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Book ; Online: Democratic Multiplicity

Tully, James / Cherry, Keith / Forman, Fonna / Morefield, Jeanne / Nichols, Joshua / Ouziel, Pablo / Owen, David / Schmidtke, Oliver / Cherry, Keith

Perceiving, Enacting, and Integrating Democratic Diversity

(Social Sciences)

2022

Series title	Social Sciences
Keywords	political theory ; political philosophy ; comparative politics ; Asian studies
Language	0\|e
Size	1 Online-Ressource
Publisher	Cambridge University Press
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021620016
ISBN	9781009178365 ; 1009178369
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Healthcare staff mental health trajectories during the COVID-19 pandemic: findings from the COVID-19 Staff Wellbeing Survey.

Jordan, Julie-Ann / Shannon, Ciaran / Browne, Dympna / Carroll, Emma / Maguire, Jennifer / Kerrigan, Keith / Hannan, Sinead / McCarthy, Thomas / Tully, Mark A / Mulholland, Ciaran / Dyer, Kevin F W

BJPsych open

2023 Volume 9, Issue 4, Page(s) e112

Abstract: Background: Cross-sectional studies have shown that the COVID-19 pandemic has had a significant impact on the mental health of healthcare staff. However, it is less well understood how working over the long term in successive COVID-19 waves affects ... ...

Abstract	Background: Cross-sectional studies have shown that the COVID-19 pandemic has had a significant impact on the mental health of healthcare staff. However, it is less well understood how working over the long term in successive COVID-19 waves affects staff well-being. Aims: To identify subpopulations within the health and social care staff workforce with differentiated trajectories of mental health symptoms during phases of the COVID-19 pandemic. Method: The COVID-19 Staff Wellbeing Survey assessed health and social care staff well-being within an area of the UK at four time points, separated by 3-month intervals, spanning November 2020 to August 2021. Results: Growth mixture models were performed on the depression, anxiety and post-traumatic stress disorder longitudinal data. Two class solutions provided the best fit for all models. The vast majority of the workforce were best represented by the low-symptom class trajectory, where by symptoms were consistently below the clinical cut-off for moderate-to-severe symptoms. A sizable minority (13-16%) were categorised as being in the high-symptom class, a group who had symptom levels in the moderate-to-severe range throughout the peaks and troughs of the pandemic. In the depression, anxiety and post-traumatic stress disorder models, the high-symptom class perceived communication from their organisation to be less effective than the low-symptom class. Conclusions: This research identified a group of health service staff who reported persistently high mental health symptoms during the pandemic. This group of staff may well have particular needs in terms of the provision of well-being support services.
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2829557-2
ISSN	2056-4724
ISSN	2056-4724
DOI	10.1192/bjo.2023.497
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 Staff Wellbeing Survey: longitudinal survey of psychological well-being among health and social care staff in Northern Ireland during the COVID-19 pandemic.

Jordan, Julie-Ann / Shannon, Ciaran / Browne, Dympna / Carroll, Emma / Maguire, Jennifer / Kerrigan, Keith / Hannan, Sinead / McCarthy, Thomas / Tully, Mark A / Mulholland, Ciaran / Dyer, Kevin F W

BJPsych open

2021 Volume 7, Issue 5, Page(s) e159

Abstract: Background: Throughout the coronavirus disease 2019 (COVID-19) pandemic, health and social care workers have faced unprecedented professional demands, all of which are likely to have placed considerable strain on their psychological well-being.: Aims!# ...

