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Article ; Online: Occurrence, multiphase partition and risk assessment of organic amine pesticides in drinking water source of Xiang River, China.

Jiao, Cao / Wu, Linjunyue / Zhao, Wenyu / Cai, Minghong / Liu, Yanju / Xie, Sha

2024 Volume 46, Issue 3, Page(s) 105

Abstract: ... on the Xiang River (XR), a representative drinking water source, as the research area to investigate ...

Abstract	The extensive use of organic amine pesticides (OAPs) in agricultural practices has resulted in the contamination of water environments, posing threats to ecosystems and human health. This study focused on the Xiang River (XR), a representative drinking water source, as the research area to investigate the occurrence characteristics of 34 OAPs. Diphenylamine emerged as the most prevalent OAP in surface water due to industrial and agricultural activities, while cycloate dominated in sediments due to cumulative effects. Generally, the concentration of OAPs in a mixed tap water sample was lower than those in surface water samples, indicating OAPs can be removed by water plants to a certain extent. The water-sediment distribution coefficients (k
MeSH term(s)	Humans ; Drinking Water ; Pesticides ; Amines ; Ecosystem ; Rivers ; China ; Risk Assessment
Chemical Substances	Drinking Water ; Pesticides ; Amines
Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-024-01900-z
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Zs.A 4723: Show issues

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Article: Antifungal Mechanisms of a Chinese Herbal Medicine, Cao Huang Gui Xiang, Against

Yue, Huizhen / Xu, Xiaolong / He, Shasha / Cui, Xuran / Guo, Yuhong / Zhao, Jingxia / Peng, Bing / Liu, Qingquan

Frontiers in pharmacology

2022 Volume 13, Page(s) 813818

Abstract: Cao Huang Gui Xiang (CHGX) formula, a Chinese herbal medicine, has been empirically used ...

Abstract	Cao Huang Gui Xiang (CHGX) formula, a Chinese herbal medicine, has been empirically used for the treatment of
Language	English
Publishing date	2022-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.813818
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Article ; Online: Ssc-mir-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene.

Yuan, Wei / Qin, Hai / Bi, Huan / Zhao, Depeng / Zhang, Yiyu / Chen, Wei

BMC genomics

2023 Volume 24, Issue 1, Page(s) 369

Abstract: ... in Xiang pigs by transcriptome sequencing, and to validate their targeted regulatory relationships ... and white skin tissues of Jianbai Xiang pigs. miRNA-221-3p was identified as a candidate miRNA ... the expression of TYR, TYRP1, and DCT genes in Jianbai Xiang pig melanocytes P < 0.01, which in turn decreased ...

Abstract	Background: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that regulate gene expression by down-regulating it. Several studies have suggested that miRNAs plays a crucial role in mammalian skin color production. The TYRP1 gene, a member of the tyrosine family, is an important candidate gene that affects melanogenesis. This study aimed to identify genes and miRNAs that affect melanin production in Xiang pigs by transcriptome sequencing, and to validate their targeted regulatory relationships. Results: 17 miRNAs and 1,230 genes were significantly differentially expressed (P < 0.05) in the black and white skin tissues of Jianbai Xiang pigs. miRNA-221-3p was identified as a candidate miRNA for melanin formation and its target gene, TYRP1, was selected. The TYRP1 gene is a member of the TYR gene family, which evolved from the TYR gene through chromosome segmental duplication. The function of the gene was highly conserved throughout the evolutionary process. overexpression of TYRP1 gene significantly increased the expression of TYR, TYRP1, and DCT genes P < 0.01, which led to an increase in the relative content of melanin. Silencing of TYRP1 through the use of TYRP1-siRNA significantly reduced the expression of TYR, TYRP1, and DCT genes in Jianbai Xiang pig melanocytes P < 0.01, which in turn decreased the relative melanin content. The targeted binding relationship between ssc-miR-221-3p and TYRP1 gene was validated. After transfection of porcine melanocytes with ssc-miR-221-3p mimic, the expression of ssc-miR-221-3p was significantly up-regulated (P < 0.01). Furthermore, the mRNA and protein levels of TYR, TYRP1, and DCT genes were significantly down-regulated (P < 0.01), and melanin content in cells was significantly reduced (P < 0.01). Conclusion: The TYRP1 gene affects melanogenesis in melanocytes of Jianbai Xiang pigs, and ssc-miR-221-3p targets the TYRP1 gene to regulate melanogenesis in melanocytes of Jianbai Xiang pigs.
MeSH term(s)	Swine ; Animals ; Melanins ; Melanocytes ; Tyrosine ; Biological Evolution ; Chromosome Duplication ; MicroRNAs/genetics ; RNA, Small Untranslated ; Mammals
Chemical Substances	Melanins ; Tyrosine (42HK56048U) ; MicroRNAs ; RNA, Small Untranslated
Language	English
Publishing date	2023-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09451-w
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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages.

