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  1. Article: Emotional Distress During the COVID-19 Pandemic: Psycho-Oncology Perspective.

    Bergerot, Paulo Gustavo / Bergerot, Cristiane Decat / Philip, Errol J

    Oncology (Williston Park, N.Y.)

    2020  Volume 34, Issue 7, Page(s) 270–271

    Abstract: Patients with cancer represent a vulnerable population and are at greater risk of developing serious complications as a result of a COVID-19 infection. In response, oncology societies around the world have proposed changes to their standards of care. ... ...

    Abstract Patients with cancer represent a vulnerable population and are at greater risk of developing serious complications as a result of a COVID-19 infection. In response, oncology societies around the world have proposed changes to their standards of care. These changes have helped guide health care providers in prioritizing clinical management of patients with cancer: identifying situations in which urgent intervention is needed and those that can be triaged until the risk of infection has lessened.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Critical Pathways/trends ; Delivery of Health Care/methods ; Delivery of Health Care/organization & administration ; Humans ; Neoplasms/epidemiology ; Neoplasms/psychology ; Organizational Innovation ; Pandemics/prevention & control ; Patient Care Management/organization & administration ; Patient Care Management/trends ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Psycho-Oncology/methods ; Psycho-Oncology/trends ; Psychological Distress ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fear of Cancer Recurrence or Progression: What Is It and What Can We Do About It?

    Bergerot, Cristiane Decat / Philip, Errol J / Bergerot, Paulo Gustavo / Siddiq, Namrah / Tinianov, Stacey / Lustberg, Maryam

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2021  Volume 42, Page(s) 1–10

    Abstract: Patients with cancer face a trajectory marked by emotional and physical distress that can be associated with both diagnosis and treatment. Fear of cancer recurrence or progression has been considered one of the most common unmet needs reported by ... ...

    Abstract Patients with cancer face a trajectory marked by emotional and physical distress that can be associated with both diagnosis and treatment. Fear of cancer recurrence or progression has been considered one of the most common unmet needs reported by patients diagnosed with both localized and metastatic disease. Fear of cancer recurrence or progression has been defined as the "fear, worry, or concern relating to the possibility that cancer will come back or progress." Often overlooked by health care teams, fear of cancer recurrence or progression has been associated with impaired quality of life and psychosocial adjustment, elevated emotional distress, and a range of physical symptoms. Several interventions for fear of cancer recurrence or progression are currently under investigation. Early recognition, support, and validation of feelings associated with fear of cancer recurrence or progression, and appropriate referrals to psychosocial oncology, can be beneficial for many patients. Assessing patients early in their cancer trajectory, and at important milestones, including a change in therapies, at the end of active treatment, and during follow-up visits, can help identify individuals at risk and help individuals engage in supportive programs.
    MeSH term(s) Anxiety ; Fear/psychology ; Humans ; Neoplasm Recurrence, Local/epidemiology ; Quality of Life/psychology
    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_100031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Psycho-Oncology and the Relevance of a Biopsychosocial Screening Program.

    Bergerot, Cristiane D / Bergerot, Paulo Gustavo / Molina, Lorena Nm / Lee, David / Philip, Errol J / Bultz, Barry D

    Oncology (Williston Park, N.Y.)

    2022  Volume 36, Issue 9, Page(s) 552–556

    Abstract: A 40-year-old unmarried Brazilian woman, Ms A, received a diagnosis of papillary renal cell carcinoma (RCC) in February 2020; she underwent nephrectomy the following month. In August, she began to experience generalized pain with subsequent scans ... ...

    Abstract A 40-year-old unmarried Brazilian woman, Ms A, received a diagnosis of papillary renal cell carcinoma (RCC) in February 2020; she underwent nephrectomy the following month. In August, she began to experience generalized pain with subsequent scans revealing metastatic disease to the supraclavicular lymph node, liver, and vagina. In October 2020, Ms A started first-line systemic combination treatment with nivolumab (Opdivo; 3 mg/kg) plus ipilimumab (Yervoy; 1 mg/kg) every 3 weeks for 4 doses, followed by nivolumab (3 mg/kg) every 2 weeks, to be taken for 2 years. In April 2021, follow-up testing revealed a partial response to therapy, and a complete response was evident in August 2021. Ms A was first screened for biopsychosocial distress by the supportive care team in October 2020, and she completed the Edmonton Symptom Assessment System (ESAS) evaluation.During her fourth cycle of treatment in October 2020, the patient was assessed with the ESAS. During her medical visits, Ms A also expressed concern regarding her physical symptoms and admitted frequent self-monitoring for signs of recurrence or progression. Her oncologist prescribed tramadol for pain and the supportive care team recommended increased engagement in physical activity. Upon further assessment, the patient reported a belief that her psychosocial symptoms, worry about recurrence or progression, and time spent self-monitoring were a normal part of her cancer experience.
    MeSH term(s) Adult ; Carcinoma, Renal Cell/drug therapy ; Female ; Humans ; Ipilimumab/therapeutic use ; Kidney Neoplasms/drug therapy ; Nivolumab/therapeutic use ; Pain ; Psycho-Oncology ; Tramadol/therapeutic use
    Chemical Substances Ipilimumab ; Nivolumab (31YO63LBSN) ; Tramadol (39J1LGJ30J)
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    DOI 10.46883/2022.25920972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Systemic therapy and COVID19: Immunotherapy and chemotherapy.