Abstract	Background: Throughout the coronavirus disease 2019 (COVID-19) pandemic, health and social care workers have faced unprecedented professional demands, all of which are likely to have placed considerable strain on their psychological well-being. Aims: To measure the national prevalence of mental health symptoms within healthcare staff, and identify individual and organisational predictors of well-being. Method: The COVID-19 Staff Wellbeing Survey is a longitudinal online survey of psychological well-being among health and social care staff in Northern Ireland. The survey included four time points separated by 3-month intervals; time 1 (November 2020; Results: At time 1 and 2, a high proportion of staff reported moderate-to-severe symptoms of depression (30-36%), anxiety (26-27%), post-traumatic stress (30-32%) and insomnia (27-28%); overall, significance tests and effect size data suggested psychological well-being was generally stable between November 2020 and February 2021 for health and social care staff. Multiple linear regression models indicated that perceptions of less effective communication within their organisation predicted greater levels of anxiety, depression, post-traumatic stress and insomnia. Conclusions: This study highlights the need to offer psychological support to all health and social care staff, and to communicate with staff regularly, frequently and clearly regarding COVID-19 to help protect staff psychological well-being.
Language	English
Publishing date	2021-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2829557-2
ISSN	2056-4724
ISSN	2056-4724
DOI	10.1192/bjo.2021.988
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Article ; Online: Emotional enhancement of memory: how norepinephrine enables synaptic plasticity.

Tully, Keith / Bolshakov, Vadim Y

Molecular brain

2010 Volume 3, Page(s) 15

Abstract: Changes in synaptic strength are believed to underlie learning and memory. We explore the idea that norepinephrine is an essential modulator of memory through its ability to regulate synaptic mechanisms. Emotional arousal leads to activation of the locus ...

Abstract	Changes in synaptic strength are believed to underlie learning and memory. We explore the idea that norepinephrine is an essential modulator of memory through its ability to regulate synaptic mechanisms. Emotional arousal leads to activation of the locus coeruleus with the subsequent release of norepineprine in the brain, resulting in the enhancement of memory. Norepinephrine activates both pre- and post-synaptic adrenergic receptors at central synapses with different functional outcomes, depending on the expression pattern of these receptors in specific neural circuitries underlying distinct behavioral processes. We review the evidence for noradrenergic modulation of synaptic plasticity with consideration of how this may contribute to the mechanisms of learning and memory.
MeSH term(s)	Animals ; Emotions/physiology ; Hippocampus/physiology ; Learning/physiology ; Memory/physiology ; Neuronal Plasticity/physiology ; Norepinephrine/metabolism ; Second Messenger Systems/physiology ; Synaptic Transmission/physiology ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	gamma-Aminobutyric Acid (56-12-2) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2010-05-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2436057-0
ISSN	1756-6606 ; 1756-6606
ISSN (online)	1756-6606
ISSN	1756-6606
DOI	10.1186/1756-6606-3-15
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Article ; Online: Emotional enhancement of memory

Tully Keith / Bolshakov Vadim Y

Molecular Brain, Vol 3, Iss 1, p

how norepinephrine enables synaptic plasticity

2010 Volume 15

Abstract: Abstract Changes in synaptic strength are believed to underlie learning and memory. We explore the idea that norepinephrine is an essential modulator of memory through its ability to regulate synaptic mechanisms. Emotional arousal leads to activation of ... ...

Abstract	Abstract Changes in synaptic strength are believed to underlie learning and memory. We explore the idea that norepinephrine is an essential modulator of memory through its ability to regulate synaptic mechanisms. Emotional arousal leads to activation of the locus coeruleus with the subsequent release of norepineprine in the brain, resulting in the enhancement of memory. Norepinephrine activates both pre- and post-synaptic adrenergic receptors at central synapses with different functional outcomes, depending on the expression pattern of these receptors in specific neural circuitries underlying distinct behavioral processes. We review the evidence for noradrenergic modulation of synaptic plasticity with consideration of how this may contribute to the mechanisms of learning and memory.
Keywords	Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	612
Language	English
Publishing date	2010-05-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Distinct intracellular calcium profiles following influx through N- versus L-type calcium channels: role of Ca2+-induced Ca2+ release.