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of ethnopharmacology

2023 Volume 312, Page(s) 116444

Abstract: ... of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule ...

Abstract	Ethnopharmacological relevance: Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. Aim of the study: This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. Materials and methods: The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE Results: The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. Conclusion: SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
MeSH term(s)	Mice ; Animals ; Plaque, Atherosclerotic/metabolism ; Cholesterol, HDL ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Atherosclerosis/etiology ; Macrophages ; Cholesterol/metabolism ; Lysosomes/metabolism ; Apolipoproteins E
Chemical Substances	Cholesterol, HDL ; Cholesterol (97C5T2UQ7J) ; Apolipoproteins E
Language	English
Publishing date	2023-04-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
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Zs.A 1494: Show issues

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Article: Corrigendum: Antifungal mechanisms of a Chinese herbal medicine, Cao Huang Gui Xiang, against

Yue, Huizhen / Xu, Xiaolong / He, Shasha / Cui, Xuran / Guo, Yuhong / Zhao, Jingxia / Peng, Bing / Liu, Qingquan

Frontiers in pharmacology

2022 Volume 13, Page(s) 977030

Abstract: This corrects the article DOI: 10.3389/fphar.2022.813818.]. ...

Abstract	[This corrects the article DOI: 10.3389/fphar.2022.813818.].
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.977030
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Article: Xiang Qin Kang Gan Granules Treated the Human Coronavirus 229E Induced Pneumonia with Damp-Heat Syndrome in Mice.

Cao, Fang / Liu, Zhaoheng / Hao, Qingxun / Zhao, Ronghua / Bao, Lei / Cui, Xiaolan / Jiao, Yang

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

2022 Volume 2022, Page(s) 7609550

Abstract: Coronavirus disease 2019 (COVID-19), which causes severe respiratory illness, was first reported in Wuhan, China. The etiology of the disease is a new novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was ... ...

Abstract	Coronavirus disease 2019 (COVID-19), which causes severe respiratory illness, was first reported in Wuhan, China. The etiology of the disease is a new novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was reported to share the same origin as SARS-CoV, causing severe public health events in 2002. Unlike the SARS-CoV, which was conquered in the early summer of 2003, this virus was still contagious widely and reached a pandemic level. It can still spread fast even if the season's temperature is raised. Here, we made a model of pneumonia of human coronavirus 229E (HCoV-229E) with damp-heat syndrome treated by Xiangqin Kanggan granules to find a new medicine for treating these kinds of infectious diseases coronaviruses induced.
Language	English
Publishing date	2022-09-23
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1057056-1
ISSN	1712-9532 ; 1180-2332
ISSN	1712-9532 ; 1180-2332
DOI	10.1155/2022/7609550
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Zs.A 3099: Show issues

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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of Ethnopharmacology. 2023 Aug., v. 312 p.116444-

2023

Abstract: ... of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts ...

Abstract	Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE⁻/⁻ mice fed a cholesterol-enriched diet. The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
Keywords	Oriental traditional medicine ; adipose tissue ; atherosclerosis ; chloroquine ; diet ; high density lipoprotein cholesterol ; hyperlipidemia ; lipid metabolism ; liquid chromatography ; macrophages ; risk factors ; tandem mass spectrometry ; Adipose tissue macrophage ; Lysosomal activity ; Postprandial cholesterol level ; San-wei-tan-xiang capsule
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Characterization and difference of lipids and metabolites from Jianhe White Xiang and Large White pork by high-performance liquid chromatography-tandem mass spectrometry.

Zhang, Run / Yang, Man / Hou, Xinhua / Hou, Renda / Wang, Ligang / Shi, Lijun / Zhao, Fuping / Liu, Xin / Meng, Qingshi / Wang, Lixian / Zhang, Longchao

Food research international (Ottawa, Ont.)

2022 Volume 162, Issue Pt A, Page(s) 111946

Abstract: ... Large White (LW) pigs). The Jianhe White Xiang (JWX) pig, one of the Chinese Xiang pigs, is known ...