    Gulati, Shuchi / Muddasani, Ramya / Gustavo Bergerot, Paulo / Pal, Sumanta K

    Urologic oncology

    2020  Volume 39, Issue 4, Page(s) 213–220

    Abstract: As the novel severe acute respiratory syndrome coronavirus-2 related pandemic - Corona Virus Disease 2019 (COVID-19) has emerged, decision making in the context of cancer treatment has become more complex. The apprehension of using drugs that could ... ...

    Abstract As the novel severe acute respiratory syndrome coronavirus-2 related pandemic - Corona Virus Disease 2019 (COVID-19) has emerged, decision making in the context of cancer treatment has become more complex. The apprehension of using drugs that could adversely affect infected patients, the risk of not using life-saving treatments and the complexities related to the type of cancer itself, all must be taken into consideration before proceeding with treatment. Data from large registries such as COVID-19 and Cancer Consortium, Thoracic Cancers International COVID-19 Collaboration (TERAVOLT) and NCI COVID-19 in Cancer Patients Study will hopefully provide granularity on the outcomes of patients with cancer who are infected with COVID-19. As these efforts are underway, this review aims to shed light on the management of patients with genitourinary malignancies being treated with systemic therapies while infected with COVID-19.
    MeSH term(s) COVID-19 ; China ; Humans ; Immunotherapy ; Neoplasms/drug therapy ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2020-12-26
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2020.12.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Emotional Distress During the COVID-19 Pandemic: Psycho-Oncology Perspective

    Bergerot, Paulo Gustavo / Bergerot, Cristiane Decat / Philip, Errol J

    Oncology (Williston Park)

    Abstract: Patients with cancer represent a vulnerable population and are at greater risk of developing serious complications as a result of a COVID-19 infection. In response, oncology societies around the world have proposed changes to their standards of care. ... ...

    Abstract Patients with cancer represent a vulnerable population and are at greater risk of developing serious complications as a result of a COVID-19 infection. In response, oncology societies around the world have proposed changes to their standards of care. These changes have helped guide health care providers in prioritizing clinical management of patients with cancer: identifying situations in which urgent intervention is needed and those that can be triaged until the risk of infection has lessened.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #648015
    Database COVID19

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  6. Article ; Online: Anxiety, Depression, and Coping Strategies during Chemotherapy Treatment: A Comparison of Older and Younger Adults with Advanced Cancer in Brazil.

    Bergerot, Cristiane Decat / Philip, Errol J / Bergerot, Paulo Gustavo / Razavi, Marianne / Lee, David / Clark, Karen Lynn / Loscalzo, Matthew / Pal, Sumanta Kumar / Dale, William

    Cancer investigation

    2023  Volume 41, Issue 9, Page(s) 781–788

    Abstract: We sought to examine differences in anxiety, depression and coping strategies among younger (<64-year old) and older (≥65-year old) patients. Patients were assessed at baseline (T1), mid-point (T2) and on the last day of treatment (T3) using the Hospital ...

    Abstract We sought to examine differences in anxiety, depression and coping strategies among younger (<64-year old) and older (≥65-year old) patients. Patients were assessed at baseline (T1), mid-point (T2) and on the last day of treatment (T3) using the Hospital Anxiety and Depression Scale and the Ways of Coping. A linear mixed modeling approach was used. The study included 200 patients (gender: 70% women; diagnosis: 30% breast, 22% hematological, 18% gastrointestinal; disease stage: 60% advanced). Older patients who used an emotion-focused coping strategy had a greater decrease in anxiety at T3 compared to those that used problem-focused coping (
    MeSH term(s) Humans ; Adult ; Female ; Middle Aged ; Aged ; Male ; Depression/epidemiology ; Brazil/epidemiology ; Adaptation, Psychological ; Anxiety ; Neoplasms/drug therapy
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2023.2274033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Patient-reported Outcome Measures in Metastatic Urinary Cancers.