Tully, Keith / Treistman, Steven N

Journal of neurophysiology

2004 Volume 92, Issue 1, Page(s) 135–143

Abstract: Selective activation of neuronal functions by Ca(2+) is determined by the kinetic profile of the intracellular calcium ([Ca(2+)](i)) signal in addition to its amplitude. Concurrent electrophysiology and ratiometric calcium imaging were used to measure ... ...

Abstract	Selective activation of neuronal functions by Ca(2+) is determined by the kinetic profile of the intracellular calcium ([Ca(2+)](i)) signal in addition to its amplitude. Concurrent electrophysiology and ratiometric calcium imaging were used to measure transmembrane Ca(2+) current and the resulting rise and decay of [Ca(2+)](i) in differentiated pheochromocytoma (PC12) cells. We show that equal amounts of Ca(2+) entering through N-type and L-type voltage-gated Ca(2+) channels result in significantly different [Ca(2+)](i) temporal profiles. When the contribution of N-type channels was reduced by omega-conotoxin MVIIA treatment, a faster [Ca(2+)](i) decay was observed. Conversely, when the contribution of L-type channels was reduced by nifedipine treatment, [Ca(2+)](i) decay was slower. Potentiating L-type current with BayK8644, or inactivating N-type channels by shifting the holding potential to -40 mV, both resulted in a more rapid decay of [Ca(2+)](i). Channel-specific differences in [Ca(2+)](i) decay rates were abolished by depleting intracellular Ca(2+) stores with thapsigargin or by blocking ryanodine receptors with ryanodine, suggesting the involvement of Ca(2+)-induced Ca(2+) release (CICR). Further support for involvement of CICR is provided by the demonstration that caffeine slowed [Ca(2+)](i) decay while ryanodine at high concentrations increased the rate of [Ca(2+)](i) decay. We conclude that Ca(2+) entering through N-type channels is amplified by ryanodine receptor mediated CICR. Channel-specific activation of CICR provides a mechanism whereby the kinetics of intracellular Ca(2+) leaves a fingerprint of the route of entry, potentially encoding the selective activation of a subset of Ca(2+)-sensitive processes within the neuron.
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium/pharmacology ; Calcium Channel Blockers/pharmacology ; Calcium Channels, L-Type/metabolism ; Calcium Channels, L-Type/secretion ; Calcium Channels, N-Type/metabolism ; Calcium Channels, N-Type/secretion ; Calcium Signaling/drug effects ; Calcium Signaling/physiology ; Intracellular Fluid/drug effects ; Intracellular Fluid/metabolism ; Intracellular Fluid/secretion ; PC12 Cells ; Rats
Chemical Substances	Calcium Channel Blockers ; Calcium Channels, L-Type ; Calcium Channels, N-Type ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2004-07
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.01004.2003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Keeping in check painful synapses in central amygdala.

Tully, Keith / Li, Yan / Bolshakov, Vadim Y

Neuron

2007 Volume 56, Issue 5, Page(s) 757–759

Abstract: Glutamatergic projections from the parabrachial nucleus to the central amygdala are implicated in pain transmission. In this issue of Neuron, Delaney et al. identify a new form of adrenergic modulation at these synapses, demonstrating that noradrenaline- ... ...

Abstract	Glutamatergic projections from the parabrachial nucleus to the central amygdala are implicated in pain transmission. In this issue of Neuron, Delaney et al. identify a new form of adrenergic modulation at these synapses, demonstrating that noradrenaline-induced suppression of glutamate release is mediated by a decrease in the number of sites of synaptic transmission without changes in probability of release.
MeSH term(s)	Adrenergic alpha-Agonists/pharmacology ; Amygdala/cytology ; Amygdala/physiopathology ; Animals ; Emotions/physiology ; Glutamic Acid/physiology ; Humans ; Nerve Fibers/physiology ; Neural Pathways/physiology ; Neurotransmitter Agents/physiology ; Norepinephrine/pharmacology ; Pain/physiopathology ; Pain/psychology ; Synapses/physiology ; Synaptic Transmission/drug effects
Chemical Substances	Adrenergic alpha-Agonists ; Neurotransmitter Agents ; Glutamic Acid (3KX376GY7L) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2007-12-06
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2007.11.011
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Article: Intermittent bradyarrhythmia in a Hispaniolan Amazon parrot (Amazona ventralis).