Abstract	The quality of pork, such as intramuscular fat (IMF) content and flavor, can affect the acceptance of the consumer. Many studies have reported on the pork quality of Chinese local and commercial pigs (for example Large White (LW) pigs). The Jianhe White Xiang (JWX) pig, one of the Chinese Xiang pigs, is known for its high IMF and pork flavor. However, studies investigating the characterization and difference of lipids and metabolites between the JWX and LW pork are limited. Herein, we performed metabolomic and lipidomic profiling of JWX and LW pork by high-performance liquid chromatography-tandem mass spectrometry. The IMF and meat redness (a*) of the JWX pork were significantly higher than those of the LW pork. Metabolomic profiling revealed that 118 out of 501 polar metabolites, such as carnitine, amino acids, sugar, and dipeptide, were significantly different between the two types of pork. Additionally, the screened metabolites were mainly related to carnitine synthesis, phospholipid metabolism, sugar metabolism, and amino acid metabolism. Lipidomic profiling identified 100 of 376 lipids, which contained carnitine, diglyceride, triglyceride (TG), sphingomyelin, cardiolipin, fatty acid, phosphatidylcholine (PC), and phosphatidylethanolamine (PE), which were significantly different between the two types of pork under the positive and negative ion modes (variable importance in projection (VIP) > 1, p < 0.05, and fold change (FC) > 2 or FC < 0.5). All of the different TG substances were up-regulated in the JWX pork, and their carbon chain length was longer than that of the residual TGs. In addition, the JWX pork had more double bonds of PC and PE substances than LW pork. Thus, our findings provide comprehensive metabolomic and lipidomic profiles between the JWX and LW pork and a basic understanding on increasing the pork quality.
MeSH term(s)	Swine ; Animals ; Chromatography, High Pressure Liquid ; Pork Meat ; Red Meat ; Tandem Mass Spectrometry ; Carnitine ; Lecithins ; Triglycerides ; Sugars
Chemical Substances	Carnitine (S7UI8SM58A) ; Lecithins ; Triglycerides ; Sugars
Language	English
Publishing date	2022-09-27
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.111946
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Article ; Online: Mu-Xiang-You-Fang protects PC12 cells against OGD/R-induced autophagy via the AMPK/mTOR signaling pathway.

Ma, Hui-Xia / Hou, Fan / Chen, Ai-Ling / Li, Ting-Ting / Zhu, Ya-Fei / Zhao, Qi-Peng

Journal of ethnopharmacology

2020 Volume 252, Page(s) 112583

Abstract: Ethnopharmacological relevance: Mu-Xiang-You-Fang (MXYF) is a classic prescription of Hui medicine ...

Abstract	Ethnopharmacological relevance: Mu-Xiang-You-Fang (MXYF) is a classic prescription of Hui medicine. It is composed of five herbs and has been used to treat ischemic stroke for many years. However, the potential pharmacological mechanisms of MXYF remain unclear. The present research is aimed to investigate the protective effect and possible mechanisms of MXYF treatment in an in vitro model of cerebral ischemia-reperfusion injury. Materials and methods: An oxygen-glucose deprivation and reperfusion (OGD/R) model of PC12 cells was established. The effect of MXYF on the cell viability after OGD/R injury was determined using a cell counting kit (CCK-8) assay. The colorimetric method was used to determine the lactate dehydrogenase (LDH) leakage rate. The calcium concentration was determined by the chemical fluorescence method, and mitochondrial membrane potential was determined using flow cytometry. Monodansylcadaverine (MDC) staining and electron microscopic analysis were then conducted to detect autophagy after oxygen-glucose deprivation and reperfusion in PC12 cells. Immunofluorescence and western blot analyses were used to detect the expression of proteins associated with autophagy. Results: It was found that MXYF (1, 2, 4 μg/mL) could significantly increase cell viability and mitochondrial membrane potential and decrease the calcium concentration and LDH release rate in PC12 cells. After OGD/R injury in PC12 cells, the number of autophagosomes and autophagolysosome significantly increased. MXYF (4 μg/mL) inhibited the autophagy induced by OGD/R and inhibited the expression of LC3, beclin1, p-AMPK, and ULK1. In contrast, the expression of p-mTOR, p-p70s6k, and p62 was significantly enhanced. Conclusions: These findings suggest that MXYF inhibits autophagy after OGD/R-induced PC12 cell injury through the AMPK-mTOR pathway. Thus, MXYF might have therapeutic potential in treating ischemic stroke.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Animals ; Autophagy/drug effects ; Cell Hypoxia ; Drugs, Chinese Herbal/pharmacology ; Glucose/deficiency ; Neuroprotective Agents/pharmacology ; Oxygen ; PC12 Cells ; Rats ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Mu-Xiang-You-Fang ; Neuroprotective Agents ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; mTOR protein, rat (EC 2.7.1.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2) ; Oxygen (S88TT14065)
Language	English
Publishing date	2020-01-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112583
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Zs.A 1494: Show issues

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Article ; Online: NIR Rapid Assessments of Blumea balsamifera (Ai-na-xiang) in China.

Yu, Fu-Lai / Zhao, Na / Wu, Zhi-Sheng / Huang, Mei / Wang, Dan / Zhang, Ying-Bo / Hu, Xuan / Chen, Xiao-Lu / Huang, Lu-Qi / Pang, Yu-Xin

Molecules (Basel, Switzerland)

2017 Volume 22, Issue 10

Abstract: ... Blumea ... ...

Abstract	Blumea balsamifera
MeSH term(s)	Algorithms ; Asteraceae/chemistry ; Discriminant Analysis ; Flavones/chemistry ; Green Chemistry Technology/methods ; Least-Squares Analysis ; Spectroscopy, Near-Infrared/methods
Chemical Substances	Flavones ; flavone (S2V45N7G3B)
Language	English
Publishing date	2017-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules22101730
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