    Bergerot, Cristiane Decat / Bergerot, Paulo Gustavo / Philip, Errol J / Pal, Sumanta Kumar

    European urology focus

    2019  Volume 6, Issue 1, Page(s) 26–30

    Abstract: Patient-reported outcome measures (PROMs) have widely been used to assess treatment-related symptoms in clinical trials and provide insight into the patients' perspective during treatment. This mini-review sought to outline the benefits of measuring ... ...

    Abstract Patient-reported outcome measures (PROMs) have widely been used to assess treatment-related symptoms in clinical trials and provide insight into the patients' perspective during treatment. This mini-review sought to outline the benefits of measuring patient-reported outcomes, describe the most common measures used in recent pivotal studies in metastatic urinary cancers, and summarize the main findings published in the last 2 yr. In general, European Organization for Research and Treatment Cancer QLQC30 and Functional Assessment of Cancer Therapy were the most common PROMs used in these trials. PROMs provided important information concerning patients' quality of life and symptom burden during treatment, including insight into how these drugs may be tolerated in real-world clinical circumstances; however, many still do not assess patients' social and emotional experiences. Based on this mini-review, the combination of a symptomatic toxicity scale and validated quality of life measure represents a reliable strategy to assess patient perspectives during treatment. PATIENT SUMMARY: In this mini-review on patient-reported outcomes measures (PROMs), we explored data from recent pivotal studies in metastatic urinary cancer. We found that all recent clinical trials in metastatic urinary cancers assessed patient-reported outcomes, primarily through the use of quality of life measures. We recommend the use of both a symptomatic toxicity scale and a quality of life scale to evaluate PROMs.
    MeSH term(s) Carcinoma, Renal Cell/secondary ; Carcinoma, Renal Cell/therapy ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Male ; Neoplasm Metastasis ; Patient Reported Outcome Measures ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy
    Language English
    Publishing date 2019-03-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2019.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Distress and Quality of Life Among Patients with Advanced Genitourinary Cancers.

    Bergerot, Cristiane Decat / Philip, Errol J / Bergerot, Paulo Gustavo / Pal, Sumanta Kumar

    European urology focus

    2019  Volume 6, Issue 6, Page(s) 1150–1154

    Abstract: Patients with advanced genitourinary cancers face many challenges throughout their disease trajectory, and many will experience clinically relevant psychosocial distress. Certain groups, including female gender, younger age (and older age for suicide), ... ...

    Abstract Patients with advanced genitourinary cancers face many challenges throughout their disease trajectory, and many will experience clinically relevant psychosocial distress. Certain groups, including female gender, younger age (and older age for suicide), unmarried status, and non-clear cell histology, remain at a higher risk, and evidence suggests that those with kidney and bladder cancers may be at an increased risk of suicide. Routine psychosocial screening, with brief validated tools, has the ability to identify patients' unmet needs, assist the health care team in addressing such symptoms, and subsequently improve quality of life, adherence, and clinical outcomes. Effective supportive care modalities are available that address common patient needs in the context of incurable disease (eg, emotional and physical symptoms); however, challenges remain in terms of patient acceptance and access through insurance coverage. As a result, remote home-based interventions have emerged with the potential to mitigate emotional symptom burden and improve disease adjustment. In this study, we highlight studies reporting on the prevalence of psychosocial distress and associated risk factors in advanced genitourinary cancers, and review evidence-based interventions for the management of distress, including distress screening and psychosocial interventions. PATIENT SUMMARY: This mini-review reports the prevalence of psychosocial distress and associated risk factors among patients with advanced kidney, bladder, or prostate cancer. We found that patients with these types of advanced genitourinary cancers are at a great risk of distress, including suicide, with consequent impairments in quality of life. We recommend that a distress screening program be incorporated as the standard of care and that referrals to appropriate psychosocial interventions be available to assist patients in greatest need.
    MeSH term(s) Humans ; Neoplasm Staging ; Psychological Distress ; Quality of Life ; Urogenital Neoplasms/pathology ; Urogenital Neoplasms/psychology
    Language English
    Publishing date 2019-11-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2019.10.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of a Biopsychosocial Screening Program on Clinical and Hospital-Based Outcomes in Cancer.