Rembert, Melanie S / Smith, Julie A / Strickland, Keith N / Tully, Thomas N

Journal of avian medicine and surgery

2008 Volume 22, Issue 1, Page(s) 31–40

Abstract: A clinically normal 2-year-old Hispaniolan Amazon parrot (Amazona ventralis) was found to have periodic second-degree atrioventricular (AV) block with variable nodal conductions while anesthetized with isoflurane during a thermal-support research project. ...

Abstract	A clinically normal 2-year-old Hispaniolan Amazon parrot (Amazona ventralis) was found to have periodic second-degree atrioventricular (AV) block with variable nodal conductions while anesthetized with isoflurane during a thermal-support research project. Arrhythmias were observed on 5 successive weekly electrocardiograms. A complete cardiac evaluation, including a diagnostic electrocardiogram, revealed intermittent bradyarrhythmias ranging from a 2:1 to a 7:1 second-degree AV block, with concurrent hypotensive episodes during the nodal blocks. Results of a complete blood cell count, plasma biochemical profile, blood gas analysis, and atropine-response test, as well as radiography and auscultation, revealed no obvious cause for the arrhythmias. Echocardiography demonstrated cardiac wall thickness, chamber size, and systolic function similar to other psittacine birds. On return to the colony, the parrot continued to be outwardly asymptomatic despite the dramatic conduction disturbances. Although cardiac arrhythmias, including second-degree AV block, have been widely reported in birds, the wide variation of nodal conductions, the intermittent nature, and an arrhythmia with a 7:1 second-degree AV block that spontaneously reverts to normal as seen in this case have not been well documented in parrots.
MeSH term(s)	Amazona ; Animals ; Bird Diseases/diagnosis ; Bird Diseases/diagnostic imaging ; Bird Diseases/physiopathology ; Bradycardia/diagnosis ; Bradycardia/veterinary ; Diagnosis, Differential ; Echocardiography/veterinary ; Electrocardiography/veterinary
Language	English
Publishing date	2008-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2174190-6
ISSN	1938-2871 ; 1082-6742
ISSN (online)	1938-2871
ISSN	1082-6742
DOI	10.1647/2006-0248.1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pre-operative modification of dietary glycemic index improves pre but not post-operative indices of insulin resistance in patients undergoing coronary artery bypass graft surgery.

Tully, Victoria / Wolever, Thomas M S / Darling, Pauline / Errett, Lee / Keith, Mary E

Journal of the American College of Nutrition

2008 Volume 27, Issue 1, Page(s) 168–176

Abstract: Background: Improving insulin sensitivity in coronary artery bypass grafting (CABG) patients may translate into improved glycemic control and postoperative outcomes. The implementation of a low glycemic index (LGI) diet in the pre-operative period may ... ...

