 1.04 kg/day. The conformation, fat grade and killing out proportion of beef steers grazing chicory/ryegrass or ryegrass were not found to differ. No differences in FEC, O. ostertagi antibody or plasma pepsinogen levels of beef steers grazing either chicory/ryegrass or ryegrass were observed. Overall, there were no detrimental effects of including chicory in swards grazed by beef cattle on their performance, carcass characteristics or helminth parasitism, when compared with steers grazing ryegrass.
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article: Potential of Chlorophyll-Rich Feed Ingredients To Improve Detection of Fecal Contamination in the Abattoir

    Lee, Michael R.F / Scott, Mark B / Veberg-Dahl, Annette / Evans, Phil R / Theobald, Vince J / Lundby, Frank / Scollan, Nigel D / Wold, Jens-Petter

    Journal of food protection. 2013 Mar., v. 76, no. 3

    2013  

    Abstract: The use of fecal fluorescence to improve detection of contamination of carcasses in the abattoir was previously reported. However, incidents of false negatives can result when animals are offered diets that contain little chlorophyll (e.g., concentrate). ...

    Abstract The use of fecal fluorescence to improve detection of contamination of carcasses in the abattoir was previously reported. However, incidents of false negatives can result when animals are offered diets that contain little chlorophyll (e.g., concentrate). Here, we investigated the potential of incorporating a high-chlorophyll-containing feed ingredient (concentrated alfalfa extract; CAE) into the diets of sheep and cattle to improve fecal fluorescence intensity. The sheep experiment evaluated the fecal fluorescence of animals from pasture, when fed a concentrate-barley straw diet and when the concentrate diet incorporated CAE (100 g of dry matter a day). Fecal chlorophyll and metabolite content was highest on the pasture-fed animals and increased significantly over the concentrate diet when CAE was included. Subsequently fluorescent intensity was increased from 15,000 to 36,000 arbitrary units for concentrate and CAE-concentrate diets, respectively, compared with 59,000 for the pasture-fed animals. The cattle experiment investigated the potential of CAE to improve fluorescence of feces from a concentrate diet as well as a silage diet at two levels of incorporation (75 and 150 g CAE/kg of dry matter intake). This study also determined the fluorescence of digesta and carcass contamination in the abattoir on a subset of carcasses. In agreement with the sheep study, CAE significantly improved fluorescence of feces and digesta when added to a concentrate diet, but had little effect on improving fecal fluorescence from the silage-fed animals. This was thought to be related to greater chlorophyll degradation in the rumen or/and the dark nature of the silage feces acting as a quencher of emitted fluoresced light. Incorporating high-chlorophyll-containing plant ingredients into ruminant concentrate diets will improve detection of fecal contamination by reducing false-negative readings. However, they will have little effect on false-positive readings due to the range of wavelengths emitted by natural chlorophyll and its metabolites. Implications and potential solutions for this are discussed.
    Keywords alfalfa ; cattle ; chlorophyll ; diet ; digesta ; dry matter intake ; feces ; feed concentrates ; fluorescence ; ingredients ; meat carcasses ; metabolites ; pastures ; rumen ; sheep ; silage ; slaughterhouses ; straw ; wavelengths
    Language English
    Size p. 516-522.
    Document type Article
    ZDB-ID 243284-5
    ISSN 1944-9097 ; 0362-028X
    ISSN (online) 1944-9097
    ISSN 0362-028X
    DOI 10.4315/0362-028X.JFP-12-353
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: Potential of chlorophyll-rich feed ingredients to improve detection of fecal contamination in the abattoir.

    Lee, Michael R F / Scott, Mark B / Veberg-Dahl, Annette / Evans, Phil R / Theobald, Vince J / Lundby, Frank / Scollan, Nigel D / Wold, Jens-Petter

    Journal of food protection

    2012  Volume 76, Issue 3, Page(s) 516–522

    Abstract: The use of fecal fluorescence to improve detection of contamination of carcasses in the abattoir was previously reported. However, incidents of false negatives can result when animals are offered diets that contain little chlorophyll (e.g., concentrate). ...

    Abstract The use of fecal fluorescence to improve detection of contamination of carcasses in the abattoir was previously reported. However, incidents of false negatives can result when animals are offered diets that contain little chlorophyll (e.g., concentrate). Here, we investigated the potential of incorporating a high-chlorophyll-containing feed ingredient (concentrated alfalfa extract; CAE) into the diets of sheep and cattle to improve fecal fluorescence intensity. The sheep experiment evaluated the fecal fluorescence of animals from pasture, when fed a concentrate-barley straw diet and when the concentrate diet incorporated CAE (100 g of dry matter a day). Fecal chlorophyll and metabolite content was highest on the pasture-fed animals and increased significantly over the concentrate diet when CAE was included. Subsequently fluorescent intensity was increased from 15,000 to 36,000 arbitrary units for concentrate and CAE-concentrate diets, respectively, compared with 59,000 for the pasture-fed animals. The cattle experiment investigated the potential of CAE to improve fluorescence of feces from a concentrate diet as well as a silage diet at two levels of incorporation (75 and 150 g CAE/kg of dry matter intake). This study also determined the fluorescence of digesta and carcass contamination in the abattoir on a subset of carcasses. In agreement with the sheep study, CAE significantly improved fluorescence of feces and digesta when added to a concentrate diet, but had little effect on improving fecal fluorescence from the silage-fed animals. This was thought to be related to greater chlorophyll degradation in the rumen or/and the dark nature of the silage feces acting as a quencher of emitted fluoresced light. Incorporating high-chlorophyll-containing plant ingredients into ruminant concentrate diets will improve detection of fecal contamination by reducing false-negative readings. However, they will have little effect on false-positive readings due to the range of wavelengths emitted by natural chlorophyll and its metabolites. Implications and potential solutions for this are discussed.
    MeSH term(s) Abattoirs ; Animal Feed ; Animals ; Biomarkers/analysis ; Cattle ; Chlorophyll/analysis ; Feces/chemistry ; Fluorescence ; Food Contamination/analysis ; Food Microbiology ; Humans ; Meat/analysis ; Meat/microbiology ; Sheep
    Chemical Substances Biomarkers ; Chlorophyll (1406-65-1)
    Language English
    Publishing date 2012-10-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 243284-5
    ISSN 1944-9097 ; 0362-028X
    ISSN (online) 1944-9097
    ISSN 0362-028X
    DOI 10.4315/0362-028X.JFP-12-353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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