    Bergerot, Cristiane Decat / Bergerot, Paulo Gustavo / Molina, Lorena Nascimento Manrique / Freitas, Alici Natalia de Souza / do Nascimento, Karla Lucia / Philip, Errol J / Lee, David / Sacchi, Luana Lourenção / Nazario, Jose Lucas Ferreira / Matos Neto, João Nunes / Buso, Marco Murilo / Soto-Perez-De-Celis, Enrique / Florez, Narjust

    JCO oncology practice

    2023  Volume 19, Issue 6, Page(s) e822–e828

    Abstract: Background: The integration of a biopsychosocial screening (BPS) program has been proposed by international agencies to better identify and effectively manage unmet needs among patients with cancer. We sought to evaluate the effect of a BPS program on ... ...

    Abstract Background: The integration of a biopsychosocial screening (BPS) program has been proposed by international agencies to better identify and effectively manage unmet needs among patients with cancer. We sought to evaluate the effect of a BPS program on hospital admissions and length of stay (LOS) among a diverse sample of patients with cancer and receiving treatment in Brazil.
    Methods: A retrospective analysis was performed from March 2020 to December 2021. Eligible patients were diagnosed with cancer and were receiving treatment at a private practice in Brazil. Clinical characteristics, participation in the BPS program, hospital admissions, reason, and LOS in hospital were evaluated. We compared the number of hospital admissions and LOS between groups (participation
    Results: A total of 1,014 patients were included in the analysis. Baseline clinical characteristics were well balanced between groups (n = 459 patients who participated and n = 555 patients who did not). The median age of patients was 63 years. Breast and hematological cancers were the most common types of cancer; 60% were diagnosed at an advanced disease stage. A smaller proportion of patients who participated in the BPS program were hospitalized compared with patients who did not participate (8%
    Conclusion: Engagement in a BPS program was associated with reduced hospital admissions and LOS. This study provides novel insight into the potential broader implications of BPS programs for clinical care systems. Future studies are needed to explore the mechanisms behind such associations.
    MeSH term(s) Humans ; Middle Aged ; Retrospective Studies ; Early Detection of Cancer ; Hospitalization ; Neoplasms ; Hospitals
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.22.00751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Racial and ethnic differences in perceptions of germline or somatic DNA sequencing among patients with advanced prostate, urothelial, or kidney cancer.

    Bergerot, Cristiane Decat / Philip, Errol J / Malhotra, Jasnoor / Bergerot, Paulo Gustavo / Castro, Daniela V / Govindarajan, Ameish / Salgia, Sabrina / Salgia, Meghan / Salgia, Nicholas / Hsu, JoAnn / Meza, Luis / Zengin, Zeynep B / Liu, Sandy / Chehrazi-Raffle, Alex / Tripathi, Abhishek / Dorff, Tanya / Pal, Sumanta

    Journal of genetic counseling

    2023  

    Abstract: We sought to determine racial and ethnic differences in perceptions (quality of communication, expectations, and concerns) of germline or somatic DNA sequencing (genomic profiling). Patients with prostate, urothelial, or kidney cancer were surveyed using ...

    Abstract We sought to determine racial and ethnic differences in perceptions (quality of communication, expectations, and concerns) of germline or somatic DNA sequencing (genomic profiling). Patients with prostate, urothelial, or kidney cancer were surveyed using a questionnaire that assessed previous experience, beliefs, expectations, and concerns regarding genomic profiling. Descriptive statistics and chi-square tests were used to identify factors associated with patients' perceptions of genomic profiling. A total of 150 consecutive patients were enrolled. The majority were male (74%) with a mean age of 68 years old. Most patients underwent somatic testing (54%), 24% undertook germline testing, and 21% undertook both tests. Significant differences were found across racial and/or ethnicity concerning factors that could have influenced patients' decision to pursue genomic profiling, including ability to guide the type of treatment (White: 54.1% vs. other ethnic groups: 43.9%, p = 0.04) and potential to improve treatment response (White: 10.1% vs. other ethnic groups: 22.0%, p = 0.04). Other ethnic group of patients were more concerned about learning that the cancer was less treatable or aggressive (43.8% vs. 27.7%, p = 0.01) and anxious about what would be learnt from genomic profiling (34.4% vs. 21.3, p = 0.01) as compared to White patients. Our findings reinforce the importance of developing culturally tailored education to help patients participate actively in decisions about genomic profiling.
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1117799-8
    ISSN 1573-3599 ; 1059-7700
    ISSN (online) 1573-3599
    ISSN 1059-7700
    DOI 10.1002/jgc4.1786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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