Abstract	Background: Improving insulin sensitivity in coronary artery bypass grafting (CABG) patients may translate into improved glycemic control and postoperative outcomes. The implementation of a low glycemic index (LGI) diet in the pre-operative period may improve insulin sensitivity and subsequently impact on the development of post-operative insulin resistance. The aim of this study was to determine whether a short term LGI diet would reduce postoperative insulin resistance. Methods: Eleven non-diabetic patients referred for elective CABG surgery were randomized to consume either a high glycemic index (HGI)(5) or LGI (6) diet for three weeks prior to their surgery. Outcomes, including insulin sensitivity (SITT, HOMA), were measured at baseline, preoperatively and postoperatively. Results: Substitution of HGI or LGI foods resulted in an average 8.6 unit increase, or 11.0 unit decrease, respectively, in glycemic index. Insulin sensitivity (HOMA) improved significantly in the LGI group preoperatively compared to the HGI group (p = 0.018). Insulin sensitivity (SITT) was significantly reduced postoperatively in both groups, but no significant difference was found between groups. There was a trend in the LGI group towards improved glycemic control which warrants further investigation. Conclusion: A preoperative LGI diet presents a non-invasive cardio-protective opportunity warranting clinical trial.
MeSH term(s)	Aged ; Area Under Curve ; C-Reactive Protein/metabolism ; Coronary Artery Bypass ; Coronary Disease/metabolism ; Coronary Disease/surgery ; Dietary Carbohydrates/administration & dosage ; Dietary Carbohydrates/classification ; Dietary Carbohydrates/metabolism ; Glycemic Index ; Humans ; Insulin/metabolism ; Insulin Resistance ; Interleukin-6/blood ; Male ; Middle Aged ; Postoperative Period ; Preoperative Care/methods ; Prospective Studies ; Serum Amyloid A Protein/metabolism ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Dietary Carbohydrates ; Insulin ; Interleukin-6 ; Serum Amyloid A Protein ; Tumor Necrosis Factor-alpha ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2008-04-30
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	603204-7
ISSN	1541-1087 ; 0731-5724
ISSN (online)	1541-1087
ISSN	0731-5724
DOI	10.1080/07315724.2008.10719688
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Article ; Online: Strategies to enable large-scale proteomics for reproducible research.

Poulos, Rebecca C / Hains, Peter G / Shah, Rohan / Lucas, Natasha / Xavier, Dylan / Manda, Srikanth S / Anees, Asim / Koh, Jennifer M S / Mahboob, Sadia / Wittman, Max / Williams, Steven G / Sykes, Erin K / Hecker, Michael / Dausmann, Michael / Wouters, Merridee A / Ashman, Keith / Yang, Jean / Wild, Peter J / deFazio, Anna /

Balleine, Rosemary L / Tully, Brett / Aebersold, Ruedi / Speed, Terence P / Liu, Yansheng / Reddel, Roger R / Robinson, Phillip J / Zhong, Qing

Nature communications

2020 Volume 11, Issue 1, Page(s) 3793

Abstract: Reproducible research is the bedrock of experimental science. To enable the deployment of large-scale proteomics, we assess the reproducibility of mass spectrometry (MS) over time and across instruments and develop computational methods for improving ... ...

Abstract	Reproducible research is the bedrock of experimental science. To enable the deployment of large-scale proteomics, we assess the reproducibility of mass spectrometry (MS) over time and across instruments and develop computational methods for improving quantitative accuracy. We perform 1560 data independent acquisition (DIA)-MS runs of eight samples containing known proportions of ovarian and prostate cancer tissue and yeast, or control HEK293T cells. Replicates are run on six mass spectrometers operating continuously with varying maintenance schedules over four months, interspersed with ~5000 other runs. We utilise negative controls and replicates to remove unwanted variation and enhance biological signal, outperforming existing methods. We also design a method for reducing missing values. Integrating these computational modules into a pipeline (ProNorM), we mitigate variation among instruments over time and accurately predict tissue proportions. We demonstrate how to improve the quantitative analysis of large-scale DIA-MS data, providing a pathway toward clinical proteomics.
MeSH term(s)	Biomarkers, Tumor/analysis ; Cell Line, Tumor ; Female ; HEK293 Cells ; Humans ; Male ; Mass Spectrometry/methods ; Ovarian Neoplasms ; Prostatic Neoplasms ; Proteome/analysis ; Proteomics/methods ; Reproducibility of Results ; Saccharomyces cerevisiae
Chemical Substances	Biomarkers, Tumor ; Proteome
Language	English
Publishing date	2020-07-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-17641-3
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